| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J E Yuste, M B Echeverry, F Ros-Bernal, A Gomez, C M Ros, C M Campuzano, E Fernandez-Villalba, M T Herrer. 7-Nitroindazole down-regulates dopamine/DARPP-32 signaling in neostriatal neurons in a rat model of Parkinson's disease. Neuropharmacology. vol 63. issue 7. 2013-02-12. PMID:22877786. |
our quantitative histological findings show that treatment with 7-ni significantly reduced 6-ohda-induced dopaminergic damage in the dorsolateral striatum and substantia nigra pars compacta (snpc). |
2013-02-12 |
2023-08-12 |
rat |
| N Rampersaud, A Harkavyi, G Giordano, R Lever, J Whitton, P S Whitto. Exendin-4 reverses biochemical and behavioral deficits in a pre-motor rodent model of Parkinson's disease with combined noradrenergic and serotonergic lesions. Neuropeptides. vol 46. issue 5. 2013-02-12. PMID:22921965. |
n-(2-chloroethyl)-n-ethyl-2-bromobenzylamine (dsp-4), a selective noradrenergic neurotoxin, and parachloroampetamine (pca), a selective serotonergic neurotoxin, were utilized concomitantly with bilateral 6-hydroxydopamine (6-ohda) injections into the striatum to produce a pre-motor rodent model of pd with partial deficits in the dopaminergic, noradrenergic, and serotonergic systems. |
2013-02-12 |
2023-08-12 |
Not clear |
| Lars Tönges, Tobias Frank, Lars Tatenhorst, Kim A Saal, Jan C Koch, Éva M Szego, Mathias Bähr, Jochen H Weishaupt, Paul Lingo. Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease. Brain : a journal of neurology. vol 135. issue Pt 11. 2013-02-04. PMID:23087045. |
furthermore, dopaminergic terminals were preserved as demonstrated by analysis of neurite network in vitro, striatal fibre density and by neurochemical analysis of the levels of dopamine and its metabolites in the striatum. |
2013-02-04 |
2023-08-12 |
mouse |
| Nadine Y Lettfuss, Kristina Fischer, Vesna Sossi, Bernd J Pichler, Andreas von Ameln-Mayerhofe. Imaging DA release in a rat model of L-DOPA-induced dyskinesias: a longitudinal in vivo PET investigation of the antidyskinetic effect of MDMA. NeuroImage. vol 63. issue 1. 2013-01-29. PMID:22766162. |
our data show that l-dopa-induced da release is attenuated in the parkinsonian striatum after chronic l-dopa pretreatment and that the antidyskinetic mechanism of mdma does not depend primarily on dopaminergic neurotransmission. |
2013-01-29 |
2023-08-12 |
rat |
| Roberto Cosimo Melcangi, Donatella Caruso, Giovanna Levandis, Federico Abbiati, Marie-Therese Armentero, Fabio Blandin. Modifications of neuroactive steroid levels in an experimental model of nigrostriatal degeneration: potential relevance to the pathophysiology of Parkinson's disease. Journal of molecular neuroscience : MN. vol 46. issue 1. 2013-01-24. PMID:21671084. |
to this aim, using an experimental model of loss of nigrostriatal dopaminergic neurons obtained by stereotaxic injection of the neurotoxin 6-hydroxydopamine (6-ohda), we evaluated by liquid chromatography tandem mass spectrometry the levels of several neuroactive steroids in the striatum and cerebral cortex of 6-ohda-lesioned male rats. |
2013-01-24 |
2023-08-12 |
rat |
| Dimitrios Kontis, Eirini Theochar. Dopamine in anorexia nervosa: a systematic review. Behavioural pharmacology. vol 23. issue 5-6. 2013-01-17. PMID:22854306. |
however, recent neuroimaging studies lend support to the increase in binding of dopaminergic receptors in the striatum, which favors the opposite theory that intrasynaptic dopamine is indeed decreased. |
2013-01-17 |
