| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Negin Nouraei, Lauren Zarger, Justin N Weilnau, Jimin Han, Daniel M Mason, Rehana K Lea. Investigation of the therapeutic potential of N-acetyl cysteine and the tools used to define nigrostriatal degeneration in vivo. Toxicology and applied pharmacology. vol 296. 2016-07-28. PMID:26879220. |
nac-treated animals exhibited higher levels of the dopaminergic terminal marker tyrosine hydroxylase (th) in the striatum 10d after 6-ohda. |
2016-07-28 |
2023-08-13 |
mouse |
| Fernando Caravaggio, Margaret Hahn, Shinichiro Nakajima, Philip Gerretsen, Gary Remington, Ariel Graff-Guerrer. Reduced insulin-receptor mediated modulation of striatal dopamine release by basal insulin as a possible contributing factor to hyperdopaminergia in schizophrenia. Medical hypotheses. vol 85. issue 4. 2016-07-12. PMID:26118462. |
we hypothesize that, (i) insulin receptor expression and/or function is reduced in midbrain dopamine neurons in persons with schizophrenia, (ii) basal insulin should reduce dopaminergic transmission in the striatum via these receptors, and (iii) this modulation of dopaminergic transmission by basal insulin is reduced in the brains of persons with schizophrenia. |
2016-07-12 |
2023-08-13 |
Not clear |
| William C Reid, Wael G Ibrahim, Saejeong J Kim, Frank Denaro, Rafael Casas, Dianne E Lee, Dragan Maric, Dima A Hammou. Characterization of neuropathology in the HIV-1 transgenic rat at different ages. Journal of neuroimmunology. vol 292. 2016-07-12. PMID:26943969. |
using immunofluorescent staining of the tg brain, we found astrocytic dysfunction/damage, as well as dopaminergic neuronal loss/dysfunction, both of which worsening significantly in the striatum with age. |
2016-07-12 |
2023-08-13 |
rat |
| H Ding, R Underwood, N Lavalley, T A Yacoubia. 14-3-3 inhibition promotes dopaminergic neuron loss and 14-3-3θ overexpression promotes recovery in the MPTP mouse model of Parkinson's disease. Neuroscience. vol 307. 2016-07-06. PMID:26314634. |
14-3-3θ overexpression using this approach did not reduce mptp-induced dopaminergic cell loss in the substantia nigra nor the depletion of dopamine (da) and its metabolites in the striatum at three weeks after mptp administration. |
2016-07-06 |
2023-08-13 |
mouse |
| Eric M Merzetti, Brian E Stavele. spargel, the PGC-1α homologue, in models of Parkinson disease in Drosophila melanogaster. BMC neuroscience. vol 16. 2016-07-06. PMID:26502946. |
these symptoms arise from a decrease of available dopamine in the striatum of the brain resulting from the breakdown and death of dopaminergic (da) neurons. |
2016-07-06 |
2023-08-13 |
drosophila_melanogaster |
| P V Lovell, B Kasimi, J Carleton, T A Velho, C V Mell. Living without DAT: Loss and compensation of the dopamine transporter gene in sauropsids (birds and reptiles). Scientific reports. vol 5. 2016-06-28. PMID:26364979. |
we also found that the unprecedented loss of this important gene is compensated for by the expression of the noradrenaline transporter (nat) gene, and not the serotonin transporter genes, in dopaminergic cells, which explains the peculiar pharmacology of the da reuptake activity previously noted in bird striatum. |
2016-06-28 |
2023-08-13 |
Not clear |
| Yukiko Ogura, Takeshi Izumi, Mitsuhiro Yoshioka, Toshiya Matsushim. Dissociation of the neural substrates of foraging effort and its social facilitation in the domestic chick. Behavioural brain research. vol 294. 2016-06-14. PMID:26235329. |
based on zajonc's "drive theory," we hypothesized that facilitation and drive have shared neural mechanisms, and that dopaminergic projections from the midbrain to striatum are involved. |
