| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Apostolos Papandreou, Nivedita Singh, Lorita Gianfrancesco, Dimitri Budinger, Katy Barwick, Alexander Agrotis, Christin Luft, Ying Shao, An-Sofie Lenaerts, Allison Gregory, Suh Young Jeong, Penelope Hogarth, Susan Hayflick, Serena Barral, Janos Kriston-Vizi, Paul Gissen, Manju A Kurian, Robin Kettele. Cardiac glycosides restore autophagy flux in an iPSC-derived neuronal model of WDR45 deficiency. bioRxiv : the preprint server for biology. 2023-09-25. PMID:37745522. |
we have developed a patient-derived, induced pluripotent stem cell (ipsc)-based midbrain dopaminergic neuronal cell model of bpan (3 patient, 2 age-matched controls and 2 isogenic control lines) which shows defective autophagy and aberrant gene expression in key neurodegenerative, neurodevelopmental and collagen pathways. |
2023-09-25 |
2023-10-07 |
Not clear |
| Eun A Ra, Min Seong Kim, Gabsang Le. Optogenetic induction of alpha-synuclein aggregation in human dopaminergic neurons to model Parkinson's disease pathology. STAR protocols. vol 4. issue 4. 2023-09-24. PMID:37742181. |
here, we present a protocol for optogenetic induction of α-syn aggregation in human midbrain dopaminergic (mda) neurons, facilitating a detailed pd pathology study. |
2023-09-24 |
2023-10-07 |
human |
| Sibylle Frase, Julius Steddin, Enya Paschen, Maximilian Lenz, Pasquale Conforti, Carola A Haas, Andreas Vlachos, Christian Schachtrup, Jonas A Hos. Dense dopaminergic innervation of the peri-infarct cortex despite dopaminergic cell loss after a pure motor-cortical stroke in rats. Journal of neurochemistry. 2023-09-22. PMID:37735852. |
however, ischemic stroke also leads to the remote degeneration of dopaminergic midbrain neurons, possibly interfering with this beneficial effect. |
2023-09-22 |
2023-10-07 |
rat |
| Sibylle Frase, Julius Steddin, Enya Paschen, Maximilian Lenz, Pasquale Conforti, Carola A Haas, Andreas Vlachos, Christian Schachtrup, Jonas A Hos. Dense dopaminergic innervation of the peri-infarct cortex despite dopaminergic cell loss after a pure motor-cortical stroke in rats. Journal of neurochemistry. 2023-09-22. PMID:37735852. |
thus, dopaminergic midbrain neurons projecting into the pic were identified based on mr signal and immunoreactivity against tyrosine hydroxylase (th), a marker for dopaminergic neurons. |
2023-09-22 |
2023-10-07 |
rat |
| Sibylle Frase, Julius Steddin, Enya Paschen, Maximilian Lenz, Pasquale Conforti, Carola A Haas, Andreas Vlachos, Christian Schachtrup, Jonas A Hos. Dense dopaminergic innervation of the peri-infarct cortex despite dopaminergic cell loss after a pure motor-cortical stroke in rats. Journal of neurochemistry. 2023-09-22. PMID:37735852. |
despite a 25% ipsilesional loss of dopaminergic midbrain neurons after pts, the number and spatial distribution of dopaminergic neurons projecting to the pic was not different compared to sham controls. |
2023-09-22 |
2023-10-07 |
rat |
| Fernando Falkenburger Melleu, Newton Sabino Cantera. Pathways from the Superior Colliculus to the Basal Ganglia. Current neuropharmacology. 2023-09-13. PMID:37702174. |
moreover, we discuss how information from the sc might also be relayed to the basal ganglia through midbrain tectonigral and tectotegmental projections directed at the substantia nigra compacta and ventrotegmental area, respectively, influencing the dopaminergic outflow to the dorsal and ventral striatum. |
2023-09-13 |
2023-10-07 |
Not clear |
| Megan Caldwell, Vanessa Ayo-Jibunoh, Josue Criollo Mendoza, Katherine R Brimblecombe, Lauren M Reynolds, Xin Yan Zhu Jiang, Colin Alarcon, Elizabeth Fiore, Jacquelyn N Tomaio, Greg R Phillips, Susana Mingote, Cecilia Flores, Patrizia Casaccia, Jia Liu, Stephanie J Cragg, Dan P McCloskey, Leora Yetnikof. Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum. Brain structure & function. 2023-09-05. PMID:37668732. |
