| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gerard Eric Dwyer, Erik Johnsen, Kenneth Hugdah. NMDAR dysfunction and the regulation of dopaminergic transmission in schizophrenia. Schizophrenia research. vol 271. 2024-07-13. PMID:39002526. |
furthermore, this article presents a model for schizophrenia illustrating how dysfunction in the nrt may interrupt prefrontal regulation of midbrain dopaminergic neurons, and how dysfunction in the pptg may drive increased, irregular burst firing. |
2024-07-13 |
2024-07-16 |
Not clear |
| Joohyun An, Minkyu Shin, Geunyoung Beak, Jinho Yoon, Seewoo Kim, Hyeon-Yeol Cho, Jeong-Woo Cho. Drug Evaluation of Parkinson's Disease Patient-Derived Midbrain Organoids Using Mesoporous Au Nanodot-Patterned 3D Concave Electrode. ACS sensors. 2024-07-02. PMID:38954790. |
after the treatment of pd midbrain organoids with levodopa, the drug for pd, the increase in dopamine level was detected due to the activation of dopaminergic neurons by the drug. |
2024-07-02 |
2024-07-06 |
human |
| Vidhi Bhatt, Halak Shukla, Anand Krishna Tiwar. Parkinson's Disease and Mitotherapy-Based Approaches towards α-Synucleinopathies. Journal of integrative neuroscience. vol 23. issue 6. 2024-06-28. PMID:38940084. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta region of the midbrain and the formation of intracellular protein aggregates known as lewy bodies, of which a major component is the protein α-synuclein. |
2024-06-28 |
2024-06-30 |
Not clear |
| Luke J Vano, Robert A McCutcheon, Grazia Rutigliano, Stephen J Kaar, Valeria Finelli, Giovanna Nordio, George Wellby, Jan Sedlacik, Ben Statton, Eugenii A Rabiner, Rong Ye, Mattia Veronese, Seth C Hopkins, Kenneth S Koblan, Ian P Everall, Oliver D Howe. Mesostriatal Dopaminergic Circuit Dysfunction in Schizophrenia: A Multimodal Neuromelanin-sensitive MRI and [18F]-DOPA PET Study. Biological psychiatry. 2024-06-28. PMID:38942349. |
striatal hyperdopaminergia is implicated in the pathoetiology of schizophrenia, but how this relates to dopaminergic midbrain activity is unclear. |
2024-06-28 |
2024-07-01 |
Not clear |
| Antonio Del Casale, Martina Nicole Modesti, Giovanna Gentile, Cecilia Guariglia, Stefano Ferracuti, Maurizio Simmaco, Marina Borr. Is the Hedgehog Pathway Involved in the Pathophysiology of Schizophrenia? A Systematic Review of Current Evidence of Neural Molecular Correlates and Perspectives on Drug Development. Current issues in molecular biology. vol 46. issue 6. 2024-06-26. PMID:38920990. |
the hh pathway is crucial in the development of midbrain dopaminergic neurons, neuroplasticity mechanisms, regulating astrocyte phenotype and function, brain-derived neurotrophic factor expression, brain glutamatergic neural transmission, and responses to antipsychotics. |
2024-06-26 |
2024-06-29 |
human |
| Stuart B Murray, Joel P Diaz-Fong, Vienna W T Mak, Jamie D Feusne. Assessing midbrain neuromelanin and its relationship to reward learning in anorexia nervosa: Stage 1 of a registered report. Brain and behavior. vol 14. issue 6. 2024-06-20. PMID:38898625. |
neuromelanin-sensitive magnetic resonance imaging (mri) is an emerging method to index midbrain neuromelanin-a by-product of dopaminergic synthesis. |
2024-06-20 |
2024-06-22 |
Not clear |
| Tiziano Balzano, Natalia López-González Del Rey, Noelia Esteban-García, Alejandro Reinares-Sebastián, José A Pineda-Pardo, Inés Trigo-Damas, José A Obeso, Javier Bles. Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates. NPJ Parkinson's disease. vol 10. issue 1. 2024-06-19. PMID:38886348. |
we aimed to investigate the contribution of glial cell activation and immune cell infiltration in the selective vulnerability of ventral dopaminergic neurons within the midbrain in a non-human primate model of pd. |
2024-06-19 |
2024-06-21 |
monkey |
| Tiziano Balzano, Natalia López-González Del Rey, Noelia Esteban-García, Alejandro Reinares-Sebastián, José A Pineda-Pardo, Inés Trigo-Damas, José A Obeso, Javier Bles. Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates. NPJ Parkinson's disease. vol 10. issue 1. 2024-06-19. PMID:38886348. |
higher vascular density within the ventral region of the snc may be a relevant factor for differential vulnerability of dopaminergic neurons in the midbrain. |
2024-06-19 |
2024-06-21 |
monkey |
| Maya Belghazi, Cécile Iborra, Ophélie Toutendji, Manon Lasserre, Dominique Debanne, Jean-Marc Goaillard, Béatrice Marquèze-Poue. High-Resolution Proteomics Unravel a Native Functional Complex of Cav1.3, SK3, and Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in Midbrain Dopaminergic Neurons. Cells. vol 13. issue 11. 2024-06-19. PMID:38891076. |
high-resolution proteomics unravel a native functional complex of cav1.3, sk3, and hyperpolarization-activated cyclic nucleotide-gated channels in midbrain dopaminergic neurons. |
2024-06-19 |
2024-06-21 |
Not clear |
