| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M L Eckard, K Welle, M Sobolewski, D A Cory-Slecht. A Behavioral Timing Intervention Upregulates Striatal Serotonergic Markers and Reduces Impulsive Action in Adult Male Mice. Behavioural brain research. 2022-12-20. PMID:36539165. |
thus, we assessed how a fixed-interval (fi) intervention initiated during late adolescence and extending into adulthood affected dopaminergic and serotonergic analytes in the frontal cortex and striatum and subsequent impulsive action in adult male and female mice. |
2022-12-20 |
2023-08-14 |
mouse |
| Shamsher Singh, Kanupriya Chauha. Pharmacological approach using Doxycycline and Tocopherol in rotenone induced oxidative stress, neuroinflammation and Parkinson's like symptoms. The International journal of neuroscience. 2022-12-01. PMID:36453937. |
rotenone is a neurotoxin which selectively degenerate dopaminergic neurons in striatum, leading to cause pd like symptoms. |
2022-12-01 |
2023-08-14 |
Not clear |
| Yongjun Wang, Zhengjia Pu, Yiran Zhang, Zhaohui Du, Zeming Guo, Qunhua Ba. Exercise training has a protective effect in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model with improved neural and intestinal pathology and modified intestinal flora. Behavioural brain research. 2022-12-01. PMID:36455673. |
the results showed in these pd mice, exercise training improved their motility, increased the dopamine (da) content in the striatum, along with promoted the gene expression of tyrosine hydroxylase and brain-derived neurotrophic factor in the striatum, which suggests this exercise training might protect striatal dopaminergic neurons from mptp damage; the results also showed exercise training promoted recovery from ileal pathology, reduced the gene expression of intestinal inflammatory factors, and significantly altered the composition and structure of the intestinal flora in these mice. |
2022-12-01 |
2023-08-14 |
mouse |
| Li-Jin Chen, Jeng-Rung Chen, Guo-Fang Tsen. Modulation of striatal glutamatergic, dopaminergic and cholinergic neurotransmission pathways concomitant with motor disturbance in rats with kaolin-induced hydrocephalus. Fluids and barriers of the CNS. vol 19. issue 1. 2022-11-27. PMID:36437472. |
here, we used a kaolin-injection juvenile rat model to explore the effects of acute and chronic hydrocephalus, 1 and 5 weeks post-treatment, respectively on the three major neurotransmission pathways (glutamatergic, dopaminergic and cholinergic) in the striatum. |
2022-11-27 |
2023-08-14 |
rat |
| Laura A Struzyna, Kevin D Browne, Justin C Burrell, Wisberty J Gordián Vélez, Kathryn L Wofford, Hilton M Kaplan, N Sanjeeva Murthy, H Isaac Chen, John E Duda, Rodrigo A España, D Kacy Culle. Axonal Tract Reconstruction Using a Tissue-Engineered Nigrostriatal Pathway in a Rat Model of Parkinson's Disease. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430464. |
immunohistochemistry and fscv established that transplanted te-nsps survived, maintained their axonal tract projections, extended dopaminergic neurites into host tissue, and released dopamine in the striatum. |
2022-11-26 |
2023-08-14 |
rat |
| Richard L Jayaraj, Sheikh Azimullah, Khatija A Parekh, Shreesh K Ojha, Rami Beira. Effect of citronellol on oxidative stress, neuroinflammation and autophagy pathways in an Heliyon. vol 8. issue 11. 2022-11-17. PMID:36387498. |
we further evaluated the effect of citronellol on dopaminergic neurons in substantia nigra pars compacta (snpc) and striatum (st) which are key anatomical structures in pd. |
2022-11-17 |
2023-08-14 |
rat |
| Sergi Ferré, Laura I Sarasola, César Quiroz, Francisco Ciruel. Presynaptic adenosine receptor heteromers as key modulators of glutamatergic and dopaminergic neurotransmission in the striatum. Neuropharmacology. 2022-11-14. PMID:36375695. |
presynaptic adenosine receptor heteromers as key modulators of glutamatergic and dopaminergic neurotransmission in the striatum. |
