| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gunjan Thakur, Vikas Kumar, Keun Woo Lee, Chungkil Wo. Structural Insights and Development of LRRK2 Inhibitors for Parkinson's Disease in the Last Decade. Genes. vol 13. issue 8. 2022-08-26. PMID:36011337. |
parkinson's disease (pd) is the second most prevalent neurodegenerative disease, characterized by the specific loss of dopaminergic neurons in the midbrain. |
2022-08-26 |
2023-08-14 |
Not clear |
| Sara Bagnoli, Baldassare Fronte, Carlo Bibbiani, Eva Terzibasi Tozzini, Alessandro Cellerin. Quantification of noradrenergic-, dopaminergic-, and tectal-neurons during aging in the short-lived killifish Nothobranchius furzeri. Aging cell. 2022-08-20. PMID:35986561. |
parkinson's disease (pd) is characterized by phosphorylation and aggregation of the protein α-synuclein and ensuing neuronal death progressing from the noradrenergic locus coeruleus to midbrain dopaminergic neurons. |
2022-08-20 |
2023-08-14 |
Not clear |
| Deborah Pré, Alexander T Wooten, Steven Biesmans, Sandy Hinckley, Haowen Zhou, Sean P Sherman, Priyanka Kakad, Jeffrey Gearhart, Anne G Ban. Development of a platform to investigate long-term potentiation in human iPSC-derived neuronal networks. Stem cell reports. 2022-08-19. PMID:35985330. |
here we describe a multi-electrode array (mea)-based assay to investigate chemically induced ltp (cltp) across entire networks of hipsc-derived midbrain dopaminergic (da) and cortical neuronal populations that lasts for days, allowing studies of the late phases of ltp and enabling detection of associated molecular changes. |
2022-08-19 |
2023-08-14 |
human |
| Lydia Hellrung, Matthias Kirschner, James Sulzer, Ronald Sladky, Frank Scharnowski, Marcus Herdener, Philippe N Toble. Analysis of individual differences in neurofeedback training illuminates successful self-regulation of the dopaminergic midbrain. Communications biology. vol 5. issue 1. 2022-08-19. PMID:35986202. |
analysis of individual differences in neurofeedback training illuminates successful self-regulation of the dopaminergic midbrain. |
2022-08-19 |
2023-08-14 |
human |
| Lydia Hellrung, Matthias Kirschner, James Sulzer, Ronald Sladky, Frank Scharnowski, Marcus Herdener, Philippe N Toble. Analysis of individual differences in neurofeedback training illuminates successful self-regulation of the dopaminergic midbrain. Communications biology. vol 5. issue 1. 2022-08-19. PMID:35986202. |
the dopaminergic midbrain is associated with reinforcement learning, motivation and decision-making - functions often disturbed in neuropsychiatric disorders. |
2022-08-19 |
2023-08-14 |
human |
| Lydia Hellrung, Matthias Kirschner, James Sulzer, Ronald Sladky, Frank Scharnowski, Marcus Herdener, Philippe N Toble. Analysis of individual differences in neurofeedback training illuminates successful self-regulation of the dopaminergic midbrain. Communications biology. vol 5. issue 1. 2022-08-19. PMID:35986202. |
previous research has shown that dopaminergic midbrain activity can be endogenously modulated via neurofeedback. |
2022-08-19 |
2023-08-14 |
human |
| Yuanxi Li, Bing Zhang, Xiaochuan Pan, Yihong Wang, Xuying Xu, Rubin Wang, Zhiqiang Li. Dopamine-Mediated Major Depressive Disorder in the Neural Circuit of Ventral Tegmental Area-Nucleus Accumbens-Medial Prefrontal Cortex: From Biological Evidence to Computational Models. Frontiers in cellular neuroscience. vol 16. 2022-08-15. PMID:35966208. |
