| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arman Rahimmi, Farnoosh Khosrobakhsh, Esmael Izadpanah, Mohammad Raman Moloudi, Kambiz Hassanzade. N-acetylcysteine prevents rotenone-induced Parkinson's disease in rat: An investigation into the interaction of parkin and Drp1 proteins. Brain research bulletin. vol 113. 2016-01-04. PMID:25732239. |
dopamine levels of dopaminergic areas in rat brain including substantia nigra (sn) and striatum (st) were assessed using high performance liquid chromatography analysis to measure the loss of dopamine. |
2016-01-04 |
2023-08-13 |
rat |
| Sabeena Sharma, Samardeep Singh, Vishavdeep Sharma, Vijay Pal Singh, Rahul Deshmuk. Neurobiology of l-DOPA induced dyskinesia and the novel therapeutic strategies. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 70. 2016-01-04. PMID:25776513. |
pd is caused by selective degeneration of the dopaminergic neurons, which originate in the substantia nigra pars compacta (snc) and project into the striatum. |
2016-01-04 |
2023-08-13 |
Not clear |
| Mei Jiaming, Chaoshi Ni. Comparing neuroprotective effects of CDNF-expressing bone marrow derived mesenchymal stem cells via differing routes of administration utilizing an in vivo model of Parkinson's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 36. issue 2. 2015-12-31. PMID:25159816. |
therapeutic effects were evaluated by observing dopaminergic (da) neurons both in the substantia nigra compacta (snc) and within the striatum and by monitoring apomorphine-induced rotational behavior (circling). |
2015-12-31 |
2023-08-13 |
rat |
| Germaine Korner, Daniela Noain, Ming Ying, Magnus Hole, Marte I Flydal, Tanja Scherer, Gabriella Allegri, Anahita Rassi, Ralph Fingerhut, Damasia Becu-Villalobos, Samyuktha Pillai, Stephan Wueest, Daniel Konrad, Anna Lauber-Biason, Christian R Baumann, Laurence A Bindoff, Aurora Martinez, Beat Thön. Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency. Brain : a journal of neurology. vol 138. issue Pt 10. 2015-12-28. PMID:26276013. |
this hypomorphic mouse model thus provides understanding on pathomechanisms in type b tyrosine hydroxylase deficiency and a platform for the evaluation of novel therapeutics for movement disorders with loss of dopaminergic input to the striatum. |
2015-12-28 |
2023-08-13 |
mouse |
| Carmelo Sgobio, David A Kupferschmidt, Guohong Cui, Lixin Sun, Zheng Li, Huaibin Cai, David M Lovinge. Optogenetic measurement of presynaptic calcium transients using conditional genetically encoded calcium indicator expression in dopaminergic neurons. PloS one. vol 9. issue 10. 2015-12-22. PMID:25360513. |
calcium triggers dopamine release from presynaptic terminals of midbrain dopaminergic (mda) neurons in the striatum. |
2015-12-22 |
2023-08-13 |
mouse |
| Juha Punnonen, James L Miller, Timothy J Collier, Jeffrey R Spence. Agonists of the tissue-protective erythropoietin receptor in the treatment of Parkinson's disease. Current topics in medicinal chemistry. vol 15. issue 10. 2015-12-15. PMID:25832721. |
when delivered directly to the striatum, rhepo protects dopaminergic neurons in animal models of pd. |
2015-12-15 |
2023-08-13 |
human |
| Xiang-Yun Li, Guang-Hai Mei, Qiang Dong, Yu Zhang, Zhuang-Li Guo, Jing-Jing Su, Yu-Ping Tang, Xue-Hong Jin, Hou-Guang Zhou, Yan-Yan Huan. Enhanced Neuroprotective Effects of Coadministration of Tetrandrine with Glutathione in Preclinical Model of Parkinson's Disease. Parkinson's disease. vol 2015. 2015-12-15. PMID:26664824. |
levels in the redox system, dopamine (da) metabolism, dopaminergic neuronal survival, and apoptosis of the substantia nigra (sn) and striatum, as well as the rotational behavior of animals were examined after a 50-day administration of gsh + tet (or gsh) and/or l-3,4-dihydroxyphenylalanine (l-dopa) to pd rats. |
