| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roger A Barker, Janelle Drouin-Ouellet, Malin Parma. Cell-based therapies for Parkinson disease—past insights and future potential. Nature reviews. Neurology. vol 11. issue 9. 2016-03-21. PMID:26240036. |
parkinson disease (pd) is characterized by loss of the a9 nigral neurons that provide dopaminergic innervation to the striatum. |
2016-03-21 |
2023-08-13 |
Not clear |
| G Herrera-Meza, J Manzo, M E Hernández, M Miquel, L I Garcí. Induction of mandibular tremor using electrolytic lesion of the ventrolateral striatum or using subchronic haloperidol therapy in male rats: an electromyographic comparison. Neurologia (Barcelona, Spain). vol 29. issue 7. 2016-03-18. PMID:24332783. |
tremulous jaw movement (tjms) in rats can be induced pharmacologically by striatal dopaminergic manipulation or electrolytic lesion of ventrolateral striatum (vls). |
2016-03-18 |
2023-08-12 |
rat |
| Mojtaba Golpich, Elham Amini, Fatemeh Hemmati, Norlinah Mohamed Ibrahim, Behrouz Rahmani, Zahurin Mohamed, Azman Ali Raymond, Leila Dargahi, Rasoul Ghasemi, Abolhassan Ahmadian. Glycogen synthase kinase-3 beta (GSK-3β) signaling: Implications for Parkinson's disease. Pharmacological research. vol 97. 2016-03-01. PMID:25829335. |
parkinson's disease (pd) is a chronic neurodegenerative movement disorder characterized by the progressive and massive loss of dopaminergic neurons by neuronal apoptosis in the substantia nigra pars compacta and depletion of dopamine in the striatum, which lead to pathological and clinical abnormalities. |
2016-03-01 |
2023-08-13 |
Not clear |
| Weixing Shen, Joshua L Plotkin, Veronica Francardo, Wai Kin D Ko, Zhong Xie, Qin Li, Tim Fieblinger, Jürgen Wess, Richard R Neubig, Craig W Lindsley, P Jeffrey Conn, Paul Greengard, Erwan Bezard, M Angela Cenci, D James Surmeie. M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia. Neuron. vol 88. issue 4. 2016-03-01. PMID:26590347. |
a balanced interaction between dopaminergic and cholinergic signaling in the striatum is critical to goal-directed behavior. |
2016-03-01 |
2023-08-13 |
mouse |
| I F Labunets, S A Talanov, R G Vasilyev, A E Rodnichenko, N A Utko, I A Kyzminova, B S Kopjak, E V Podjachenko, V F Sagach, G M Butenk. [THYMIC HORMONES, ANTIOXIDANT ENZYMES AND NEUROGENESIS OF BULBUS OLFACTORIUS IN RATS WITH PARKINSONISM: THE EFFECT OF MELATONIN]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994). vol 61. issue 5. 2016-03-01. PMID:26845842. |
rats with motor asymmetry in the apomorphine test and significant damage of the dopaminergic neurons in the-substantia nigra have decreased levels of superoxide dismutase, catalase and glutathione peroxidase activities in striatum (1.3-1.4 times) and blood thymulin content (8 times) compared to control group. |
2016-03-01 |
2023-08-13 |
rat |
| Jin Ma, Li-Hong Long, Zhuang-Li Hu, Hai Zhang, Jun Han, Lan Ni, Fang Wang, Jian-Guo Chen, Peng-Fei W. Activation of D1-like receptor-dependent phosphatidylinositol signal pathway by SKF83959 inhibits voltage-gated sodium channels in cultured striatal neurons. Brain research. vol 1615. 2016-02-29. PMID:25912434. |
a d1-like dopamine receptor-dependent phosphatidylinositol signal pathway exists in the striatum, however little is known about its role in the dopaminergic modulation of striatal neuronal excitability. |
2016-02-29 |
2023-08-13 |
Not clear |
| Karin Foerde, Erin Kendall Braun, E Tory Higgins, Daphna Shoham. Motivational modes and learning in Parkinson's disease. Social cognitive and affective neuroscience. vol 10. issue 8. 2016-02-26. PMID:25552569. |
