| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rachel J Boyd, Sarah A McClymont, Nelson B Barrientos, Paul W Hook, William D Law, Rebecca J Rose, Eric L Waite, Jay Rathinavelu, Dimitrios Avramopoulos, Andrew S McCallio. Evaluating the mouse neural precursor line, SN4741, as a suitable proxy for midbrain dopaminergic neurons. BMC genomics. vol 24. issue 1. 2023-06-07. PMID:37286935. |
here, we are using a combination of classic and contemporary genomic techniques - karyotyping, rt-qpcr, single cell rna-seq, bulk rna-seq, and atac-seq - to characterize the transcriptional landscape, chromatin landscape, and genomic architecture of this cell line, and evaluate its suitability as a proxy for midbrain dopaminergic neurons in the study of parkinson disease. |
2023-06-07 |
2023-08-14 |
mouse |
| Charlotte Helf, Maria Kober, Franz Markert, Jennifer Lanto, Leonie Overhoff, Kathrin Badstübner-Meeske, Alexander Storch, Mareike Fause. Subthalamic nucleus deep brain stimulation induces nigrostriatal dopaminergic plasticity in a stable rat model of Parkinson's disease. Neuroreport. vol 34. issue 10. 2023-06-04. PMID:37270842. |
in the context of identifying disease-modifying effects of stn-dbs by prompting cellular plasticity in midbrain dopaminergic systems, we analyzed neuronal tyrosine hydroxylase and c-fos expression in the substantia nigra pars compacta (snpc) and ventral tegmental area (vta). |
2023-06-04 |
2023-08-14 |
rat |
| Nikolaos Patikas, Rizwan Ansari, Emmanouil Metzakopia. Single-cell transcriptomics identifies perturbed molecular pathways in midbrain organoids using α-Synuclein triplication Parkinson's Disease patient-derived iPSCs. Neuroscience research. 2023-06-04. PMID:37271312. |
here, we generate midbrain dopaminergic(mda) organoids from induced pluripotent stem cells(ipsc) from healthy and parkinson's disease(pd) donors and assess them as a human pd model using single-cell rnaseq. |
2023-06-04 |
2023-08-14 |
human |
| Subham Preetam, Swathi Jonnalagadda, Lamha Kumar, Rajeswari Rath, Soham Chattopadhyay, Badrah S Alghamdi, Adel Mohammad Abuzenadahg, Niraj Jha, Akash Gautam, Sumira Malik, Ghulam Md Ashra. Therapeutic potential of Lipid Nanosystems for the treatment of Parkinson's disease: an updated review. Ageing research reviews. 2023-06-02. PMID:37268112. |
parkinson's disease (pd) is primarily the second most common neurological disorder, caused by the degeneration of dopaminergic neurons in the midbrain, which is primarily responsible for the onset of the disease. |
2023-06-02 |
2023-08-14 |
Not clear |
| Martyna M Grochowska, Federico Ferraro, Ana Carreras Mascaro, Domenico Natale, Amber Winkelaar, Valerie Boumeester, Guido J Breedveld, Vincenzo Bonifati, Wim Mandemaker. deCLUTTER2+ pipeline to analyze calcium traces in a novel stem cell model for ventral midbrain patterned astrocytes. Disease models & mechanisms. 2023-06-01. PMID:37260295. |
increasing evidence suggests multiple roles for astrocytes in parkinson's disease (pd), nudging a shift in the research focus, which historically pivoted around the ventral midbrain dopaminergic neurons (vmdans). |
2023-06-01 |
2023-08-14 |
human |
| Niraj Kumar Singh, Ashini Singh, Mini Varshney, Ritik Agrawa. A research update on Exendin-4 as a novel molecule against Parkinson's disease. Current molecular medicine. 2023-05-31. PMID:37254536. |
pathophysiologically, pd is associated with the gradual degeneration of dopaminergic neurons in the substantia nigra pars compacta of the midbrain, neuroinflammation, increased accumulation of the alpha (α)-synuclein, overburden of oxidative stress, and mitochondrial dysfunction. |
2023-05-31 |
2023-08-14 |
Not clear |
| João D Magalhães, Emanuel Candeias, Inês Melo-Marques, Diana F Silva, A Raquel Esteves, Nuno Empadinhas, Sandra Morais Cardos. Intestinal infection triggers mitochondria-mediated α-synuclein pathology: relevance to Parkinson's disease. Cellular and molecular life sciences : CMLS. vol 80. issue 6. 2023-05-30. PMID:37249642. |
parkinson's disease (pd) is a multifactorial neurodegenerative disease characterized by the loss of dopaminergic neurons in the midbrain. |
2023-05-30 |
2023-08-14 |
Not clear |
