| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Soutarou Taguchi, Jun-ichi Niwa, Tohru Ibi, Manabu Doy. [Dyskinesia-hyperpyrexia syndrome in a patient with Parkinson's disease: a case report]. Rinsho shinkeigaku = Clinical neurology. vol 55. issue 3. 2016-09-01. PMID:25786757. |
in advanced stage pd, loss of dopaminergic neurons impairs the dopamine holding capacity of the striatum and exogenous dopaminergic drugs can result in uncontrollable and excessive fluctuations in dopamine concentration. |
2016-09-01 |
2023-08-13 |
Not clear |
| Goichi Beck, Koei Shinzawa, Hideki Hayakawa, Kousuke Baba, Hisae Sumi-Akamaru, Yoshihide Tsujimoto, Hideki Mochizuk. Progressive Axonal Degeneration of Nigrostriatal Dopaminergic Neurons in Calcium-Independent Phospholipase A2β Knockout Mice. PloS one. vol 11. issue 4. 2016-09-01. PMID:27078024. |
to clarify whether a deficiency of ipla2β leads to the degeneration of nigrostriatal dopaminergic neurons, we analyzed the striatum of ipla2β-ko mice. |
2016-09-01 |
2023-08-13 |
mouse |
| Li-Min Mao, John Q Wan. Dopaminergic and cholinergic regulation of Fyn tyrosine kinase phosphorylation in the rat striatum in vivo. Neuropharmacology. vol 99. 2016-08-30. PMID:26277342. |
dopaminergic and cholinergic regulation of fyn tyrosine kinase phosphorylation in the rat striatum in vivo. |
2016-08-30 |
2023-08-13 |
rat |
| Shuke Nie, Yan Xu, Guiqin Chen, Kai Ma, Chao Han, Zhenli Guo, Zhentao Zhang, Keqiang Ye, Xuebing Ca. Small molecule TrkB agonist deoxygedunin protects nigrostriatal dopaminergic neurons from 6-OHDA and MPTP induced neurotoxicity in rodents. Neuropharmacology. vol 99. 2016-08-30. PMID:26282118. |
dopaminergic neurons loss in the substantia nigra (sn) and dopamine (da) content loss in the striatum correlate well with disease severity in parkinson's disease (pd). |
2016-08-30 |
2023-08-13 |
mouse |
| Rongyi Zhou, Xinmin Han, Jiaojiao Wang, Jichao Su. Baicalin may have a therapeutic effect in attention deficit hyperactivity disorder. Medical hypotheses. vol 85. issue 6. 2016-08-30. PMID:26604025. |
animal experiments showed that it protects dopaminergic neurons in the striatum, hippocampus and substantia nigra. |
2016-08-30 |
2023-08-13 |
Not clear |
| Pavle Matak, Andrija Matak, Sarah Moustafa, Dipendra K Aryal, Eric J Benner, William Wetsel, Nancy C Andrew. Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 13. 2016-08-29. PMID:26929359. |
there was gradual depletion of dopaminergic projections in the striatum followed by death of dopaminergic neurons in the substantia nigra. |
2016-08-29 |
2023-08-13 |
mouse |
| M W Howe, D A Dombec. Rapid signalling in distinct dopaminergic axons during locomotion and reward. Nature. vol 535. issue 7613. 2016-08-24. PMID:27398617. |
dopaminergic projection axons from the midbrain to the striatum are crucial for motor control, as their degeneration in parkinson disease results in profound movement deficits. |
2016-08-24 |
2023-08-13 |
mouse |
| Carine Chassain, Christophe Melon, Pascal Salin, Flora Vitale, Sébastien Couraud, Franck Durif, Lydia Kerkerian-Le Goff, Paolo Gubellin. Metabolic, synaptic and behavioral impact of 5-week chronic deep brain stimulation in hemiparkinsonian rats. Journal of neurochemistry. vol 136. issue 5. 2016-08-22. PMID:26576509. |
