| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Debasmita Tripathy, Poonam Verma, Dominic N Nthenge-Ngumbau, Meghna Banerjee, Kochupurackal P Mohanakuma. Regenerative therapy in experimental parkinsonism: mixed population of differentiated mouse embryonic stem cells, rather than magnetically sorted and enriched dopaminergic cells provide neuroprotection. CNS neuroscience & therapeutics. vol 20. issue 8. 2015-03-30. PMID:24954161. |
the objective of the study was to develop regenerative therapy by transplanting varied populations of dopaminergic neurons, differentiated from mouse embryonic stem cells (mes) in the striatum for correcting experimental parkinsonism in rats. |
2015-03-30 |
2023-08-13 |
mouse |
| Lior Greenbaum, Bernard Lere. Pharmacogenetics of antipsychotic-induced movement disorders as a resource for better understanding Parkinson's disease modifier genes. Frontiers in neurology. vol 6. 2015-03-09. PMID:25750634. |
aip vulnerability variants could also be related to latent impairment in the nigrostriatal pathway, affecting its functionality, and leading to subclinical dopaminergic deficits in the striatum. |
2015-03-09 |
2023-08-13 |
Not clear |
| Meghan R Hennis, Katherine W Seamans, Marian A Marvin, Bradford H Casey, Matthew S Goldber. Behavioral and neurotransmitter abnormalities in mice deficient for Parkin, DJ-1 and superoxide dismutase. PloS one. vol 8. issue 12. 2015-02-23. PMID:24386432. |
surprisingly, mice bearing similar loss-of-function mutations in parkin and dj-1 do not show age-dependent loss of nigral dopaminergic neurons or depletion of dopamine in the striatum. |
2015-02-23 |
2023-08-12 |
mouse |
| David A Kupferschmidt, Patrick A Cody, David M Lovinger, Margaret I Davi. Brain BLAQ: Post-hoc thick-section histochemistry for localizing optogenetic constructs in neurons and their distal terminals. Frontiers in neuroanatomy. vol 9. 2015-02-20. PMID:25698938. |
following viral-mediated transduction of optogenetic constructs and fluorescent proteins in mouse cortical pyramidal and dopaminergic neurons, we used blaq to assess innervation patterns in the striatum, a region in which autofluorescence often obscures the imaging of fine neural processes. |
2015-02-20 |
2023-08-13 |
mouse |
| Adriana Galvan, Annaelle Devergnas, Thomas Wichman. Alterations in neuronal activity in basal ganglia-thalamocortical circuits in the parkinsonian state. Frontiers in neuroanatomy. vol 9. 2015-02-20. PMID:25698937. |
most of the mentioned electrophysiologic changes are probably related to the degeneration of diencephalic dopaminergic neurons, leading to dopamine loss in the striatum and other basal ganglia nuclei, although degeneration of non-dopaminergic cell groups may also have a role. |
2015-02-20 |
2023-08-13 |
Not clear |
| Yi-Hsien Tsou, Ching-Ting Shih, Cheng-Hsin Ching, Jui-Yen Huang, Chauying J Jen, Lung Yu, Yu-Min Kuo, Fong-Sen Wu, Jih-Ing Chuan. Treadmill exercise activates Nrf2 antioxidant system to protect the nigrostriatal dopaminergic neurons from MPP+ toxicity. Experimental neurology. vol 263. 2015-02-09. PMID:25286336. |
we found that mpp(+) induced early decreases in total glutathione level and nrf2/γgclc (catalytic subunit of γgcl) expression, but late upregulation of ho-1 expression in association with loss of nigral dopaminergic neurons and downregulation of tyrosine hydroxylase and dopamine transporter expression in the striatum. |
2015-02-09 |
2023-08-13 |
rat |
