| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akira Fushiki, David Ng, Zachary R Lewis, Archana Yadav, Tatiana Saraiva, Luke A Hammand, Christoph Wirblich, Bosiljka Tasic, Vilas Menon, Joaquim Alves da Silva, Rui M Cost. A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor Deficits in Parkinson's Disease. bioRxiv : the preprint server for biology. 2025-01-11. PMID:39763754. |
in parkinson's disease, dopaminergic neurons (dans) in the midbrain gradually degenerate, with ventral substantia nigra pars compacta (snc) dans exhibiting greater vulnerability. |
2025-01-11 |
2025-01-13 |
mouse |
| Nandita Ravichandran, Mahalaxmi Iyer, Deenathayalan Uvarajan, Laxmi Kirola, Sindduja Muthu Kumra, Harysh Winster Suresh Babu, Dibbanti HariKrishnaReddy, Balachandar Vellingiri, Arul Narayanasam. New insights on the regulators and inhibitors of RhoA-ROCK signalling in Parkinson's disease. Metabolic brain disease. vol 40. issue 1. 2025-01-08. PMID:39775342. |
a multifaceted and widely prevalent neurodegenerative disease, parkinson's disease (pd) is typified by the loss of dopaminergic neurons in the midbrain. |
2025-01-08 |
2025-01-13 |
Not clear |
| José María Salazar Campos, Lena F Burbulla, Sarah Jäke. Are oligodendrocytes bystanders or drivers of Parkinson's disease pathology? PLoS biology. vol 23. issue 1. 2025-01-08. PMID:39777410. |
the major pathological feature of parkinson 's disease (pd), the second most common neurodegenerative disease and most common movement disorder, is the predominant degeneration of dopaminergic neurons in the substantia nigra, a part of the midbrain. |
2025-01-08 |
2025-01-13 |
Not clear |
| Yeo-Jin Yi, Michael C Kreißl, Oliver Speck, Emrah Düzel, Dorothea Hämmere. Decoding Salience: A Functional Magnetic Resonance Imaging Investigation of Reward and Contextual Unexpectedness in Memory Encoding and Retrieval. Human brain mapping. vol 46. issue 1. 2025-01-07. PMID:39764707. |
by using advanced image processing techniques tailored to examine midbrain and brainstem nuclei with high precision, our study additionally aimed to elucidate differential activation patterns in subcortical nuclei in response to reward-associated and contextually unexpected stimuli, including distinct pathways involving in particular dopaminergic modulation. |
2025-01-07 |
2025-01-13 |
human |
| Elizabeth Carrazana, Leonardo Montalbán-Gutiérrez, Pedro Chana-Cuevas, Natalia Salvadore. Advancing Parkinson's diagnosis: seed amplification assay for α-synuclein detection in minimally invasive samples. Molecular and cellular biochemistry. 2025-01-06. PMID:39760833. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by tremor, rigidity, and bradykinesia, beginning with early loss of dopaminergic neurons in the ventrolateral substantia nigra and advancing to broader neurodegeneration in the midbrain. |
2025-01-06 |
2025-01-08 |
Not clear |
| Grace A Selecky, Kristen R Whitney, Margaret M Krassner, Alessandra Cervera, Claudia De Sanctis, Victoria Flores Almazan, Sean Thomas Delica, SoongHo Kim, Kurt W Farrell, Thomas D Christie, Megan A Iida, Lily Sarrafha, Gustavo Parfitt, Ruth H Walker, Melissa J Nirenberg, Giulietta M Riboldi, Steven J Frucht, Tim Ahfeldt, Sally Temple, John F Crar. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751331. |
progressive supranuclear palsy (psp), the most common primary tauopathy, is typified by selective vulnerability of dopaminergic neurons and glia in the midbrain leading to an atypical parkinsonian movement disorder. |
2025-01-03 |
2025-01-05 |
human |
