| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Agnieszka Boroń, Aleksandra Suchanecka, Krzysztof Chmielowiec, Jolanta Chmielowiec, Jolanta Masiak, Grzegorz Trybek, Aleksandra Strońska-Pluta, Monika Rychel, Anna Grzywac. Analysis of the International journal of molecular sciences. vol 25. issue 12. 2024-06-27. PMID:38928154. |
a surge in bdnf levels in the ventral tegmental area (the region from which the dopaminergic neurons of the mesocorticolimbic dopamine system originate and extend to the dorsolateral and ventromedial striatum) triggers a state of reward similar to that produced by opiates in animal studies. |
2024-06-27 |
2024-06-29 |
Not clear |
| Vittorio Calabrese, Naomi Osakabe, Foziya Khan, Uwe Wenzel, Sergio Modafferi, Lidia Nicolosi, Tilman Fritsch, Ursula M Jacob, Ali S Abdelhameed, Luay Rasha. Frankincense: A neuronutrient to approach Parkinson's disease treatment. Open medicine (Warsaw, Poland). vol 19. issue 1. 2024-06-24. PMID:38911256. |
parkinson's disease (pd), characterized by tremor, slowness of movement, stiffness, and poor balance, is due to a significant loss of dopaminergic neurons in the substantia nigra pars compacta and dopaminergic nerve terminals in the striatum with deficit of dopamine. |
2024-06-24 |
2024-06-26 |
Not clear |
| Savannah R Linen, Nelson H Chang, Ellen J Hess, Garrett B Stanley, Christian Waiblinge. Sensory-Behavioral Deficits in Parkinson's Disease: Insights from a 6-OHDA Mouse Model. bioRxiv : the preprint server for biology. 2024-06-19. PMID:38895263. |
parkinson's disease (pd) is characterized by the degeneration of dopaminergic neurons in the striatum, predominantly associated with motor symptoms. |
2024-06-19 |
2024-06-21 |
mouse |
| Olivier Kerdiles, Méryl-Farelle Oye Mintsa Mi-Mba, Katherine Coulombe, Cyntia Tremblay, Vincent Émond, Martine Saint-Pierre, Clémence Rouxel, Line Berthiaume, Pierre Julien, Francesca Cicchetti, Frédéric Calo. Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson's disease. Neural regeneration research. vol 20. issue 2. 2024-06-06. PMID:38819068. |
the present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of parkinson's disease. |
2024-06-06 |
2024-06-08 |
mouse |
| Shu-Chuan Yang, Kun-Ruey Shie. Higher exploratory and vigilant behaviors related to higher central dopaminergic activities of Formosan wood mice (Apodemus semotus) in light-dark exploration tests. Pharmacology, biochemistry, and behavior. 2024-05-28. PMID:38806117. |
we also measured the levels of da and 3,4-dihydroxyphenylacetic acid (dopac), the primary metabolite of da, to assess the dopaminergic activity of the medial prefrontal cortex, striatum, and nucleus accumbens. |
2024-05-28 |
2024-06-03 |
mouse |
| María Teresa Ibarra-Gutiérrez, Norma Serrano-García, Mireya Alcaraz-Zubeldia, José Pedraza-Chaverri, Marisol Orozco-Ibarr. An exploratory study on the ability of manganese to supplement rotenone neurotoxicity in rats. Brain research. vol 1839. 2024-05-22. PMID:38768935. |
notably, while these substances do not target the same dopaminergic regions, a notable escalation in toxicity is evident in the striatum, the brain region where their toxic effects converge. |
2024-05-22 |
2024-05-27 |
rat |
| Qian Wang, Yuhan Wang, Francesca-Fang Liao, Fu-Ming Zho. Dopaminergic inhibition of the inwardly rectifying potassium current in direct pathway medium spiny neurons in normal and parkinsonian striatum. bioRxiv : the preprint server for biology. 2024-05-15. PMID:38746264. |
dopaminergic inhibition of the inwardly rectifying potassium current in direct pathway medium spiny neurons in normal and parkinsonian striatum. |
2024-05-15 |
2024-05-27 |