| G Elliott Wimmer, Erin Kendall Braun, Nathaniel D Daw, Daphna Shoham. Episodic memory encoding interferes with reward learning and decreases striatal prediction errors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 45. 2015-01-20. PMID:25378157. |
the striatum and its dopaminergic inputs are known to support incremental reward-based learning, while the hippocampus is known to support encoding of single events (episodic memory). |
2015-01-20 |
2023-08-13 |
human |
| Heli Chauhan, Bryan A Killinger, Cheryl V Miller, Anna Moszczynsk. Single and binge methamphetamine administrations have different effects on the levels of dopamine D2 autoreceptor and dopamine transporter in rat striatum. International journal of molecular sciences. vol 15. issue 4. 2015-01-19. PMID:24717411. |
at high doses, meth causes a selective degeneration of dopaminergic terminals in the striatum. |
2015-01-19 |
2023-08-13 |
rat |
| Dave J Hayes, Bianca Jupp, Steve J Sawiak, Emiliano Merlo, Daniele Caprioli, Jeffrey W Dalle. Brain γ-aminobutyric acid: a neglected role in impulsivity. The European journal of neuroscience. vol 39. issue 11. 2015-01-16. PMID:24460847. |
here we review the lesser-studied role of γ-aminobutyric acid (gaba) in impulsivity, a major target of the dopaminergic and noradrenergic systems in the prefrontal cortex and striatum, and consider how abnormalities in this inhibitory neurotransmitter might contribute to several forms of impulsive behaviour in humans and experimental animals. |
2015-01-16 |
2023-08-12 |
Not clear |
| Ariadna Recasens, Benjamin Deha. Alpha-synuclein spreading in Parkinson's disease. Frontiers in neuroanatomy. vol 8. 2015-01-08. PMID:25565982. |
of particular importance, it was the seminal observation of lewy bodies (lb), a histopathological signature of pd, in grafted fetal dopaminergic neurons in the striatum of pd patients. |
2015-01-08 |
2023-08-13 |
Not clear |
| M R Williams, K Galvin, B O'Sullivan, C D MacDonald, E W K Ching, F Turkheimer, O D Howes, R K B Pearce, S R Hirsch, M Maie. Neuropathological changes in the substantia nigra in schizophrenia but not depression. European archives of psychiatry and clinical neuroscience. vol 264. issue 4. 2015-01-05. PMID:24374935. |
the substantia nigra is a basal ganglia nucleus responsible for the production of dopamine and projection of dopaminergic neurons to the striatum. |
2015-01-05 |
2023-08-12 |
Not clear |
| Claudia Heine, Heike Frank. Organotypic slice co-culture systems to study axon regeneration in the dopaminergic system ex vivo. Methods in molecular biology (Clifton, N.J.). vol 1162. 2015-01-05. PMID:24838961. |
organotypic slice co-cultures are suitable tools to study axonal regeneration and development (growth or regrowth) of different projection systems of the cns under ex vivo conditions.in this chapter, we describe in detail the reconstruction of the mesocortical and nigrostriatal dopaminergic projection system culturing tissue slices from the ventral tegmental area/substantia nigra (vta/sn) with the prefrontal cortex (pfc) or the striatum (str). |
2015-01-05 |
2023-08-13 |
Not clear |
| Ana María Espinosa-Oliva, Rocío M de Pablos, Marti Santiag. In vivo effect of apomorphine and haloperidol on MPP neurotoxicity. Pharmacology. vol 93. issue 3-4. 2015-01-02. PMID:24556705. |
the involvement of dopaminergic (daergic) receptor drugs in the neuroprotection against the neurotoxic action of 1-methyl-4-phenylpyridinium (mpp(+)) in the daergic terminals in striatum was studied using an intracerebral microdialysis technique. |
2015-01-02 |
2023-08-12 |
Not clear |
| Jeffrey Cockburn, Anne G E Collins, Michael J Fran. A reinforcement learning mechanism responsible for the valuation of free choice. Neuron. vol 83. issue 3. 2014-12-29. PMID:25066083. |
