| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francisco José Sanz, Cristina Solana-Manrique, Verónica Muñoz-Soriano, Pablo Calap-Quintana, María Dolores Moltó, Nuria Parici. Identification of potential therapeutic compounds for Parkinson's disease using Drosophila and human cell models. Free radical biology & medicine. vol 108. 2018-04-09. PMID:28455141. |
it is caused by a loss of dopaminergic neurons in the substantia nigra pars compacta, leading to a decrease in dopamine levels in the striatum and thus producing movement impairment. |
2018-04-09 |
2023-08-13 |
human |
| Andrea Herrera-Soto, Gabriela Díaz-Veliz, Sergio Mora, Patricia Muñoz, Pablo Henny, Harry W M Steinbusch, Juan Segura-Aguila. On the Role of DT-Diaphorase Inhibition in Aminochrome-Induced Neurotoxicity In Vivo. Neurotoxicity research. vol 32. issue 1. 2018-03-27. PMID:28285345. |
however, when administered exogenously into rat striatum, aminochrome is able to produce damage to dopaminergic neurons. |
2018-03-27 |
2023-08-13 |
rat |
| Mari H Savolainen, Katrina Albert, Mikko Airavaara, Timo T Myöhäne. Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activation and shows various phenotypes of Parkinson's disease in young and adult mouse. Experimental brain research. vol 235. issue 7. 2018-03-22. PMID:28439627. |
we found that lactacystin induced a parkinson's disease-like motor phenotype 5-7 days after injection in young and adult mice, and this was associated with widespread neuroinflammation based on glial cell markers, asyn accumulation in substantia nigra, striatal dopamine decrease, and loss of dopaminergic cell bodies in the substantia nigra and terminals in the striatum. |
2018-03-22 |
2023-08-13 |
mouse |
| Daijiro Yanagisawa, Keisuke Oda, Masatoshi Inden, Shigehiro Morikawa, Toshiro Inubushi, Takashi Taniguchi, Masanori Hijioka, Yoshihisa Kitamura, Ikuo Tooyam. Fluorodopa is a Promising Fluorine-19 MRI Probe for Evaluating Striatal Dopaminergic Function in a Rat Model of Parkinson's Disease. Journal of neuroscience research. vol 95. issue 7. 2018-03-12. PMID:27792255. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra projecting to the striatum. |
2018-03-12 |
2023-08-13 |
rat |
| Alberto J Rico, Iria G Dopeso-Reyes, Eva Martínez-Pinilla, Diego Sucunza, Diego Pignataro, Elvira Roda, David Marín-Ramos, José L Labandeira-García, Susan R George, Rafael Franco, José L Lancieg. Neurochemical evidence supporting dopamine D1-D2 receptor heteromers in the striatum of the long-tailed macaque: changes following dopaminergic manipulation. Brain structure & function. vol 222. issue 4. 2018-03-05. PMID:27612857. |
neurochemical evidence supporting dopamine d1-d2 receptor heteromers in the striatum of the long-tailed macaque: changes following dopaminergic manipulation. |
2018-03-05 |
2023-08-13 |
monkey |
| Elena A Kozina, Aleksandr R Kim, Anna Y Kurina, Michael V Ugrumo. Cooperative synthesis of dopamine by non-dopaminergic neurons as a compensatory mechanism in the striatum of mice with MPTP-induced Parkinsonism. Neurobiology of disease. vol 98. 2018-02-27. PMID:27940203. |
using a combination of techniques: retrograde tracing, qpcr and immunolabeling for th, aadc and map2, we showed that the striatum of mice with normal and degraded dopaminergic system comprises of monoenzymatic th- and aadc-containing neurons. |
2018-02-27 |
2023-08-13 |
mouse |
| Elena A Kozina, Aleksandr R Kim, Anna Y Kurina, Michael V Ugrumo. Cooperative synthesis of dopamine by non-dopaminergic neurons as a compensatory mechanism in the striatum of mice with MPTP-induced Parkinsonism. Neurobiology of disease. vol 98. 2018-02-27. PMID:27940203. |
