| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Salvatore Pulcrano, Roberto De Gregorio, Claudia De Sanctis, Laura Lahti, Carla Perrone-Capano, Donatella Ponti, Umberto di Porzio, Thomas Perlmann, Massimiliano Caiazzo, Floriana Volpicelli, Gian Carlo Bellench. Lmx1a-Dependent Activation of miR-204/211 Controls the Timing of Nurr1-Mediated Dopaminergic Differentiation. International journal of molecular sciences. vol 23. issue 13. 2022-07-09. PMID:35805964. |
the development of midbrain dopaminergic (da) neurons requires a fine temporal and spatial regulation of a very specific gene expression program. |
2022-07-09 |
2023-08-14 |
mouse |
| Salvatore Pulcrano, Roberto De Gregorio, Claudia De Sanctis, Laura Lahti, Carla Perrone-Capano, Donatella Ponti, Umberto di Porzio, Thomas Perlmann, Massimiliano Caiazzo, Floriana Volpicelli, Gian Carlo Bellench. Lmx1a-Dependent Activation of miR-204/211 Controls the Timing of Nurr1-Mediated Dopaminergic Differentiation. International journal of molecular sciences. vol 23. issue 13. 2022-07-09. PMID:35805964. |
using published transcriptomic data, we found a significant enrichment of mir-204/211 target genes in midbrain dopaminergic neurons where lmx1a was selectively deleted at embryonic stages. |
2022-07-09 |
2023-08-14 |
mouse |
| Salvatore Pulcrano, Roberto De Gregorio, Claudia De Sanctis, Laura Lahti, Carla Perrone-Capano, Donatella Ponti, Umberto di Porzio, Thomas Perlmann, Massimiliano Caiazzo, Floriana Volpicelli, Gian Carlo Bellench. Lmx1a-Dependent Activation of miR-204/211 Controls the Timing of Nurr1-Mediated Dopaminergic Differentiation. International journal of molecular sciences. vol 23. issue 13. 2022-07-09. PMID:35805964. |
thus, our data indicate the lmx1a-mir-204/211-nurr1 axis as a key component in the cascade of events that ultimately lead to mature midbrain dopaminergic neurons differentiation and point to mir-204/211 as the molecular switch regulating the timing of nurr1 expression. |
2022-07-09 |
2023-08-14 |
mouse |
| Jiwei Liu, Li Yang, Han Li, Yichuan Cai, Jiali Feng, Zelan H. Conditional ablation of protein tyrosine phosphatase receptor U in midbrain dopaminergic neurons results in reduced neuronal size. Journal of chemical neuroanatomy. 2022-07-06. PMID:35792205. |
conditional ablation of protein tyrosine phosphatase receptor u in midbrain dopaminergic neurons results in reduced neuronal size. |
2022-07-06 |
2023-08-14 |
mouse |
| Jiwei Liu, Li Yang, Han Li, Yichuan Cai, Jiali Feng, Zelan H. Conditional ablation of protein tyrosine phosphatase receptor U in midbrain dopaminergic neurons results in reduced neuronal size. Journal of chemical neuroanatomy. 2022-07-06. PMID:35792205. |
protein tyrosine phosphatase receptor u (ptpru) is involved in midbrain patterning during early stages of development and is continuously expressed in the adult midbrain areas where dopaminergic neurons reside in. |
2022-07-06 |
2023-08-14 |
mouse |
| Jiwei Liu, Li Yang, Han Li, Yichuan Cai, Jiali Feng, Zelan H. Conditional ablation of protein tyrosine phosphatase receptor U in midbrain dopaminergic neurons results in reduced neuronal size. Journal of chemical neuroanatomy. 2022-07-06. PMID:35792205. |
however, whether ptpru is also involved in the maintenance and survival of midbrain dopaminergic (mda) neurons during the late stages of development or in the adult midbrain still remains unknown. |
2022-07-06 |
2023-08-14 |
mouse |
| Haley M Geertsma, Konrad M Ricke, Maxime W C Rousseau. Assessment of Dopaminergic Neurodegeneration in Mice. Methods in molecular biology (Clifton, N.J.). vol 2515. 2022-07-01. PMID:35776351. |
in addition, we outline the protocol for the analysis of the dopaminergic terminals in the striatum, the projection area of midbrain dopaminergic neurons, as a readout for the integrity of the nigrostriatal projections. |
2022-07-01 |
2023-08-14 |
mouse |
| Mona Abdollahi, Margaret Fahnestoc. Nurr1 Is Not an Essential Regulator of BDNF in Mouse Cortical Neurons. International journal of molecular sciences. vol 23. issue 12. 2022-06-27. PMID:35743300. |
nurr1 regulates bdnf in midbrain dopaminergic neurons and cerebellar granule cells. |
2022-06-27 |
2024-09-01 |
mouse |
| Mona Abdollahi, Margaret Fahnestoc. Nurr1 Is Not an Essential Regulator of BDNF in Mouse Cortical Neurons. International journal of molecular sciences. vol 23. issue 12. 2022-06-27. PMID:35743300. |
therefore, in contrast to midbrain dopaminergic neurons and cerebellar granule cells, nurr1 does not regulate bdnf in cortical neurons. |
2022-06-27 |
2024-09-01 |
mouse |
| Krishnan Sriram, Gary X Lin, Amy M Jefferson, Walter McKinney, Mark C Jackson, Jared L Cumpston, James B Cumpston, Howard D Leonard, Michael L Kashon, Jeffrey S Feda. Biological effects of inhaled crude oil vapor VI. Altered biogenic amine neurotransmitters and neural protein expression. Toxicology and applied pharmacology. 2022-06-24. PMID:35750205. |
