| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kristina Sabaroedin, Jeggan Tiego, Alex Fornit. Circuit-Based Approaches to Understanding Corticostriatothalamic Dysfunction Across the Psychosis Continuum. Biological psychiatry. 2022-10-17. PMID:36253195. |
considerable attention has focused on the role of corticostriatothalamic (cst) circuits, given that they regulate and are modulated by the activity of dopaminergic cells in the midbrain. |
2022-10-17 |
2023-08-14 |
human |
| Taylor J Stevenson, Rebecca H Johnson, Jimmy Savistchenko, Justin Rustenhoven, Zoe Woolf, Leon C D Smyth, Helen C Murray, Richard L M Faull, Jason Correia, Patrick Schweder, Peter Heppner, Clinton Turner, Ronald Melki, Birger V Dieriks, Maurice A Curtis, Michael Draguno. Pericytes take up and degrade α-synuclein but succumb to apoptosis under cellular stress. Scientific reports. vol 12. issue 1. 2022-10-15. PMID:36243723. |
parkinson's disease (pd) is characterised by the progressive loss of midbrain dopaminergic neurons and the presence of aggregated α-synuclein (α-syn). |
2022-10-15 |
2023-08-14 |
human |
| Yun Jung Bae, Jong-Min Kim, Byung Se Choi, Yoo Sung Song, Yoonho Nam, Se Jin Cho, Jae Hyoung Kim, Sang Eun Ki. [MRI Findings in Parkinson's Disease: Radiologic Assessment of Nigrostriatal Degeneration]. Taehan Yongsang Uihakhoe chi. vol 83. issue 3. 2022-10-14. PMID:36238511. |
parkinson's disease (pd) is a movement disorder that develops due to degenerative loss of dopaminergic cells in the substantia nigra of the midbrain. |
2022-10-14 |
2023-08-14 |
Not clear |
| Razan Sheta, Maxime Teixeira, Walid Idi, Marion Pierre, Aurelie de Rus Jacquet, Vincent Emond, Cornelia E Zorca, Benoît Vanderperre, Thomas M Durcan, Edward A Fon, Frédéric Calon, Mohamed Chahine, Abid Oueslat. Combining NGN2 programming and dopaminergic patterning for a rapid and efficient generation of hiPSC-derived midbrain neurons. Scientific reports. vol 12. issue 1. 2022-10-13. PMID:36229560. |
combining ngn2 programming and dopaminergic patterning for a rapid and efficient generation of hipsc-derived midbrain neurons. |
2022-10-13 |
2023-08-14 |
human |
| Deepika N P, Mohammed Shameer Kondengadan, Sherouk Hussein Sweilam, Md Habibur Rahman, K M Muhasina, Puja Ghosh, Divya Bhargavi, Divya Jyothi Palati, Fathi Maiz, B Duraiswam. Neuroprotective role of coconut oil for the prevention and treatment of Parkinson's disease: potential mechanisms of action. Biotechnology & genetic engineering reviews. 2022-10-08. PMID:36208039. |
parkinson's disease (pd) is the second most progressive nd after alzheimer's disease (ad), which affects the motor system and is characterized by the loss of dopaminergic neurons from the nigrostriatal pathway in the midbrain, leading to bradykinesia, rigidity, resting tremor, postural instability and non-motor symptoms such as cognitive declines, psychiatric disturbances, autonomic failures, sleep difficulties, and pain syndrome. |
2022-10-08 |
2023-08-14 |
Not clear |
| Astrid Gieske, Tobias Somme. Independent effects of emotional arousal and reward anticipation on episodic memory formation. Cerebral cortex (New York, N.Y. : 1991). 2022-10-07. PMID:36205480. |
our results further suggest that reward anticipation enhances memory formation rather by an increase in anticipation-related arousal-reflected in activity in the dorsal anterior cingulate cortex-and not dopaminergic midbrain activity. |
2022-10-07 |
2023-08-14 |
Not clear |
