| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amirah E-E Aly, Tao Sun, Yongzhi Zhang, Zejun Li, Margee Kyada, Qingxi Ma, Linas Padegimas, Ozge Sesenoglu-Laird, Mark J Cooper, Nathan J McDannold, Barbara L Waszcza. Focused ultrasound enhances transgene expression of intranasal hGDNF DNA nanoparticles in the sonicated brain regions. Journal of controlled release : official journal of the Controlled Release Society. 2023-05-01. PMID:37127076. |
additionally, fus with intranasal delivery increased transgene expression in the sonicated hemisphere by over 80%, altered cellular transfection patterns at the sonication sites, and improved penetration of plasmid nps into the brain parenchyma (with a 1-fold and 3-fold increase in proximity of transgene expression to neurons in the forebrain and midbrain respectively, and a 40% increase in proximity of transgene expression to dopaminergic neurons in the substantia nigra). |
2023-05-01 |
2023-08-14 |
Not clear |
| Delaney L Davis, Daniel B Metzger, Philip H Vann, Jessica M Wong, Ritu A Shetty, Michael J Forster, Nathalie Sumie. Effects of chronic methamphetamine exposure on rewarding behavior and neurodegeneration markers in adult mice. Psychopharmacology. 2023-05-01. PMID:37127834. |
the midbrain and striatum, regions involved in reward circuit, were assessed for markers associated with neurotoxicity, dopaminergic function, neuroinflammation and epigenetic changes after behavioral testing.previous exposure to chronic meth did not have significant short-term effects on cpp response but led to a decreased cpp response in 10-month-old females. |
2023-05-01 |
2023-08-14 |
mouse |
| Benjamin D Hobson, Adrien T Stanley, Mark B De Los Santos, Bruce Culbertson, Eugene V Mosharov, Peter A Sims, David Sulze. Conserved and cell type-specific transcriptional responses to IFN-γ in the ventral midbrain. Brain, behavior, and immunity. 2023-04-26. PMID:37100211. |
we found that ifn-γ upregulated mhc-i and associated mrnas in ventral midbrain microglia, astrocytes, oligodendrocytes, and gabaergic, glutamatergic, and dopaminergic neurons. |
2023-04-26 |
2023-08-14 |
mouse |
| Naisarg Gamit, Arun Dharmarajan, Gautam Sethi, Sudha Warrie. Want of Wnt in Parkinson's disease: Could sFRP disrupt interplay between Nurr1 and Wnt signaling? Biochemical pharmacology. 2023-04-23. PMID:37088155. |
nuclear receptor related 1 (nurr1) is a transcription factor known to regulate the development and maintenance of midbrain dopaminergic (mda) neurons. |
2023-04-23 |
2023-08-14 |
Not clear |
| L Sofia Gonzalez, Austen A Fisher, Shane P D'Souza, Evelin M Cotella, Richard A Lang, J Elliott Robinso. Ventral striatum dopamine release encodes unique properties of visual stimuli in mice. eLife. vol 12. 2023-04-17. PMID:37067979. |
in this circuitry, ascending dopaminergic projections from the ventral midbrain innervate targets throughout the limbic forebrain, such as the ventral striatum/nucleus accumbens (nac). |
2023-04-17 |
2023-08-14 |
mouse |
| Athanasios Kournoutis, Terje Johanse. LC3B is a cofactor for LMX1B-mediated transcription of autophagy genes in dopaminergic neurons. The Journal of cell biology. vol 222. issue 5. 2023-04-10. PMID:37036692. |
cell biol.https://doi.org/10.1083/jcb.201910133) report that nuclear lc3b binds to the lim homeodomain transcription factor lmx1b and acts as a cofactor for lmx1b-mediated transcription of autophagy genes, providing stress protection and ensuring survival of midbrain dopaminergic neurons. |
2023-04-10 |
2023-08-14 |
Not clear |
