| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana L Gutiérrez-Valdez, Ricardo García-Ruiz, Verónica Anaya-Martínez, Carmen Torres-Esquivel, Jesús Espinosa-Villanueva, Leonardo Reynoso-Erazo, Rocio Tron-Alvarez, Patricia Aley-Medina, Javier Sánchez-Betancourt, Enrique Montiel-Flores, María R Avila-Cost. The combination of oral L-DOPA/rimonabant for effective dyskinesia treatment and cytological preservation in a rat model of Parkinson's disease and L-DOPA-induced dyskinesia. Behavioural pharmacology. vol 24. issue 8. 2014-11-15. PMID:24196024. |
oral coadministration of ld (30 mg/kg) and rimonabant (1 mg/kg) significantly decreased abnormal involuntary movements and dystonia, possibly through the conservation of some functional tyrosine hydroxylase-immunoreactive dopaminergic cells, which in turn translates into a well-preserved neuropil of a less denervated striatum. |
2014-11-15 |
2023-08-12 |
rat |
| G Martella, M Maltese, R Nisticò, T Schirinzi, G Madeo, G Sciamanna, G Ponterio, A Tassone, G Mandolesi, V Vanni, M Pignatelli, P Bonsi, A Pisan. Regional specificity of synaptic plasticity deficits in a knock-in mouse model of DYT1 dystonia. Neurobiology of disease. vol 65. 2014-11-13. PMID:24503369. |
additionally, we found an abnormal responsiveness of cholinergic interneurons to d2r activation, consisting in an excitatory response rather than the expected inhibition, further confirming an imbalance between dopaminergic and cholinergic signaling in the striatum. |
2014-11-13 |
2023-08-12 |
mouse |
| Susumu Urakawa, Dai Mitsushima, Michito Shimozuru, Yasuo Sakuma, Yasuhiko Kond. An enriched rearing environment calms adult male rat sexual activity: implication for distinct serotonergic and hormonal responses to females. PloS one. vol 9. issue 2. 2014-11-08. PMID:24505330. |
furthermore, following exposure to a female, increases in serotonin levels in the nucleus accumbens and the striatum were significantly suppressed in ee males, whereas dopaminergic responses were similar between the groups. |
2014-11-08 |
2023-08-12 |
rat |
| Hyo Geun Kim, Gunhyuk Park, Ying Piao, Min Seo Kang, Youngmi Kim Pak, Seon-Pyo Hong, Myung Sook O. Effects of the root bark of Paeonia suffruticosa on mitochondria-mediated neuroprotection in an MPTP-induced model of Parkinson's disease. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 65. 2014-10-28. PMID:24389454. |
parkinson's disease (pd) is generally characterized by the progressive loss of dopaminergic neurons projecting from the substantia nigra pars compacta (snpc) to the striatum that results in movement dysfunction, but also entails mitochondrial dysfunction. |
2014-10-28 |
2023-08-12 |
mouse |
| Hidetoshi Komatsu, Minoru Maruyama, Shuuhei Yao, Tokuyuki Shinohara, Kensuke Sakuma, Sachiko Imaichi, Tomoko Chikatsu, Kanako Kuniyeda, Foo Kok Siu, Lam Sock Peng, Katherine Zhuo, Lay Sock Mun, Tan Min Han, Yoshio Matsumoto, Tadatoshi Hashimoto, Nobuyuki Miyajima, Yasuaki Itoh, Kazuhiro Ogi, Yugo Habata, Masaaki Mor. Anatomical transcriptome of G protein-coupled receptors leads to the identification of a novel therapeutic candidate GPR52 for psychiatric disorders. PloS one. vol 9. issue 2. 2014-10-28. PMID:24587241. |
the striatum, in which dopamine d1 and d2 receptors are enriched, is strongly innervated by the ventral tegmental area (vta), which is the origin of dopaminergic cell bodies of the mesocorticolimbic dopamine system_enref_3 and plays a central role in the development of psychiatric disorders_enref_4. |
2014-10-28 |
2023-08-12 |
mouse |
| Jeffrey D Lenz, Mary Kay Lob. Optogenetic insights into striatal function and behavior. Behavioural brain research. vol 255. 2014-10-27. PMID:23628212. |
these studies confirmed the classical hypothesis of movement control and reward seeking behavior through direct versus indirect pathway msns; illuminated a selective role for tans in cocaine reward; dissected the roles of glutamatergic and dopaminergic inputs to striatum in reward; and highlighted a role for striatal signaling molecules including an adrenergic g-protein coupled receptor in reward and the rho-gtpase rac1 in cocaine reward and cocaine induced structural plasticity. |
2014-10-27 |
2023-08-12 |
