| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Graziella Madeo, Tommaso Schirinzi, Giuseppina Martella, E Claudio Latagliata, Francesca Puglisi, Jie Shen, Enza Maria Valente, Mauro Federici, Nicola B Mercuri, Stefano Puglisi-Allegra, Paola Bonsi, Antonio Pisan. PINK1 heterozygous mutations induce subtle alterations in dopamine-dependent synaptic plasticity. Movement disorders : official journal of the Movement Disorder Society. vol 29. issue 1. 2014-09-19. PMID:24167038. |
although nigral dopaminergic neurons exhibited normal morphological and electrophysiological properties with normal responses to dopamine receptor activation, a significantly lower dopamine release was measured in the striatum of pink1(+/-) mice compared with control mice, suggesting that a decrease in stimulus-evoked dopamine overflow acts as a major determinant for the ltp deficit. |
2014-09-19 |
2023-08-12 |
mouse |
| Toshio Obata, Masahiro Aomin. Protective effect of tamoxifen, a synthetic non-steroidal antiestrogen, on phenelzine and 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical generation in rat striatum. Research communications in molecular pathology and pharmacology. vol 122-123. 2014-09-15. PMID:25022031. |
the present study examined whether tamoxifen could suppress antidepressant drug phenelzine can increase an active dopaminergic neurotoxin, 1-methyl-4-phenylpyridinium ion (mpp+)-induced hydroxyl radical (*oh) generation in the extracellular fluid of rat striatum, using in vivo microdialysis system. |
2014-09-15 |
2023-08-13 |
rat |
| Y Yabuki, Y Ohizumi, A Yokosuka, Y Mimaki, K Fukunag. Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice. Neuroscience. vol 259. 2014-09-11. PMID:24316474. |
nonetheless, nobiletin treatment did not block loss of dopaminergic neurons seen in the mptp-treated mouse midbrain, nor did it rescue decreased tyrosine hydroxylase (th) protein levels seen in the striatum or hippocampal ca1 region of these mice. |
2014-09-11 |
2023-08-12 |
mouse |
| Domingo Afonso-Oramas, Ignacio Cruz-Muros, Javier Castro-Hernández, Josmar Salas-Hernández, Pedro Barroso-Chinea, Sonia García-Hernández, José L Lanciego, Tomás González-Hernánde. Striatal vessels receive phosphorylated tyrosine hydroxylase-rich innervation from midbrain dopaminergic neurons. Frontiers in neuroanatomy. vol 8. 2014-09-10. PMID:25206324. |
the presence of phosphorylated th in vessel terminals indicates they are probably the main source of basal th activity in the striatum, and that after activation of midbrain dopaminergic neurons, da release onto vessels precedes that onto neurons. |
2014-09-10 |
2023-08-13 |
rat |
| Hyung Ho Yoon, Joongkee Min, Nari Shin, Yong Hwan Kim, Jin-Mo Kim, Yu-Shik Hwang, Jun-Kyo Francis Suh, Onyou Hwang, Sang Ryong Jeo. Are human dental papilla-derived stem cell and human brain-derived neural stem cell transplantations suitable for treatment of Parkinson's disease? Neural regeneration research. vol 8. issue 13. 2014-09-10. PMID:25206413. |
tyrosine hydroxylase (dopaminergic neuronal marker) staining and g protein-activated inward rectifier potassium channel 2 (a9 dopaminergic neuronal marker) were positive in the lesioned side of striatum in the human brain-derived neural stem cell group. |
2014-09-10 |
2023-08-13 |
human |
| Yunchun Tai, Ling Chen, Enping Huang, Chao Liu, Xingyi Yang, Pingming Qiu, Huijun Wan. Protective effect of alpha-synuclein knockdown on methamphetamine-induced neurotoxicity in dopaminergic neurons. Neural regeneration research. vol 9. issue 9. 2014-09-10. PMID:25206917. |
these results suggest that α-synuclein has the capacity to reverse methamphetamine-induced apoptosis of dopaminergic neurons in the rat striatum by inhibiting oxidative stress and improving dopaminergic system function. |
2014-09-10 |
2023-08-13 |
rat |
