| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ahmed Sharaf, Belal Rahhal, Björn Spittau, Eleni Rouss. Localization of reelin signaling pathway components in murine midbrain and striatum. Cell and tissue research. vol 359. issue 2. 2015-10-27. PMID:25418135. |
the loss of apoer2 and vldlr expression in the mature midbrain and striatum implies that reelin functions are restricted to migratory events and early postnatal maturation and are dispensable for the maintenance of dopaminergic neurons. |
2015-10-27 |
2023-08-13 |
mouse |
| Caroline A Browne, Joachim Hanke, Claudia Rose, Irene Walsh, Tara Foley, Gerard Clarke, Herbert Schwegler, John F Cryan, Deniz Yilmazer-Hank. Effect of acute swim stress on plasma corticosterone and brain monoamine levels in bidirectionally selected DxH recombinant inbred mouse strains differing in fear recall and extinction. Stress (Amsterdam, Netherlands). vol 17. issue 6. 2015-10-26. PMID:25117886. |
moreover, the dopaminergic system was activated differentially in the medial prefrontal cortex and striatum of the two strains by acute stress. |
2015-10-26 |
2023-08-13 |
mouse |
| Mojtaba Golpich, Behrouz Rahmani, Norlinah Mohamed Ibrahim, Leila Dargahi, Zahurin Mohamed, Azman Ali Raymond, Abolhassan Ahmadian. Preconditioning as a potential strategy for the prevention of Parkinson's disease. Molecular neurobiology. vol 51. issue 1. 2015-10-20. PMID:24696268. |
parkinson's disease (pd) is a chronic neurodegenerative movement disorder characterized by the progressive and massive loss of dopaminergic neurons by neuronal apoptosis in the substantia nigra pars compacta and depletion of dopamine in the striatum, which lead to pathological and clinical abnormalities. |
2015-10-20 |
2023-08-13 |
Not clear |
| Yu Deng, Congcong Jiao, Chao Mi, Bin Xu, Yuehui Li, Fei Wang, Wei Liu, Zhaofa X. Melatonin inhibits manganese-induced motor dysfunction and neuronal loss in mice: involvement of oxidative stress and dopaminergic neurodegeneration. Molecular neurobiology. vol 51. issue 1. 2015-10-20. PMID:24969583. |
administration of mncl2 (50 mg/kg) for 2 weeks significantly induced hypokinesis, dopaminergic neurons degeneration and loss, neuronal ultrastructural damage, and apoptosis in the substantia nigra and the striatum. |
2015-10-20 |
2023-08-13 |
mouse |
| Yu Deng, Congcong Jiao, Chao Mi, Bin Xu, Yuehui Li, Fei Wang, Wei Liu, Zhaofa X. Melatonin inhibits manganese-induced motor dysfunction and neuronal loss in mice: involvement of oxidative stress and dopaminergic neurodegeneration. Molecular neurobiology. vol 51. issue 1. 2015-10-20. PMID:24969583. |
in conclusion, mn treatment resulted in motor dysfunction and neuronal loss, possibly involving an interaction between oxidative stress and dopaminergic neurodegeneration in the substantia nigra and the striatum. |
2015-10-20 |
2023-08-13 |
mouse |
| David N Hauser, Christopher T Primiani, Rebekah G Langston, Ravindran Kumaran, Mark R Cookso. The Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice. eNeuro. vol 2. issue 1. 2015-10-14. PMID:26464968. |
furthermore, we did not observe any difference in dopaminergic terminal immunostaining in the striatum of these mice. |
2015-10-14 |
2023-08-13 |
mouse |
| Matthew T Silvestrini, Dali Yin, Alastair J Martin, Valerie G Coppes, Preeti Mann, Paul S Larson, Philip A Starr, Xianmin Zeng, Nalin Gupta, S S Panter, Tejal A Desai, Daniel A Li. Interventional magnetic resonance imaging-guided cell transplantation into the brain with radially branched deployment. Molecular therapy : the journal of the American Society of Gene Therapy. vol 23. issue 1. 2015-09-30. PMID:25138755. |
