| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Willyan Franco Hilario, Alice Laschuk Herlinger, Lorena Bianchine Areal, Lívia Silveira de Moraes, Tamara Andrea Alarcon Ferreira, Tassiane Emanuelle Servane Andrade, Cristina Martins-Silva, Rita Gomes Wanderley Pire. Cholinergic and Dopaminergic Alterations in Nigrostriatal Neurons Are Involved in Environmental Enrichment Motor Protection in a Mouse Model of Parkinson's Disease. Journal of molecular neuroscience : MN. vol 60. issue 4. 2017-03-23. PMID:27660217. |
pd pharmacotherapy has been based on dopamine replacement in the striatum with the dopaminergic precursor 3,4-dihydroxyphenylalanine (l-dopa) and/or with dopaminergic agonists, alongside anticholinergic drugs in order to mitigate the motor abnormalities. |
2017-03-23 |
2023-08-13 |
mouse |
| Elżbieta Lorenc-Koci, Anna Czarnecka, Kinga Kamińska, Joanna Knutelska, Małgorzata Zygmunt, Magdalena Dude. Contribution of the nitric oxide donor molsidomine and the antiparkinsonian drug l-DOPA to the modulation of the blood pressure in unilaterally 6-OHDA-lesioned rats. Pharmacological reports : PR. vol 69. issue 1. 2017-03-23. PMID:27764702. |
in parkinson's disease (pd), dopaminergic denervation of the striatum leads to disturbances in the nitrergic system in the basal ganglia. |
2017-03-23 |
2023-08-13 |
rat |
| Jintanaporn Wattanathorn, Chatchada Sutalangk. Novel Food Supplement "CP1" Improves Motor Deficit, Cognitive Function, and Neurodegeneration in Animal Model of Parkinson's Disease. Rejuvenation research. vol 19. issue 4. 2017-03-21. PMID:26414358. |
the memory enhancing effect of cp1 might occur through the improved oxidative stress and the enhanced cholinergic function, whereas the effect to improve motor disorder of cp1 might occur through the enhanced dopaminergic function in striatum by decreasing the degeneration of dopaminergic neurons and the suppression of mao-b. |
2017-03-21 |
2023-08-13 |
rat |
| José-Luis Ríos, María Onteniente, Dolores Picazo, María-Carmen Montesino. Medicinal Plants and Natural Products as Potential Sources for Antiparkinson Drugs. Planta medica. vol 82. issue 11-12. 2017-03-16. PMID:27224274. |
treatments for parkinson's disease aim for improving these motor symptoms by increasing the dopaminergic signal in the striatum with levodopa in combination with enzyme inhibitors or anticholinergic drugs. |
2017-03-16 |
2023-08-13 |
Not clear |
| Adriana Wawer, Ilona Joniec-Maciejak, Anna Sznejder-Pachołek, Joanna Schwenkgrub, Agnieszka Ciesielska, Dagmara Mirowska-Guze. Exogenous α-Synuclein Monomers Alter Dopamine Metabolism in Murine Brain. Neurochemical research. vol 41. issue 8. 2017-03-03. PMID:27161373. |
we have demonstrated that a single injection of asn monomers into the substantia nigra pars compacta or striatum is sufficient to affect dopaminergic neurotransmission in murine nigro-striatal system. |
2017-03-03 |
2023-08-13 |
mouse |
| Jan Luzny, Katerina Ivanov. DatSCAN In Differential Diagnostics of Lewy Body Disease. Archives of Iranian medicine. vol 19. issue 6. 2017-03-02. PMID:27293063. |
datscan showed deficient dopaminergic presynaptic transport in substantia nigra and striatum. |
2017-03-02 |
2023-08-13 |
Not clear |
| Jan Luzny, Katerina Ivanov. DatSCAN In Differential Diagnostics of Lewy Body Disease. Archives of Iranian medicine. vol 19. issue 6. 2017-03-02. PMID:27293063. |
deficient dopaminergic presynaptic transport in substantia nigra and striatum is typical for lewy body disease. |
2017-03-02 |
2023-08-13 |
Not clear |
| Henrik H Hansen, Pia Weikop, Maria D Mikkelsen, Frederik Rode, Jens D Mikkelse. The pan-Kv7 (KCNQ) Channel Opener Retigabine Inhibits Striatal Excitability by Direct Action on Striatal Neurons In Vivo. Basic & clinical pharmacology & toxicology. vol 120. issue 1. 2017-02-08. PMID:27377794. |
the effect of retigabine likely involves the inhibition of the activity in mesencephalic dopaminergic neurons projecting to the striatum, but whether kv7 channels expressed in the striatum may also play a role is not resolved. |
2017-02-08 |
2023-08-13 |
rat |
| Hongjun Xie, Jie W. Silica nanoparticles induce alpha-synuclein induction and aggregation in PC12-cells. Chemico-biological interactions. vol 258. 2017-01-31. PMID:27613482. |
previously, we found that sio2-nps enter the brain and, more specifically, the dopaminergic neurons in the striatum. |
2017-01-31 |
2023-08-13 |
Not clear |
| E R Mingazov, M V Ugrumo. Gene expression of proteins of the vesicle cycle in the striatum and motor cortex under functional failure of nigrostriatal system. Doklady. Biochemistry and biophysics. vol 470. issue 1. 2017-01-25. PMID:27817030. |
degeneration of dopaminergic neurons in the substantia nigra and the decrease in the dopamine level in the striatum lead to dysfunctions of motor behavior. |
2017-01-25 |
2023-08-13 |
