| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sanghyun Park, Chan Wook Park, Jang Hyeon Eom, Mi-Young Jo, Hye-Jin Hur, Sung Kyoung Choi, Jae Souk Lee, Seung Taek Nam, Ki-Sang Jo, Young Woo Oh, Jungil Lee, Sieun Kim, Do-Hun Kim, Chul-Yong Park, Su Jin Kim, Ho-Young Lee, Myung Soo Cho, Dae-Sung Kim, Dong-Wook Ki. Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson's disease. Cell stem cell. 2023-12-12. PMID:38086390. |
human embryonic stem cell (hesc)-derived midbrain dopaminergic (mda) cell transplantation is a promising therapeutic strategy for parkinson's disease (pd). |
2023-12-12 |
2023-12-17 |
human |
| Andrea Di Credico, Amélie Weiss, Massimo Corsini, Giulia Gaggi, Barbara Ghinassi, Johannes H Wilbertz, Angela Di Baldassarr. Machine learning identifies phenotypic profile alterations of human dopaminergic neurons exposed to bisphenols and perfluoroalkyls. Scientific reports. vol 13. issue 1. 2023-12-11. PMID:38081991. |
parkinson's disease (pd) is the second most common neurodegenerative disease and is characterized by the loss of midbrain dopaminergic neurons. |
2023-12-11 |
2023-12-17 |
human |
| Andrea Di Credico, Amélie Weiss, Massimo Corsini, Giulia Gaggi, Barbara Ghinassi, Johannes H Wilbertz, Angela Di Baldassarr. Machine learning identifies phenotypic profile alterations of human dopaminergic neurons exposed to bisphenols and perfluoroalkyls. Scientific reports. vol 13. issue 1. 2023-12-11. PMID:38081991. |
in this study, the effect of bps and pfs at different concentrations within the real-life exposure range (0.01, 0.1, 1, and 2 µm) on the phenotypic profile of human stem cell-derived midbrain dopaminergic neurons (mdans) was analyzed. |
2023-12-11 |
2023-12-17 |
human |
| Pedro Rifes, Marc Isaksson, Charlotte Rusimbi, Adrián Ramón Santonja, Jenny Nelander, Thomas Laurell, Agnete Kirkeb. Identifying secreted biomarkers of dopaminergic ventral midbrain progenitor cells. Stem cell research & therapy. vol 14. issue 1. 2023-12-10. PMID:38072935. |
identifying secreted biomarkers of dopaminergic ventral midbrain progenitor cells. |
2023-12-10 |
2023-12-17 |
human |
| Pedro Rifes, Marc Isaksson, Charlotte Rusimbi, Adrián Ramón Santonja, Jenny Nelander, Thomas Laurell, Agnete Kirkeb. Identifying secreted biomarkers of dopaminergic ventral midbrain progenitor cells. Stem cell research & therapy. vol 14. issue 1. 2023-12-10. PMID:38072935. |
ventral midbrain (vm) dopaminergic progenitor cells derived from human pluripotent stem cells have the potential to replace endogenously lost dopamine neurons and are currently in preclinical and clinical development for treatment of parkinson's disease (pd). |
2023-12-10 |
2023-12-17 |
human |
| Adolfo López-Ornelas, Itzel Escobedo-Avila, Gabriel Ramírez-García, Rolando Lara-Rodarte, César Meléndez-Ramírez, Beetsi Urrieta-Chávez, Tonatiuh Barrios-García, Verónica A Cáceres-Chávez, Xóchitl Flores-Ponce, Francia Carmona, Carlos Alberto Reynoso, Carlos Aguilar, Nora E Kerik, Luisa Rocha, Leticia Verdugo-Díaz, Víctor Treviño, José Bargas, Verónica Ramos-Mejía, Juan Fernández-Ruiz, Aurelio Campos-Romo, Iván Velasc. Human Embryonic Stem Cell-Derived Immature Midbrain Dopaminergic Neurons Transplanted in Parkinsonian Monkeys. Cells. vol 12. issue 23. 2023-12-09. PMID:38067166. |
human embryonic stem cell-derived immature midbrain dopaminergic neurons transplanted in parkinsonian monkeys. |
2023-12-09 |
2023-12-17 |
human |
| Adolfo López-Ornelas, Itzel Escobedo-Avila, Gabriel Ramírez-García, Rolando Lara-Rodarte, César Meléndez-Ramírez, Beetsi Urrieta-Chávez, Tonatiuh Barrios-García, Verónica A Cáceres-Chávez, Xóchitl Flores-Ponce, Francia Carmona, Carlos Alberto Reynoso, Carlos Aguilar, Nora E Kerik, Luisa Rocha, Leticia Verdugo-Díaz, Víctor Treviño, José Bargas, Verónica Ramos-Mejía, Juan Fernández-Ruiz, Aurelio Campos-Romo, Iván Velasc. Human Embryonic Stem Cell-Derived Immature Midbrain Dopaminergic Neurons Transplanted in Parkinsonian Monkeys. Cells. vol 12. issue 23. 2023-12-09. PMID:38067166. |