Not clear |
| Lina Ding, Long Wang, Jiaxin Yang, Cuicui Jiang, Xifeng Sun, Huite Huang, Xiuyuan Zhan, Feilong Liu, Qunlin Zhan. (+)-Borneol Protects Dopaminergic Neuronal Loss in Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson's Disease Mice: A Study of Dopamine Level using In Vivo Brain Microdialysis. ACS chemical neuroscience. 2024-05-15. PMID:38747405. |
it is worth noting that the enhanced level of da by (+)-borneol was enabled by the reduction in loss of tyrosine hydroxylase-immunoreactive dopaminergic neurons in the substantia nigra and striatum and promotion of reserpine- or nomifensine-induced da release in pd mice. |
2024-05-15 |
2024-05-27 |
mouse |
| Shogo Togawa, Noriyoshi Usui, Miyuki Doi, Yuki Kobayashi, Yoshihisa Koyama, Yukiko Nakamura, Koh Shinoda, Hikaru Kobayashi, Shoichi Shimad. Neuroprotective effects of Si-based hydrogen-producing agent on 6-hydroxydopamine-induced neurotoxicity in juvenile mouse model. Behavioural brain research. 2024-05-09. PMID:38723675. |
the si-based agent safeguards against the degradation and neuronal cell death of dopaminergic neurons and loss of dopaminergic fibers in the striatum (str) and ventral tegmental area (vta) caused by 6-ohda. |
2024-05-09 |
2024-05-27 |
mouse |
| Lucio Della Guardia, Andrew C Shi. Obesity-induced tissue alterations resist weight loss: A mechanistic review. Diabetes, obesity & metabolism. 2024-05-09. PMID:38720199. |
moreover, both obese animals and humans demonstrate impaired dopaminergic signalling and diminished responses to nutrient intake in the striatum, which tend to persist after weight loss. |
2024-05-09 |
2024-05-27 |
Not clear |
| Kristin N Meyer, Joseph B Hopfinger, Elena M Vidrascu, Charlotte A Boettiger, Donita L Robinson, Margaret A Sherida. From learned value to sustained bias: how reward conditioning changes attentional priority. Frontiers in human neuroscience. vol 18. 2024-05-01. PMID:38689827. |
one theory posits that dopaminergic signaling in the striatum during reward conditioning leads to changes in visual cortical and parietal representations of the stimulus used, and this, in turn, sustains attentional bias even when reward is discontinued. |
2024-05-01 |
2024-05-03 |
Not clear |
| Mukaddes Pala, Ismail Meral, Nilgün Pala Acikgoz, Murat Mengi, Meryem Betül Erdim Gokce, Rumeysa Unsal, Yalcin Polat, Fahri Akbas, Senay Gorucu Yilma. Thymoquinone ameliorates symptoms of Parkinson's disease in a 6-OHDA rat model by downregulation of miR-204-3p. Behavioural pharmacology. 2024-04-25. PMID:38660812. |
striatum samples were stained with hematoxylin-eosin to determine the effect of dopaminergic lesions. |
2024-04-25 |
2024-04-28 |
rat |
| Hao Yang, XiaoLi Yang, SiLu Ya. A dynamic computational model of the parallel circuit on the basal ganglia-cortex associated with Parkinson's disease dementia. Biological cybernetics. 2024-04-21. PMID:38644417. |
more importantly, the spatiotemporal course of dopamine depletion in parkinson's disease patients is well simulated, which states that with the loss of dopaminergic neurons projecting to the striatum, motor dysfunction of parkinson's disease is first observed, whereas cognitive impairment occurs after a period of onset of motor dysfunction. |
2024-04-21 |
2024-04-24 |
Not clear |
| Merve Direktor, Peter Gass, Dragos Int. Understanding the therapeutic action of antipsychotics: from molecular to cellular targets with focus on the islands of Calleja. The international journal of neuropsychopharmacology. 2024-04-17. PMID:38629703. |
finally, we will discuss the implications of new data showing ongoing adult neurogenesis of the islands of calleja, as a very promising antipsychotic target linking long-life neurodevelopment and dopaminergic dysfunction in the striatum. |
