| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O F Elabi, K Duskova, J S Davies, E L Lan. The Impact of Ghrelin on the Survival and Efficacy of Dopaminergic Fetal Grafts in the 6-OHDA-Lesioned Rat. Neuroscience. vol 395. 2019-03-05. PMID:30414880. |
the presence of the ghrelin receptor (ghsr1a) on the dopaminergic neurons of the substantia nigra raises the possibility that a potential application for this property of ghrelin may be as an adjunctive neuroprotective agent to enhance and support the survival and integration of dopaminergic cells transplanted into the striatum. |
2019-03-05 |
2023-08-13 |
rat |
| Ben Sagot, Li Li, Fu-Ming Zho. Hyperactive Response of Direct Pathway Striatal Projection Neurons to L-dopa and D1 Agonism in Freely Moving Parkinsonian Mice. Frontiers in neural circuits. vol 12. 2019-03-04. PMID:30104963. |
taken together, these results provide the first evidence from freely moving animals that in parkinsonian striatum, identified behavior-promoting dspns become hyperactive upon the administration of l-dopa or a d1 agonist, likely contributing to the profound dopaminergic motor stimulation in parkinsonian animals and pd patients. |
2019-03-04 |
2023-08-13 |
mouse |
| Nora A Herweg, Tobias Sommer, Nico Bunzec. Retrieval Demands Adaptively Change Striatal Old/New Signals and Boost Subsequent Long-Term Memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 3. 2019-02-28. PMID:29217684. |
the striatum is a central part of the dopaminergic mesolimbic system and contributes both to the encoding and retrieval of long-term memories. |
2019-02-28 |
2023-08-13 |
human |
| Justin N Weilnau, Michael A Carcella, Kristin M Miner, Tarun N Bhatia, Daniel F Hutchison, Deepti B Pant, Negin Nouraei, Rehana K Lea. Evidence for cross-hemispheric preconditioning in experimental Parkinson's disease. Brain structure & function. vol 223. issue 3. 2019-02-26. PMID:29103154. |
6-ohda-induced loss of dopaminergic terminals in the contralateral striatum was ablated by cross-hemispheric preconditioning, as shown by two independent markers of the dopaminergic phenotype, each measured by two blinded observers. |
2019-02-26 |
2023-08-13 |
Not clear |
| Marc Dos Santos, Emma N Cahill, Gregory Dal Bo, Peter Vanhoutte, Jocelyne Caboche, Bruno Giros, Nicolas Hec. Cocaine increases dopaminergic connectivity in the nucleus accumbens. Brain structure & function. vol 223. issue 2. 2019-02-25. PMID:29027032. |
in these mice, specific labeling of dopaminergic boutons was observed in the striatum. |
2019-02-25 |
2023-08-13 |
mouse |
| Marc Dos Santos, Emma N Cahill, Gregory Dal Bo, Peter Vanhoutte, Jocelyne Caboche, Bruno Giros, Nicolas Hec. Cocaine increases dopaminergic connectivity in the nucleus accumbens. Brain structure & function. vol 223. issue 2. 2019-02-25. PMID:29027032. |
our results show that chronic cocaine administration induces structural plasticity of dopaminergic boutons that could participate in dopamine-dependent neuronal adaptations in the striatum. |
2019-02-25 |
2023-08-13 |
mouse |
| Lucas C Armstrong, Glenn E Kirsch, Nikolai B Fedorov, Caiyun Wu, Yuri A Kuryshev, Abby L Sewell, Zhiqi Liu, Arianne L Motter, Carmine S Leggett, Michael S Or. High-Throughput Patch Clamp Screening in Human α6-Containing Nicotinic Acetylcholine Receptors. SLAS discovery : advancing life sciences R & D. vol 22. issue 6. 2019-02-21. PMID:28298165. |
the α6β2β3 nachr subtype is expressed in terminals of dopaminergic neurons that project to the nucleus accumbens and striatum and modulate dopamine release in brain regions involved in nicotine addiction. |