| Giulia Tomagra, Claudio Franchino, Emilio Carbone, Andrea Marcantoni, Alberto Pasquarelli, Federico Picollo, Valentina Carabell. Methodologies for Detecting Quantal Exocytosis in Adrenal Chromaffin Cells Through Diamond-Based MEAs. Methods in molecular biology (Clifton, N.J.). vol 2565. 2022-10-07. PMID:36205897. |
diamond-based multiarray sensors are suitable to detect in real-time exocytosis and action potentials from cultured, spontaneously firing chromaffin cells, primary hippocampal neurons, and midbrain dopaminergic neurons. |
2022-10-07 |
2023-08-14 |
Not clear |
| Gabriela Henríquez, Lois Méndez, Edward Castañeda, Amy Wagler, Soyoung Jeon, Mahesh Naraya. Preclinical Model to Evaluate Outcomes of Amyloid Cross-Toxicity in the Rodent Brain. ACS chemical neuroscience. 2022-10-04. PMID:36194532. |
however, aβ insult provoked intraneuronal inclusions positive for phosphorylated α-synuclein in dopaminergic neurons and were seen throughout the midbrain, a pathognomonic biomarker suggesting parkinson's pathogenesis. |
2022-10-04 |
2023-08-14 |
Not clear |
| Huijia Yang, Song Li, Weidong L. Intestinal Permeability, Dysbiosis, Inflammation and Enteric Glia Cells: The Intestinal Etiology of Parkinson's Disease. Aging and disease. vol 13. issue 5. 2022-10-03. PMID:36186124. |
over time, our knowledge of pd has progressed from the detection of midbrain dopaminergic deficits to the identification of a multifaceted disease with a variety of central and peripheral manifestations, with increased attention to the intestinal tract. |
2022-10-03 |
2023-08-14 |
Not clear |
| Yao-Lin Li, Zhong-Xuan Wang, Chang-Zhou Ying, Bao-Rong Zhang, Jia-Li P. Decoding the Role of Familial Parkinson's Disease-Related Genes in DNA Damage and Repair. Aging and disease. vol 13. issue 5. 2022-10-03. PMID:36186134. |
parkinson's disease (pd) is a neurodegenerative disease characterized by the degeneration of midbrain substantia nigra pars compacta dopaminergic neurons and the formation of lewy bodies. |
2022-10-03 |
2023-08-14 |
Not clear |
| Sofía Puvogel, Astrid Alsema, Laura Kracht, Maree J Webster, Cynthia Shannon Weickert, Iris E C Sommer, Bart J L Egge. Single-nucleus RNA sequencing of midbrain blood-brain barrier cells in schizophrenia reveals subtle transcriptional changes with overall preservation of cellular proportions and phenotypes. Molecular psychiatry. 2022-10-03. PMID:36192459. |
besides the dopaminergic system, the midbrain contains other cell types that may be involved in schizophrenia pathophysiology. |
2022-10-03 |
2023-08-14 |
Not clear |
| Jia Shang, Bin Li, Han Fan, Peidi Liu, Wen Zhao, Tao Chen, Pu Chen, Longqiu Yan. Sevoflurane promotes premature differentiation of dopaminergic neurons in hiPSC-derived midbrain organoids. Frontiers in cell and developmental biology. vol 10. 2022-09-30. PMID:36176283. |
sevoflurane promotes premature differentiation of dopaminergic neurons in hipsc-derived midbrain organoids. |
2022-09-30 |
2023-08-14 |
Not clear |
| Aurore Vuidel, Loïc Cousin, Beatrice Weykopf, Simone Haupt, Zahra Hanifehlou, Nicolas Wiest-Daesslé, Michaela Segschneider, Joohyun Lee, Yong-Jun Kwon, Michael Peitz, Arnaud Ogier, Laurent Brino, Oliver Brüstle, Peter Sommer, Johannes H Wilbert. High-content phenotyping of Parkinson's disease patient stem cell-derived midbrain dopaminergic neurons using machine learning classification. Stem cell reports. 2022-09-30. PMID:36179692. |
high-content phenotyping of parkinson's disease patient stem cell-derived midbrain dopaminergic neurons using machine learning classification. |
2022-09-30 |
2023-08-14 |
Not clear |