2022-11-14 |
2023-08-14 |
Not clear |
| Uttam Ojha, Shristi Khanal, Pil-Hoon Park, Jin Tae Hong, Dong-Young Cho. Intermittent fasting protects the nigral dopaminergic neurons from MPTP-mediated dopaminergic neuronal injury in mice. The Journal of nutritional biochemistry. 2022-11-12. PMID:36370926. |
we observed that alternate-day fasting attenuated mptp-induced dopaminergic neuronal loss and astroglial activation in the substantia nigra and the striatum. |
2022-11-12 |
2023-08-14 |
mouse |
| Jeffrey Kim, Etienne W Daadi, Thomas Oh, Elyas S Daadi, Marcel M Daad. Human Induced Pluripotent Stem Cell Phenotyping and Preclinical Modeling of Familial Parkinson's Disease. Genes. vol 13. issue 11. 2022-11-11. PMID:36360174. |
the pathological hallmark of pd is the degeneration of dopaminergic neurons in the substantia nigra pars compacta region of the brain and post-mortem lewy pathology, which leads to the loss of projecting axons innervating the striatum and to impaired motor and cognitive functions. |
2022-11-11 |
2023-08-14 |
human |
| Shashank Vasudevan, Andrea Dotti, Janko Kajtez, Alberto Martínez-Serrano, Carsten Gundlach, Sandrina Campos Maçãs, Karin Lauschke, Anne-Marie Vinngaard, Silvia García López, Marta Pereira, Arto Heiskanen, Stephan S Keller, Jenny Emnéu. Omnidirectional leaky opto-electrical fiber for optogenetic control of neurons in cell replacement therapy. Bioelectrochemistry (Amsterdam, Netherlands). vol 149. 2022-11-08. PMID:36345111. |
the pathophysiological progress of parkinson's disease leads through degeneration of dopaminergic neurons in the substantia nigra to complete cell death and lack of dopamine in the striatum where it modulates motor functions. |
2022-11-08 |
2023-08-14 |
Not clear |
| María-de-Los-Angeles Andrade-Oliva, Yazmín Debray-García, Guadalupe-Elide Morales-Figueroa, Juan Escamilla-Sánchez, Omar Amador-Muñoz, Raúl V Díaz-Godoy, Michael Kleinman, Benjamín Florán, José-Antonio Arias-Montaño, Andrea De Vizcaya-Rui. Effect of subchronic exposure to ambient fine and ultrafine particles on rat motor activity and Inhalation toxicology. 2022-11-03. PMID:36325922. |
exposure of rats to ambient fine (fp) or ultrafine (ufp) particles induces oxidative and inflammatory responses in the striatum, a neuronal nucleus with dense dopaminergic innervation and critically involved in the control of motor activity. |
2022-11-03 |
2023-08-14 |
rat |
| Nozomi Asaok. [NOX1/NADPH Oxidase Facilitates Repetitive Behaviors by Enhancing D Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 142. issue 11. 2022-11-03. PMID:36328442. |
dysfunction of dopaminergic modulation in the striatum is thought to be a key neural mechanism underlying compulsive behavior repetition; however, the mechanistic links between dopaminergic abnormalities and compulsivity remain unclear. |
2022-11-03 |
2023-08-14 |
mouse |
| Kynon J M Benjamin, Qiang Chen, Andrew E Jaffe, Joshua M Stolz, Leonardo Collado-Torres, Louise A Huuki-Myers, Emily E Burke, Ria Arora, Arthur S Feltrin, André Rocha Barbosa, Eugenia Radulescu, Giulio Pergola, Joo Heon Shin, William S Ulrich, Amy Deep-Soboslay, Ran Tao, Thomas M Hyde, Joel E Kleinman, Jennifer A Erwin, Daniel R Weinberger, Apuã C M Paquol. Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes. Nature neuroscience. 2022-11-02. PMID:36319771. |
most studies of gene expression in the brains of individuals with schizophrenia have focused on cortical regions, but subcortical nuclei such as the striatum are prominently implicated in the disease, and current antipsychotic drugs target the striatum's dense dopaminergic innervation. |
2022-11-02 |
2023-08-14 |
Not clear |
| Eva M Szego, Laura Malz, Nadine Bernhardt, Angela Rösen-Wolff, Björn H Falkenburger, Hella Luksc. Constitutively active STING causes neuroinflammation and degeneration of dopaminergic neurons in mice. eLife. vol 11. 2022-10-31. PMID:36314770. |