| Aderbal S Aguiar, Fabrine Sales Massafera Tristão, Majid Amar, Caroline Chevarin, Viviane Glaser, Roberta de Paula Martins, Eduardo Luiz Gasnhar Moreira, Raymond Mongeau, Laurence Lanfumey, Rita Raisman-Vozari, Alexandra Latini, Rui D S Predige. Six weeks of voluntary exercise don't protect C57BL/6 mice against neurotoxicity of MPTP and MPP(+). Neurotoxicity research. vol 25. issue 2. 2014-09-07. PMID:23873578. |
here, the intranasal administration of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp, 65 mg/kg) caused death of dopaminergic neurons in the substantia nigra pars compacta and depletion of dopamine in the striatum of c57bl/6 mice. |
2014-09-07 |
2023-08-12 |
mouse |
| Elisabet Cuyas, Patricia Robledo, Nieves Pizarro, Magí Farré, Elena Puerta, Norberto Aguirre, Rafael de la Torr. 3,4-methylenedioxymethamphetamine induces gene expression changes in rats related to serotonergic and dopaminergic systems, but not to neurotoxicity. Neurotoxicity research. vol 25. issue 2. 2014-09-07. PMID:23949956. |
in order to further clarify this issue, we used quantitative pcr to study the long-term changes induced by acute administration of mdma (5 mg/kg × 3) in the expression of genes related to serotonergic and dopaminergic systems, as well as those related to cellular toxicity in the cortex, hippocampus, striatum, and brain stem of rats. |
2014-09-07 |
2023-08-12 |
human |
| Wonju Kim, Mi Jung Im, Cheol Hyoung Park, C Justin Lee, Sukwoo Choi, Bong-June Yoo. Remodeling of the dendritic structure of the striatal medium spiny neurons accompanies behavioral recovery in a mouse model of Parkinson's disease. Neuroscience letters. vol 557 Pt B. 2014-08-18. PMID:24176882. |
acute mptp treatment rapidly damaged dopaminergic neurons and their terminals within the striatum and caused behavioral impairments. |
2014-08-18 |
2023-08-12 |
mouse |
| Hiroyoshi Ariga, Kazuko Takahashi-Niki, Izumi Kato, Hiroshi Maita, Takeshi Niki, Sanae M M Iguchi-Arig. Neuroprotective function of DJ-1 in Parkinson's disease. Oxidative medicine and cellular longevity. vol 2013. 2014-08-13. PMID:23766857. |
parkinson's disease (pd) is caused by dopaminergic neuronal death in the substantia nigra, resulting in a reduced level of dopamine in the striatum. |
2014-08-13 |
2023-08-12 |
Not clear |
| Patrick Oeckl, Bastian Hengerer, Boris Ferge. G-protein coupled receptor 6 deficiency alters striatal dopamine and cAMP concentrations and reduces dyskinesia in a mouse model of Parkinson's disease. Experimental neurology. vol 257. 2014-08-13. PMID:24747358. |
in conclusion, the depletion of gpr6 reduces camp concentrations in the striatum and alters the striatal dopaminergic system. |
2014-08-13 |
2023-08-13 |
mouse |
| Kimberlee D'Ardenne, Terry Lohrenz, Krystle A Bartley, P Read Montagu. Computational heterogeneity in the human mesencephalic dopamine system. Cognitive, affective & behavioral neuroscience. vol 13. issue 4. 2014-08-11. PMID:23943512. |
model-based studies in humans have suggested an analogous computational heterogeneity, in which dopaminergic targets in striatum encode both experience-based learning signals and counterfactual learning signals that are based on hypothetical information. |
2014-08-11 |
2023-08-12 |
human |
| O Sader-Mazbar, Y Loboda, M J Rabey, J P M Finber. Increased L-DOPA-derived dopamine following selective MAO-A or -B inhibition in rat striatum depleted of dopaminergic and serotonergic innervation. British journal of pharmacology. vol 170. issue 5. 2014-08-08. PMID:23992249. |
increased l-dopa-derived dopamine following selective mao-a or -b inhibition in rat striatum depleted of dopaminergic and serotonergic innervation. |
2014-08-08 |
2023-08-12 |
rat |
| O Sader-Mazbar, Y Loboda, M J Rabey, J P M Finber. Increased L-DOPA-derived dopamine following selective MAO-A or -B inhibition in rat striatum depleted of dopaminergic and serotonergic innervation. British journal of pharmacology. vol 170. issue 5. 2014-08-08. PMID:23992249. |
we sought to clarify the roles of mao-a and mao-b in deamination of da formed from exogenous l-dopa in rat striatum depleted of dopaminergic, or both dopaminergic and serotonergic innervations. |