the abnormal dopaminergic pathways of the midbrain cortical and limbic system are the key pathological regions of mdd, particularly the ventral tegmental area- nucleus accumbens- medial prefrontal cortex (vta-nac-mpfc) neural circuit. |
2022-08-15 |
2023-08-14 |
Not clear |
| Lingmin Liang, Yao Tian, Lin Feng, Chaoqun Wang, Guihai Feng, Glyn Nigel Stacey, Ng Shyh-Chang, Jun Wu, Baoyang Hu, Wei Li, Jie Hao, Liu Wang, Yukai Wan. Single-cell transcriptomics reveals the cell fate transitions of human dopaminergic progenitors derived from hESCs. Stem cell research & therapy. vol 13. issue 1. 2022-08-13. PMID:35964138. |
midbrain dopaminergic (da) progenitors derived from human pluripotent stem cells are considered to be a promising treatment for parkinson's disease (pd). |
2022-08-13 |
2023-08-14 |
human |
| Alessandro Petese, Franca L Fries, Bianca Broske, Ralf Stumm, Sandra Blaes. Lineage analysis of eNeuro. 2022-08-12. PMID:35961772. |
lineage analysis of midbrain dopaminergic (mda) neurons are generated from a ventral midbrain progenitor zone over a time span of several days (embryonic day (e)10.0-e14.5 in mouse). |
2022-08-12 |
2023-08-14 |
mouse |
| Walaa F Alsanie, Sherin Abdelrahman, Majid Alhomrani, Ahmed Gaber, Hamza Habeeballah, Heba A Alkhatabi, Raed I Felimban, Charlotte A E Hauser, Hossam H Tayeb, Abdulhakeem S Alamri, Bassem M Raafat, Sirajudheen Anwar, Khaled A Alswat, Yusuf S Althobaiti, Yousif A Asir. Prenatal Exposure to Gabapentin Alters the Development of Ventral Midbrain Dopaminergic Neurons. Frontiers in pharmacology. vol 13. 2022-08-09. PMID:35942222. |
prenatal exposure to gabapentin alters the development of ventral midbrain dopaminergic neurons. |
2022-08-09 |
2023-08-14 |
Not clear |
| May Hui, Kevin T Beie. Defining the interconnectivity of the medial prefrontal cortex and ventral midbrain. Frontiers in molecular neuroscience. vol 15. 2022-08-08. PMID:35935333. |
though dopaminergic cells themselves are spatially restricted to the midbrain and constitute a relatively small proportion of all neurons, their projections influence many brain regions. |
2022-08-08 |
2023-08-14 |
Not clear |
| Lukas Leupold, Veronika Sigutova, Elizaveta Gerasimova, Martin Regensburger, Sebastian Zundler, Friederike Zunke, Wei Xiang, Beate Winner, Iryna Prot. The Quest for Anti-α-Synuclein Antibody Specificity-Lessons Learnt From Flow Cytometry Analysis. Frontiers in neurology. vol 13. 2022-08-01. PMID:35911883. |
we further utilize our workflow to demonstrate the ability of the 2a7 antibody to distinguish between physiological differences in asyn expression in neuronal and non-neuronal cells from the cortical organoids, and in neural progenitors and midbrain dopaminergic neurons from healthy controls and in patients with parkinson's disease who have asyn gene locus duplication. |
2022-08-01 |
2023-08-14 |
human |
| Tianyi Dou, Dmitry Kurousk. Phosphatidylcholine and Phosphatidylserine Uniquely Modify the Secondary Structure of α-Synuclein Oligomers Formed in Their Presence at the Early Stages of Protein Aggregation. ACS chemical neuroscience. 2022-07-29. PMID:35904551. |
these aggregates are the underlying molecular cause of an onset of the irreversible degeneration of dopaminergic neurons in midbrain, hypothalamus, and thalamus, a pathology known as parkinson's disease. |
2022-07-29 |
2023-08-14 |
Not clear |