furthermore, we demonstrated that the proportion of da produced through cooperative synthesis in the striatum of mptp-treated mice increases as the degradation of dopaminergic system proceeds. |
2018-02-27 |
2023-08-13 |
mouse |
| Elena A Kozina, Aleksandr R Kim, Anna Y Kurina, Michael V Ugrumo. Cooperative synthesis of dopamine by non-dopaminergic neurons as a compensatory mechanism in the striatum of mice with MPTP-induced Parkinsonism. Neurobiology of disease. vol 98. 2018-02-27. PMID:27940203. |
an increase in the proportion of cooperative synthesis of da alongside degradation of the dopaminergic system is also proved by an increase of both th gene expression and the number of th-immunoreactive structures in the striatum. |
2018-02-27 |
2023-08-13 |
mouse |
| Deniz Kirik, Erik Cederfjäll, Glenda Halliday, Åsa Petersé. Gene therapy for Parkinson's disease: Disease modification by GDNF family of ligands. Neurobiology of disease. vol 97. issue Pt B. 2018-02-12. PMID:27616425. |
several clinical trials have been performed to test the capacity of glial-cell line derived neurotrophic factor and neurturin to rescue degenerating dopaminergic neurons in the substantia nigra and their axon terminals in the striatum by delivery of these neurotrophic factors either as purified protein or by means of viral vector mediated gene delivery to the brain. |
2018-02-12 |
2023-08-13 |
Not clear |
| Bing Li, Rui Chen, Ling Chen, Pingming Qiu, Xiuyun Ai, Enping Huang, Weiye Huang, Chuanxiang Chen, Chao Liu, Zhoumeng Lin, Wei-Bing Xie, Huijun Wan. Effects of DDIT4 in Methamphetamine-Induced Autophagy and Apoptosis in Dopaminergic Neurons. Molecular neurobiology. vol 54. issue 3. 2018-02-07. PMID:26873849. |
to test the hypothesis, we determined changes of ddit4 protein expression and the level of autophagy in rat catecholaminergic pc12 cells and human dopaminergic sh-sy5y cells, and in the hippocampus, prefrontal cortex, and striatum of sprague dawley rats exposed to meth. |
2018-02-07 |
2023-08-13 |
human |
| Annika H Runegaard, Kathrine L Jensen, Ciarán M Fitzpatrick, Ditte Dencker, Pia Weikop, Ulrik Gether, Mattias Rickha. Preserved dopaminergic homeostasis and dopamine-related behaviour in hemizygous TH-Cre mice. The European journal of neuroscience. vol 45. issue 1. 2018-02-01. PMID:27453291. |
our data show that th-cre mice display preserved dopaminergic homeostasis with unaltered levels of th and dopamine as well as unaffected dopamine turnover in striatum. |
2018-02-01 |
2023-08-13 |
mouse |
| Marcia Spoelder, Peter Hesseling, Matthew Styles, Annemarie M Baars, José G Lozeman-van 't Klooster, Heidi M B Lesscher, Louk J M J Vanderschure. Dopaminergic neurotransmission in ventral and dorsal striatum differentially modulates alcohol reinforcement. The European journal of neuroscience. vol 45. issue 1. 2018-02-01. PMID:27521051. |
dopaminergic neurotransmission in the striatum has been widely implicated in the reinforcing properties of substances of abuse. |
2018-02-01 |
2023-08-13 |
rat |
| Marcia Spoelder, Peter Hesseling, Matthew Styles, Annemarie M Baars, José G Lozeman-van 't Klooster, Heidi M B Lesscher, Louk J M J Vanderschure. Dopaminergic neurotransmission in ventral and dorsal striatum differentially modulates alcohol reinforcement. The European journal of neuroscience. vol 45. issue 1. 2018-02-01. PMID:27521051. |
in conclusion, dopaminergic neurotransmission acts in concert in subregions of the striatum to modulate different aspects of alcohol-directed behaviour. |
2018-02-01 |
2023-08-13 |
rat |
| Erika Nallely Orendain-Jaime, Jorge Manuel Ortega-Ibarra, Silvia Josefina López-Pére. Evidence of sexual dimorphism in D1 and D2 dopaminergic receptors expression in frontal cortex and striatum of young rats. Neurochemistry international. vol 100. 2018-01-31. PMID:27600160. |
