| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Annie J Zalon, Drew J Quiriconi, Caleb Pitcairn, Joseph R Mazzull. α-Synuclein: Multiple pathogenic roles in trafficking and proteostasis pathways in Parkinson's disease. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2024-02-29. PMID:38420922. |
parkinson's disease (pd) is a common age-related neurodegenerative disorder characterized by the loss of dopaminergic neurons in the midbrain. |
2024-02-29 |
2024-03-02 |
Not clear |
| Silke Nuber, Xiaoqun Zhang, Thomas D McCaffery, Tim E Moors, Marie-Alexandre Adom, Wolf N Hahn, Dylan Martin, Maria Ericsson, Arathi Tripathi, Ulf Dettmer, Per Svenningsson, Dennis J Selko. Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes. NPJ Parkinson's disease. vol 10. issue 1. 2024-02-29. PMID:38424059. |
both 1d and 3d mice undergo loss of striatal th+ fibers and midbrain dopaminergic neurons by 12 mos and a bradykinesia responsive to l-dopa. |
2024-02-29 |
2024-03-03 |
mouse |
| Ankul Singh S, Aarita Sood, Chitra Vellapandia. The Role of Ocimene in Decreasing α-Synuclein Aggregation using Rotenone-induced Rat Model. Central nervous system agents in medicinal chemistry. 2024-02-27. PMID:38409725. |
parkinson's disease is defined by the loss of dopaminergic neurons in the midbrain of substantia nigra associated with lewy bodies. |
2024-02-27 |
2024-03-02 |
rat |
| Jake Sondag Boles, Jenny Holt, Cassandra L Cole, Noelle K Neighbarger, Nikhil M Urs, Oihane Uriarte Huarte, Malú Gámez Tanse. Locus coeruleus injury modulates ventral midbrain neuroinflammation during DSS-induced colitis. bioRxiv : the preprint server for biology. 2024-02-26. PMID:38405709. |
in all, this study supports the growing appreciation for the lc as neuroprotective against inflammation-induced brain injury and draws attention to the potential for neergic interventions to exert disease-modifying effects under conditions where peripheral inflammation may compromise ventral midbrain dopaminergic neurons and increase the risk for development of pd. |
2024-02-26 |
2024-02-28 |
mouse |
| Fatema Currim, Shatakshi Shukla, Jyoti Singh, Dhruv Gohel, Minal Mane, Anjali Shinde, Milton Roy, Shani Goyani, Hitesh Vasiyani, Aswathy Chandran, Jean-Christophe Rochet, Jason Cannon, Rajesh Sing. Neuronal exosomal miRNAs modulate mitochondrial functions and cell death in bystander neuronal cells under Parkinson's disease stress conditions. Neurotoxicology. 2024-02-24. PMID:38401688. |
parkinson's disease (pd) is a chronic neurodegenerative disorder characterized by progressive loss of midbrain dopaminergic neurons in the substantia nigra part of the brain. |
2024-02-24 |
2024-02-27 |
Not clear |
| Qingfang Liu, Yao Zhao, Sumedha Attanti, Joel L Voss, Geoffrey Schoenbaum, Thorsten Kahn. Midbrain signaling of identity prediction errors depends on orbitofrontal cortex networks. Nature communications. vol 15. issue 1. 2024-02-24. PMID:38402210. |
previous work across species has shown that the dopaminergic midbrain responds to violations in expected reward identity and that the lateral orbitofrontal cortex (ofc) represents reward identity expectations. |
2024-02-24 |
2024-02-27 |
Not clear |
| Qingfang Liu, Yao Zhao, Sumedha Attanti, Joel L Voss, Geoffrey Schoenbaum, Thorsten Kahn. Midbrain signaling of identity prediction errors depends on orbitofrontal cortex networks. Nature communications. vol 15. issue 1. 2024-02-24. PMID:38402210. |
these results support the idea that ipe signals in the dopaminergic midbrain are computed based on outcome expectations represented in the lateral ofc. |