| Karis A Clark, Andrew J White, Wojciech Paslawski, Kellianne D Alexander, Shaoning Peng, Tracy L Young-Pearse, Per Svenningsson, Dennis J Selkoe, Gary P H H. Parkinson disease-associated toxic exposures selectively upregulate vesicular glutamate transporter vGlut2 in a model of human cortical neurons. Molecular biology of the cell. 2025-01-02. PMID:39745872. |
motor symptoms primarily involve midbrain dopaminergic neurons, while cognitive dysfunction involves cortical neurons. |
2025-01-02 |
2025-01-05 |
human |
| Karis A Clark, Andrew J White, Wojciech Paslawski, Kellianne D Alexander, Shaoning Peng, Tracy L Young-Pearse, Per Svenningsson, Dennis J Selkoe, Gary P H H. Parkinson disease-associated toxic exposures selectively upregulate vesicular glutamate transporter vGlut2 in a model of human cortical neurons. Molecular biology of the cell. 2025-01-02. PMID:39745872. |
in rodents, rare midbrain dopaminergic neurons which co-express the vesicular glutamate transporter 2 (vglut2) are resistant to various toxins which induce dopaminergic neurodegeneration. |
2025-01-02 |
2025-01-05 |
human |
| Xiaoxuan Sun, Lili Yin, Zhongjun Qiao, Muhammad Younus, Guoqing Chen, Xi Wu, Jie Li, Xinjiang Kang, Huadong Xu, Li Zhou, Yinglin Li, Min Gao, Xingyu Du, Yuqi Hang, Zhaohan Lin, Liyuan Sun, Qinglong Wang, Ruiying Jiao, Lun Wang, Meiqin Hu, Yuan Wang, Rong Huang, Yiman Li, Qihui Wu, Shujiang Shang, Shu Guo, Qian Lei, Haifeng Shu, Lianghong Zheng, Shirong Wang, Feipeng Zhu, Panli Zuo, Bing Liu, Changhe Wang, Quanfeng Zhang, Zhuan Zho. Action Potential Firing Patterns Regulate Dopamine Release via Voltage-Sensitive Dopamine D2 Autoreceptors in Mouse Striatum In Vivo. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-12-28. PMID:39731325. |
midbrain dopaminergic neurons generate both tonic and phasic action potential (ap) firing patterns in behavior mice. |
2024-12-28 |
2024-12-30 |
mouse |
| Talita Rodrigues, Getulio Nicola Bressan, Patrícia Zorzi Juliani, Maria Eduarda Brandli da Silva, Roselei Fachinett. Ketamine impairs the performance of male mice in novel recognition object test and reduces the immunoreactivity of GAD Pharmacology, biochemistry, and behavior. 2024-12-26. PMID:39725040. |
the peroxisome proliferator-activated receptors-gamma (ppar-γ) are expressed in dopaminergic neurons of the midbrain participating in the modulation of neurotransmitters release like dopamine. |
2024-12-26 |
2024-12-29 |
mouse |
| Qiaochu Jiang, Konstantin I Bakhurin, Ryan N Hughes, Bryan Lu, Shaolin Ruan, Henry H Yi. GABAergic neurons from the ventral tegmental area represent and regulate force vectors. bioRxiv : the preprint server for biology. 2024-12-23. PMID:39713374. |
the ventral tegmental area (vta), a midbrain region associated with motivated behaviors, consists predominantly of dopaminergic (da) neurons and gabaergic (gaba) neurons. |
2024-12-23 |
2024-12-25 |
mouse |
| Mitchell J Vaughn, Nandini Yellamelli, R Michael Burger, Julie S Haa. Dopamine receptors D1, D2, and D4 modulate electrical synapses and excitability in the thalamic reticular nucleus. Journal of neurophysiology. 2024-12-20. PMID:39706150. |
the trn receives dopaminergic innervation from the midbrain, and it is known to express high concentrations of d1 and d4 receptors. |
2024-12-20 |
2024-12-24 |
Not clear |
| Fiona Weiss, Laura Hughes, Yuhong Fu, Cedric Bardy, Glenda M Halliday, Nicolas Dzamk. Astrocytes contribute to toll-like receptor 2-mediated neurodegeneration and alpha-synuclein pathology in a human midbrain Parkinson's model. Translational neurodegeneration. vol 13. issue 1. 2024-12-16. PMID:39681872. |
parkinson's disease (pd) is characterised by degeneration of ventral midbrain dopaminergic (da) neurons and abnormal deposition of α-synuclein (α-syn) in neurons. |
2024-12-16 |
2024-12-21 |
human |