2014-08-08 |
2023-08-12 |
rat |
| Gabriela P Chaves-Kirsten, Caio H Y Mazucanti, Caroline C Real, Bruna M Souza, Luiz R G Britto, Andréa S Torrã. Temporal changes of CB1 cannabinoid receptor in the basal ganglia as a possible structure-specific plasticity process in 6-OHDA lesioned rats. PloS one. vol 8. issue 10. 2014-08-02. PMID:24116178. |
the present study evaluated the cb1 expression in four basal ganglia structures, namely striatum, external globus pallidus (egp), internal globus pallidus (igp) and substantia nigra pars reticulata (snpr) of rats 1, 5, 10, 20, and 60 days after unilateral intrastriatal 6-hydroxydopamine injections, that causes retrograde dopaminergic degeneration. |
2014-08-02 |
2023-08-12 |
rat |
| Elżbieta Lorenc-Koci, Anna Czarnecka, Tomasz Lenda, Kinga Kamińska, Jolanta Konieczn. Molsidomine, a nitric oxide donor, modulates rotational behavior and monoamine metabolism in 6-OHDA lesioned rats treated chronically with L-DOPA. Neurochemistry international. vol 63. issue 8. 2014-07-22. PMID:24090640. |
some biochemical and histological studies of parkinson's disease patients' brains and 6-ohda-lesioned rats suggest that dopaminergic dennervation of the striatum leads to the nitrergic system hypofunction in this structure. |
2014-07-22 |
2023-08-12 |
rat |
| Ji-Hi Pyo, You-Kyung Jeong, Sujung Yeo, Je-Hyun Lee, Mi-Young Jeong, Sung-Hoon Kim, Yeong-Gon Choi, Sabina Li. Neuroprotective effect of trans-cinnamaldehyde on the 6-hydroxydopamine-induced dopaminergic injury. Biological & pharmaceutical bulletin. vol 36. issue 12. 2014-07-14. PMID:24292051. |
at 7 d after the 6-ohda injection, 6-ohda led to a severe loss of tyrosine hydroxylase (th)-positive dopaminergic neurons in the striatum and substantia nigra (sn). |
2014-07-14 |
2023-08-12 |
mouse |
| Ji-Hi Pyo, You-Kyung Jeong, Sujung Yeo, Je-Hyun Lee, Mi-Young Jeong, Sung-Hoon Kim, Yeong-Gon Choi, Sabina Li. Neuroprotective effect of trans-cinnamaldehyde on the 6-hydroxydopamine-induced dopaminergic injury. Biological & pharmaceutical bulletin. vol 36. issue 12. 2014-07-14. PMID:24292051. |
on the other hand, tca dramatically maintained the number of th-positive dopaminergic neurons in the striatum and sn regions of the 6-ohda-treated mice, which indicates that tca is able to inhibit the 6-ohda-induced reduction of th expression in the dopaminergic neurons in the striatum and sn regions. |
2014-07-14 |
2023-08-12 |
mouse |
| Sven R Suwijn, Kora de Bruin, Rob M A de Bie, Jan Booi. The role of SPECT imaging of the dopaminergic system in translational research on Parkinson's disease. Parkinsonism & related disorders. vol 20 Suppl 1. 2014-07-11. PMID:24262177. |
imaging of the dopaminergic system with single photon emission computed tomography (spect), and particularly of the dopamine transporter (dat) located in the striatum, is a well accepted tool in clinical practice to confirm or exclude loss of nigrostriatal dopamine (da) neurons in patients suspected to suffer from parkinson's disease (pd). |
2014-07-11 |
2023-08-12 |
human |
| Henriqueta Dias Cardoso, Eraldo Fonseca dos Santos Junior, David Filipe de Santana, Catarina Gonçalves-Pimentel, Monara Kaélle Angelim, Alinny R Isaac, Cláudia Jacques Lagranha, Rubem Carlos Araújo Guedes, Eduardo Isidoro Beltrão, Edgar Morya, Marcelo Cairrão Araújo Rodrigues, Belmira Lara da Silveira Andrade-da-Cost. Omega-3 deficiency and neurodegeneration in the substantia nigra: involvement of increased nitric oxide production and reduced BDNF expression. Biochimica et biophysica acta. vol 1840. issue 6. 2014-07-03. PMID:24361617. |
our previous study demonstrated that essential fatty acid (efa) dietary restriction over two generations induced midbrain dopaminergic cell loss and oxidative stress in the substantia nigra (sn) but not in the striatum of young rats. |
2014-07-03 |
2023-08-12 |
rat |