in adult mice expressing n153s sting, the number of dopaminergic neurons was smaller than in controls, as was the density of dopaminergic axon terminals and the concentration of dopamine in the striatum. |
2022-10-31 |
2023-08-14 |
mouse |
| Sara Abidar, Lucian Hritcu, Mohamed Nhir. The Natural Neuroprotective Compounds Used in the 6-Hydroxydopamine-Induced Parkinson's Disease in Zebrafish: The Current Applications and Perspectives. CNS & neurological disorders drug targets. 2022-10-28. PMID:36306449. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the degeneration of the dopaminergic neurons in the substantia nigra pars compacta, resulting in the loss of dopamine in the striatum, leading thus to the pd classic movement symptoms: resting tremor, rigidity, and bradykinesia/akinesia. |
2022-10-28 |
2023-08-14 |
zebrafish |
| Seunghwan Shim, Da Un Jeong, Hyemi Kim, Chae Yun Kim, Hyejun Park, Yinglan Jin, Kyung Min Kim, Hwa Jeong Lee, Dong Hwan Kim, Yun Soo Bae, Yongseok Cho. Discovery of a NADPH oxidase inhibitor, (E)-3-cyclohexyl-5-(4-((2-hydroxyethyl)(methyl)amino)benzylidene)-1-methyl-2-thioxoimidazolidin-4-oneone, as a novel therapeutic for Parkinson's disease. European journal of medicinal chemistry. vol 244. 2022-10-24. PMID:36274279. |
oral administration of compound 11 (30 mg/kg/daily, 4 weeks) into the mice resulted in suppression of dopaminergic neuronal death in substantia nigra (sn) and in striatum as well as inhibition of microglial migration into sn. |
2022-10-24 |
2023-08-14 |
mouse |
| Allen P F Chen, Jeffrey M Malgady, Lu Chen, Kaiyo W Shi, Eileen Cheng, Joshua L Plotkin, Shaoyu Ge, Qiaojie Xion. Nigrostriatal dopamine pathway regulates auditory discrimination behavior. Nature communications. vol 13. issue 1. 2022-10-08. PMID:36209150. |
we demonstrated that the optogenetic inhibition of dopaminergic projections from the substantia nigra pars compacta to the auditory striatum specifically impairs mouse choice performance but not movement in an auditory frequency discrimination task. |
2022-10-08 |
2023-08-14 |
mouse |
| Song-Yu Guo, Rong-Xiao Guan, Xiao-Dong Chi, Yue-Zhang, Ao-Ran Sui, Wei Zhao, Supratik Kundu, Jin-Yi Yang, Jie Zhao, Shao L. Scorpion venom heat-resistant synthetic peptide protects dopamine neurons against 6-hydroxydopamine neurotoxicity in C. elegans. Brain research bulletin. 2022-10-03. PMID:36191729. |
the main pathological feature is the degeneration and loss of dopaminergic neurons in the substantia nigra, which leads to the significant decrease of dopamine content in the striatum. |
2022-10-03 |
2023-08-14 |
caenorhabditis_elegans |
| Meijun Pang, Rui Peng, Yiwen Wang, Yi Zhu, Peng Wang, Bernard Moussian, Yanfang Su, Xiuyun Liu, Dong Min. Molecular understanding of the translational models and the therapeutic potential natural products of Parkinson's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 155. 2022-09-24. PMID:36152409. |
the mechanism of parkinson's disease still remains unknown, however, studies already proved that the damage or absence of dopaminergic neurons located in the substantia nigra and the decreased dopamine in the striatum are significantly related to parkinson's disease. |
2022-09-24 |
2023-08-14 |
Not clear |
| Alexander N Rodichkin, Melissa K Edler, Jennifer L McGlothan, Tomás R Guilart. Pathophysiological studies of aging Slc39a14 knockout mice to assess the progression of Manganese-Induced Dystonia-Parkinsonism. Neurotoxicology. 2022-09-24. PMID:36152728. |
neurochemical, neuropathological, and functional assessment of the dopaminergic system of the basal ganglia revealed absence of neurodegenerative changes of dopamine (da) neurons in the substantia nigra pars compacta (snc), with no changes in da or metabolite concentrations in the striatum of slc39a14-ko mice relative to wildtype (wt). |
2022-09-24 |
2023-08-14 |
mouse |