| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stefanie Seiler, Stefano Di Santo, Hans Rudolf Widme. Nogo-A Neutralization Improves Graft Function in a Rat Model of Parkinson's Disease. Frontiers in cellular neuroscience. vol 10. 2016-04-19. PMID:27092052. |
transplantation of fetal human ventral mesencephalic (vm) dopaminergic neurons into the striatum is a promising strategy to compensate for the characteristic dopamine deficit observed in parkinson's disease (pd). |
2016-04-19 |
2023-08-13 |
human |
| Julia Muellner, Iman Gharrad, Marie-Odile Habert, Aurélie Kas, Jean-Baptiste Martini, Florence Cormier-Dequaire, Khadija Tahiri, Marie Vidailhet, Niklaus Meier, Alexis Brice, Michael Schuepbach, Alain Mallet, Andreas Hartmann, Jean-Christophe Corvo. Dopaminergic denervation severity depends on COMT Val158Met polymorphism in Parkinson's disease. Parkinsonism & related disorders. vol 21. issue 5. 2016-04-18. PMID:25753458. |
we investigated dopaminergic denervation in the striatum in pd patients according to comt rs4680 genotype. |
2016-04-18 |
2023-08-13 |
Not clear |
| Stephanie E Tedford, Amanda L Persons, T Celeste Napie. Dopaminergic lesions of the dorsolateral striatum in rats increase delay discounting in an impulsive choice task. PloS one. vol 10. issue 4. 2016-04-15. PMID:25927685. |
dopaminergic lesions of the dorsolateral striatum in rats increase delay discounting in an impulsive choice task. |
2016-04-15 |
2023-08-13 |
rat |
| Stephanie E Tedford, Amanda L Persons, T Celeste Napie. Dopaminergic lesions of the dorsolateral striatum in rats increase delay discounting in an impulsive choice task. PloS one. vol 10. issue 4. 2016-04-15. PMID:25927685. |
the current study evaluated the influence of dopaminergic inputs to the dorsolateral striatum on impulsive choice, one aspect of impulsive behavior. |
2016-04-15 |
2023-08-13 |
rat |
| Stephanie E Tedford, Amanda L Persons, T Celeste Napie. Dopaminergic lesions of the dorsolateral striatum in rats increase delay discounting in an impulsive choice task. PloS one. vol 10. issue 4. 2016-04-15. PMID:25927685. |
these data reveal a contribution of dopaminergic inputs to the dorsolateral striatum on impulsive choice behavior, and provide new insights into neural substrates underlying discounting behaviors. |
2016-04-15 |
2023-08-13 |
rat |
| Erica J Melief, Eiron Cudaback, Nikolas L Jorstad, Emily Sherfield, Nadia Postupna, Angela Wilson, Martin Darvas, Kathleen S Montine, C Dirk Keene, Thomas J Montin. Partial depletion of striatal dopamine enhances penetrance of cognitive deficits in a transgenic mouse model of Alzheimer's disease. Journal of neuroscience research. vol 93. issue 9. 2016-04-12. PMID:25824456. |
depletion of da in the striatum exacerbated the cognitive impairment seen in a mouse model of early-stage ad; this may be due to a protective effect of dopaminergic innervation against aβ striatal neurotoxicity. |
2016-04-12 |
2023-08-13 |
mouse |
| Sandy Stayte, Peggy Rentsch, Kong M Li, Bryce Visse. Activin A protects midbrain neurons in the 6-hydroxydopamine mouse model of Parkinson's disease. PloS one. vol 10. issue 4. 2016-04-12. PMID:25902062. |
parkinson's disease (pd) is a chronic neurodegenerative disease characterized by a significant loss of dopaminergic neurons within the substantia nigra pars compacta (snpc) and a subsequent loss of dopamine (da) within the striatum. |
2016-04-12 |
2023-08-13 |
mouse |