Not clear |
| Hanne Schevernels, Klaas Bombeke, Ruth M Krebs, C Nico Boehle. Preparing for (valenced) action: The role of differential effort in the orthogonalized go/no-go task. Psychophysiology. vol 53. issue 2. 2017-01-18. PMID:26481327. |
functional magnetic resonance imaging results from this task showed that typical areas of the "reward network," like the dopaminergic midbrain and the striatum, predominantly encode action rather than valence, displaying enhanced activity when preparing for action (go) compared to inaction (no-go). |
2017-01-18 |
2023-08-13 |
Not clear |
| Katarzyna Kuter, Manuela Kratochwil, Sven-Hendric Marx, Sonja Hartwig, Stephan Lehr, Michiru D Sugawa, Norbert A Denche. Native DIGE proteomic analysis of mitochondria from substantia nigra and striatum during neuronal degeneration and its compensation in an animal model of early Parkinson's disease. Archives of physiology and biochemistry. vol 122. issue 5. 2017-01-17. PMID:27467289. |
selective toxin 6-ohda was applied to kill dopaminergic neurons in substantia nigra and disturb neuronal transmission in striatum. |
2017-01-17 |
2023-08-13 |
Not clear |
| Simon J G Lewis, James M Shin. The Next Step: A Common Neural Mechanism for Freezing of Gait. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 22. issue 1. 2017-01-10. PMID:25398230. |
this cascade may be triggered through dopaminergic depletion in the striatum and over-activity within the subthalamic nucleus. |
2017-01-10 |
2023-08-13 |
Not clear |
| Vito Di Maio, Francesco Ventriglia, Silvia Santill. A model of dopamine regulation of glutamatergic synapse on medium size spiny neurons. Bio Systems. vol 142-143. 2017-01-03. PMID:26957078. |
spiny neurons of striatum receive glutamatergic synapses on dendritic spines on the neck of which project dopaminergic synapses. |
2017-01-03 |
2023-08-13 |
Not clear |
| Hongyoon Choi, Gi Jeong Cheon, Han-Joon Kim, Seung Hong Choi, Yong-Il Kim, Keon Wook Kang, June-Key Chung, E Edmund Kim, Dong Soo Le. Gray matter correlates of dopaminergic degeneration in Parkinson's disease: A hybrid PET/MR study using (18) F-FP-CIT. Human brain mapping. vol 37. issue 5. 2016-12-30. PMID:26846350. |
to measure dopaminergic degeneration in pd, binding ratio (br) of dopamine transporter in striatum was evaluated by (18) f-fp-cit. |
2016-12-30 |
2023-08-13 |
Not clear |
| Candace H Carriere, Na Hyea Kang, Lennard P Nile. Chronic low-dose melatonin treatment maintains nigrostriatal integrity in an intrastriatal rotenone model of Parkinson's disease. Brain research. vol 1633. 2016-12-26. PMID:26740407. |
parkinson's disease is a major neurodegenerative disorder which primarily involves the loss of dopaminergic neurons in the substantia nigra and related projections in the striatum. |
2016-12-26 |
2023-08-13 |
rat |
| Karin Foerde, Bernd Figner, Bradley B Doll, Isabel C Woyke, Erin Kendall Braun, Elke U Weber, Daphna Shoham. Dopamine Modulation of Intertemporal Decision-making: Evidence from Parkinson Disease. Journal of cognitive neuroscience. vol 28. issue 5. 2016-12-26. PMID:26836514. |
to assess the role of dopamine in intertemporal decisions, we tested parkinson disease patients who suffer from dopamine depletion in the striatum, in either high (on medication, pdon) or low (off medication, pdoff) dopaminergic states. |
2016-12-26 |
2023-08-13 |
Not clear |
| Angelina R A Pikstra, Anouk van der Hoorn, Klaus L Leenders, Bauke M de Jon. Relation of 18-F-Dopa PET with hypokinesia-rigidity, tremor and freezing in Parkinson's disease. NeuroImage. Clinical. vol 11. 2016-12-21. PMID:26909330. |
we hypothesized to find a stronger correlation between dopaminergic depletion in the striatum and hypokinesia-rigidity compared to tremor. |
2016-12-21 |
2023-08-13 |
Not clear |
| Larisa Tratnjek, Gordana Glavan, Tanja Višnjar, Marko Živi. Upregulation and axonal transport of synaptotagmin-IV in the direct-pathway medium spiny neurons in hemi-parkinsonian rats induced by dopamine D1 receptor stimulation. The European journal of neuroscience. vol 43. issue 7. 2016-12-19. PMID:26750488. |
in the hemi-parkinsonian rats with unilateral lesions of dopaminergic nigrostriatal neurons syt-iv and substance-p (sp) mrnas could be upregulated within the dopaminergically hypersensitive striatum of the lesioned brain hemisphere via the stimulation of striatal dopamine d1 (d1-r), but not d2 receptors. |
2016-12-19 |
2023-08-13 |
rat |
| Esther K Diekhof, Melanie Ratnayak. Menstrual cycle phase modulates reward sensitivity and performance monitoring in young women: Preliminary fMRI evidence. Neuropsychologia. vol 84. 2016-12-16. PMID:26471712. |
variations in dopaminergic transmission and d2-receptor (drd2) density in the striatum may thereby incline the individual to be either more reward- or punishment-sensitive. |
2016-12-16 |
2023-08-13 |
human |