dopaminergic axon terminals were identified in the corpus callosum of dat-cre mice after injection of an eyfp reporter virus into the midbrain. |
2023-09-05 |
2023-09-07 |
mouse |
| Shannon N Bennett, Austin B Chang, Forrest D Rogers, Parker Jones, Catherine Jensen Peñ. Thyroid hormones mediate the impact of early-life stress on ventral tegmental area gene expression and behavior. bioRxiv : the preprint server for biology. 2023-09-04. PMID:37662236. |
we hypothesized that thyroid hormone signaling may link experience of els with transcriptional dysregulation within the dopaminergic midbrain, and ultimately behavior. |
2023-09-04 |
2023-09-07 |
mouse |
| Yongyi Li, Mingwei Zhu, Wen-Xiong Chen, Jing Luo, Xin Li, Yangyang Cao, Meng Zheng, Shanshan Ma, Zhilan Xiao, Yani Zhang, Linyan Jiang, Xiumin Wang, Ting Tan, Xia Li, Qian Gong, Xiaoli Xiong, Jun Wang, Mingxi Tang, Mingtao Li, Ya-Ping Tan. A novel mutation in intron 1 of Wnt1 causes developmental loss of dopaminergic neurons in midbrain and ASD-like behaviors in rats. Molecular psychiatry. 2023-09-01. PMID:37658228. |
a novel mutation in intron 1 of wnt1 causes developmental loss of dopaminergic neurons in midbrain and asd-like behaviors in rats. |
2023-09-01 |
2023-09-07 |
rat |
| Louisa A Christie, Nicola L Brice, Anna Rowland, Louise Dickson, Rishi Anand, Martin Teall, Kevin J Doyle, Lakshminarayana Narayana, Christine Mitchell, Jenna R M Harvey, Victoria Mulligan, Lee A Dawson, Stephanie J Cragg, Mark Carlton, Roland W Bürl. Discovery of Journal of medicinal chemistry. 2023-08-31. PMID:37651656. |
discovery of nicotinic acetylcholine receptor (nachr) α6 subunit rna expression is relatively restricted to midbrain regions and is located presynaptically on dopaminergic neurons projecting to the striatum. |
2023-08-31 |
2023-09-07 |
Not clear |
| Valerio Ricci, Domenico de Berardis, Giovanni Martinotti, Giuseppe Main. Neurotrophic Factors In Cannabis-Induced Psychosis: An Update. Current topics in medicinal chemistry. 2023-08-30. PMID:37644743. |
in particular, nerve growth factor (ngf) plays an important role in the survival and function of cholinergic neurons while brain-derived neurotrophic factor (bdnf) is involved in synaptic plasticity and the maintenance of midbrain dopaminergic and cholinergic neurons. |
2023-08-30 |
2023-09-07 |
Not clear |
| Valerio Ricci, Domenico de Berardis, Giovanni Martinotti, Giuseppe Main. Neurotrophic Factors In Cannabis-Induced Psychosis: An Update. Current topics in medicinal chemistry. 2023-08-30. PMID:37644743. |
glial cell derived neurotrophic factor (gdnf) promotes the survival of midbrain dopaminergic neurons and neuregulin 1 (nrg-1) contributes to glutamatergic signals regulating the n-methyl-d-aspartate (nmda). |
2023-08-30 |
2023-09-07 |
Not clear |
| Licia Vellucci, Mariateresa Ciccarelli, Elisabetta Filomena Buonaguro, Michele Fornaro, Giordano D'Urso, Giuseppe De Simone, Felice Iasevoli, Annarita Barone, Andrea de Bartolomei. The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia. Biomolecules. vol 13. issue 8. 2023-08-26. PMID:37627285. |
an integrative view exploring this topic should take into account the following aspects: (i) the implication for glutamate, dopamine, and serotonin neurotransmission as demonstrated by genetic findings; (ii) the growing neuroimaging evidence of the common brain regions and dysfunctional circuits involved in both diseases; (iii) the pharmacological modulation of dopaminergic, serotoninergic, and glutamatergic systems as current therapeutic strategies in schizophrenia ocs; (iv) the recent discovery of midbrain dopamine neurons and dopamine d1- and d2-like receptors as orchestrating hubs in repetitive and psychotic behaviors; (v) the contribution of n-methyl-d-aspartate receptor subunits to both psychosis and ocd neurobiology. |