2015-12-15 |
2023-08-13 |
rat |
| Emma Arvidsson, Thomas Viereckel, Sanja Mikulovic, Åsa Wallén-Mackenzi. Age- and sex-dependence of dopamine release and capacity for recovery identified in the dorsal striatum of C57/Bl6J mice. PloS one. vol 9. issue 6. 2015-12-14. PMID:24925086. |
in the present study, we used an intracranial kcl-stimulation challenge paradigm to provoke release from dopaminergic terminals in the dorsal striatum of anaesthetized c57/bl6j mice. |
2015-12-14 |
2023-08-13 |
mouse |
| J P Wijnen, J Haarsma, V O Boer, P R Luijten, S van der Stigchel, S F W Neggers, D W J Klom. Detection of lactate in the striatum without contamination of macromolecules by J-difference editing MRS at 7T. NMR in biomedicine. vol 28. issue 4. 2015-12-09. PMID:25802216. |
if sufficiently stable, lactate measurements may be used to investigate alterations in dopaminergic signalling in the striatum, facilitating the detection and diagnosis of metabolic deficits. |
2015-12-09 |
2023-08-13 |
human |
| Blanca Estela Jaramillo-Loranca, Linda Garcés-Ramírez, Alicia Angélica Munguía Rosales, Carolina Luna Ramírez, Genaro Vargas Hernández, Oscar Morales-Dionisio, Kateri González-Elizalde, Gonzalo Flores, Sergio Zamudio, Fidel De La Cruz-Lópe. The sigma agonist 1,3-di-o-tolyl-guanidine reduces the morphological and behavioral changes induced by neonatal ventral hippocampus lesion in rats. Synapse (New York, N.Y.). vol 69. issue 4. 2015-12-04. PMID:25682743. |
sigma receptors have been located in brain areas involved in motor functions, including the dopaminergic projections from the substantia nigra to the striatum. |
2015-12-04 |
2023-08-13 |
rat |
| Blanca Estela Jaramillo-Loranca, Linda Garcés-Ramírez, Alicia Angélica Munguía Rosales, Carolina Luna Ramírez, Genaro Vargas Hernández, Oscar Morales-Dionisio, Kateri González-Elizalde, Gonzalo Flores, Sergio Zamudio, Fidel De La Cruz-Lópe. The sigma agonist 1,3-di-o-tolyl-guanidine reduces the morphological and behavioral changes induced by neonatal ventral hippocampus lesion in rats. Synapse (New York, N.Y.). vol 69. issue 4. 2015-12-04. PMID:25682743. |
the sigma receptor agonist 1,3-di-o-tolyl-guanidine (dtg) was found to increase dopamine release in the striatum, nucleus accumbens, and prefrontal cortex, in a dose-dependent manner, after central as well as peripheral administration, suggesting a modulatory role of these receptors on the dopaminergic system. |
2015-12-04 |
2023-08-13 |
rat |
| Peter T Bell, Moran Gilat, Claire O'Callaghan, David A Copland, Michael J Frank, Simon J G Lewis, James M Shin. Dopaminergic basis for impairments in functional connectivity across subdivisions of the striatum in Parkinson's disease. Human brain mapping. vol 36. issue 4. 2015-12-03. PMID:25425542. |
dopaminergic basis for impairments in functional connectivity across subdivisions of the striatum in parkinson's disease. |
2015-12-03 |
2023-08-13 |
Not clear |
| V Annese, C Barcia, F Ros-Bernal, A Gómez, C M Ros, V De Pablos, E Fernández-Villalba, M E De Stefano, M-T Herrer. Evidence of oligodendrogliosis in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism. Neuropathology and applied neurobiology. vol 39. issue 2. 2015-11-13. PMID:22443457. |
mice and nonhuman primates administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) represent elective experimental models of parkinsonism, in which degeneration of the nigrostriatal dopaminergic pathway is associated with prominent neuroinflammation, characterized by activated microglia and astrocytes in both substantia nigra (sn) and striatum. |
2015-11-13 |
2023-08-12 |
mouse |