2023-08-12 |
Not clear |
| Anne Almey, Edward J Filardo, Teresa A Milner, Wayne G Brak. Estrogen receptors are found in glia and at extranuclear neuronal sites in the dorsal striatum of female rats: evidence for cholinergic but not dopaminergic colocalization. Endocrinology. vol 153. issue 11. 2013-01-17. PMID:22919059. |
estrogen receptors are found in glia and at extranuclear neuronal sites in the dorsal striatum of female rats: evidence for cholinergic but not dopaminergic colocalization. |
2013-01-17 |
2023-08-12 |
rat |
| Christian Beste, Ann-Kathrin Stock, Vanessa Ness, Jörg T Epplen, Larissa Arnin. Differential effects of ADORA2A gene variations in pre-attentive visual sensory memory subprocesses. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 22. issue 8. 2013-01-16. PMID:22240468. |
the adora2a gene encodes the adenosine a(2a) receptor that is highly expressed in the striatum where it plays a role in modulating glutamatergic and dopaminergic transmission. |
2013-01-16 |
2023-08-12 |
human |
| Abdeljalil Elgot, Omar El Hiba, Halima Gamran. Alteration of dopaminergic innervation and voluntary movements after long period of thirst in a semi-desert rodent, Meriones shawi: behavioral and immunohistochemical studies. Comptes rendus biologies. vol 335. issue 7. 2013-01-11. PMID:22847013. |
we used tyrosine hydroxylase immunohistochemistry (th: the key enzyme of catecholamine biosynthesis) to evaluate the effects of prolonged dehydration on the dopaminergic system in both substancia nigra pars compacta and ventral tegmental area (snpc and vta), which are the main sources of dopamine input to several brain areas; the immunolabelling was performed also in both the medial forebrain bundle and the caudate putamen (striatum). |
2013-01-11 |
2023-08-12 |
Not clear |
| Paul J Cocker, Katherine Dinelle, Rick Kornelson, Vesna Sossi, Catharine A Winstanle. Irrational choice under uncertainty correlates with lower striatal D(2/3) receptor binding in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 44. 2013-01-04. PMID:23115182. |
given that dopaminergic projections to the striatum signal reward expectancy and modulate decision-making, individual differences in da signaling could influence the extent of such biases. |
2013-01-04 |
2023-08-12 |
rat |
| Barbara Bosier, Giulio G Muccioli, Birgit Mertens, Sophie Sarre, Yvette Michotte, Didier M Lambert, Emmanuel Herman. Differential modulations of striatal tyrosine hydroxylase and dopamine metabolism by cannabinoid agonists as evidence for functional selectivity in vivo. Neuropharmacology. vol 62. issue 7. 2012-12-20. PMID:22365976. |
supporting a possible long-lasting control on dopaminergic activity, we noticed a significant hu 210-mediated increase in th expression in the striatum that was concomitant with an increase in striatal dopamine content. |
2012-12-20 |
2023-08-12 |
rat |
| John Man Tak Chu, Ying Shing Chan, Liang Wei Chen, Ken Kin Lam Yun. Neurokinin receptor 3 peptide exacerbates 6-hydroxydopamine-induced dopaminergic degeneration in rats through JNK pathway. Journal of neurochemistry. vol 123. issue 3. 2012-12-19. PMID:22762252. |
by administrating nk3 receptor agonist senktide into 6-hydroxydopamine (6-ohda)-lesioned rats, exacerbation of dopaminergic degeneration was found in striatum and substantia nigra pars compacta. |
2012-12-19 |
2023-08-12 |
rat |
| Sonia Gandhi, Annika Vaarmann, Zhi Yao, Michael R Duchen, Nicholas W Wood, Andrey Y Abramo. Dopamine induced neurodegeneration in a PINK1 model of Parkinson's disease. PloS one. vol 7. issue 5. 2012-12-13. PMID:22662171. |