2024-02-24 |
2024-02-27 |
Not clear |
| Mingjie Zhang, Congyan Duan, Weifang Lin, Honghua Wu, Lu Chen, Hong Guo, Minyu Yu, Qi Liu, Yaling Nie, Hong Wang, Shaoxia Wan. Levistilide A Exerts a Neuroprotective Effect by Suppressing Glucose Metabolism Reprogramming and Preventing Microglia Polarization Shift: Implications for Parkinson's Disease. Molecules (Basel, Switzerland). vol 29. issue 4. 2024-02-24. PMID:38398662. |
in vivo experiments further corroborated these findings, demonstrating that la mitigated the death of th-positive dopaminergic neurons and reduced microglia activation in the ventral snpc brain region of the midbrain and the striatum. |
2024-02-24 |
2024-02-26 |
Not clear |
| Lingling Zhang, Hao Yan. Research progress of neural stem cells as a source of dopaminergic neurons for cell therapy in Parkinson's disease. Molecular biology reports. vol 51. issue 1. 2024-02-24. PMID:38400887. |
parkinson's disease (pd) is a neurodegenerative disease, the most characteristic pathological feature is the progressive loss of dopaminergic (da) neurons in the substantia nigra pars compactus (snpc) of the mesencephalon, along with reduced dopamine content in the striatum. |
2024-02-24 |
2024-02-27 |
Not clear |
| Emad Albadawi, Ahmed El-Tokhy, Muayad Albadrani, Mohammed Adel, Randa El-Gamal, Wael Zaarina, Mosaab Salah El-Din El-Agawy, Hassan Reda Hassan Elsaye. The role of stinging nettle (Urtica dioica L.) in the management of rotenone-induced Parkinson's disease in rats. Tissue & cell. vol 87. 2024-02-22. PMID:38387425. |
the results showed that nettle caused recovery of midbrain dopaminergic neurons, by inhibiting apoptosis, inflammation, and oxidative stress and by restoring the autophagic machinery with clearance of α-synuclein deposits. |
2024-02-22 |
2024-02-25 |
rat |
| Alp Ozgun, David J Lomboni, Amy Aylsworth, Allison Macdonald, William A Staines, Marzia Martina, Michael G Schlossmacher, Joseph S Tauskela, John Woulfe, Fabio Variol. Unraveling the assembloid: Real-time monitoring of dopaminergic neurites in an inter-organoid pathway connecting midbrain and striatal regions. Materials today. Bio. vol 25. 2024-02-19. PMID:38371467. |
unraveling the assembloid: real-time monitoring of dopaminergic neurites in an inter-organoid pathway connecting midbrain and striatal regions. |
2024-02-19 |
2024-02-21 |
Not clear |
| Andy Yang, Rony Chidiac, Emma Russo, Hendrik Steenland, Quinn Pauli, Robert Bonin, Levi L Blazer, Jarrett J Adams, Sachdev S Sidhu, Aleksandrina Goeva, Ali Salahpour, Stephane Anger. Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification. Development (Cambridge, England). 2024-02-15. PMID:38358799. |
stimulation of wnt/β-catenin signaling in hpsc with a tetravalent antibody, which selectively triggers fzd5 and lrp6 clustering, leads to midbrain progenitor differentiation and give rise to functional dopaminergic neurons in vitro and in vivo. |
2024-02-15 |
2024-02-17 |
Not clear |
| Natalia Ivliev. Free will: An Example of the Dopaminergic System. Integrative psychological & behavioral science. 2024-02-14. PMID:38351379. |
using the functions of the midbrain dopaminergic system as an example, this article provides an overview of this neurophysiological basis. |
2024-02-14 |
2024-02-16 |
Not clear |