| Chiao-Chi V Chen, Yen-Yu I Shih, Chen Chan. Dopaminergic imaging of nonmotor manifestations in a rat model of Parkinson's disease by fMRI. Neurobiology of disease. vol 49. 2015-11-10. PMID:22842018. |
nociceptive stimuli under normal conditions elicit decreases in cerebral blood volume (cbv) in the striatum via dopaminergic neurotransmission. |
2015-11-10 |
2023-08-12 |
rat |
| Amol P Yadav, Romulo Fuentes, Hao Zhang, Thais Vinholo, Chi-Han Wang, Marco Aurelio M Freire, Miguel A L Nicoleli. Chronic spinal cord electrical stimulation protects against 6-hydroxydopamine lesions. Scientific reports. vol 4. 2015-11-10. PMID:24452435. |
dcs-treated rats exhibited a higher density of dopaminergic innervation in the striatum and higher neuronal cell count in the substantia nigra pars compacta compared to a control group. |
2015-11-10 |
2023-08-12 |
rat |
| L Zhao, L X He, S N Huang, L J Gong, L Li, Y Y Lv, Z M Qia. Protection of dopamine neurons by vibration training and up-regulation of brain-derived neurotrophic factor in a MPTP mouse model of Parkinson's disease. Physiological research. vol 63. issue 5. 2015-11-09. PMID:24908088. |
here, we investigated the effects of longer duration (4 weeks) of low amplitude vibration (lav) training on the numbers of dopaminergic neurons in the substantia nigra by immunostaining and the levels of dopamine (da) and brain-derived neurotrophic factor (bdnf) in the striatum by hplc and elisa in the chronic mptp lesion mouse. |
2015-11-09 |
2023-08-13 |
mouse |
| Xi-Jun He, Kazuyuki Uchida, Chiaki Megumi, Nobuaki Tsuge, Hiroyuki Nakayam. Dietary curcumin supplementation attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in C57BL mice. Journal of toxicologic pathology. vol 28. issue 4. 2015-11-05. PMID:26538809. |
treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) significantly induced the loss of dopaminergic cells in the substantia nigra and deletion of dopamine in the striatum, which was attenuated by long-term (7 weeks) dietary supplementation with curcumin at a concentration of 0.5% or 2.0% (w/w). |
2015-11-05 |
2023-08-13 |
mouse |
| Hiromi Suzuki, Kenji Ono, Makoto Sawad. Protective effect of INI-0602, a gap junction inhibitor, on dopaminergic neurodegeneration of mice with unilateral 6-hydroxydopamine injection. Journal of neural transmission (Vienna, Austria : 1996). vol 121. issue 11. 2015-11-04. PMID:24744047. |
ini-0602 treatment blocked not only dopaminergic loss in both the striatum and substantia nigra, but also apomorphine-induced rotational behavior. |
2015-11-04 |
2023-08-13 |
mouse |
| Susanna Waters, Henrik Ponten, Malin Edling, Boel Svanberg, Daniel Klamer, Nicholas Water. The dopaminergic stabilizers pridopidine and ordopidine enhance cortico-striatal Arc gene expression. Journal of neural transmission (Vienna, Austria : 1996). vol 121. issue 11. 2015-11-04. PMID:24817271. |
to further understand the neuropharmacological effects of pridopidine and ordopidine, and how they differ from other dopaminergic compounds in vivo, we assessed the expression of activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (arc), an immediate early gene marker associated with synaptic activation, in the frontal cortex and striatum. |
2015-11-04 |
2023-08-13 |
Not clear |
| Raquel Gomez-Sintes, Analia Bortolozzi, Francesc Artigas, José J Luca. Reduced striatal dopamine DA D2 receptor function in dominant-negative GSK-3 transgenic mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 9. 2015-11-02. PMID:25088904. |
taking together, the present results show that dominant negative gsk-3 transgenic mice show reduced da d2-r-mediated function in striatum and further support a link between dopaminergic neurotransmission and gsk-3 activity. |
2015-11-02 |
2023-08-13 |
mouse |