| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew T C Manion, Erica R Glasper, Kuan Hong Wan. A sex difference in mouse dopaminergic projections from the midbrain to basolateral amygdala. Biology of sex differences. vol 13. issue 1. 2022-12-30. PMID:36585727. |
previous anatomical tracing studies in mammalian species have revealed a prominent circuit projection connecting the dopaminergic midbrain ventral tegmental area (vta) to the basolateral amygdala (bla), which is involved in emotional processing and associative learning. |
2022-12-30 |
2023-08-14 |
mouse |
| Jun Cui, Joseph Carey, Renee A Reijo Per. Identification of DOT1L inhibitor in a screen for factors that promote dopaminergic neuron survival. Frontiers in aging neuroscience. vol 14. 2022-12-29. PMID:36578445. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic (da) neurons in the substantia nigra region of the midbrain. |
2022-12-29 |
2023-08-14 |
Not clear |
| Changcheng Lu, Shuhui Qu, Zhangfeng Zhong, Hua Luo, Si San Lei, Hai-Jing Zhong, Huanxing Su, Yitao Wang, Cheong-Meng Chon. The effects of bioactive components from the rhizome of Frontiers in pharmacology. vol 13. 2022-12-19. PMID:36532787. |
the effects of bioactive components from the rhizome of parkinson's disease (pd) is an age-related chronic neurodegenerative disease caused by the death and degeneration of dopaminergic neurons in the substantia nigra of the midbrain. |
2022-12-19 |
2023-08-14 |
Not clear |
| Jun Lu, Siamak K Sorooshyar. Machine Learning Identifies a Rat Model of Parkinson's Disease via Sleep-Wake Electroencephalogram. Neuroscience. 2022-12-05. PMID:36470477. |
alpha-synuclein induced degeneration of the midbrain substantia nigra pars compact (snc) dopaminergic neurons causes parkinson's disease (pd). |
2022-12-05 |
2023-08-14 |
rat |
| Manabu Kubota, Keisuke Takahata, Kiwamu Matsuoka, Yasunori Sano, Yasuharu Yamamoto, Kenji Tagai, Ryosuke Tarumi, Hisaomi Suzuki, Shin Kurose, Shinichiro Nakajima, Hiroki Shiwaku, Chie Seki, Kazunori Kawamura, Ming-Rong Zhang, Hidehiko Takahashi, Yuhei Takado, Makoto Higuch. Positron Emission Tomography Assessments of Phosphodiesterase 10A in Patients With Schizophrenia. Schizophrenia bulletin. 2022-12-02. PMID:36458958. |
phosphodiesterase 10a (pde10a) is a highly expressed enzyme in the basal ganglia, where cortical glutamatergic and midbrain dopaminergic inputs are integrated. |
2022-12-02 |
2023-08-14 |
Not clear |
| Ahsas Goyal, Anant Agrawal, Aanchal Verma, Nandini Dube. The PI3K-AKT pathway: A plausible therapeutic target in Parkinson's disease. Experimental and molecular pathology. 2022-11-27. PMID:36436571. |
parkinson's disease is a common progressive and multifactorial neurodegenerative disease, characterized by the loss of midbrain dopaminergic neurons. |
2022-11-27 |
2023-08-14 |
Not clear |
| Laura A Struzyna, Kevin D Browne, Justin C Burrell, Wisberty J Gordián Vélez, Kathryn L Wofford, Hilton M Kaplan, N Sanjeeva Murthy, H Isaac Chen, John E Duda, Rodrigo A España, D Kacy Culle. Axonal Tract Reconstruction Using a Tissue-Engineered Nigrostriatal Pathway in a Rat Model of Parkinson's Disease. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430464. |
neurons were isolated from the ventral mesencephalon of transgenic rats selectively expressing the green fluorescent protein in dopaminergic neurons with subsequent fluorescent-activated cell sorting to enrich a population to 60% purity. |
2022-11-26 |
2023-08-14 |
rat |
