| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas G McWilliams, Laura Howard, Sean Wyatt, Alun M Davie. TNF superfamily member APRIL enhances midbrain dopaminergic axon growth and contributes to the nigrostriatal projection in vivo. Experimental neurology. vol 298. issue Pt A. 2017-11-06. PMID:28911883. |
in vivo, there was a significant reduction in the density of midbrain dopaminergic projections to the striatum in april-/- embryos compared with wild type littermates at e14. |
2017-11-06 |
2023-08-13 |
mouse |
| Kyung Moon Lee, Yujeong Lee, Hye Jeong Chun, Ah Hyun Kim, Ju Yeon Kim, Joo Yeon Lee, Akihito Ishigami, Jaewon Le. Neuroprotective and anti-inflammatory effects of morin in a murine model of Parkinson's disease. Journal of neuroscience research. vol 94. issue 10. 2017-11-03. PMID:27265894. |
in the mouse model, morin pretreatment ameliorated motor dysfunction, protected against dopaminergic neuronal losses in sn and striatum, and alleviated mptp-induced astrocyte activation. |
2017-11-03 |
2023-08-13 |
mouse |
| Ingrid Morales, Alberto Sanchez, Clara Rodriguez-Sabate, Manuel Rodrigue. Striatal astrocytes engulf dopaminergic debris in Parkinson's disease: A study in an animal model. PloS one. vol 12. issue 10. 2017-10-27. PMID:29028815. |
rats were injected in the lateral ventricles with 6-hydroxydopamine (25μg), inducing a dopaminergic denervation of the striatum not accompanied by non-selective tissue damage. |
2017-10-27 |
2023-08-13 |
rat |
| Anja Drinkut, Karsten Tillack, Durga P Meka, Jorg B Schulz, Sebastian Kügler, Edgar R Krame. Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model. Cell death & disease. vol 7. issue 9. 2017-10-25. PMID:27607574. |
to address this question we overexpressed gdnf in the striatum of mice deficient for ret in dopaminergic neurons and subsequently challenged these mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
2017-10-25 |
2023-08-13 |
mouse |
| Haisong Jiang, Sung-Ung Kang, Shuran Zhang, Senthilkumar Karuppagounder, Jinchong Xu, Yong-Kyu Lee, Bong-Gu Kang, Yunjong Lee, Jianmin Zhang, Olga Pletnikova, Juan C Troncoso, Shelia Pirooznia, Shaida A Andrabi, Valina L Dawson, Ted M Dawso. Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons. eNeuro. vol 3. issue 4. 2017-10-25. PMID:27622213. |
adult conditional pgc-1α knock-out mice show a significant loss of dopaminergic neurons that is accompanied by a reduction of dopamine in the striatum. |
2017-10-25 |
2023-08-13 |
mouse |
| Pierre Berthet, Mikael Lindahl, Philip J Tully, Jeanette Hellgren-Kotaleski, Anders Lansne. Functional Relevance of Different Basal Ganglia Pathways Investigated in a Spiking Model with Reward Dependent Plasticity. Frontiers in neural circuits. vol 10. 2017-10-23. PMID:27493625. |
the architecture of the network features the two pathways commonly described in bg, the direct (denoted d1) and the indirect (denoted d2) pathway, as well as a loop involving striatum and the dopaminergic system. |
2017-10-23 |
2023-08-13 |
Not clear |
| Shida Zhou, Xinxing Du, Junxia Xie, Jun Wan. Interleukin-6 regulates iron-related proteins through c-Jun N-terminal kinase activation in BV2 microglial cell lines. PloS one. vol 12. issue 7. 2017-10-06. PMID:28672025. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn) and subsequent da depletion in the striatum. |
2017-10-06 |
2023-08-13 |
Not clear |
| Dominic Thibault, Nicolas Giguère, Fabien Loustalot, Marie-Josée Bourque, Charles Ducrot, Salah El Mestikawy, Louis-Éric Trudea. Homeostatic regulation of excitatory synapses on striatal medium spiny neurons expressing the D2 dopamine receptor. Brain structure & function. vol 221. issue 4. 2017-10-03. PMID:25782435. |
the striatum is also innervated by dopaminergic (daergic) terminals, some of which release glutamate as a co-transmitter. |
2017-10-03 |
2023-08-13 |
Not clear |
| Edward Rockenstein, Jennifer Clarke, Catherine Viel, Nicholas Panarello, Christopher M Treleaven, Changyoun Kim, Brian Spencer, Anthony Adame, Hyejung Park, James C Dodge, Seng H Cheng, Lamya S Shihabuddin, E Masliah, S Pablo Sard. Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson's disease. Human molecular genetics. vol 25. issue 13. 2017-09-21. PMID:27126635. |
adeno-associated virus-mediated expression of glucocerebrosidase in the thy1-snca mouse striatum led to decrease in the levels of the proteinase k-resistant fraction of α-synuclein, amelioration of behavioral aberrations and protection from loss of striatal dopaminergic markers. |
2017-09-21 |
2023-08-13 |
mouse |
| Daniel Komnig, Silke Imgrund, Arno Reich, Stefan Gründer, Björn H Falkenburge. ASIC1a Deficient Mice Show Unaltered Neurodegeneration in the Subacute MPTP Model of Parkinson Disease. PloS one. vol 11. issue 11. 2017-09-18. PMID:27820820. |
we determined the number of dopaminergic neurons in the substantia nigra, assayed by stereological counting 14 days after the last mptp injection, the number of nissl positive neurons in the substantia nigra, and the concentration of catecholamines in the striatum. |
2017-09-18 |
2023-08-13 |
mouse |