| Jesus Alarcon-Gil, Ana Sierra-Magro, Jose A Morales-Garcia, Marina Sanz-SanCristobal, Sandra Alonso-Gil, Marta Cortes-Canteli, Mireia Niso-Santano, Guadalupe Martínez-Chacón, Jose M Fuentes, Angel Santos, Ana Perez-Castill. Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson's Disease: The Implication of Lipid Droplets and Lipophagy. Cells. vol 11. issue 15. 2022-07-27. PMID:35892594. |
the principal pathological feature of pd is the progressive loss of dopaminergic neurons in the ventral midbrain. |
2022-07-27 |
2023-08-14 |
mouse |
| Jordan D Prahl, Steven E Pierce, Edwin J C Schans, Gerhard A Coetzee, Trevor Tyso. The Parkinson's Disease Variant rs356182 Regulates Neuronal Differentiation Independently from Alpha-Synuclein. Human molecular genetics. 2022-07-22. PMID:35866299. |
we use crispr-cas9 in luhmes cells, a model for dopaminergic midbrain neurons, to generate precise hemizygous lesions at rs356182. |
2022-07-22 |
2023-08-14 |
Not clear |
| Jaron T Colas, Neil M Dundon, Raphael T Gerraty, Natalie M Saragosa-Harris, Karol P Szymula, Koranis Tanwisuth, J Michael Tyszka, Camilla van Geen, Harang Ju, Arthur W Toga, Joshua I Gold, Dani S Bassett, Catherine A Hartley, Daphna Shohamy, Scott T Grafton, John P O'Dohert. Reinforcement learning with associative or discriminative generalization across states and actions: fMRI at 3 T and 7 T. Human brain mapping. 2022-07-21. PMID:35860954. |
with high-resolution high-field fmri targeting the dopaminergic midbrain, the grl model's rpe signals (alongside value and decision signals) were localized within not only the striatum but also the substantia nigra and the ventral tegmental area, including specific effects of generalization that also extend to the hippocampus. |
2022-07-21 |
2023-08-14 |
human |
| Rayan Fakih, Véronique Sauvé, Kalle Gehrin. Feedforward activation of PRKN/parkin. Autophagy. 2022-07-15. PMID:35838500. |
parkinson disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the midbrain. |
2022-07-15 |
2023-08-14 |
Not clear |
| Kamil Pradel, Gniewosz Drwięga, Lukasz Chrobok, Tomasz Błasia. Racing and Pacing in the Reward System: A Multi-Clock Circadian Control Over Dopaminergic Signalling. Frontiers in physiology. vol 13. 2022-07-11. PMID:35812323. |
level of motivation, responsiveness to rewards and punishment, invigoration of exploratory behaviours, and motor performance are subject to daily fluctuations that emerge from circadian rhythms in neuronal activity of the midbrain's dopaminergic system. |
2022-07-11 |
2023-08-14 |
human |
| Kamil Pradel, Gniewosz Drwięga, Lukasz Chrobok, Tomasz Błasia. Racing and Pacing in the Reward System: A Multi-Clock Circadian Control Over Dopaminergic Signalling. Frontiers in physiology. vol 13. 2022-07-11. PMID:35812323. |
these processes cause dopamine levels released in structures innervated by midbrain dopaminergic neurons (e.g., the striatum) to oscillate in a circadian fashion. |
2022-07-11 |
2023-08-14 |
human |
| Kamil Pradel, Gniewosz Drwięga, Lukasz Chrobok, Tomasz Błasia. Racing and Pacing in the Reward System: A Multi-Clock Circadian Control Over Dopaminergic Signalling. Frontiers in physiology. vol 13. 2022-07-11. PMID:35812323. |
previous studies have shown that the information about the value and salience of stimuli perceived by the animal is encoded in the neuronal activity of brain structures innervating midbrain dopaminergic centres. |
2022-07-11 |
2023-08-14 |
human |