| Vedad Delic, Joshua H Karp, Maynard Guzman, Gabriel R Arismendi, Katherine J Stalnaker, Julia A Burton, Kathleen E Murray, Joshua P Stamos, Kevin D Beck, Arpine Sokratian, Andrew B West, Bruce A Citro. Repetitive mild TBI causes pTau aggregation in nigra without altering preexisting fibril induced Parkinson's-like pathology burden. Acta neuropathologica communications. vol 10. issue 1. 2022-11-26. PMID:36435806. |
pd is classically characterized by deficits in fine motor movement control resulting from progressive neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta (snpc) midbrain region. |
2022-11-26 |
2023-08-14 |
rat |
| Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Shouta Serizawa, Fumiko Kihara-Negishi, Koichi J Homma, Shinji Yamaguch. Dopaminergic nuclei in the chick midbrain express serotonin receptor subfamily genes. Frontiers in physiology. vol 13. 2022-11-25. PMID:36425295. |
dopaminergic nuclei in the chick midbrain express serotonin receptor subfamily genes. |
2022-11-25 |
2023-08-14 |
chicken |
| Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Shouta Serizawa, Fumiko Kihara-Negishi, Koichi J Homma, Shinji Yamaguch. Dopaminergic nuclei in the chick midbrain express serotonin receptor subfamily genes. Frontiers in physiology. vol 13. 2022-11-25. PMID:36425295. |
another important neural modulatory system exists in the midbrain, the dopaminergic system, which is associated to reward processing and motivation control. |
2022-11-25 |
2023-08-14 |
chicken |
| Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Shouta Serizawa, Fumiko Kihara-Negishi, Koichi J Homma, Shinji Yamaguch. Dopaminergic nuclei in the chick midbrain express serotonin receptor subfamily genes. Frontiers in physiology. vol 13. 2022-11-25. PMID:36425295. |
recently, midbrain dopaminergic neurons were shown to be innervated by serotonergic neurons and modulated by 5-ht, with the crosstalk between serotonergic and dopaminergic systems attracting increased attention. |
2022-11-25 |
2023-08-14 |
chicken |
| Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Shouta Serizawa, Fumiko Kihara-Negishi, Koichi J Homma, Shinji Yamaguch. Dopaminergic nuclei in the chick midbrain express serotonin receptor subfamily genes. Frontiers in physiology. vol 13. 2022-11-25. PMID:36425295. |
in birds, previous studies revealed that midbrain dopaminergic neurons are located in the a8-a10 homologous clusters. |
2022-11-25 |
2023-08-14 |
chicken |
| Gurvir S Virdi, Minee L Choi, James R Evans, Zhi Yao, Dilan Athauda, Stephanie Strohbuecker, Raja S Nirujogi, Anna I Wernick, Noelia Pelegrina-Hidalgo, Craig Leighton, Rebecca S Saleeb, Olga Kopach, Haya Alrashidi, Daniela Melandri, Jimena Perez-Lloret, Plamena R Angelova, Sergiy Sylantyev, Simon Eaton, Simon Heales, Dmitri A Rusakov, Dario R Alessi, Tilo Kunath, Mathew H Horrocks, Andrey Y Abramov, Rickie Patani, Sonia Gandh. Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons. NPJ Parkinson's disease. vol 8. issue 1. 2022-11-24. PMID:36424392. |
protein aggregation and calcium dysregulation are hallmarks of familial parkinson's disease in midbrain dopaminergic neurons. |
2022-11-24 |
2023-08-14 |
human |
| Gurvir S Virdi, Minee L Choi, James R Evans, Zhi Yao, Dilan Athauda, Stephanie Strohbuecker, Raja S Nirujogi, Anna I Wernick, Noelia Pelegrina-Hidalgo, Craig Leighton, Rebecca S Saleeb, Olga Kopach, Haya Alrashidi, Daniela Melandri, Jimena Perez-Lloret, Plamena R Angelova, Sergiy Sylantyev, Simon Eaton, Simon Heales, Dmitri A Rusakov, Dario R Alessi, Tilo Kunath, Mathew H Horrocks, Andrey Y Abramov, Rickie Patani, Sonia Gandh. Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons. NPJ Parkinson's disease. vol 8. issue 1. 2022-11-24. PMID:36424392. |