2016-06-14 |
2023-08-13 |
chicken |
| Chiu-Ku Huang, Yen-Ting Chang, Tamara G Amstislavskaya, Maria A Tikhonova, Chih-Li Lin, Ching-Sui Hung, Te-Jen Lai, Ying-Jui H. Synergistic effects of ceftriaxone and erythropoietin on neuronal and behavioral deficits in an MPTP-induced animal model of Parkinson's disease dementia. Behavioural brain research. vol 294. 2016-06-14. PMID:26296668. |
lesioning also caused neurodegeneration in the nigrostriatal dopaminergic system and the hippocampal ca1 area and these changes were reduced or eliminated by treatment with cef, epo, or cef+epo, with the combination having a greater effect than single treatment in the densities of daergic terminals in the striatum and neurons in the hippocampal ca1 area. |
2016-06-14 |
2023-08-13 |
rat |
| Yu Zhang, I-Wei Wu, Shannon Buckley, Christopher S Coffey, Eric Foster, Susan Mendick, John Seibyl, Norbert Schuf. Diffusion tensor imaging of the nigrostriatal fibers in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 9. 2016-06-08. PMID:25920732. |
the depletion of these neurons is thought to reduce the dopaminergic function of the nigrostriatal pathway, as well as the neural fibers that link the substantia nigra to the striatum (putamen and caudate), causing a dysregulation in striatal activity that ultimately leads to lack of movement control. |
2016-06-08 |
2023-08-13 |
Not clear |
| Abid Oueslati, Blaise Lovisa, John Perrin, Georges Wagnières, Hubert van den Bergh, Yanik Tardy, Hilal A Lashue. Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease. PloS one. vol 10. issue 10. 2016-06-07. PMID:26484876. |
this treatment also significantly reduced dopaminergic neuronal loss in the injected substantia nigra and preserved dopaminergic fibers in the ipsilateral striatum. |
2016-06-07 |
2023-08-13 |
human |
| Yolanda Gómez-Gálvez, Cristina Palomo-Garo, Javier Fernández-Ruiz, Concepción Garcí. Potential of the cannabinoid CB(2) receptor as a pharmacological target against inflammation in Parkinson's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 64. 2016-05-31. PMID:25863279. |
inflammation is an important pathogenic factor in parkinson's disease (pd), so that it can contribute to kill dopaminergic neurons of the substantia nigra and to enhance the dopaminergic denervation of the striatum. |
2016-05-31 |
2023-08-13 |
mouse |
| Wenda Jiang, Zhejian Wang, Yiyang Jiang, Meili Lu, Xin L. Ginsenoside Rg1 Ameliorates Motor Function in an Animal Model of Parkinson's Disease. Pharmacology. vol 96. issue 1-2. 2016-05-23. PMID:26065578. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra (sn) and diminished dopamine levels in the striatum. |
2016-05-23 |
2023-08-13 |
rat |
| Chiung-Chih Chang, Jung-Lung Hsu, Wen-Neng Chang, Shu-Hua Huang, Chi-Wei Huang, Ya-Ting Chang, Nai-Ching Chen, Chun-Chung Lui, Chen-Chang Lee, Shih-Wei Hs. Metabolic Covariant Network in Relation to Nigrostriatal Degeneration in Carbon Monoxide Intoxication-Related Parkinsonism. Frontiers in neuroscience. vol 10. 2016-05-20. PMID:27199649. |
the functional network that correlated with striatum pre-synaptic dopaminergic uptakes included the midbrain, thalamus, caudate, lateral frontal cortex, ventral striatum, ventral, or dorsal anterior cingulate cortex. |
2016-05-20 |
2023-08-13 |
Not clear |
| James P Trujillo, Niels J H M Gerrits, Chris Vriend, Henk W Berendse, Odile A van den Heuvel, Ysbrand D van der Wer. Impaired planning in Parkinson's disease is reflected by reduced brain activation and connectivity. Human brain mapping. vol 36. issue 9. 2016-05-09. PMID:26096737. |