| Alberto Avila-Luna, Jacqueline Prieto-Leyva, Arturo Gálvez-Rosas, Alfonso Alfaro-Rodriguez, Rigoberto Gonzalez-Pina, Antonio Bueno-Nav. D1 Antagonists and D2 Agonists Have Opposite Effects on the Metabolism of Dopamine in the Rat Striatum. Neurochemical research. vol 40. issue 7. 2016-04-11. PMID:25981954. |
in conclusion, administration of the d2r agonist bromocriptine decreased dopaminergic synthesis and metabolism in the striatum; in contrast, administration of the d1r antagonist sch-23390 induced the opposite effects. |
2016-04-11 |
2023-08-13 |
rat |
| Perdita Cheshire, Scott Ayton, Kelly L Bertram, Helen Ling, Abi Li, Catriona McLean, Glenda M Halliday, Sean S O'Sullivan, Tamas Revesz, David I Finkelstein, Elsdon Storey, David R William. Serotonergic markers in Parkinson's disease and levodopa-induced dyskinesias. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 6. 2016-04-07. PMID:25649148. |
we obtained brain tissue from 44 pd cases and 17 age-matched controls and assessed monoamine levels and the serotonin and dopamine transporters in the striatum, and the extent of dopaminergic and serotonergic cell preservation in the substantia nigra (sn) and the dorsal raphe nuclei (drn), respectively. |
2016-04-07 |
2023-08-13 |
Not clear |
| Perdita Cheshire, Scott Ayton, Kelly L Bertram, Helen Ling, Abi Li, Catriona McLean, Glenda M Halliday, Sean S O'Sullivan, Tamas Revesz, David I Finkelstein, Elsdon Storey, David R William. Serotonergic markers in Parkinson's disease and levodopa-induced dyskinesias. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 6. 2016-04-07. PMID:25649148. |
as expected, pd patients demonstrated a severe loss of all dopaminergic markers, including dopamine (p < 0.0001) and the dopamine transporter (p < 0.0001) in the striatum, and dopaminergic neurons (p < 0.001) in the sn, compared with controls. |
2016-04-07 |
2023-08-13 |
Not clear |
| Perdita Cheshire, Scott Ayton, Kelly L Bertram, Helen Ling, Abi Li, Catriona McLean, Glenda M Halliday, Sean S O'Sullivan, Tamas Revesz, David I Finkelstein, Elsdon Storey, David R William. Serotonergic markers in Parkinson's disease and levodopa-induced dyskinesias. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 6. 2016-04-07. PMID:25649148. |
no difference was seen in levels of serotonergic and dopaminergic markers in the striatum between pd patients with and without dyskinesias, or between cases separated according to the clinical severity of their dyskinesias. |
2016-04-07 |
2023-08-13 |
Not clear |
| Richa Pahuja, Kavita Seth, Anshi Shukla, Rajendra Kumar Shukla, Priyanka Bhatnagar, Lalit Kumar Singh Chauhan, Prem Narain Saxena, Jharna Arun, Bhushan Pradosh Chaudhari, Devendra Kumar Patel, Sheelendra Pratap Singh, Rakesh Shukla, Vinay Kumar Khanna, Pradeep Kumar, Rajnish Kumar Chaturvedi, Kailash Chand Gupt. Trans-blood brain barrier delivery of dopamine-loaded nanoparticles reverses functional deficits in parkinsonian rats. ACS nano. vol 9. issue 5. 2016-04-05. PMID:25825926. |
da nps were internalized in dopaminergic sh-sy5y cells and dopaminergic neurons in the substantia nigra and striatum, regions affected in pd. |
2016-04-05 |
2023-08-13 |
rat |
| Kazuko Takahashi-Niki, Ayako Inafune, Naruyuki Michitani, Yoshitaka Hatakeyama, Kotaro Suzuki, Mai Sasaki, Yoshihisa Kitamura, Takeshi Niki, Sanae M M Iguchi-Ariga, Hiroyoshi Arig. DJ-1-dependent protective activity of DJ-1-binding compound no. 23 against neuronal cell death in MPTP-treated mouse model of Parkinson's disease. Journal of pharmacological sciences. vol 127. issue 3. 2016-04-05. PMID:25837927. |