human embryonic stem cell-derived dopaminergic neurons were biocompatible with the imri-guided rbd platform and successfully delivered with imri guidance into the swine striatum. |
2015-09-30 |
2023-08-13 |
human |
| Yuan Liu, Xiaoning Zeng, Yujian Hui, Chenlei Zhu, Jie Wu, Devin H Taylor, Juan Ji, Weimin Fan, Zuhu Huang, Jun H. Activation of α7 nicotinic acetylcholine receptors protects astrocytes against oxidative stress-induced apoptosis: implications for Parkinson's disease. Neuropharmacology. vol 91. 2015-09-28. PMID:25486621. |
systemic administration of nicotine dramatically alleviated mptp-induced symptoms, protected dopaminergic neurons against degeneration, inhibited astrocytes and microglia activation in the substantia nigra pars compacta (snpc) and blocked the decrease of gdnf in the striatum by activating α7-nachrs. |
2015-09-28 |
2023-08-13 |
Not clear |
| Chao-Yu Hsu, Ching-Sui Hung, Hung-Ming Chang, Wen-Chieh Liao, Shih-Chun Ho, Ying-Jui H. Ceftriaxone prevents and reverses behavioral and neuronal deficits in an MPTP-induced animal model of Parkinson's disease dementia. Neuropharmacology. vol 91. 2015-09-28. PMID:25499022. |
dopaminergic degeneration in the substantia nigra pars compacta and striatum was observed on days 3 and 15. |
2015-09-28 |
2023-08-13 |
rat |
| Jianyu Wu, Chao Sheng, Zhongfeng Liu, Weili Jia, Bin Wang, Mo Li, Linlin Fu, Zhenhua Ren, Jing An, Lisi Sang, Gongru Song, Yanchuan Wu, Yanling Xu, Shuyan Wang, Zhiguo Chen, Qi Zhou, Y Alex Zhan. Lmx1a enhances the effect of iNSCs in a PD model. Stem cell research. vol 14. issue 1. 2015-09-25. PMID:25460246. |
although few inscs survived 11weeks after transplantation, the improved motor performance in insc-lmx1a group did correlate with a greater tyrosine hydroxylase (th) signal abundance in the lesioned area of striatum, suggesting that inscs may have worked through a non-autonomous manner to enhance the functions of remaining endogenous dopaminergic neurons in brain. |
2015-09-25 |
2023-08-13 |
mouse |
| Federico Nemmi, Umberto Sabatini, Olivier Rascol, Patrice Péra. Parkinson's disease and local atrophy in subcortical nuclei: insight from shape analysis. Neurobiology of aging. vol 36. issue 1. 2015-09-21. PMID:25174648. |
parkinson's disease (pd) is characterized by loss of dopaminergic neurons in the substantia nigra pars compacta, inducing dopaminergic depletion in the striatum. |
2015-09-21 |
2023-08-13 |
human |
| Jang-Won Lee, Victor Tapias, Roberto Di Maio, J Timothy Greenamyre, Jason R Canno. Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats. Neurobiology of aging. vol 36. issue 1. 2015-09-21. PMID:25174649. |
at ages of 4, 8, and 12 months, our characterization showed that expression of g2019s lrrk2 induced oxidative stress in striatum and substantia nigra, increased inducible nitric oxide synthase expression in nigral dopamine neurons, and abnormal morphology of nigral dopaminergic neurons in transgenic rats compared with wild-type, without inducing overt neurodegeneration in nigrostriatal dopaminergic neurons. |
2015-09-21 |
2023-08-13 |
human |
| Sophie Sérrière, Aurélie Doméné, Johnny Vercouillie, Céline Mothes, Sylvie Bodard, Nuno Rodrigues, Denis Guilloteau, Sylvain Routier, Guylène Page, Sylvie Chalo. Assessment of the Protection of Dopaminergic Neurons by an α7 Nicotinic Receptor Agonist, PHA 543613 Using [(18)F]LBT-999 in a Parkinson's Disease Rat Model. Frontiers in medicine. vol 2. 2015-09-21. PMID:26389120. |
