| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A C Martel, P Apicell. Insights into the interaction between time and reward prediction on the activity of striatal tonically active neurons: A pilot study in rhesus monkeys. Physiological reports. vol 12. issue 17. 2024-09-09. PMID:39245818. |
prior studies have documented the role of the striatum and its dopaminergic input in time processing, but the contribution of local striatal cholinergic innervation has not been specifically investigated. |
2024-09-09 |
2024-09-11 |
monkey |
| Isobel Green, Ryunosuke Amo, Mitsuko Watabe-Uchid. Shifting attention to orient or avoid: a unifying account of the tail of the striatum and its dopaminergic inputs. Current opinion in behavioral sciences. vol 59. 2024-09-09. PMID:39247613. |
shifting attention to orient or avoid: a unifying account of the tail of the striatum and its dopaminergic inputs. |
2024-09-09 |
2024-09-11 |
Not clear |
| Charalampos Brakatselos, Alexia Polissidis, George Ntoulas, Michail-Zois Asprogerakas, Olga Tsarna, Anastasia Vamvaka-Iakovou, Gerasimos Nakas, Anastasios Delis, Petros Tzimas, Leandros Skaltsounis, Joana Silva, Foteini Delis, Joao Filipe Oliveira, Ioannis Sotiropoulos, Katerina Antonio. Multi-level therapeutic actions of cannabidiol in ketamine-induced schizophrenia psychopathology in male rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-09-06. PMID:39242923. |
repeated ket model is characterized by schizophrenia-like symptomatology and alterations in glutamatergic and dopaminergic activity mainly in the pfc and the dorsomedial striatum (dms), through a bi-directional pattern. |
2024-09-06 |
2024-09-10 |
rat |
| Kaushik Narasimhan, Abrar Hakami, Giulia Comini, Tommy Patton, Ben Newland, Eilis Dow. Cryogel microcarriers loaded with glial cell line-derived neurotrophic factor enhance the engraftment of primary dopaminergic neurons in a rat model of Parkinson's disease. Journal of neural engineering. 2024-09-04. PMID:39231475. |
in this context, to develop a proof-of-concept, the aim of this-study was to determine the efficacy of gdnf-loaded cryogel microcarriers by assessing their impact on the survival of, and reinnervation by, primary dopaminergic grafts after intra-striatal delivery in parkinsonian rat brains.
approach: rat embryonic day 14 ventral midbrain cells were transplanted into the 6-hydroxydopamine-lesioned striatum either alone, or with gdnf, or with unloaded cryogel microcarriers, or with gdnf-loaded cryogel microcarriers. |
2024-09-04 |
2024-09-08 |
rat |
| Xiang Zuo, Hui-Juan Bai, Qi-Li Zhao, Shu-Hui Zhang, Xin Zhao, Xi-Zeng Fen. 17β-Trenbolone Exposure Enhances Muscle Activity and Exacerbates Parkinson's Disease Progression in Male Mice. Molecular neurobiology. 2024-09-02. PMID:39222261. |
this exacerbated neuronal apoptosis, ultimately intensifying dopaminergic neuronal degeneration and death in the substantia nigra and striatum of pd mice. |
2024-09-02 |
2024-09-04 |
mouse |
| Yiting Ni, Qiaowen Tong, Mengying Xu, Jiayi Gu, Hua Y. Gut Microbiota-Induced Modulation of the Central Nervous System Function in Parkinson's Disease Through the Gut-Brain Axis and Short-Chain Fatty Acids. Molecular neurobiology. 2024-08-12. PMID:39134825. |
notably, fecal microbiota transplantation (fmt) from healthy to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced pd mouse models significantly improved motor function, enhanced dopamine and serotonin levels in the striatum, and increased the number of dopaminergic neurons in the substantia nigra while reducing glial cell activation. |
2024-08-12 |
2024-08-16 |
mouse |