parkinson's disease (pd) is caused by dopaminergic cell death in the substantia nigra, leading to a reduced level of dopamine in the striatum. |
2016-04-05 |
2023-08-13 |
mouse |
| Mohammad Moshahid Khan, Smita Zaheer, Ramasamy Thangavel, Margi Patel, Duraisamy Kempuraj, Asgar Zahee. Absence of glia maturation factor protects dopaminergic neurons and improves motor behavior in mouse model of parkinsonism. Neurochemical research. vol 40. issue 5. 2016-04-01. PMID:25754447. |
in the present study, we demonstrate that absence of gmf suppresses dopaminergic (da) neuron loss, glial activation, and expression of proinflammatory mediators in the substantia nigra pars compacta (sn) and striatum (str) of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) treated mice. |
2016-04-01 |
2023-08-13 |
mouse |
| Pierre Berthet, Anders Lansne. Optogenetic stimulation in a computational model of the basal ganglia biases action selection and reward prediction error. PloS one. vol 9. issue 3. 2016-03-31. PMID:24614169. |
it remains to experimentally test how the dopaminergic neurons are affected by specific stimulations of neurons in the striatum and to relate data to predictions of our model. |
2016-03-31 |
2023-08-12 |
mouse |
| O Lindval. Clinical translation of stem cell transplantation in Parkinson's disease. Journal of internal medicine. vol 279. issue 1. 2016-03-31. PMID:26332959. |
clinical trials of intrastriatal transplantation of human foetal mesencephalic tissue have shown that the grafted dopaminergic neurons re-innervate the striatum, restore striatal dopamine release and, in some cases, induce major, long-lasting improvement of motor function. |
2016-03-31 |
2023-08-13 |
human |
| O Lindval. Clinical translation of stem cell transplantation in Parkinson's disease. Journal of internal medicine. vol 279. issue 1. 2016-03-31. PMID:26332959. |
however, nonmotor symptoms originating from degeneration outside the striatum or in nondopaminergic systems are not alleviated by intrastriatal implantation of dopaminergic neurons. |
2016-03-31 |
2023-08-13 |
human |
| D Val-Laillet, E Aarts, B Weber, M Ferrari, V Quaresima, L E Stoeckel, M Alonso-Alonso, M Audette, C H Malbert, E Stic. Neuroimaging and neuromodulation approaches to study eating behavior and prevent and treat eating disorders and obesity. NeuroImage. Clinical. vol 8. 2016-03-29. PMID:26110109. |
in particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. |
2016-03-29 |
2023-08-13 |
human |
| Jae-Sun Choi, Woom-Yee Bae, Chan Park, Joo-Won Jeon. Zingerone activates VMAT2 during MPP(+) -induced Cell Death. Phytotherapy research : PTR. vol 29. issue 11. 2016-03-29. PMID:26282055. |
parkinson's disease (pd) is characterized by a progressive and selective loss of dopaminergic neurons in the substantia nigra pars compacta (snpc) and striatum. |
2016-03-29 |
2023-08-13 |
Not clear |
| Jennifer R Ayers-Ringler, Alfredo Oliveros, Yanyan Qiu, Daniel M Lindberg, David J Hinton, Raymond M Moore, Surendra Dasari, Doo-Sup Cho. Label-Free Proteomic Analysis of Protein Changes in the Striatum during Chronic Ethanol Use and Early Withdrawal. Frontiers in behavioral neuroscience. vol 10. 2016-03-25. PMID:27014007. |
the striatum, composed primarily of medium spiny gabaergic neurons, glutamatergic and dopaminergic nerve terminals and astrocytes, is relatively homogeneous for proteomic analysis. |
2016-03-25 |
2023-08-13 |
Not clear |