2019-02-21 |
2023-08-13 |
human |
| Alexander B Pupyshev, Tatiana A Korolenko, Anna A Akopyan, Tamara G Amstislavskaya, Maria A Tikhonov. Suppression of autophagy in the brain of transgenic mice with overexpression of А53Т-mutant α-synuclein as an early event at synucleinopathy progression. Neuroscience letters. vol 672. 2019-02-18. PMID:29203207. |
the results were further supported by the data on tyrosine hydroxylase immunostaining that indicated its significant decrease in the striatum but not in s.nigra of transgenic mice and might be more related to earlier damage of dopaminergic neurites than to the somas due to disturbed formation of autophagosomes at the neuron periphery. |
2019-02-18 |
2023-08-13 |
mouse |
| Sakari Leino, Sini K Koski, Raisa Hänninen, Tuukka Tapanainen, Saara Rannanpää, Outi Salmine. Attenuated dopaminergic neurodegeneration and motor dysfunction in hemiparkinsonian mice lacking the α5 nicotinic acetylcholine receptor subunit. Neuropharmacology. vol 138. 2019-02-13. PMID:29940207. |
unilateral dopaminergic lesions were induced in wild-type and α5-ko mice by 6-hydroxydopamine injections into the striatum or the medial forebrain bundle. |
2019-02-13 |
2023-08-13 |
mouse |
| Herschel S Dhekne, Izumi Yanatori, Rachel C Gomez, Francesca Tonelli, Federico Diez, Birgitt Schüle, Martin Steger, Dario R Alessi, Suzanne R Pfeffe. A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain. eLife. vol 7. 2019-02-12. PMID:30398148. |
moreover, cholinergic neurons in the striatum of lrrk2 r1441c mice show decreased ciliation, which will decrease their ability to sense sonic hedgehog in a neuro-protective circuit that supports dopaminergic neurons. |
2019-02-12 |
2023-08-13 |
mouse |
| Mei Liu, Eun-Joo Shin, Duy-Khanh Dang, Chun-Hui Jin, Phil Ho Lee, Ji Hoon Jeong, Seok-Joo Park, Yong-Sun Kim, Bin Xing, Tao Xin, Guoying Bing, Hyoung-Chun Ki. Trichloroethylene and Parkinson's Disease: Risk Assessment. Molecular neurobiology. vol 55. issue 7. 2019-02-04. PMID:29270919. |
following 8 months of tce treatment, there was a progressive and selective loss of 50% of the dopaminergic neurons in mouse substantia nigra (sn) and about 50% loss of dopamine and 72% loss of 3,4-dihydroxyphenylacetic acid in the striatum, respectively. |
2019-02-04 |
2023-08-13 |
mouse |
| Sonia Abad, Carla Ramon, David Pubill, Jorge Camarasa, Antonio Camins, Elena Escubed. Adolescent exposure to MDMA induces dopaminergic toxicity in substantia nigra and potentiates the amyloid plaque deposition in the striatum of APPswe/PS1dE9 mice. Biochimica et biophysica acta. vol 1862. issue 9. 2019-01-28. PMID:27344237. |
adolescent exposure to mdma induces dopaminergic toxicity in substantia nigra and potentiates the amyloid plaque deposition in the striatum of appswe/ps1de9 mice. |
2019-01-28 |
2023-08-13 |
mouse |
| Jickssa M Gemechu, Akhil Sharma, Dongyue Yu, Yuran Xie, Olivia M Merkel, Anna Moszczynsk. Characterization of Dopaminergic System in the Striatum of Young Adult Park2 Scientific reports. vol 8. issue 1. 2018-12-12. PMID:29367643. |
characterization of dopaminergic system in the striatum of young adult park2 mutations in parkin gene (park2) are linked to early-onset autosomal recessive parkinson's disease (pd) and young-onset sporadic pd. |
2018-12-12 |
2023-08-13 |
rat |
| Jickssa M Gemechu, Akhil Sharma, Dongyue Yu, Yuran Xie, Olivia M Merkel, Anna Moszczynsk. Characterization of Dopaminergic System in the Striatum of Young Adult Park2 Scientific reports. vol 8. issue 1. 2018-12-12. PMID:29367643. |