| Zuzana Bacova, Tomas Havranek, Denisa Mihalj, Veronika Borbelyova, Kristina Kostrubanicova, Michaela Kramarova, Daniela Ostatnikova, Jan Bako. Reduced Neurite Arborization in Primary Dopaminergic Neurons in Autism-Like Shank3B-Deficient Mice. Molecular neurobiology. 2024-12-09. PMID:39654001. |
significantly reduced neurite outgrowth was observed in primary dopaminergic neurons from the midbrain and striatum of shank3-deficient compared to wt mice. |
2024-12-09 |
2024-12-12 |
mouse |
| Yuma Sato, Masayuki Matsumoto, Tadachika Koganezaw. The dopaminergic system mediates the lateral habenula-induced autonomic cardiovascular responses. Frontiers in physiology. vol 15. 2024-12-06. PMID:39640253. |
in this study, we examined the participation of the midbrain dopaminergic system in the cardiovascular response elicited by activation of the lhb. |
2024-12-06 |
2024-12-08 |
rat |
| Sara Nolbrant, Jenelle L Wallace, Jingwen Ding, Tianjia Zhu, Jess L Sevetson, Janko Kajtez, Isabella A Baldacci, Emily K Corrigan, Kaylynn Hoglin, Reed McMullen, Matthew T Schmitz, Arnar Breevoort, Dani Swope, Fengxia Wu, Bryan J Pavlovic, Sofie R Salama, Agnete Kirkeby, Hao Huang, Nathan K Schaefer, Alex A Polle. Interspecies Organoids Reveal Human-Specific Molecular Features of Dopaminergic Neuron Development and Vulnerability. bioRxiv : the preprint server for biology. 2024-11-28. PMID:39605599. |
the disproportionate expansion of telencephalic structures during human evolution involved tradeoffs that imposed greater connectivity and metabolic demands on midbrain dopaminergic neurons. |
2024-11-28 |
2024-11-30 |
human |
| You-Yen Lin, De-Maw Chuang, Cheng-Yu Chi, Shih-Ya Hun. Intranasal administration of mesenchymal stem cells overexpressing FGF21 demonstrates therapeutic potential in experimental Parkinson's disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2024-11-28. PMID:39609161. |
parkinson's disease (pd) is a prevalent movement disorder characterized by mitochondrial dysfunction and dopaminergic neuronal loss in the substantia nigra of the midbrain. |
2024-11-28 |
2024-12-01 |
mouse |
| Jintae Kim, Mi-Yoon Chan. Gene Therapy for Parkinson's Disease Using Midbrain Developmental Genes to Regulate Dopaminergic Neuronal Maintenance. International journal of molecular sciences. vol 25. issue 22. 2024-11-27. PMID:39596436. |
gene therapy for parkinson's disease using midbrain developmental genes to regulate dopaminergic neuronal maintenance. |
2024-11-27 |
2024-11-29 |
Not clear |
| Riko Nakanishi, Yuki Kurauchi, Shunsuke Kotani, Natsuko Hitora-Imamura, Takahiro Seki, Hiroshi Katsuk. Structurally Distinct Nurr1 Ligands Exhibit Different Pharmacological Characteristics in Regulating Inflammatory Responses of Microglial BV-2 Cells. Biological & pharmaceutical bulletin. vol 47. issue 11. 2024-11-27. PMID:39603614. |
nurr1 (nr4a2) is a member of nuclear receptor superfamily that regulates gene transcription in midbrain dopaminergic neurons and also inhibits nuclear factor-κb-mediated inflammatory responses in brain microglial cells. |
2024-11-27 |
2024-11-30 |
Not clear |
| Alan D Kaye, Kassady A Perkinson, Noah J Spillers, Alexis J Vega, Caylin J Roberts, Evan M Downs, Melissa M Sheth, David W McGregor, Shahab Ahmadzadeh, Jibin Mathew, Sahar Shekooh. Parkinson's Disease: A Narrative of the Evolving Understanding of the Role of α-Synuclein in Screening. Current issues in molecular biology. vol 46. issue 11. 2024-11-26. PMID:39590351. |
parkinson's disease (pd) is a debilitating neurodegenerative disorder caused by the loss of dopaminergic neurons in the midbrain, leading to symptoms such as tremors, bradykinesia, postural instability, dementia, and depression. |
2024-11-26 |
2024-11-29 |
Not clear |