altogether, these data show that chronic stn hfs efficiently counteracts metabolic and synaptic defects due to dopaminergic lesion in both the striatum and snr. |
2016-08-22 |
2023-08-13 |
rat |
| Katrina L Paumier, Kelvin C Luk, Fredric P Manfredsson, Nicholas M Kanaan, Jack W Lipton, Timothy J Collier, Kathy Steece-Collier, Christopher J Kemp, Stephanie Celano, Emily Schulz, Ivette M Sandoval, Sheila Fleming, Elliott Dirr, Nicole K Polinski, John Q Trojanowski, Virginia M Lee, Caryl E Sortwel. Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration. Neurobiology of disease. vol 82. 2016-08-19. PMID:26093169. |
pff injected rats exhibited bilateral reductions in striatal dopaminergic innervation at 60 and 180 days and bilateral decreases in homovanillic acid; however, dopamine reduction was observed only in the striatum ipsilateral to pff injection. |
2016-08-19 |
2023-08-13 |
mouse |
| Jenni Kononoff Vanhanen, Saara Nuutinen, Mervi Tuominen, Pertti Panul. Histamine H3 Receptor Regulates Sensorimotor Gating and Dopaminergic Signaling in the Striatum. The Journal of pharmacology and experimental therapeutics. vol 357. issue 2. 2016-08-16. PMID:26945087. |
histamine h3 receptor regulates sensorimotor gating and dopaminergic signaling in the striatum. |
2016-08-16 |
2023-08-13 |
mouse |
| Johannes C M Schlachetzki, Thomas Grimm, Zinayida Schlachetzki, Nada M B Ben Abdallah, Benjamin Ettle, Patrizia Vöhringer, Boris Ferger, Beate Winner, Silke Nuber, Jürgen Winkle. Dopaminergic lesioning impairs adult hippocampal neurogenesis by distinct modification of α-synuclein. Journal of neuroscience research. vol 94. issue 1. 2016-08-05. PMID:26451750. |
we observed a persistent reduction of striatal dopamine and a loss of tyrosine hydroxylase-expressing neurons in the substantia nigra pars compacta in contrast to a complete recovery of tyrosine hydroxylase-immunoreactive dopaminergic fibers within the striatum. |
2016-08-05 |
2023-08-13 |
Not clear |
| Bryan A Killinger, Anna Moszczynsk. Epothilone D prevents binge methamphetamine-mediated loss of striatal dopaminergic markers. Journal of neurochemistry. vol 136. issue 3. 2016-08-05. PMID:26465779. |
exposure to binge methamphetamine (meth) can result in a permanent or transient loss of dopaminergic (daergic) markers such as dopamine (da), dopamine transporter, and tyrosine hydroxylase (th) in the striatum. |
2016-08-05 |
2023-08-13 |
rat |
| Pothitos M Pitychoutis, Arnauld Belmer, Imane Moutkine, Joëlle Adrien, Luc Maroteau. Mice Lacking the Serotonin Htr2B Receptor Gene Present an Antipsychotic-Sensitive Schizophrenic-Like Phenotype. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 12. 2016-08-02. PMID:25936642. |
we assessed the effects of the genetic and the pharmacological ablation of 5-ht2b receptors in mice subjected to a comprehensive series of behavioral test screenings for schizophrenic-like symptoms and investigated relevant dopaminergic and glutamatergic neurochemical alterations in the cortex and the striatum. |
2016-08-02 |
2023-08-13 |
mouse |
| Jui-Chih Chang, Shey-Lin Wu, Ko-Hung Liu, Ya-Hui Chen, Chieh-Sen Chuang, Fu-Chou Cheng, Hong-Lin Su, Yau-Huei Wei, Shou-Jen Kuo, Chin-San Li. Allogeneic/xenogeneic transplantation of peptide-labeled mitochondria in Parkinson's disease: restoration of mitochondria functions and attenuation of 6-hydroxydopamine-induced neurotoxicity. Translational research : the journal of laboratory and clinical medicine. vol 170. 2016-08-02. PMID:26730494. |