sub-chronic cov exposure caused significant reductions in ne, epi and da in the dopaminergic brain regions, striatum (str) and midbrain (mb), and a large increase in 5-ht in the str. |
2022-06-24 |
2023-08-14 |
rat |
| Wanying Zhu, Mengdan Tao, Yuan Hong, Shanshan Wu, Chu Chu, Zhilong Zheng, Xiao Han, Qian Zhu, Min Xu, Andrew G Ewing, Xing Guo, Yan Li. Dysfunction of vesicular storage in young-onset Parkinson's patient-derived dopaminergic neurons and organoids revealed by single cell electrochemical cytometry. Chemical science. vol 13. issue 21. 2022-06-23. PMID:35733907. |
human dopaminergic (da) neurons and midbrain organoids were derived from an induced pluripotent stem cell line from one yopd patient. |
2022-06-23 |
2023-08-14 |
human |
| Xing Cai, Hailan Liu, Bing Feng, Meng Yu, Yang He, Hesong Liu, Chen Liang, Yongjie Yang, Longlong Tu, Nan Zhang, Lina Wang, Na Yin, Junying Han, Zili Yan, Chunmei Wang, Pingwen Xu, Qi Wu, Qingchun Tong, Yanlin He, Yong X. Publisher Correction: A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice. Nature neuroscience. 2022-06-21. PMID:35729403. |
publisher correction: a d2 to d1 shift in dopaminergic inputs to midbrain 5-ht neurons causes anorexia in mice. |
2022-06-21 |
2023-08-14 |
mouse |
| Arjun Patel, Catherine A Olang, Gregory Lewis, Kesava Mandalaneni, Nikhilesh Anand, Vasavi Rakesh Gorantl. An Overview of Parkinson's Disease: Curcumin as a Possible Alternative Treatment. Cureus. vol 14. issue 5. 2022-06-20. PMID:35719816. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain and basal ganglia, followed by dopamine deficiency in the brain. |
2022-06-20 |
2023-08-14 |
Not clear |
| Taylor Russo, Markus Riesslan. Age-Related Midbrain Inflammation and Senescence in Parkinson's Disease. Frontiers in aging neuroscience. vol 14. 2022-06-20. PMID:35721008. |
we hypothesize that secretion of pro-inflammatory factors by senescent cells in the midbrain triggers neuroinflammation resulting in immune cell-mediated killing of midbrain dopaminergic (da) neurons in pd. |
2022-06-20 |
2023-08-14 |
Not clear |
| Xinguo Zhang, Ruiqi Zhang, Maher Un Nisa Awan, Jie Ba. The Mechanism and Function of Glia in Parkinson's Disease. Frontiers in cellular neuroscience. vol 16. 2022-06-20. PMID:35722618. |
pd is thought to be the loss of midbrain dopaminergic neurons, but it has recently been discovered that glia also affects brain tissue homeostasis, defense, and repair in pd. |
2022-06-20 |
2023-08-14 |
Not clear |
| Mario Bogdanov, Sophia LoParco, A Ross Otto, Madeleine Shar. Dopaminergic medication increases motivation to exert cognitive control by reducing subjective effort costs in Parkinson's patients. Neurobiology of learning and memory. 2022-06-20. PMID:35724812. |
to address this question, we assessed cognitive effort avoidance in patients (n = 38) with parkinson's disease, a condition characterized by loss of midbrain dopaminergic neurons, both on and off dopaminergic medication and compared them to healthy controls (n = 24). |
2022-06-20 |
2023-08-14 |
human |
| Peibo Xu, Hui He, Qinqin Gao, Yingying Zhou, Ziyan Wu, Xiao Zhang, Linyu Sun, Gang Hu, Qian Guan, Zhiwen You, Xinyue Zhang, Wenping Zheng, Man Xiong, Yuejun Che. Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcome in a Parkinson's disease model. The Journal of clinical investigation. 2022-06-14. PMID:35700056. |
human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcome in a parkinson's disease model. |
2022-06-14 |
2023-08-14 |
mouse |
| Peibo Xu, Hui He, Qinqin Gao, Yingying Zhou, Ziyan Wu, Xiao Zhang, Linyu Sun, Gang Hu, Qian Guan, Zhiwen You, Xinyue Zhang, Wenping Zheng, Man Xiong, Yuejun Che. Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcome in a Parkinson's disease model. The Journal of clinical investigation. 2022-06-14. PMID:35700056. |
however, the heterogeneity of hpsc-derived donor cells and the low yield of midbrain dopaminergic (mda) neurons after transplantation hinder its broad clinical application. |
2022-06-14 |
2023-08-14 |
mouse |
| Matthew J Reid, Maria Rogdaki, Lucia Dutan, Bjørn Hanger, Kaarin Sabad, Roland Nagy, Dwaipayan Adhya, Simon Baron-Cohen, Grainne McAlonan, Jack Price, Anthony C Vernon, Oliver D Howes, Deepak P Srivastav. Cell line specific alterations in genes associated with dopamine metabolism and signaling in midbrain dopaminergic neurons derived from 22q11.2 deletion carriers with elevated dopamine synthesis capacity. Schizophrenia research. 2022-06-14. PMID:35701280. |
cell line specific alterations in genes associated with dopamine metabolism and signaling in midbrain dopaminergic neurons derived from 22q11.2 deletion carriers with elevated dopamine synthesis capacity. |
2022-06-14 |
2023-08-14 |
Not clear |
| Theodora Mourtzi, Ilias Kazani. Endogenous Neural regeneration research. vol 17. issue 12. 2022-06-06. PMID:35662194. |
from the first fetal midbrain intrastriatal graft to the most recent conversion of astrocytes into dopaminergic neurons, we have gained equally, significant insights and questions still looking for an answer. |
2022-06-06 |
2023-08-14 |
Not clear |