our goal was to examine dopaminergic (daergic) system in the striatum of 2 month-old pko rats in order to characterize compensatory mechanisms that may have occurred within the system. |
2018-12-12 |
2023-08-13 |
rat |
| Pranay Srivastava, Yogesh K Dhuriya, Richa Gupta, Rajendra K Shukla, Rajesh S Yadav, Hari N Dwivedi, Aditya B Pant, Vinay K Khann. Protective Effect of Curcumin by Modulating BDNF/DARPP32/CREB in Arsenic-Induced Alterations in Dopaminergic Signaling in Rat Corpus Striatum. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:27966075. |
protective effect of curcumin by modulating bdnf/darpp32/creb in arsenic-induced alterations in dopaminergic signaling in rat corpus striatum. |
2018-12-11 |
2023-08-13 |
rat |
| Pranay Srivastava, Yogesh K Dhuriya, Richa Gupta, Rajendra K Shukla, Rajesh S Yadav, Hari N Dwivedi, Aditya B Pant, Vinay K Khann. Protective Effect of Curcumin by Modulating BDNF/DARPP32/CREB in Arsenic-Induced Alterations in Dopaminergic Signaling in Rat Corpus Striatum. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:27966075. |
in continuation to that, the present study is focused to decipher the molecular mechanisms associated with alterations in dopaminergic signaling on arsenic exposure in corpus striatum and assess the protective efficacy of curcumin. |
2018-12-11 |
2023-08-13 |
rat |
| Pranay Srivastava, Yogesh K Dhuriya, Richa Gupta, Rajendra K Shukla, Rajesh S Yadav, Hari N Dwivedi, Aditya B Pant, Vinay K Khann. Protective Effect of Curcumin by Modulating BDNF/DARPP32/CREB in Arsenic-Induced Alterations in Dopaminergic Signaling in Rat Corpus Striatum. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:27966075. |
modulation in the expression of bdnf and pgsk3β in corpus striatum by curcumin exhibits the importance of neuronal survival pathway in arsenic-induced dopaminergic dysfunctions. |
2018-12-11 |
2023-08-13 |
rat |
| Pranay Srivastava, Yogesh K Dhuriya, Richa Gupta, Rajendra K Shukla, Rajesh S Yadav, Hari N Dwivedi, Aditya B Pant, Vinay K Khann. Protective Effect of Curcumin by Modulating BDNF/DARPP32/CREB in Arsenic-Induced Alterations in Dopaminergic Signaling in Rat Corpus Striatum. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:27966075. |
the results exhibit that curcumin modulates bdnf/darpp32/creb in arsenic-induced alterations in dopaminergic signaling in rat corpus striatum. |
2018-12-11 |
2023-08-13 |
rat |
| Jin Gyu Choi, Namkwon Kim, In Gyoung Ju, Hyeyoon Eo, Su-Min Lim, Se-Eun Jang, Dong-Hyun Kim, Myung Sook O. Oral administration of Proteus mirabilis damages dopaminergic neurons and motor functions in mice. Scientific reports. vol 8. issue 1. 2018-12-11. PMID:29352191. |
administration of p. mirabilis isolated from pd mice significantly induced motor deficits, selectively caused dopaminergic neuronal damage and inflammation in substantia nigra and striatum, and stimulated α-synuclein aggregation in the brain as well as in the colon. |
2018-12-11 |
2023-08-13 |
mouse |
| Liping Zhang, Lingyu Zhang, Lin Li, Christian Hölsche. Neuroprotective effects of the novel GLP-1 long acting analogue semaglutide in the MPTP Parkinson's disease mouse model. Neuropeptides. vol 71. 2018-12-11. PMID:30017231. |
in addition, both glp-1 analogues rescued the decrease of tyrosine hydroxylase (th) levels, alleviated the inflammation response, reduced lipid peroxidation, inhibited the apoptosis pathway, and also increased autophagy- related protein expression, to protect dopaminergic neurons in the substantia nigra and striatum. |
2018-12-11 |
2023-08-13 |
mouse |