parkinson's disease results from a progressive loss of dopaminergic inputs to the striatum and leads to impairments in motivation and learning from feedback. |
2016-02-26 |
2023-08-13 |
Not clear |
| Tanya Sippy, Damien Lapray, Sylvain Crochet, Carl C H Peterse. Cell-Type-Specific Sensorimotor Processing in Striatal Projection Neurons during Goal-Directed Behavior. Neuron. vol 88. issue 2. 2016-02-10. PMID:26439527. |
the striatum is thought to play a key role in reward-based learning and action selection, receiving glutamatergic sensorimotor signals and dopaminergic reward signals. |
2016-02-10 |
2023-08-13 |
mouse |
| Sybren F de Kloet, Huibert D Mansvelder, Taco J De Vrie. Cholinergic modulation of dopamine pathways through nicotinic acetylcholine receptors. Biochemical pharmacology. vol 97. issue 4. 2016-02-09. PMID:26208783. |
profound modulatory cholinergic input from the pedunculopontine and laterodorsal tegmentum to dopaminergic midbrain nuclei as well as local cholinergic interneuron projections to dopamine neuron axons in the striatum may play a major role in the effects of nicotine. |
2016-02-09 |
2023-08-13 |
Not clear |
| Danqing Xia. Acupuncture for Parkinson's Disease: a review of clinical, animal, and functional Magnetic Resonance Imaging studies. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. vol 35. issue 6. 2016-02-09. PMID:26742319. |
animal studies have consistently show that this treatment is both neuroprotective, protecting dopaminergic neurons from degeneration and also restorative, restoring tyrosine hydroxylase positive dopaminergic terminals in striatum, resulting in improvements in motor performance in animal models of parkinsonism. |
2016-02-09 |
2023-08-13 |
Not clear |
| Anne-Marike Schiffer, Florian Waszak, Nick Yeun. The role of prediction and outcomes in adaptive cognitive control. Journal of physiology, Paris. vol 109. issue 1-3. 2016-02-08. PMID:25698177. |
the model lastly envisages a role for hierarchical projections from the striatum to dopaminergic midbrain areas that enable more rostral frontal areas to bias the selection of inputs from more posterior frontal areas via their respective representations in the basal ganglia. |
2016-02-08 |
2023-08-13 |
human |
| Ingrid Morales, Alberto Sanchez, Clara Rodriguez-Sabate, Manuel Rodrigue. The degeneration of dopaminergic synapses in Parkinson's disease: A selective animal model. Behavioural brain research. vol 289. 2016-02-05. PMID:25907749. |
this procedure can also be used to analyze mechanisms involved in the dopaminergic re-innervation of the striatum, and the role of astrocytes and microglia in both processes. |
2016-02-05 |
2023-08-13 |
rat |
| Ingrid Morales, Alberto Sanchez, Clara Rodriguez-Sabate, Manuel Rodrigue. The degeneration of dopaminergic synapses in Parkinson's disease: A selective animal model. Behavioural brain research. vol 289. 2016-02-05. PMID:25907749. |
adult sprague-dawley rats were injected in the lateral ventricles with increasing doses of 6-hydroxydopamine (12-50 μg), which generated a dose-dependent loss of dopaminergic synapses and axons in the striatum, followed by an axonal sprouting (weeks later) and by a progressive recovery of striatal dopaminergic synapses (months later). |
2016-02-05 |
2023-08-13 |
rat |
| Dipannita Basu, Yuxin Tian, Patricia Hui, Jayant Bhandari, Rodney L Johnson, Ram K Mishr. Change in expression of vesicular protein synapsin II by chronic treatment with D2 allosteric modulator PAOPA. Peptides. vol 66. 2016-02-04. PMID:25703303. |