| Jill B Becke. Sex differences in addiction. Dialogues in clinical neuroscience. vol 18. issue 4. 2017-09-15. PMID:28179811. |
estradiol treatment of ovariectomized female rats enhances stimulated dopamine release in the dorsolateral striatum, but not in the nucleus accumbens, resulting in a sex difference in the balance between these two dopaminergic projections. |
2017-09-15 |
2023-08-13 |
rat |
| Anouk Schrantee, Bart Ferguson, Diederick Stoffers, Jan Booij, Serge Rombouts, Liesbeth Renema. Effects of dexamphetamine-induced dopamine release on resting-state network connectivity in recreational amphetamine users and healthy controls. Brain imaging and behavior. vol 10. issue 2. 2017-09-14. PMID:26149196. |
our findings thus support the use of ica-based resting-state functional connectivity as a tool to investigate acute, but not chronic, alterations induced by damph on dopaminergic processing in the striatum. |
2017-09-14 |
2023-08-13 |
human |
| Wei Wei, Shengyuan Ding, Fu-Ming Zho. Dopaminergic treatment weakens medium spiny neuron collateral inhibition in the parkinsonian striatum. Journal of neurophysiology. vol 117. issue 3. 2017-09-13. PMID:27927785. |
dopaminergic treatment weakens medium spiny neuron collateral inhibition in the parkinsonian striatum. |
2017-09-13 |
2023-08-13 |
mouse |
| Wei Wei, Shengyuan Ding, Fu-Ming Zho. Dopaminergic treatment weakens medium spiny neuron collateral inhibition in the parkinsonian striatum. Journal of neurophysiology. vol 117. issue 3. 2017-09-13. PMID:27927785. |
these results indicate that in the parkinsonian striatum, dopaminergic treatment can presynaptically weaken the d2-msn→d2-msn collateral inhibition and disinhibit the surrounding d2-msns, whereas the d1-msn→d1-msn collateral inhibition is weakened by the loss of the presynaptic d1 receptor facilitation, disinhibiting the surrounding d1-msns. |
2017-09-13 |
2023-08-13 |
mouse |
| Wei Wei, Shengyuan Ding, Fu-Ming Zho. Dopaminergic treatment weakens medium spiny neuron collateral inhibition in the parkinsonian striatum. Journal of neurophysiology. vol 117. issue 3. 2017-09-13. PMID:27927785. |
together, these newly discovered effects can disrupt the msn circuits in the parkinsonian striatum and may contribute to dopaminergic treatment-induced aberrant motor and nonmotor behaviors in pd. |
2017-09-13 |
2023-08-13 |
mouse |
| Kirsten R Müller-Vahl, Gesa Loeber, Alexandra Kotsiari, Linda Müller-Engling, Helge Frielin. Gilles de la Tourette syndrome is associated with hypermethylation of the dopamine D2 receptor gene. Journal of psychiatric research. vol 86. 2017-09-12. PMID:27883923. |
in addition, it can be speculated that spontaneous fluctuations of tics may be caused by short-term alterations of methylation levels of dopaminergic genes resulting in dynamic changes of tonic/phasic dopaminergic signaling in the striatum and thalamo-cortical output pathways. |
2017-09-12 |
2023-08-13 |
Not clear |
| Simon R W Stott, Shaista Hayat, Tom Carnwath, Shaady Garas, Jonathan P Sleeman, Roger A Barke. CD24 expression does not affect dopamine neuronal survival in a mouse model of Parkinson's disease. PloS one. vol 12. issue 2. 2017-09-07. PMID:28182766. |
our results indicate that in the absence of cd24, there is a reduction in the protective effects of gdnf on the dopaminergic fibres in the striatum, but no difference in the survival of the cell bodies in the midbrain. |
2017-09-07 |
2023-08-13 |
mouse |
| Prafulla Chandra Tiwari, Rishi Pa. The potential role of neuroinflammation and transcription factors in Parkinson disease. Dialogues in clinical neuroscience. vol 19. issue 1. 2017-09-07. PMID:28566949. |
an increased level of inducible nitric oxide synthase observed in the substantia nigra and striatum of pd patients suggests that both cytokine-and chemokine-induced toxicity and inflammation lead to oxidative stress that contributes to degeneration of dopaminergic neurons and to disease progression. |
2017-09-07 |
2023-08-13 |
Not clear |
| Amina El Ayadi, Michael J Zigmond, Amanda D Smit. IGF-1 protects dopamine neurons against oxidative stress: association with changes in phosphokinases. Experimental brain research. vol 234. issue 7. 2017-09-04. PMID:26894890. |
both concentrations of igf-1 protected tyrosine hydroxylase (th) immunoreactive terminals in striatum at 4 weeks but not at 1 week, indicating that igf-induced restoration of the dopaminergic phenotype occurred over several weeks. |
2017-09-04 |
2023-08-13 |
rat |
| Mary Ann Raghanti, Melissa K Edler, Alexa R Stephenson, Lakaléa J Wilson, William D Hopkins, John J Ely, Joseph M Erwin, Bob Jacobs, Patrick R Hof, Chet C Sherwoo. Human-specific increase of dopaminergic innervation in a striatal region associated with speech and language: A comparative analysis of the primate basal ganglia. The Journal of comparative neurology. vol 524. issue 10. 2017-08-30. PMID:26715195. |
the dopaminergic innervation of the striatum has been implicated in learning processes and in the development of human speech and language. |
2017-08-30 |
2023-08-13 |
mouse |