although widely held that these impairments arise from dopaminergic denervation of the striatum, not all executive functions are affected early on, and the underlying neural dynamics are not fully understood. |
2016-05-09 |
2023-08-13 |
Not clear |
| I Ruiz-DeDiego, J R Naranjo, D Hervé, R Moratall. Dopaminergic regulation of olfactory type G-protein α subunit expression in the striatum. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 8. 2016-05-06. PMID:25772224. |
dopaminergic regulation of olfactory type g-protein α subunit expression in the striatum. |
2016-05-06 |
2023-08-13 |
Not clear |
| Tatsuya Sasaki, Keyue Liu, Takashi Agari, Takao Yasuhara, Jun Morimoto, Mihoko Okazaki, Hayato Takeuchi, Atsuhiko Toyoshima, Susumu Sasada, Aiko Shinko, Akihiko Kondo, Masahiro Kameda, Ikuko Miyazaki, Masato Asanuma, Cesario V Borlongan, Masahiro Nishibori, Isao Dat. Anti-high mobility group box 1 antibody exerts neuroprotection in a rat model of Parkinson's disease. Experimental neurology. vol 275 Pt 1. 2016-04-29. PMID:26555088. |
the treatment with anti-hmgb1 mab significantly preserved dopaminergic neurons in substantia nigra pars compacta and dopaminergic terminals inherent in the striatum, and attenuated pd behavioral symptoms compared to the control mab-treated group. |
2016-04-29 |
2023-08-13 |
rat |
| Agnese Salvadè, Vincenza D'Angelo, Giuseppe Di Giovanni, Gerd Tinkhauser, Giuseppe Sancesario, Claudio Städler, Jens C Möller, Alessandro Stefani, Alain Kaelin-Lang, Salvatore Galat. Distinct roles of cortical and pallidal β and γ frequencies in hemiparkinsonian and dyskinetic rats. Experimental neurology. vol 275 Pt 1. 2016-04-29. PMID:26571194. |
we found a significant and bilateral power increase in the high βb frequencies (20-30 hz) within the first 10 days after 6-hydroxydopamine (6-ohda) lesion, which was in accordance with a significant depletion of dopaminergic fibers in the striatum. |
2016-04-29 |
2023-08-13 |
rat |
| Hyung-Wook Kim, Won-Seok Choi, Noah Sorscher, Hyung Joon Park, François Tronche, Richard D Palmiter, Zhengui Xi. Genetic reduction of mitochondrial complex I function does not lead to loss of dopamine neurons in vivo. Neurobiology of aging. vol 36. issue 9. 2016-04-25. PMID:26070241. |
however, compared with control mice, ndufs4 cko mice exhibited an age-dependent reduction of dopamine in the striatum and increased α-synuclein phosphorylation in dopaminergic neurons of the substantia nigra pars compacta. |
2016-04-25 |
2023-08-13 |
mouse |
| Krystyna Stepień, Anna Dzierzega-Lecznar, Irena Ta. [The role of neuromelanin in Parkinson's disease--new concepts]. Wiadomosci lekarskie (Warsaw, Poland : 1960). vol 60. issue 11-12. 2016-04-23. PMID:18540183. |
progressive degeneration of dopaminergic neurons of the substantia nigra and the resulting dopamine deficiency in the striatum are neuropathological basis of the movement disorders in parkinson's disease (pd). |
2016-04-23 |
2023-08-12 |
Not clear |
| Bo Zhang, Kun Ma, Baixiang L. Inflammatory reaction regulated by microglia plays a role in atrazine-induced dopaminergic neuron degeneration in the substantia nigra. The Journal of toxicological sciences. vol 40. issue 4. 2016-04-19. PMID:26165640. |
increasing evidence indicates that atr plays a critical role in inducing physiological changes to the endocrine and reproductive systems, and further may affect the nigrostriatal dopaminergic system in the diencephalon, resulting in altered dopamine (da) levels in the striatum, transport and storage-related protein abnormalities in the synaptic terminals, motor function deficits, and degeneration of da neurons in the substantia nigra (sn). |
2016-04-19 |
2023-08-13 |
rat |