| Maya Belghazi, Cécile Iborra, Ophélie Toutendji, Manon Lasserre, Dominique Debanne, Jean-Marc Goaillard, Béatrice Marquèze-Poue. High-Resolution Proteomics Unravel a Native Functional Complex of Cav1.3, SK3, and Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in Midbrain Dopaminergic Neurons. Cells. vol 13. issue 11. 2024-06-19. PMID:38891076. |
in order to demonstrate the presence of these molecular interactions in situ, we used proximity ligation assay (pla) imaging on midbrain slices containing the substantia nigra, and we could ascertain the presence of these protein complexes specifically in substantia nigra dopaminergic neurons. |
2024-06-19 |
2024-06-21 |
Not clear |
| Shiqiang Zhang, Jingjing Zhang, Yihao Yang, Weidong Zang, Jing Ca. Activation of Pedunculopontine Tegmental Nucleus Alleviates the Pain Induced by the Lesion of Midbrain Dopaminergic Neurons. International journal of molecular sciences. vol 25. issue 11. 2024-06-19. PMID:38891832. |
activation of pedunculopontine tegmental nucleus alleviates the pain induced by the lesion of midbrain dopaminergic neurons. |
2024-06-19 |
2024-06-21 |
mouse |
| Shiqiang Zhang, Jingjing Zhang, Yihao Yang, Weidong Zang, Jing Ca. Activation of Pedunculopontine Tegmental Nucleus Alleviates the Pain Induced by the Lesion of Midbrain Dopaminergic Neurons. International journal of molecular sciences. vol 25. issue 11. 2024-06-19. PMID:38891832. |
the loss of midbrain dopaminergic (da) neurons is the fundamental pathological feature of parkinson's disease (pd). |
2024-06-19 |
2024-06-21 |
mouse |
| Hanieh Javid, Rana Rahimian, Misha Salimi, Elaheh Haghani-Samani, Mona Farhadi, Anahita Torkaman-Boutorab. Fumaria vaillantii extract protects PC12 cells against neurotoxicity induced by 6-OHDA. Molecular biology reports. vol 51. issue 1. 2024-06-17. PMID:38884894. |
parkinson's disease is a neurological disorder caused by the loss of dopaminergic neurons in the midbrain. |
2024-06-17 |
2024-06-19 |
Not clear |
| Huiqing Wang, Wenwei Mao, Yuhan Zhang, Wenhui Feng, Bo Bai, Bingyuan Ji, Jing Chen, Baohua Cheng, Fuling Ya. NOX1 triggers ferroptosis and ferritinophagy, contributes to Parkinson's disease. Free radical biology & medicine. 2024-06-14. PMID:38876456. |
the progressive loss of dopaminergic neurons in the midbrain is the hallmark of parkinson's disease (pd). |
2024-06-14 |
2024-06-17 |
Not clear |
| Tuoying Jiang, Jianan Huang, Bo Xu, Zhen Ge, Yi Li, Leiting Wei, Luyang Yu, Jinying L. Human amniotic epithelial stem cell-derived dopaminergic neuron-like cells ameliorate motor dysfunction in a rat model of Parkinson's disease. Life sciences. 2024-06-11. PMID:38862064. |
parkinson's disease (pd) remains a substantial clinical challenge due to the progressive loss of midbrain dopaminergic (da) neurons in nigrostriatal pathway. |
2024-06-11 |
2024-06-14 |
human |
| Pingping Song, Dimitri Krain. Diverse Functions of Parkin in Midbrain Dopaminergic Neurons. Movement disorders : official journal of the Movement Disorder Society. 2024-06-11. PMID:38858837. |
diverse functions of parkin in midbrain dopaminergic neurons. |
2024-06-11 |
2024-06-14 |
human |
| Pingping Song, Dimitri Krain. Diverse Functions of Parkin in Midbrain Dopaminergic Neurons. Movement disorders : official journal of the Movement Disorder Society. 2024-06-11. PMID:38858837. |
parkinson's disease (pd) is characterized by preferential degeneration of midbrain dopaminergic neurons that contributes to its typical clinical manifestation. |
2024-06-11 |
2024-06-14 |
human |
| Pingping Song, Dimitri Krain. Diverse Functions of Parkin in Midbrain Dopaminergic Neurons. Movement disorders : official journal of the Movement Disorder Society. 2024-06-11. PMID:38858837. |
in pd patient neurons, disruption of this pathway on loss of parkin leads to defective recycling of synaptic vesicles and accumulation of toxic oxidized dopamine that at least in part explains preferential vulnerability of midbrain dopaminergic neurons. |
2024-06-11 |
2024-06-14 |
human |
| Gourav Chakraborty, Niladri Patr. Elucidating the Molecular Basis of 14-3-3 Interaction with α-Synuclein: Insights from Molecular Dynamics Simulations and the Design of a Novel Protein-Protein Interaction Inhibitor. The journal of physical chemistry. B. 2024-06-10. PMID:38857533. |
parkinson's disease is a widespread age-related neurodegenerative disorder characterized by the loss of dopaminergic neurons in the midbrain along with the appearance of protein aggregates, termed as "lewy bodies" in the surviving neuronal cells. |
2024-06-10 |
2024-06-14 |
human |
| Cintia Roodveldt, Liliana Bernardino, Ozgur Oztop-Cakmak, Milorad Dragic, Kari Espolin Fladmark, Sibel Ertan, Aktas Busra, Carlos Pita, Lucia Ciglar, Gaetan Garraux, Caroline Williams-Gray, Rodrigo Pacheco, Marina Romero-Ramo. The immune system in Parkinson's disease: what we know so far. Brain : a journal of neurology. 2024-06-04. PMID:38833182. |
parkinson's disease (pd) is characterised neuropathologically by the degeneration of dopaminergic neurons in the ventral midbrain, the accumulation of α-synuclein (α-syn) aggregates in neurons, and chronic neuroinflammation. |
2024-06-04 |
2024-06-06 |
Not clear |