our small molecule-based protocol generates highly enriched midbrain dopaminergic (mda) neurons: molecular identity was confirmed using single-cell rna sequencing and proteomics, and functional identity was established through dopamine synthesis, and measures of electrophysiological activity. |
2022-11-24 |
2023-08-14 |
human |
| Zhiqian Yu, Kazuko Ueno, Ryo Funayama, Mai Sakai, Naoki Nariai, Kaname Kojima, Yoshie Kikuchi, Xue Li, Chiaki Ono, Junpei Kanatani, Jiro Ono, Kazuya Iwamoto, Kenji Hashimoto, Kengo Kinoshita, Keiko Nakayama, Masao Nagasaki, Hiroaki Tomit. Sex-Specific Differences in the Transcriptome of the Human Dorsolateral Prefrontal Cortex in Schizophrenia. Molecular neurobiology. 2022-11-22. PMID:36414910. |
an ingenuity pathway analysis revealed that the differentially expressed genes related to schizophrenia in the female group were involved in midbrain dopaminergic and γ-aminobutyric acid (gaba)-ergic neurons and microglia. |
2022-11-22 |
2023-08-14 |
human |
| Kaneyasu Nishimura, Shanzheng Yang, Ka Wai Lee, Emilía Sif Ásgrímsdóttir, Kasra Nikouei, Wojciech Paslawski, Sabine Gnodde, Guochang Lyu, Lijuan Hu, Carmen Saltó, Per Svenningsson, Jens Hjerling-Leffler, Sten Linnarsson, Ernest Arena. Single-cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation. Stem cell reports. 2022-11-18. PMID:36400027. |
in this study, we identify developmental factors important for the differentiation of human embryonic stem cells (hescs) into functional midbrain dopaminergic (mda) neurons. |
2022-11-18 |
2023-08-14 |
human |
| Zohra Rahmani, Satya Surabhi, Francisca Rojo-Cortés, Amina Dulac, Andreas Jenny, Serge Birma. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36361864. |
parkinson disease (pd) is a common neurodegenerative condition affecting people predominantly at old age that is characterized by a progressive loss of midbrain dopaminergic neurons and by the accumulation of α-synuclein-containing intraneuronal inclusions known as lewy bodies. |
2022-11-11 |
2023-08-14 |
Not clear |
| Els F Halff, Grazia Rutigliano, Anna Garcia-Hidalgo, Oliver D Howe. Trace amine-associated receptor 1 (TAAR1) agonism as a new treatment strategy for schizophrenia and related disorders. Trends in neurosciences. 2022-11-11. PMID:36369028. |
studies in rodents using taar1 knockout (taar1-ko) and overexpression models show that taar1 agonism inhibits midbrain dopaminergic and serotonergic activity, and enhances prefrontal glutamatergic function. |
2022-11-11 |
2023-08-14 |
Not clear |
| Talia Krainc, Mariana H G Monje, Morgan Kinsinger, Bernabe I Bustos, Steven J Lubb. Melanin and Neuromelanin: Linking Skin Pigmentation and Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. 2022-11-09. PMID:36350228. |
because neuromelanin and melanin share many functional characteristics and overlapping biosynthetic pathways, it has been postulated that genes involved in skin pigmentation and melanin formation may play a role in the susceptibility of vulnerable midbrain dopaminergic neurons to neurodegeneration. |
2022-11-09 |
2023-08-14 |
mouse |
| Junichi Yoshida, Maritza Oñate, Leila Khatami, Jorge Vera, Farzan Nadim, Kamran Khodakha. Cerebellar Contributions to the Basal Ganglia Influence Motor Coordination, Reward Processing, and Movement Vigor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 42. issue 45. 2022-11-09. PMID:36351826. |
we review two sets of such connections: disynaptic projections through the thalamus and direct monosynaptic projections to the midbrain dopaminergic nuclei, the vta and the snc. |
2022-11-09 |
2023-08-14 |
Not clear |