human embryonic stem cells (hescs) differentiate into specialized cells, including midbrain dopaminergic neurons (dans), and non-human primates (nhps) injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine develop some alterations observed in parkinson's disease (pd) patients. |
2023-12-09 |
2023-12-17 |
human |
| Thomas Payne, Toby Burgess, Stephen Bradley, Sarah Roscoe, Matilde Sassani, Mark J Dunning, Dena Hernandez, Sonja Scholz, Alisdair McNeill, Rosie Taylor, Li Su, Iain Wilkinson, Thomas Jenkins, Heather Mortiboys, Oliver Bandman. Multimodal assessment of mitochondrial function in Parkinson's disease. Brain : a journal of neurology. 2023-12-07. PMID:38059801. |
our data suggest that impaired oxidative phosphorylation in the striatal dopaminergic nerve terminals exceeds mitochondrial dysfunction in the midbrain of patients with early parkinson's disease. |
2023-12-07 |
2023-12-10 |
human |
| Daniel Reumann, Christian Krauditsch, Maria Novatchkova, Edoardo Sozzi, Sakurako Nagumo Wong, Michael Zabolocki, Marthe Priouret, Balint Doleschall, Kaja I Ritzau-Reid, Marielle Piber, Ilaria Morassut, Charles Fieseler, Alessandro Fiorenzano, Molly M Stevens, Manuel Zimmer, Cedric Bardy, Malin Parmar, Jürgen A Knoblic. In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain-striatum-cortex assembloids. Nature methods. 2023-12-05. PMID:38052989. |
ventral midbrain dopaminergic neurons project to the striatum as well as the cortex and are involved in movement control and reward-related cognition. |
2023-12-05 |
2023-12-10 |
human |
| Daniel Reumann, Christian Krauditsch, Maria Novatchkova, Edoardo Sozzi, Sakurako Nagumo Wong, Michael Zabolocki, Marthe Priouret, Balint Doleschall, Kaja I Ritzau-Reid, Marielle Piber, Ilaria Morassut, Charles Fieseler, Alessandro Fiorenzano, Molly M Stevens, Manuel Zimmer, Cedric Bardy, Malin Parmar, Jürgen A Knoblic. In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain-striatum-cortex assembloids. Nature methods. 2023-12-05. PMID:38052989. |
in parkinson's disease, nigrostriatal midbrain dopaminergic neurons degenerate and cause typical parkinson's disease motor-related impairments, while the dysfunction of mesocorticolimbic midbrain dopaminergic neurons is implicated in addiction and neuropsychiatric disorders. |
2023-12-05 |
2023-12-10 |
human |
| Miguel Á Luján, Dan P Covey, Reana Young-Morrison, LanYuan Zhang, Andrew Kim, Fiorella Morgado, Sachin Patel, Caroline E Bass, Carlos Paladini, Joseph F Chee. Mobilization of endocannabinoids by midbrain dopamine neurons is required for the encoding of reward prediction. Nature communications. vol 14. issue 1. 2023-11-24. PMID:37985770. |
however, it is not clear whether mobilization of 2-ag specifically from midbrain dopamine neurons is necessary for dopaminergic responses to external stimuli predicting forthcoming reward. |
2023-11-24 |
2023-11-28 |
mouse |
| Abid Ali, Kiryl Zhaliazka, Tianyi Dou, Aidan P Holman, Dmitry Kurousk. The toxicities of A30P and A53T α-synuclein fibrils can be uniquely altered by the length and saturation of fatty acids in phosphatidylserine. The Journal of biological chemistry. vol 299. issue 12. 2023-11-21. PMID:37890776. |
progressive degeneration of dopaminergic neurons in the midbrain, hypothalamus, and thalamus is a hallmark of parkinson's disease (pd). |
2023-11-21 |
2023-11-29 |
Not clear |