| K K Xue, J L Chen, Y R Wei, Y Chen, S S Han, C H Wang, Y Zhang, X Q Song, J L Chen. [Abnormal changes of static and dynamic functional connectivity of dopaminergic midbrain in patients with first-episode schizophrenia and their correlations with clinical symptoms]. Zhonghua yi xue za zhi. vol 103. issue 21. 2023-05-29. PMID:37248062. |
[abnormal changes of static and dynamic functional connectivity of dopaminergic midbrain in patients with first-episode schizophrenia and their correlations with clinical symptoms]. |
2023-05-29 |
2023-08-14 |
Not clear |
| Xin Wang, Xi Chen, Guangdong Liu, Huaibin Cai, Weidong L. The Crucial Roles of Pitx3 in Midbrain Dopaminergic Neuron Development and Parkinson's Disease-Associated Neurodegeneration. International journal of molecular sciences. vol 24. issue 10. 2023-05-27. PMID:37239960. |
the degeneration of midbrain dopaminergic (mda) neurons, particularly in the substantia nigra pars compacta (snc), is one of the most prominent pathological hallmarks of parkinson's disease (pd). |
2023-05-27 |
2023-08-14 |
mouse |
| Shane J F Cronin, Weonjin Yu, Ashley Hale, Simon Licht-Mayer, Mark J Crabtree, Joanna A Korecka, Evgenii O Tretiakov, Marco Sealey-Cardona, Mate Somlyay, Masahiro Onji, Meilin An, Jesse D Fox, Bruna Lenfers Turnes, Carlos Gomez-Diaz, Débora da Luz Scheffer, Domagoj Cikes, Vanja Nagy, Adelheid Weidinger, Alexandra Wolf, Harald Reither, Antoine Chabloz, Anoop Kavirayani, Shuan Rao, Nick Andrews, Alban Latremoliere, Michael Costigan, Gillian Douglas, Fernando Cini Freitas, Christian Pifl, Roger Walz, Robert Konrat, Don J Mahad, Andrey V Koslov, Alexandra Latini, Ole Isacson, Tibor Harkany, Penelope J Hallett, Stefan Bagby, Clifford J Woolf, Keith M Channon, Hyunsoo Shawn Je, Josef M Penninge. Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons. bioRxiv : the preprint server for biology. 2023-05-23. PMID:37214873. |
our findings pinpoint the bh4 pathway as a key metabolic program at the intersection of multiple protective mechanisms for the health and function of midbrain dopaminergic neurons, identifying it as a potential therapeutic target for pd. |
2023-05-23 |
2023-08-14 |
mouse |
| Jie Sun, Xiao-Min Lin, Dan-Hua Lu, Meng Wang, Kun Li, Sheng-Rong Li, Zheng-Qiu Li, Cheng-Jun Zhu, Zhi-Min Zhang, Chang-Yu Yan, Ming-Hai Pan, Hai-Biao Gong, Jing-Cheng Feng, Yun-Feng Cao, Feng Huang, Wan-Yang Sun, Hiroshi Kurihara, Yi-Fang Li, Wen-Jun Duan, Gen-Long Jiao, Li Zhang, Rong-Rong H. Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons. The Journal of clinical investigation. vol 133. issue 10. 2023-05-15. PMID:37183824. |
midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons. |
2023-05-15 |
2023-08-14 |
mouse |
| Jie Sun, Xiao-Min Lin, Dan-Hua Lu, Meng Wang, Kun Li, Sheng-Rong Li, Zheng-Qiu Li, Cheng-Jun Zhu, Zhi-Min Zhang, Chang-Yu Yan, Ming-Hai Pan, Hai-Biao Gong, Jing-Cheng Feng, Yun-Feng Cao, Feng Huang, Wan-Yang Sun, Hiroshi Kurihara, Yi-Fang Li, Wen-Jun Duan, Gen-Long Jiao, Li Zhang, Rong-Rong H. Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons. The Journal of clinical investigation. vol 133. issue 10. 2023-05-15. PMID:37183824. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the gradual loss of midbrain dopaminergic neurons in association with aggregation of α-synuclein. |
2023-05-15 |
2023-08-14 |
mouse |
| Jie Sun, Xiao-Min Lin, Dan-Hua Lu, Meng Wang, Kun Li, Sheng-Rong Li, Zheng-Qiu Li, Cheng-Jun Zhu, Zhi-Min Zhang, Chang-Yu Yan, Ming-Hai Pan, Hai-Biao Gong, Jing-Cheng Feng, Yun-Feng Cao, Feng Huang, Wan-Yang Sun, Hiroshi Kurihara, Yi-Fang Li, Wen-Jun Duan, Gen-Long Jiao, Li Zhang, Rong-Rong H. Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons. The Journal of clinical investigation. vol 133. issue 10. 2023-05-15. PMID:37183824. |
here, we demonstrated that preferential accumulation of peroxidized phospholipids and loss of the antioxidant enzyme glutathione peroxidase 4 (gpx4) were responsible for vulnerability of midbrain dopaminergic neurons and progressive motor dysfunctions in a mouse model of pd. |
2023-05-15 |
2023-08-14 |
mouse |
| Jayanth Anantha, Fionnuala E Wilson, Erin McCarthy, Noelia Morales Prieto, Martina Mazzocchi, Louise M Collins, Aideen M Sullivan, Gerard W O'Keeff. A combined proteomics and bioinformatics analysis of ZNHIT1-interacting proteins reveals a significant enrichment in proteins associated with mitochondrial function. Journal of chemical neuroanatomy. 2023-05-13. PMID:37178741. |