the dat density reflecting the integrity of dopaminergic neurons was significantly decreased while the intensity of neuroinflammation measured by tspo density was significantly increased in the lesioned compared to intact striatum in both groups. |
2015-09-21 |
2023-08-13 |
rat |
| Deeksha Varma, Dwaipayan Se. Role of the unfolded protein response in the pathogenesis of Parkinson's disease. Acta neurobiologiae experimentalis. vol 75. issue 1. 2015-09-16. PMID:25856519. |
it is is characterized by loss of dopaminergic neurons in the striatum and substantia nigra, coupled with the formation of intracellular lewy bodies in degenerating neurons. |
2015-09-16 |
2023-08-13 |
human |
| Monica Colamartino, Massimo Santoro, Guglielmo Duranti, Stefania Sabatini, Roberta Ceci, Antonella Testa, Luca Padua, Renata Cozz. Evaluation of levodopa and carbidopa antioxidant activity in normal human lymphocytes in vitro: implication for oxidative stress in Parkinson's disease. Neurotoxicity research. vol 27. issue 2. 2015-09-14. PMID:25355370. |
the main pathochemical hallmark of parkinson's disease (pd) is the loss of dopamine in the striatum of the brain, and the oral administration of levodopa (l-dopa) is a treatment that partially restores the dopaminergic transmission. |
2015-09-14 |
2023-08-13 |
human |
| X Jing, H Shi, C Zhang, M Ren, M Han, X Wei, X Zhang, H Lo. Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity. Neuroscience. vol 286. 2015-09-14. PMID:25449120. |
moreover, dmf ameliorated dopaminergic neurotoxicity in 6-ohda-induced pd animal models as evidenced by amelioration of locomotor dysfunction, loss in striatal dopamine, and reductions in dopaminergic neurons in the substantia nigra and striatum. |
2015-09-14 |
2023-08-13 |
mouse |
| Hiromi Sano, Miho Murata, Atsushi Namb. Zonisamide reduces nigrostriatal dopaminergic neurodegeneration in a mouse genetic model of Parkinson's disease. Journal of neurochemistry. vol 134. issue 2. 2015-09-14. PMID:25857446. |
in addition, dopaminergic terminals in the striatum and the motor function were improved in zonisamide-treated engrailed mutant mice to the levels of those in control mice. |
2015-09-14 |
2023-08-13 |
mouse |
| Maartje M J Veeneman, Ruth Damsteegt, Louk J M J Vanderschure. The nucleus accumbens shell and the dorsolateral striatum mediate the reinforcing effects of cocaine through a serial connection. Behavioural pharmacology. vol 26. issue 1-2. 2015-09-03. PMID:25325288. |
the reinforcing and addictive properties of cocaine are thought to rely on the dopaminergic innervation of the striatum. |
2015-09-03 |
2023-08-13 |
rat |
| Maartje M J Veeneman, Ruth Damsteegt, Louk J M J Vanderschure. The nucleus accumbens shell and the dorsolateral striatum mediate the reinforcing effects of cocaine through a serial connection. Behavioural pharmacology. vol 26. issue 1-2. 2015-09-03. PMID:25325288. |
we infused the dopamine receptor antagonist α-flupenthixol unilaterally into the nacc shell and infused this same antagonist into the contralateral dls, thereby disrupting dopaminergic interconnectivity within the striatum. |
2015-09-03 |
2023-08-13 |
rat |
| Liang Tan, Hongfei Ge, Jun Tang, Chuhua Fu, Wangsheng Duanmu, Yujie Chen, Rong Hu, Jianfeng Sui, Xin Liu, Hua Fen. Amantadine preserves dopamine level and attenuates depression-like behavior induced by traumatic brain injury in rats. Behavioural brain research. vol 279. 2015-08-20. PMID:25447294. |
the da concentration in the striatum of the injured rats, as well as the degeneration and apoptosis of dopaminergic neurons in the substantia nigra (sn), were checked along with the depression-like behavior. |
2015-08-20 |
2023-08-13 |
rat |