Not clear |
| Annadurai Anandhan, Kuppusamy Tamilselvam, Dhanraj Vijayraja, Nataraj Ashokkumar, Srinivasagam Rajasankar, Thamilarasan Manivasaga. Resveratrol attenuates oxidative stress and improves behaviour in 1 -methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) challenged mice. Annals of neurosciences. vol 17. issue 3. 2014-10-24. PMID:25205886. |
parkinson's disease (pd) is the most common neurodegenerative disorder, characterized by loss of dopaminergic neurons in substantia nigra and depletion of dopamine in striatum due to mitochondrial dysfunction, oxidative stress, excitotoxicity, apoptosis, inflammation and proteasome failure. |
2014-10-24 |
2023-08-13 |
mouse |
| Cinzia Nasuti, Manuel Carloni, Donatella Fedeli, Antonio Di Stefano, Lisa Marinelli, Laura Serafina Cerasa, Clara Meda, Adriana Maggi, Rosita Gabbianell. Effect of 17β-estradiol on striatal dopaminergic transmission induced by permethrin in early childhood rats. Chemosphere. vol 112. 2014-10-22. PMID:25048945. |
since 17β-estradiol can modulate positively dopaminergic system, here we sought to evaluate the effect of 17β-estradiol supplementation on an animal model developing dopaminergic alterations on nucleus of striatum after neonatal exposure to permethrin pesticide. |
2014-10-22 |
2023-08-13 |
rat |
| Mia Kim, Ki-Ho Cho, Mal-Soon Shin, Jae-Min Lee, Han-Sam Cho, Chang-Ju Kim, Dong-Hoon Shin, Hyeon Jeong Yan. Berberine prevents nigrostriatal dopaminergic neuronal loss and suppresses hippocampal apoptosis in mice with Parkinson's disease. International journal of molecular medicine. vol 33. issue 4. 2014-10-21. PMID:24535622. |
our results revealed that the injection of mptp/p induced dopaminergic neuronal death in the substantia nigra and fiber loss in the striatum. |
2014-10-21 |
2023-08-12 |
mouse |
| Abbas Haghparast, Zahra Fatahi, Shabnam Zeighamy Alamdary, Zahra Reisi, Fariba Khodaghol. Changes in the levels of p-ERK, p-CREB, and c-fos in rat mesocorticolimbic dopaminergic system after morphine-induced conditioned place preference: the role of acute and subchronic stress. Cellular and molecular neurobiology. vol 34. issue 2. 2014-10-16. PMID:24292370. |
in this study, we investigated the effects of morphine-induced conditioned place preference (cpp) on p-erk/erk ratio, p-creb/creb ratio and c-fos level in the mesocorticolimbic dopaminergic system including the nucleus accumbens (nac), amygdala (amy), striatum (str), and prefrontal cortex (pfc).our aim was to determine if acute and subchronic stress would affect these alterations. |
2014-10-16 |
2023-08-12 |
rat |
| Hiroshi Kawaguchi, Takayuki Obata, Harumasa Takano, Tsuyoshi Nogami, Tetsuya Suhara, Hiroshi It. Relation between dopamine synthesis capacity and cell-level structure in human striatum: a multi-modal study with positron emission tomography and diffusion tensor imaging. PloS one. vol 9. issue 1. 2014-10-15. PMID:24498218. |
assuming that mean diffusivity reflects the density of wide-spreading axonal terminals in the striatum, the result suggests that dopamine synthesis may be related to the density of dopaminergic neuronal fibers. |
2014-10-15 |
2023-08-12 |
human |
| Elena M Vazey, Gary Aston-Jone. Designer receptors: therapeutic adjuncts to cell replacement therapy in Parkinson's disease. The Journal of clinical investigation. vol 124. issue 7. 2014-10-06. PMID:24937425. |
in this issue of the jci, dell'anno and colleagues evaluated the use of induced dopaminergic (ida) neurons that were generated by direct fibroblast reprogramming for transplantation and demonstrated that postmitotic ida neurons stably and functionally integrate into host striatum to produce motor improvements in 6-ohda rats, a parkinson's disease model. |
2014-10-06 |
2023-08-13 |
rat |
| Erin N Newburn, Anne-Marie Duchemin, Norton H Neff, Maria Hadjiconstantino. GM1 ganglioside enhances Ret signaling in striatum. Journal of neurochemistry. vol 130. issue 4. 2014-09-29. PMID:24821093. |
our in situ studies suggest that gm1 via gfrα1 modulates ret activation and phosphorylation in the striatum and provide a putative mechanism for its effects on dopaminergic neurons. |
2014-09-29 |
2023-08-13 |
Not clear |