2024-04-17 |
2024-04-19 |
Not clear |
| Chunying Guo, Ting Wang, Haiyan Huang, Xiaolu Wang, Yugui Jiang, Jinan L. Plasminogen degrades α-synuclein, Tau and TDP-43 and decreases dopaminergic neurodegeneration in mouse models of Parkinson's disease. Scientific reports. vol 14. issue 1. 2024-04-13. PMID:38615036. |
the in vitro, ex vivo and in vivo results showed that the administered plasminogen crossed the blood‒brain barrier (bbb), entered cells, and migrated to the nucleus, increased plasmin activity intracellularly, bound to α-syn through lysine binding sites, significantly promoted α-syn, tau and tdp-43 clearance intracellularly and even intranuclearly in the brain, decreased dopaminergic neurodegeneration and increased the tyrosine hydroxylase levels in the substantia nigra and striatum, and improved motor function in pd mouse models. |
2024-04-13 |
2024-04-16 |
mouse |
| Kaustubh Supekar, Carlo de Los Angeles, Srikanth Ryali, Leila Kushan, Charlie Schleifer, Gabriela Repetto, Nicolas A Crossley, Tony Simon, Carrie E Bearden, Vinod Meno. Robust and replicable functional brain signatures of 22q11.2 deletion syndrome and associated psychosis: a deep neural network-based multi-cohort study. Molecular psychiatry. 2024-04-11. PMID:38605171. |
robust distinguishing features of 22q11.2ds-associated psychosis emerged in the anterior insula node of the salience network and the striatum node of the dopaminergic reward pathway. |
2024-04-11 |
2024-04-14 |
human |
| Cesar C Ceballos, Lei Ma, Maozhen Qin, Haining Zhon. Prevalent co-release of glutamate and GABA throughout the mouse brain. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585864. |
although dopaminergic axons release both glutamate and gaba in the striatum, deletion of dopamine neurons did not eliminate biphasic minis, indicating that the co-release originates from another neuronal type. |
2024-04-08 |
2024-04-10 |
mouse |
| Emre Uygur, Kadriye Büşra Karatay, Emine Derviş, Vedat Evren, Ayfer Yurt Kılçar, Özge Kozguş Güldü, Ceren Sezgin, Burcu Acar Çinleti, Volkan Tekin, Fazilet Zumrut Biber Muftule. Synthesis of Novel Plant-Derived Encapsulated Radiolabeled Compounds for the Diagnosis of Parkinson's Disease and the Evaluation of Biological Effects with In Vitro/In Vivo Methods. Molecular neurobiology. 2024-04-03. PMID:38568418. |
it is characterized by the loss of dopaminergic neurons in substantia nigra pars compacta (snc) and striatum. |
2024-04-03 |
2024-04-05 |
Not clear |
| Seong-Jin Yu, Yun Wang, Hui Shen, Eun-Kyung Bae, Yazhou Li, Kumar Sambamurti, Michael A Tones, Margaret M Zaleska, Barry J Hoffer, Nigel H Grei. DPP-4 inhibitors sitagliptin and PF-00734,200 mitigate dopaminergic neurodegeneration, neuroinflammation and behavioral impairment in the rat 6-OHDA model of Parkinson's disease. GeroScience. 2024-04-02. PMID:38563864. |
pre-treatment with oral sitagliptin or pf-00734,200 reduced methamphetamine (meth)-induced rotation post-lesioning and dopaminergic degeneration in lesioned substantia nigra pars compacta (snc) and striatum. |
2024-04-02 |
2024-04-04 |
human |
| Aggeliki Dimopoulou, Vasiliki Panagiotakopoulou, Theodora Mourtzi, Ilias Kazanis, Fevronia Angelato. Alpha-synuclein pathology in the "weaver" mouse, a genetic model of dopaminergic denervation. microPublication biology. vol 2024. 2024-03-29. PMID:38550606. |
our results revealed increased serine 129 phosphorylation in the midbrain, striatum, and cortex at a phase of established dopaminergic degeneration on postnatal day 100. |
2024-03-29 |
2024-03-31 |
mouse |