parkinson's disease is a common neurodegenerative disease characterised by progressive loss of dopaminergic neurons, leading to dopamine depletion in the striatum. |
2012-12-13 |
2023-08-12 |
Not clear |
| Nicolas X Tritsch, Bernardo L Sabatin. Dopaminergic modulation of synaptic transmission in cortex and striatum. Neuron. vol 76. issue 1. 2012-12-10. PMID:23040805. |
dopaminergic modulation of synaptic transmission in cortex and striatum. |
2012-12-10 |
2023-08-12 |
Not clear |
| Nicolas X Tritsch, Bernardo L Sabatin. Dopaminergic modulation of synaptic transmission in cortex and striatum. Neuron. vol 76. issue 1. 2012-12-10. PMID:23040805. |
in this review, we discuss the actions of da on ionic and synaptic signaling in neurons of the prefrontal cortex and striatum, brain areas in which dopaminergic dysfunction is thought to be central to disease. |
2012-12-10 |
2023-08-12 |
Not clear |
| Jing Pan, Hui Li, Jian-Fang Ma, Yu-Yan Tan, Qin Xiao, Jian-Qing Ding, Sheng-Di Che. Curcumin inhibition of JNKs prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease through suppressing mitochondria dysfunction. Translational neurodegeneration. vol 1. issue 1. 2012-12-06. PMID:23210631. |
the death of dopaminergic neurons and the loss of dopaminergic axon in the striatum were significantly suppressed by curcumin in mptp mouse model. |
2012-12-06 |
2023-08-12 |
mouse |
| John W Wright, Joseph W Hardin. Importance of the brain Angiotensin system in Parkinson's disease. Parkinson's disease. vol 2012. 2012-12-06. PMID:23213621. |
the primary direct consequence of this disease is the loss of dopaminergic (da) neurons in the substantia nigra and striatum. |
2012-12-06 |
2023-08-12 |
Not clear |
| Cristina Baiguera, Manuela Alghisi, Annalisa Pinna, Arianna Bellucci, Maria Antonietta De Luca, Lucia Frau, Micaela Morelli, Rosaria Ingrassia, Marina Benarese, Vanessa Porrini, Michele Pellitteri, Giuseppe Bertini, Paolo Francesco Fabene, Sandra Sigala, Maria Grazia Spillantini, Hsiou-Chi Liou, Pier Franco Spano, Marina Pizz. Late-onset Parkinsonism in NFκB/c-Rel-deficient mice. Brain : a journal of neurology. vol 135. issue Pt 9. 2012-12-05. PMID:22915735. |
nigral degeneration was accompanied by a significant loss of dopaminergic terminals and a significant reduction of dopamine and homovanillic acid levels in the striatum. |
2012-12-05 |
2023-08-12 |
mouse |
| Marcelo M S Lima, Monica L Andersen, Angela B Reksidler, Anete C Ferraz, Maria A B F Vital, Sergio Tufi. Paradoxical sleep deprivation modulates tyrosine hydroxylase expression in the nigrostriatal pathway and attenuates motor deficits induced by dopaminergic depletion. CNS & neurological disorders drug targets. vol 11. issue 4. 2012-12-03. PMID:22483308. |
besides, psd produced down-regulation on th expression within the substantia nigra pars compacta and striatum, without affecting the number or the optical density of dopaminergic neurons present in the respective areas. |
2012-12-03 |
2023-08-12 |
mouse |
| Annaik Petithomme Fev. Current status of tyrosine hydroxylase in management of Parkinson's disease. CNS & neurological disorders drug targets. vol 11. issue 4. 2012-12-03. PMID:22583428. |
the pathophysiology of parkinson's disease (pd) is largely due to the nigrostriatal dopaminergic system, with a decrease in th activity, th synthesis and th mrna in the striatum of pd and animal experimental models. |
2012-12-03 |
2023-08-12 |
Not clear |