immunoblot results revealed that the synapsin iia, but not the iib isoform, was increased in the dopaminergic regions of the striatum, nucleus accumbens, and medial prefrontal cortex. |
2016-02-04 |
2023-08-13 |
Not clear |
| Douglas G Walker, Lih-Fen Lue, Geidy Serrano, Charles H Adler, John N Caviness, Lucia I Sue, Thomas G Beac. Altered Expression Patterns of Inflammation-Associated and Trophic Molecules in Substantia Nigra and Striatum Brain Samples from Parkinson's Disease, Incidental Lewy Body Disease and Normal Control Cases. Frontiers in neuroscience. vol 9. 2016-02-02. PMID:26834537. |
inflammation in the striatum, where sn dopaminergic neurons project, is also a feature of pd brains. |
2016-02-02 |
2023-08-13 |
human |
| Yuling Zhao, Matthew J Haney, Richa Gupta, John P Bohnsack, Zhijian He, Alexander V Kabanov, Elena V Batrakov. GDNF-transfected macrophages produce potent neuroprotective effects in Parkinson's disease mouse model. PloS one. vol 9. issue 9. 2016-01-25. PMID:25229627. |
the pathobiology of parkinson's disease (pd) is associated with the loss of dopaminergic neurons in the substantia nigra pars compacta (snpc) projecting to the striatum. |
2016-01-25 |
2023-08-13 |
mouse |
| Xiao-Feng Yin, Hua-Min Xu, Yun-Xia Jiang, Yun-Lai Zhi, Yu-Xiu Liu, Heng-Wei Xiang, Kai Liu, Xiao-Dong Ding, Peng Su. Lentivirus-mediated Persephin over-expression in Parkinson's disease rats. Neural regeneration research. vol 10. issue 11. 2016-01-25. PMID:26807117. |
results found that the number of dopaminergic neurons in the substantia nigra increased, tyrosine hydroxylase expression was upregulated and concentrations of dopamine and its metabolites in corpus striatum were increased after pretreatment with persephin gene. |
2016-01-25 |
2023-08-13 |
rat |
| Reena Haobam, Debasmita Tripathy, Navneet A Kaidery, Kochupurackal P Mohanakuma. Embryonic stem cells derived neuron transplantation recovery in models of parkinsonism in relation to severity of the disorder in rats. Rejuvenation research. vol 18. issue 2. 2016-01-22. PMID:25546608. |
the survival of the grafted dopaminergic cells in the striatum was better in animals with low-severity parkinsonism, but poor in the animals with severe parkinsonism. |
2016-01-22 |
2023-08-13 |
rat |
| Yu Ri Kim, Ha Neui Kim, Malk Eun Pak, Sung Min Ahn, Ki Hwan Hong, Hwa Kyoung Shin, Byung Tae Cho. Studies on the animal model of post-stroke depression and application of antipsychotic aripiprazole. Behavioural brain research. vol 287. 2016-01-20. PMID:25845738. |
mcao+cms mice showed a decrease of proliferative and differentiated neuronal cells in the striatum and hippocampus with dopaminergic neuronal injuries in the midbrain as compared with cms and mcao alone treated mice. |
2016-01-20 |
2023-08-13 |
mouse |
| Alexandra Alvarsson, Xiaoqun Zhang, Tiberiu L Stan, Nicoletta Schintu, Banafsheh Kadkhodaei, Mark J Millan, Thomas Perlmann, Per Svenningsso. Modulation by Trace Amine-Associated Receptor 1 of Experimental Parkinsonism, L-DOPA Responsivity, and Glutamatergic Neurotransmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 41. 2016-01-19. PMID:26468205. |
these data unveil a role for taar1 in modulating the degeneration of dopaminergic neurons, the behavioral response to l-dopa, and presynaptic and postsynaptic glutamate neurotransmission in the striatum, supporting their relevance to the pathophysiology and, potentially, management of pd. |
2016-01-19 |
2023-08-13 |
mouse |