| Da Woon Lee, Young-Kyoung Ryu, Dong-Ho Chang, Hye-Yeon Park, Jun Go, So-Young Maeng, Dae Youn Hwang, Byoung-Chan Kim, Chul-Ho Lee, Kyoung-Shim Ki. Journal of microbiology and biotechnology. vol 32. issue 9. 2022-09-28. PMID:36168204. |
parkinson's disease (pd) is the second-most prevalent neurodegenerative disease and is characterized by dopaminergic neuronal death in the midbrain. |
2022-09-28 |
2023-08-14 |
Not clear |
| Xi Chen, Zhaofei Yang, Yaping Shao, Kunhyok Kim, Yuanyuan Wang, Ying Wang, Haifeng Wu, Xiaolan Xu, Weidong L. Frontiers in aging neuroscience. vol 14. 2022-09-26. PMID:36158557. |
thus, msns may serve as the emerging targets for pd therapy besides the midbrain dopaminergic neurons. |
2022-09-26 |
2023-08-14 |
Not clear |
| Michal Rafal Zareba, Wiktoria Furman, Marek Binde. Influence of age and cognitive performance on resting-state functional connectivity of dopaminergic and noradrenergic centers. Brain research. 2022-09-17. PMID:36115586. |
in turn, older age was associated with greater local synchronization within vta, its lower fc with caudate, mediodorsal thalamus, and snc, as well as higher fc of both midbrain dopaminergic seeds with red nuclei. |
2022-09-17 |
2023-08-14 |
Not clear |
| Tong Tong, Weixia Duan, Yudong Xu, Huihui Hong, Jia Xu, Guanyan Fu, Xue Wang, Lingling Yang, Ping Deng, Jingjing Zhang, Haotian He, Gaofeng Mao, Yuanqiang Lu, Xiqin Lin, Zhengping Yu, Huifeng Pi, Yong Cheng, Shangcheng Xu, Zhou Zho. Paraquat exposure induces Parkinsonism by altering lipid profile and evoking neuroinflammation in the midbrain. Environment international. vol 169. 2022-09-15. PMID:36108500. |
in summary, we presented initial investigations of pq induced molecular events related to the pd pathogenesis, capturing aspects of disturbed lipid metabolism, neuroinflammation, impairment of dopaminergic neurons in the midbrain, and an intense systemic inflammation. |
2022-09-15 |
2023-08-14 |
mouse |
| Seong Shoon Yoon, Bong Hyo Lee, Seong Ho Lee, Seong Hun Choi, Seon-Ju Jeong, Sang Chan Kim, Chae Ha Yan. Effects of isoflurane anesthesia on addictive behaviors in rats. Psychopharmacology. 2022-09-15. PMID:36109391. |
recently, it has been suggested that isoflurane might reduce dopamine release from rat midbrain dopaminergic neurons, the neurobiological substrate implicated in the reinforcing effects of abused drugs and nondrug rewards. |
2022-09-15 |
2023-08-14 |
rat |
| I R de Luzy, C Pavan, N Moriarty, C P J Hunt, Z Vandenhoven, A Khanna, J C Niclis, C W Gantner, L H Thompson, C L Paris. Identifying the optimal developmental age of human pluripotent stem cell-derived midbrain dopaminergic progenitors for transplantation in a rodent model of Parkinson's disease. Experimental neurology. 2022-09-02. PMID:36055392. |
identifying the optimal developmental age of human pluripotent stem cell-derived midbrain dopaminergic progenitors for transplantation in a rodent model of parkinson's disease. |
2022-09-02 |
2023-08-14 |
human |
| Katharina Pieger, Verena Schmitt, Carina Gauer, Nadja Gießl, Iryna Prots, Beate Winner, Jürgen Winkler, Johann Helmut Brandstätter, Wei Xian. Translocation of Distinct Alpha Synuclein Species from the Nucleus to Neuronal Processes during Neuronal Differentiation. Biomolecules. vol 12. issue 8. 2022-08-26. PMID:36009004. |
employing nu-asyn-c, we characterized asyn distribution during neuronal differentiation in midbrain dopaminergic neurons (mdans) derived from human-induced pluripotent stem cells (hipscs) and lund human mesencephalic cells, and in primary rat hippocampal neurons. |
2022-08-26 |
2023-08-14 |
human |