| Erin N Newburn, Anne-Marie Duchemin, Norton H Neff, Maria Hadjiconstantino. GM1 ganglioside enhances Ret signaling in striatum. Journal of neurochemistry. vol 130. issue 4. 2014-09-29. PMID:24821093. |
we provide evidence that the gm1 enhances the activity of ret tyrosine kinase receptor for glia cell-derived neurotrophic factor (gdnf) in the striatum in situ and in vivo, and propose that this might be a mechanism for gm1's neurotrophic actions on dopaminergic neurons. |
2014-09-29 |
2023-08-13 |
Not clear |
| Jill R Crittenden, Carolyn J Lacey, Tyrone Lee, Hilary A Bowden, Ann M Graybie. Severe drug-induced repetitive behaviors and striatal overexpression of VAChT in ChAT-ChR2-EYFP BAC transgenic mice. Frontiers in neural circuits. vol 8. 2014-09-24. PMID:24904300. |
instructive cues activate inputs to the striatum from both dopaminergic and cholinergic neurons, which are thought to work together to support motor learning and motivated behaviors. |
2014-09-24 |
2023-08-13 |
mouse |
| Graziella Madeo, Tommaso Schirinzi, Giuseppina Martella, E Claudio Latagliata, Francesca Puglisi, Jie Shen, Enza Maria Valente, Mauro Federici, Nicola B Mercuri, Stefano Puglisi-Allegra, Paola Bonsi, Antonio Pisan. PINK1 heterozygous mutations induce subtle alterations in dopamine-dependent synaptic plasticity. Movement disorders : official journal of the Movement Disorder Society. vol 29. issue 1. 2014-09-19. PMID:24167038. |
although nigral dopaminergic neurons exhibited normal morphological and electrophysiological properties with normal responses to dopamine receptor activation, a significantly lower dopamine release was measured in the striatum of pink1(+/-) mice compared with control mice, suggesting that a decrease in stimulus-evoked dopamine overflow acts as a major determinant for the ltp deficit. |
2014-09-19 |
2023-08-12 |
mouse |
| Toshio Obata, Masahiro Aomin. Protective effect of tamoxifen, a synthetic non-steroidal antiestrogen, on phenelzine and 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical generation in rat striatum. Research communications in molecular pathology and pharmacology. vol 122-123. 2014-09-15. PMID:25022031. |
the present study examined whether tamoxifen could suppress antidepressant drug phenelzine can increase an active dopaminergic neurotoxin, 1-methyl-4-phenylpyridinium ion (mpp+)-induced hydroxyl radical (*oh) generation in the extracellular fluid of rat striatum, using in vivo microdialysis system. |
2014-09-15 |
2023-08-13 |
rat |
| Y Yabuki, Y Ohizumi, A Yokosuka, Y Mimaki, K Fukunag. Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice. Neuroscience. vol 259. 2014-09-11. PMID:24316474. |
nonetheless, nobiletin treatment did not block loss of dopaminergic neurons seen in the mptp-treated mouse midbrain, nor did it rescue decreased tyrosine hydroxylase (th) protein levels seen in the striatum or hippocampal ca1 region of these mice. |
2014-09-11 |
2023-08-12 |
mouse |
| Domingo Afonso-Oramas, Ignacio Cruz-Muros, Javier Castro-Hernández, Josmar Salas-Hernández, Pedro Barroso-Chinea, Sonia García-Hernández, José L Lanciego, Tomás González-Hernánde. Striatal vessels receive phosphorylated tyrosine hydroxylase-rich innervation from midbrain dopaminergic neurons. Frontiers in neuroanatomy. vol 8. 2014-09-10. PMID:25206324. |
the presence of phosphorylated th in vessel terminals indicates they are probably the main source of basal th activity in the striatum, and that after activation of midbrain dopaminergic neurons, da release onto vessels precedes that onto neurons. |
2014-09-10 |
2023-08-13 |
rat |
| Hyung Ho Yoon, Joongkee Min, Nari Shin, Yong Hwan Kim, Jin-Mo Kim, Yu-Shik Hwang, Jun-Kyo Francis Suh, Onyou Hwang, Sang Ryong Jeo. Are human dental papilla-derived stem cell and human brain-derived neural stem cell transplantations suitable for treatment of Parkinson's disease? Neural regeneration research. vol 8. issue 13. 2014-09-10. PMID:25206413. |
tyrosine hydroxylase (dopaminergic neuronal marker) staining and g protein-activated inward rectifier potassium channel 2 (a9 dopaminergic neuronal marker) were positive in the lesioned side of striatum in the human brain-derived neural stem cell group. |
2014-09-10 |
2023-08-13 |
human |