2023-08-26 |
2023-09-07 |
Not clear |
| Natalia Siwecka, Kamil Saramowicz, Grzegorz Galita, Wioletta Rozpędek-Kamińska, Ireneusz Majstere. Inhibition of Protein Aggregation and Endoplasmic Reticulum Stress as a Targeted Therapy for α-Synucleinopathy. Pharmaceutics. vol 15. issue 8. 2023-08-26. PMID:37631265. |
the most common α-synucleinopathy, parkinson's disease (pd), is caused by abnormal accumulation of α-syn in the dopaminergic neurons of the midbrain. |
2023-08-26 |
2023-09-07 |
Not clear |
| Liqiang Chen, Samuel Daniels, Rachel Dvorak, Hong-Yuan Ch. Reduced thalamic excitation to motor cortical pyramidal tract neurons in parkinsonism. Science advances. vol 9. issue 34. 2023-08-23. PMID:37611096. |
degeneration of midbrain dopaminergic (da) neurons alters the connectivity and functionality of the basal ganglia-thalamocortical circuits in parkinson's disease (pd). |
2023-08-23 |
2023-09-07 |
Not clear |
| Christian Altbürger, Jens Holzhauser, Wolfgang Drieve. CRISPR/Cas9-based QF2 knock-in at the Frontiers in neuroanatomy. vol 17. 2023-08-21. PMID:37603776. |
because of their disease relevance, special attention has been paid to mammalian midbrain dopaminergic systems, which have important functions in motor control, reward, motivation, and cognitive function. |
2023-08-21 |
2023-09-07 |
Not clear |
| Christian Altbürger, Jens Holzhauser, Wolfgang Drieve. CRISPR/Cas9-based QF2 knock-in at the Frontiers in neuroanatomy. vol 17. 2023-08-21. PMID:37603776. |
in contrast, midbrain dopaminergic neurons in teleosts were thought to be lost secondarily. |
2023-08-21 |
2023-09-07 |
Not clear |
| Véronique Coizet, Racha Al Tannir, Arnaud Pautrat, Paul G Overto. Separation of Channels Subserving Approach and Avoidance/Escape at the Level of the Basal Ganglia and Related Brainstem Structures. Current neuropharmacology. 2023-08-18. PMID:37594168. |
in this review, we describe how brainstem structures also project to the main input structures of the basal ganglia, namely the striatum, the subthalamic nucleus and midbrain dopaminergic neurons, in the context of approach and avoidance (including escape from threat), two fundamental, mutually exclusive behavioral choices in an animal's repertoire in which the brainstem is strongly involved. |
2023-08-18 |
2023-09-07 |
Not clear |
| Akiko Terauchi, Patricia Yee, Erin M Johnson-Venkatesh, Mariel P Seiglie, Lisa Kim, Julia C Pitino, Eli Kritzer, Qiyu Zhang, Jie Zhou, Yulong Li, David D Ginty, Wei-Chung A Lee, Hisashi Umemor. The projection-specific signals that establish functionally segregated dopaminergic synapses. Cell. 2023-08-17. PMID:37591240. |
there are two anatomically and functionally distinct dopaminergic projections connecting the midbrain to striatum: nigrostriatal, which controls movement, and mesolimbic, which regulates motivation. |
2023-08-17 |
2023-09-07 |
mouse |
| Ruth Hanssen, Lionel Rigoux, Bojana Kuzmanovic, Sandra Iglesias, Alina C Kretschmer, Marc Schlamann, Kerstin Albus, Sharmili Edwin Thanarajah, Tamara Sitnikow, Corina Melzer, Oliver A Cornely, Jens C Brüning, Marc Tittgemeye. Liraglutide restores impaired associative learning in individuals with obesity. Nature metabolism. 2023-08-17. PMID:37592007. |
the dopaminergic midbrain plays a crucial role in learning adaptive behaviour and is particularly sensitive to peripheral metabolic signals, including intestinal peptides, such as glucagon-like peptide 1 (glp-1). |
2023-08-17 |
2023-09-07 |
human |