| Ana M Espinosa-Oliva, Rocío Ruiz, Manuel Sarmiento Soto, Antonio Boza-Serrano, Ana I Rodriguez-Perez, María A Roca-Ceballos, Juan García-Revilla, Marti Santiago, Sébastien Serres, Vasiliki Economopoulus, Ana E Carvajal, María D Vázquez-Carretero, Pablo García-Miranda, Oxana Klementieva, María J Oliva-Martín, Tomas Deierborg, Eloy Rivas, Nicola R Sibson, José L Labandeira-García, Alberto Machado, María J Peral, Antonio J Herrera, José L Venero, Rocío M de Pablo. Inflammatory bowel disease induces pathological α-synuclein aggregation in the human gut and brain. Neuropathology and applied neurobiology. vol 50. issue 1. 2024-02-13. PMID:38343067. |
in this work, we studied whether inflammatory bowel diseases (ibds) in humans can progress with the emergence of pathogenic α-synuclein (α-syn) in the gastrointestinal tract and midbrain dopaminergic neurons. |
2024-02-13 |
2024-02-15 |
human |
| David Zarate-Lopez, Andrea P Garzón-Partida, Oscar Gonzalez-Perez, Alma Y Gálvez-Contrera. Sex differences in autism-like behavior and dopaminergic neurons in substantia nigra of juvenile mice prenatally exposed to valproate. Developmental psychobiology. vol 66. issue 2. 2024-02-13. PMID:38351305. |
sex dimorphism in the brain, including midbrain dopaminergic circuits, can explain differences in social behavior impairment and stereotypic behaviors between male and female individuals with asd. |
2024-02-13 |
2024-02-16 |
mouse |
| Nobuyoshi Matsumoto, Miyuki Miyano, Takaya Abe, Tetsuhiko Kashima, Eriko Kato-Ishikura, Ken-Ichi Inoue, Jiayan Liu, Hiroshi Kiyonari, Haruki Takeuchi, Yuji Ikegay. Generation of Dopamine Transporter (DAT)-mCherry Knock-in Rats by CRISPR-Cas9 Genome Editing. Biological & pharmaceutical bulletin. vol 47. issue 2. 2024-02-07. PMID:38325828. |
midbrain dopaminergic neurons respond to rewards and have a crucial role in positive motivation and pleasure. |
2024-02-07 |
2024-02-10 |
rat |
| Elizabeth N Holly, Jamie Galanaugh, Marc V Fuccill. Local regulation of striatal dopamine: A diversity of circuit mechanisms for a diversity of behavioral functions? Current opinion in neurobiology. vol 85. 2024-02-03. PMID:38309106. |
we first look at historical and recent work demonstrating that striatal circuits interact with dopaminergic terminals to either initiate the release of dopamine or modulate the release of dopamine initiated by spiking in midbrain dopamine neurons, with particular attention to gabaergic and cholinergic local circuit mechanisms. |
2024-02-03 |
2024-02-06 |
Not clear |
| Mudiwa N Muwanigwa, Jennifer Modamio-Chamarro, Paul M A Antony, Gemma Gomez-Giro, Rejko Krüger, Silvia Bolognin, Jens C Schwambor. Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease. Molecular and cellular neurosciences. 2024-02-02. PMID:38307302. |
parkinson's disease (pd) is a complex, progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta in the midbrain. |
2024-02-02 |
2024-02-05 |
human |
| Mudiwa N Muwanigwa, Jennifer Modamio-Chamarro, Paul M A Antony, Gemma Gomez-Giro, Rejko Krüger, Silvia Bolognin, Jens C Schwambor. Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease. Molecular and cellular neurosciences. 2024-02-02. PMID:38307302. |
to address this, here we describe the use of patient specific human midbrain organoids harboring the snca triplication to investigate mechanisms underlying dopaminergic degeneration. |
2024-02-02 |
2024-02-05 |
human |
| Mudiwa N Muwanigwa, Jennifer Modamio-Chamarro, Paul M A Antony, Gemma Gomez-Giro, Rejko Krüger, Silvia Bolognin, Jens C Schwambor. Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease. Molecular and cellular neurosciences. 2024-02-02. PMID:38307302. |
our midbrain organoid model recapitulates key pathological hallmarks of pd, including the aggregation of α-synuclein and the progressive loss of dopaminergic neurons. |
2024-02-02 |
2024-02-05 |
human |