| Sandra Blaess, Sabine Krabb. Cell type specificity for circuit output in the midbrain dopaminergic system. Current opinion in neurobiology. vol 83. 2023-11-16. PMID:37972537. |
cell type specificity for circuit output in the midbrain dopaminergic system. |
2023-11-16 |
2023-11-20 |
Not clear |
| Sandra Blaess, Sabine Krabb. Cell type specificity for circuit output in the midbrain dopaminergic system. Current opinion in neurobiology. vol 83. 2023-11-16. PMID:37972537. |
midbrain dopaminergic neurons are a relatively small group of neurons in the mammalian brain controlling a wide range of behaviors. |
2023-11-16 |
2023-11-20 |
Not clear |
| Valentin Plateau, Jérôme Baufreton, Morgane Le Bon-Jég. Age-Dependent Modulation of Layer V Pyramidal Neuron Excitability in the Mouse Primary Motor Cortex by D1 Receptor Agonists and Antagonists. Neuroscience. 2023-11-12. PMID:37952579. |
the primary motor cortex (m1) receives dopaminergic (daergic) projections from the midbrain which play a key role in modulating motor and cognitive processes, such as motor skill learning. |
2023-11-12 |
2023-11-20 |
mouse |
| Jeffrey Kim, Etienne W Daadi, Elyas Sebastien Daadi, Thomas Oh, Michela Deleidi, Marcel M Daad. Cells. vol 12. issue 21. 2023-11-10. PMID:37947628. |
parkinson's disease (pd) is the second most prevalent neurodegenerative disease, characterized by the loss of midbrain dopaminergic neurons which leads to impaired motor and cognitive functions. |
2023-11-10 |
2023-11-20 |
Not clear |
| Olivier Lurette, Rebeca Martín-Jiménez, Mehtab Khan, Razan Sheta, Stéphanie Jean, Mia Schofield, Maxime Teixeira, Raquel Rodriguez-Aller, Isabelle Perron, Abid Oueslati, Etienne Hebert-Chatelai. Aggregation of alpha-synuclein disrupts mitochondrial metabolism and induce mitophagy via cardiolipin externalization. Cell death & disease. vol 14. issue 11. 2023-11-10. PMID:37949858. |
aggregation of α-synuclein also leads to lower mitochondrial content in human dopaminergic neurons and in mouse midbrain. |
2023-11-10 |
2023-11-20 |
mouse |
| Nicole Burkert, Shoumik Roy, Max Häusler, Dominik Wuttke, Sonja Müller, Johanna Wiemer, Helene Hollmann, Marvin Oldrati, Jorge Ramirez-Franco, Julia Benkert, Michael Fauler, Johanna Duda, Jean-Marc Goaillard, Christina Pötschke, Moritz Münchmeyer, Rosanna Parlato, Birgit Lis. Deep learning-based image analysis identifies a DAT-negative subpopulation of dopaminergic neurons in the lateral Substantia nigra. Communications biology. vol 6. issue 1. 2023-11-10. PMID:37950046. |
we utilised dlap to analyse subtypes of tyrosine hydroxylase (th)-positive dopaminergic midbrain neurons in mouse and human brain-sections. |
2023-11-10 |
2023-11-20 |
mouse |
| Zhaoyang Liu, Jessica Lemus, Irina V Smirnova, Wen Li. Rehabilitation for non-motor symptoms for patients with Parkinson's disease from an α-synuclein perspective: a narrative review. Exploration of neuroprotective therapy. vol 3. issue 4. 2023-11-03. PMID:37920444. |
pd is characterized by neuronal lewy bodies present in the substantia nigra of the midbrain and the loss of dopaminergic neurons with various motor and non-motor symptoms associated with the disease. |
2023-11-03 |
2023-11-08 |
Not clear |
| Hye Yun Kim, Jieun Lee, Hyun-Jin Kim, Byeong Eun Lee, Jaewook Jeong, Eun Jeong Cho, Hyun-Jun Jang, Kyeong Jin Shin, Min Ji Kim, Young Chan Chae, Seung Eun Lee, Kyungjae Myung, Ja-Hyun Baik, Pann-Ghill Suh, Jae-Ick Ki. PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III. Experimental & molecular medicine. 2023-11-01. PMID:37907739. |
we found that cell type-specific deletion of plcγ1 does not adversely affect the development and cellular morphology of midbrain dopamine neurons but does facilitate dopamine release from dopaminergic axon terminals in the striatum. |
2023-11-01 |
2023-11-08 |
mouse |