| Harry Costello, Anette-Eleonore Schrag, Robert Howard, Jonathan P Roise. Dissociable effects of dopaminergic medications on depression symptom dimensions in Parkinson disease. Nature. Mental health. vol 2. issue 8. 2024-08-12. PMID:39131186. |
motivational symptoms of depression are particularly prevalent in pd and emerge with loss of dopaminergic innervation of the striatum. |
2024-08-12 |
2024-08-14 |
Not clear |
| Benjamin B Tournier, Kelly Ceyzériat, Aurélien M Badina, Yesica Gloria, Aïda B Fall, Quentin Amossé, Stergios Tsartsalis, Philippe Mille. Impairment of hippocampal astrocyte-mediated striatal dopamine release and locomotion in Alzheimer's disease. NeuroImage. 2024-08-09. PMID:39122057. |
clinical and translational research has identified deficits in the dopaminergic neurotransmission in the striatum in alzheimer's disease (ad) and this could be related to the pathophysiology of psychiatric symptoms appearing even at early stages of the pathology. |
2024-08-09 |
2024-08-13 |
Not clear |
| Liqiang Chen, Hiba Douja Chehade, Hong-Yuan Ch. Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation. bioRxiv : the preprint server for biology. 2024-08-02. PMID:39091827. |
to begin to address these questions, we injected α-synuclein (αsyn) preformed fibrils (pffs) into the dorsolateral striatum of mice to seed αsyn pathology in the cortical cortex and induce degeneration of midbrain dopaminergic neurons. |
2024-08-02 |
2024-08-05 |
mouse |
| Jin Hee Kim, Jin Se Kim, In Gyoung Ju, Eugene Huh, Yujin Choi, Seungmin Lee, Jun-Young Cho, Boyoung Y Park, Myung Sook O. Coadministration of 6-Shogaol and Levodopa Alleviates Parkinson's Disease-Related Pathology in Mice. Biomolecules & therapeutics. 2024-08-02. PMID:39092515. |
moreover, 6-shogaol-only or co-treatment with 6-shogaol and l-dopa protected dopaminergic neurons in the striatum and reduced neuroinflammation in the striatum and substantia nigra. |
2024-08-02 |
2024-08-05 |
mouse |
| Joanna Sikora, Sandra Dovero, Rémi Kinet, Marie-Laure Arotcarena, Sylvain Bohic, Erwan Bezard, Pierre-Olivier Fernagut, Benjamin Deha. Nigral ATP13A2 depletion induces Parkinson's disease-related neurodegeneration in a pilot study in non-human primates. NPJ Parkinson's disease. vol 10. issue 1. 2024-08-01. PMID:39090150. |
we characterised the pattern of dopaminergic loss in the striatum and the substantia nigra, the regional distribution of α-synuclein immunoreactivity in several brain structures, and its pathological status (i.e., s129 phosphorylation), the accumulation of heavy metals in nigral sections and occurrence of lysosomal dysfunction. |
2024-08-01 |
2024-08-05 |
Not clear |
| Ying He, Ruicheng Li, Yuxi Yu, Zhiran Xu, Jiaxin Gao, Cancan Wang, Chushen Huang, Zhongquan Q. HucMSC extracellular vesicles increasing SATB 1 to activate the Wnt/β-catenin pathway in 6-OHDA-induced Parkinson's disease model. IUBMB life. 2024-07-31. PMID:39082886. |
parkinson's disease (pd) is a degenerative disorder of the nervous system characterized by the loss of dopaminergic neurons and damage of neurons in the substantia nigra (sn) and striatum, resulting in impaired motor functions. |
2024-07-31 |
2024-08-02 |
mouse |
| Roger A Barker, Anders Björklund, Malin Parma. The history and status of dopamine cell therapies for Parkinson's disease. BioEssays : news and reviews in molecular, cellular and developmental biology. 2024-07-26. PMID:39058892. |
this data has shown that developing dopamine cells when transplanted in the brain of a pwp can survive long term with clinical benefits lasting decades and with restoration of normal dopaminergic innervation in the grafted striatum. |
2024-07-26 |
2024-07-29 |
human |