evidence of sexual dimorphism in d1 and d2 dopaminergic receptors expression in frontal cortex and striatum of young rats. |
2018-01-31 |
2023-08-13 |
rat |
| Eitan Schechtman, Maria Imelda Noblejas, Aviv D Mizrahi, Omer Dauber, Hagai Bergma. Pallidal spiking activity reflects learning dynamics and predicts performance. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 41. 2018-01-30. PMID:27671661. |
most models of learning and decision making in the bg focus on the roles of the striatum and its dopaminergic inputs, commonly overlooking the complexities and interactions of bg downstream nuclei. |
2018-01-30 |
2023-08-13 |
monkey |
| Pablo Garrido-Gil, Ana I Rodriguez-Perez, Patricia Fernandez-Rodriguez, Jose L Lanciego, Jose L Labandeira-Garci. Expression of angiotensinogen and receptors for angiotensin and prorenin in the rat and monkey striatal neurons and glial cells. Brain structure & function. vol 222. issue 6. 2018-01-30. PMID:28161727. |
in the striatum, it is not clear whether angiotensin receptors are located in dopaminergic terminals, glial cells and/or the projection neurons. |
2018-01-30 |
2023-08-13 |
rat |
| Hyeonseok S Jeong, Sang-Rae Lee, Jieun E Kim, In Kyoon Lyoo, Sujung Yoon, Eun Namgung, Kyu-Tae Chang, Bom Sahn Kim, Sejung Yang, Jooyeon J Im, Saerom Jeon, Ilhyang Kang, Jiyoung Ma, Yong-An Chung, Soo Mee Li. Brain structural changes in cynomolgus monkeys administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A longitudinal voxel-based morphometry and diffusion tensor imaging study. PloS one. vol 13. issue 1. 2018-01-29. PMID:29320500. |
gm volume initially increased after the mptp injection and gradually decreased in the striatum, midbrain, and other dopaminergic areas. |
2018-01-29 |
2023-08-13 |
monkey |
| Marta Vicente-Rodríguez, Loreto Rojo Gonzalez, Esther Gramage, Rosalía Fernández-Calle, Ying Chen, Carmen Pérez-García, Marcel Ferrer-Alcón, María Uribarri, Alexis Bailey, Gonzalo Herradó. Pleiotrophin overexpression regulates amphetamine-induced reward and striatal dopaminergic denervation without changing the expression of dopamine D1 and D2 receptors: Implications for neuroinflammation. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 11. 2018-01-26. PMID:27642078. |
amphetamine caused an enhanced loss of striatal dopaminergic terminals, together with a highly significant aggravation of amphetamine-induced increase in the number of gfap-positive astrocytes, in the striatum of ptn-tg mice compared to wt mice. |
2018-01-26 |
2023-08-13 |
mouse |
| Yu Yeon Jung, Nikita Katila, Sabita Neupane, Sina Shadfar, Uttam Ojha, Sunil Bhurtel, Sunil Srivastav, Dong Ju Son, Pil-Hoon Park, Do Young Yoon, Jin Tae Hong, Dong-Young Cho. Enhanced dopaminergic neurotoxicity mediated by MPTP in IL-32β transgenic mice. Neurochemistry international. vol 102. 2018-01-25. PMID:27956238. |
immunohistochemistry showed that overexpression of il-32β significantly increased mptp-mediated loss of dopaminergic neurons in the substantia nigra and deletion of tyrosine hydroxylase-positive fibers in the striatum. |
2018-01-25 |
2023-08-13 |
mouse |
| Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita, Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar, Jun Takahash. Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model. Nature. vol 548. issue 7669. 2018-01-25. PMID:28858313. |
histological studies showed that the mature dopaminergic neurons extended dense neurites into the host striatum; this effect was consistent regardless of whether the cells were derived from patients with pd or from healthy individuals. |
2018-01-25 |
2023-08-13 |
human |