these data suggest that the reported beneficial effects of znhit1 on atp production may be mediated, at least in part, by its direct interaction with mitochondrial proteins and suggest that potential alterations in znhit1 in pd, may contribute to the known impairments in atp generation in midbrain dopaminergic neurons in pd. |
2023-05-13 |
2023-08-14 |
Not clear |
| Cheng-Bo He, Yuan Jin, Yan Li, Qian Zhang, Bai Yang, Mang Xu, Juan Yang, Xi-Nan Yi, Yu-Lin Dong, Jian Wang, Yun-Qing L. Collateral projections from the ventral tegmental area/substantia nigra pars compacta to the nucleus accumbens and insular cortex in the rat. Anatomical science international. 2023-05-10. PMID:37160827. |
midbrain dopaminergic (daergic) regions including ventral tegmental area (vta) and substantia nigra pars compacta (snc) are involved in diverse brain functions. |
2023-05-10 |
2023-08-14 |
rat |
| Maksym Galkin, Oleksandra Topcheva, Anastasiia Priss, Tatiana Borisova, Volodymyr V Shvadcha. Dopamine-Induced Oligomers of α-Synuclein Inhibit Amyloid Fibril Growth and Show No Toxicity. ACS chemical neuroscience. 2023-05-10. PMID:37162160. |
parkinson's disease is characterized by the selective death of dopaminergic neurons in the midbrain and accumulation of amyloid fibrils composed of α-synuclein (αsyn). |
2023-05-10 |
2023-08-14 |
rat |
| Mitali A Tambe, Aurelie de Rus Jacquet, Katherine E Strathearn, Gad G Yousef, Mary H Grace, Mario G Ferruzzi, Qingli Wu, James E Simon, Mary Ann Lila, Jean-Christophe Roche. Protective effects of polyphenol-rich extracts against neurotoxicity elicited by paraquat or rotenone in cellular models of Parkinson's disease. bioRxiv : the preprint server for biology. 2023-05-10. PMID:37163110. |
here, we characterized botanical extracts enriched with a mixed profile of polyphenols, as well as a set of purified polyphenolic standards, in terms of their ability to mitigate dopaminergic cell death in midbrain cultures exposed to another pd-related toxicant, paraquat (pq), and we examined underlying neuroprotective mechanisms. |
2023-05-10 |
2023-08-14 |
Not clear |
| Mitali A Tambe, Aurelie de Rus Jacquet, Katherine E Strathearn, Gad G Yousef, Mary H Grace, Mario G Ferruzzi, Qingli Wu, James E Simon, Mary Ann Lila, Jean-Christophe Roche. Protective effects of polyphenol-rich extracts against neurotoxicity elicited by paraquat or rotenone in cellular models of Parkinson's disease. bioRxiv : the preprint server for biology. 2023-05-10. PMID:37163110. |
several extracts or compounds with the ability to protect against pq neurotoxicity increased the activity of the antioxidant transcription factor nrf2 in cultured astrocytes, and pq-induced dopaminergic cell death was attenuated in nrf2-expressing midbrain cultures. |
2023-05-10 |
2023-08-14 |
Not clear |
| Guy C Brown, Marta Camacho, Caroline H Williams-Gra. The Endotoxin Hypothesis of Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. 2023-05-09. PMID:37157885. |
the evidence supporting this hypothesis includes: (1) gut dysfunction, permeability, and bacterial changes occur early in pd, (2) serum levels of lps are increased in a proportion of pd patients, (3) lps induces α-synuclein expression, aggregation, and neurotoxicity, (4) lps causes activation of peripheral monocytes leading to inflammatory cytokine production, and (5) blood lps causes brain inflammation and specific loss of midbrain dopaminergic neurons, mediated by microglia. |
2023-05-09 |
2023-08-14 |
Not clear |
| Reinis Svarcbahs, Sarah M Blossom, Helena S Baffoe-Bonnie, Kathleen A Trychta, Lacey K Greer, James Pickel, Mark J Henderson, Brandon K Harve. Atransgenic mouse line for assaying tissue-specific changes in endoplasmic reticulum proteostasis. Transgenic research. 2023-05-03. PMID:37133648. |
in lsl-sercamp × alb-cre mice, robust gluc activity was observed only in the liver and blood, whereas in lsl-sercamp × dat-cre mice, gluc activity was seen in midbrain dopaminergic neurons and tissue samples innervated by dopaminergic projections. |
2023-05-03 |
2023-08-14 |
mouse |