we propose that these choice biases are the behavioral byproduct of a credit assignment mechanism responsible for ensuring the effective delivery of dopaminergic reinforcement learning signals broadcast to the striatum. |
2014-12-29 |
2023-08-13 |
Not clear |
| Candan Depboyl. Non-serine-phosphorylated tyrosine hydroxylase expressing neurons are present in mouse striatum, accumbens and cortex that increase in number following dopaminergic denervation. Journal of chemical neuroanatomy. vol 56. 2014-12-18. PMID:24553202. |
non-serine-phosphorylated tyrosine hydroxylase expressing neurons are present in mouse striatum, accumbens and cortex that increase in number following dopaminergic denervation. |
2014-12-18 |
2023-08-12 |
mouse |
| Lais S Rodrigues, Adriano D S Targa, Ana Carolina D Noseda, Mariana F Aurich, Cláudio Da Cunha, Marcelo M S Lim. Olfactory impairment in the rotenone model of Parkinson's disease is associated with bulbar dopaminergic D2 activity after REM sleep deprivation. Frontiers in cellular neuroscience. vol 8. 2014-12-18. PMID:25520618. |
the present evidence reinforce the idea that da produced by periglomerular neurons, particularly the bulbar dopaminergic d2 receptors, is an essential participant in olfactory discrimination processes, as the snpc, and the striatum. |
2014-12-18 |
2023-08-13 |
human |
| Dalila Mango, Alessandra Bonito-Oliva, Ada Ledonne, Loredana Cappellacci, Riccardo Petrelli, Robert Nisticò, Nicola Berretta, Gilberto Fisone, Nicola Biagio Mercur. Adenosine A1 receptor stimulation reduces D1 receptor-mediated GABAergic transmission from striato-nigral terminals and attenuates l-DOPA-induced dyskinesia in dopamine-denervated mice. Experimental neurology. vol 261. 2014-12-17. PMID:25173217. |
the effect of dpcpx was also examined in a mouse model of parkinson's disease (pd), generated by unilateral denervation of the dopaminergic input to the striatum. |
2014-12-17 |
2023-08-13 |
mouse |
| Ping Liu, Liang Sun, Xu-Li Zhao, Peng Zhang, Xue-Mei Zhao, Jian Zhan. PAR2-mediated epigenetic upregulation of α-synuclein contributes to the pathogenesis of Parkinson׳s disease. Brain research. vol 1565. 2014-12-15. PMID:24747612. |
parkinson׳s disease (pd) is a common neurodegenerative disorder characterized by the selective degeneration of projecting dopaminergic neurons in the substantia nigra and diminished dopamine levels in the striatum. |
2014-12-15 |
2023-08-13 |
rat |
| Yuxin Ma, Mali Zhan, Lisi OuYang, Youlan Li, Si Chen, Jiajia Wu, Jiachang Chen, Cheng Luo, Wanlong Le. The effects of unilateral 6-OHDA lesion in medial forebrain bundle on the motor, cognitive dysfunctions and vulnerability of different striatal interneuron types in rats. Behavioural brain research. vol 266. 2014-12-12. PMID:24613235. |
after dopaminergic depletion, the numbers of calretinin (cr)+ and choline acetyltransferase (chat)+ interneurons were notably reduced while these of neuropeptide y (npy)+ were markedly increased in the striatum. |
2014-12-12 |
2023-08-12 |
rat |
| C H Carriere, N H Kang, L P Nile. Neuroprotection by valproic acid in an intrastriatal rotenone model of Parkinson's disease. Neuroscience. vol 267. 2014-12-09. PMID:24613722. |
rotenone, which is used as a pesticide and insecticide, has been shown to cause systemic inhibition of mitochondrial complex i activity, with consequent degeneration of dopaminergic neurons within the substantia nigra and striatum, as observed in parkinson's disease. |
2014-12-09 |
2023-08-12 |
rat |