| K Ushna S Islam, Sandra Blaes. The impact of the mesoprefrontal dopaminergic system on the maturation of interneurons in the murine prefrontal cortex. Frontiers in neuroscience. vol 18. 2024-07-22. PMID:39035778. |
in the striatum, dopaminergic (da) neurotransmission is required for the maturation of medium spiny neurons during a critical developmental period. |
2024-07-22 |
2024-07-24 |
mouse |
| Q L Zhou, D Ye, P C Ren, W B Pang, X M Lin, R H Cao, X S Ye, W Xiang, L Xia. A multi-omics analysis reveals vitamin D supplementation since childhood modulates molecules for signal transductions in the mouse striatum. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 178. 2024-07-22. PMID:39038374. |
additionally, our data demonstrate how vitamin d modulated neuropeptide signaling pathways, as well as cholinergic and dopaminergic synapses in the striatum, through an orchestrated mechanism involving epigenetic and transcriptional regulations. |
2024-07-22 |
2024-07-25 |
mouse |
| Michael B Ryan, Allison E Girasole, Andrew J Flores, Emily L Twedell, Matthew M McGregor, Rea Brakaj, Ronald F Paletzki, Thomas S Hnasko, Charles R Gerfen, Alexandra B Nelso. Excessive firing of dyskinesia-associated striatal direct pathway neurons is gated by dopamine and excitatory synaptic input. Cell reports. vol 43. issue 8. 2024-07-18. PMID:39024096. |
the striatum integrates dopaminergic and glutamatergic inputs to select preferred versus alternative actions. |
2024-07-18 |
2024-07-21 |
mouse |
| Mani Erfanian Abdoust, Monja Isabel Froböse, Alfons Schnitzler, Elisabeth Schreivogel, Gerhard Jocha. Dopamine and acetylcholine have distinct roles in delay- and effort-based decision-making in humans. PLoS biology. vol 22. issue 7. 2024-07-12. PMID:38995982. |
moreover, the reciprocal antagonistic interaction between dopaminergic and cholinergic transmission in the striatum suggests a potential opponent role of acetylcholine in these processes. |
2024-07-12 |
2024-07-15 |
Not clear |
| Karolina Lorek, Joanna Mączewska, Leszek Królicki, Małgorzata Chalimoniuk, Katarzyna Markowska, Sławomir Budrewicz, Magdalena Koszewicz, Łukasz Szumowski, Jarosław Marusia. Motor cortex activation mediates associations between striatal dopamine depletion and manual dexterity in Parkinson's disease. Parkinsonism & related disorders. vol 125. 2024-07-02. PMID:38955097. |
parkinson's disease (pd) presents with a progressive decline in manual dexterity, attributed to dysfunction in the basal ganglia-thalamus-cortex loop, influenced by dopaminergic deficits in the striatum. |
2024-07-02 |
2024-07-06 |
Not clear |
| Erind Alushaj, Dimuthu Hemachandra, Hooman Ganjavi, Ken N Seergobin, Manas Sharma, Alia Kashgari, Jennifer Barr, William Reisman, Ali R Khan, Penny A MacDonal. Increased mean diffusivity of the caudal motor SNc identifies patients with REM sleep behaviour disorder and Parkinson's disease. NPJ Parkinson's disease. vol 10. issue 1. 2024-07-01. PMID:38951528. |
in irbd and early pd (epd), we measured diffusion mri (dmri) in the caudal motor snc, which overlaps the nigrosome-1-the earliest-degenerating dopaminergic neurons in pd-and in the striatum. |
2024-07-01 |
2024-07-04 |
Not clear |
| Md Reyaz Alam, Vaishali Dobhal, Shamsher Sing. Neuroprotective potential of solanesol against tramadol induced zebrafish model of Parkinson's disease: insights from neurobehavioral, molecular, and neurochemical evidence. Drug and chemical toxicology. 2024-06-28. PMID:38938099. |
parkinson's disease (pd) is a prevalent neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (snpc) and subsequent depletion of dopamine in the striatum. |
2024-06-28 |
2024-06-30 |
human |