this increase was accompanied by a marked decrease in dopaminergic neuron loss in the substantia nigra pars compacta (snc) and consistent enhancement of tyrosine hydroxylase-positive immunoreaction of dopaminergic neurons in the snc and striatum. |
2016-08-02 |
2023-08-13 |
rat |
| Shervin Ravan, Diana Martinez, Mark Slifstein, Anissa Abi-Dargha. Molecular imaging in alcohol dependence. Handbook of clinical neurology. vol 125. 2016-07-28. PMID:25307582. |
studies of dopaminergic indices have provided robust evidence for deficits in d2-mediated transmission in the striatum of chronic recently detoxified alcoholics. |
2016-07-28 |
2023-08-13 |
Not clear |
| Negin Nouraei, Lauren Zarger, Justin N Weilnau, Jimin Han, Daniel M Mason, Rehana K Lea. Investigation of the therapeutic potential of N-acetyl cysteine and the tools used to define nigrostriatal degeneration in vivo. Toxicology and applied pharmacology. vol 296. 2016-07-28. PMID:26879220. |
nac-treated animals exhibited higher levels of the dopaminergic terminal marker tyrosine hydroxylase (th) in the striatum 10d after 6-ohda. |
2016-07-28 |
2023-08-13 |
mouse |
| Fernando Caravaggio, Margaret Hahn, Shinichiro Nakajima, Philip Gerretsen, Gary Remington, Ariel Graff-Guerrer. Reduced insulin-receptor mediated modulation of striatal dopamine release by basal insulin as a possible contributing factor to hyperdopaminergia in schizophrenia. Medical hypotheses. vol 85. issue 4. 2016-07-12. PMID:26118462. |
we hypothesize that, (i) insulin receptor expression and/or function is reduced in midbrain dopamine neurons in persons with schizophrenia, (ii) basal insulin should reduce dopaminergic transmission in the striatum via these receptors, and (iii) this modulation of dopaminergic transmission by basal insulin is reduced in the brains of persons with schizophrenia. |
2016-07-12 |
2023-08-13 |
Not clear |
| William C Reid, Wael G Ibrahim, Saejeong J Kim, Frank Denaro, Rafael Casas, Dianne E Lee, Dragan Maric, Dima A Hammou. Characterization of neuropathology in the HIV-1 transgenic rat at different ages. Journal of neuroimmunology. vol 292. 2016-07-12. PMID:26943969. |
using immunofluorescent staining of the tg brain, we found astrocytic dysfunction/damage, as well as dopaminergic neuronal loss/dysfunction, both of which worsening significantly in the striatum with age. |
2016-07-12 |
2023-08-13 |
rat |
| H Ding, R Underwood, N Lavalley, T A Yacoubia. 14-3-3 inhibition promotes dopaminergic neuron loss and 14-3-3θ overexpression promotes recovery in the MPTP mouse model of Parkinson's disease. Neuroscience. vol 307. 2016-07-06. PMID:26314634. |
14-3-3θ overexpression using this approach did not reduce mptp-induced dopaminergic cell loss in the substantia nigra nor the depletion of dopamine (da) and its metabolites in the striatum at three weeks after mptp administration. |
2016-07-06 |
2023-08-13 |
mouse |
| Eric M Merzetti, Brian E Stavele. spargel, the PGC-1α homologue, in models of Parkinson disease in Drosophila melanogaster. BMC neuroscience. vol 16. 2016-07-06. PMID:26502946. |
these symptoms arise from a decrease of available dopamine in the striatum of the brain resulting from the breakdown and death of dopaminergic (da) neurons. |
2016-07-06 |
2023-08-13 |
drosophila_melanogaster |