| Jeong Pyo Seo, Dong Kyun Ko. Degeneration of nigrostriatal pathway in patients with middle cerebral infarct: A diffusion tensor imaging study. Medicine. vol 102. issue 14. 2023-04-07. PMID:37026940. |
the nigrostriatal tract (nst) is a dopaminergic pathway that runs from the substantia nigra pars compacta in the midbrain to the dorsal striatum (caudate nucleus and putamen) and regulates voluntary movement via the basal ganglia motor loops. |
2023-04-07 |
2023-08-14 |
human |
| Natalia Jiménez-Moreno, Madhu Kollareddy, Petros Stathakos, Joanna J Moss, Zuriñe Antón, Deborah K Shoemark, Richard B Sessions, Ralph Witzgall, Maeve Caldwell, Jon D Lan. ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience. The Journal of cell biology. vol 222. issue 5. 2023-04-04. PMID:37014324. |
atg8-dependent lmx1b-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience. |
2023-04-04 |
2023-08-14 |
human |
| Natalia Jiménez-Moreno, Madhu Kollareddy, Petros Stathakos, Joanna J Moss, Zuriñe Antón, Deborah K Shoemark, Richard B Sessions, Ralph Witzgall, Maeve Caldwell, Jon D Lan. ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience. The Journal of cell biology. vol 222. issue 5. 2023-04-04. PMID:37014324. |
the lim homeodomain transcription factors lmx1a and lmx1b are essential mediators of midbrain dopaminergic neuronal (mdan) differentiation and survival. |
2023-04-04 |
2023-08-14 |
human |
| R Basanisi, K Marche, E Combrisson, P Apicella, A Brovell. Beta oscillations in monkey striatum encode reward prediction error signals. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-04-04. PMID:37015808. |
rpe signals are encoded in the neural activity of multiple brain areas, such as midbrain dopaminergic neurons, prefrontal cortex and striatum. |
2023-04-04 |
2023-08-14 |
monkey |
| Axel Chemla, Giuseppe Arena, Claudia Saraiva, Clara Berenguer-Escuder, Dajana Grossmann, Anne Grünewald, Christine Klein, Philip Seibler, Jens C Schwamborn, Rejko Krüge. Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson's disease patients carrying the heterozygous mutations c.1290A > G (p.T351A) or c.2067A > G (p.T610A) in the RHOT1 gene encoding Miro1. Stem cell research. vol 69. 2023-04-01. PMID:37003181. |
here, we provide a comprehensive characterization and quality assurance of both isogenic pairs, which will be used to study miro1-related molecular mechanisms underlying neurodegeneration in ipsc-derived neuronal models (e.g., midbrain dopaminergic neurons and astrocytes). |
2023-04-01 |
2023-08-14 |
Not clear |
| Walaa F Alsanie, Sherin Abdelrahman, Raed I Felimban, Heba A Alkhatabi, Ahmed Gaber, Ebtisam Abdulah Alosimi, Majid Alhomrani, Hamza Habeeballah, Charlotte A E Hauser, Abdulhakeem S Alamri, Aiysha Althobaiti, Abdulaziz Alsharif, Ahmed S Alzahrani, Mohammad S Al-Ghamdi, Bassem M Raafat, Khaled A Alswat, Yusuf S Althobaiti, Yousif A Asir. The Influence of Prenatal Exposure to Methamphetamine on the Development of Dopaminergic Neurons in the Ventral Midbrain. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982742. |
the influence of prenatal exposure to methamphetamine on the development of dopaminergic neurons in the ventral midbrain. |
2023-03-29 |
2023-08-14 |
mouse |
| Walaa F Alsanie, Sherin Abdelrahman, Raed I Felimban, Heba A Alkhatabi, Ahmed Gaber, Ebtisam Abdulah Alosimi, Majid Alhomrani, Hamza Habeeballah, Charlotte A E Hauser, Abdulhakeem S Alamri, Aiysha Althobaiti, Abdulaziz Alsharif, Ahmed S Alzahrani, Mohammad S Al-Ghamdi, Bassem M Raafat, Khaled A Alswat, Yusuf S Althobaiti, Yousif A Asir. The Influence of Prenatal Exposure to Methamphetamine on the Development of Dopaminergic Neurons in the Ventral Midbrain. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982742. |
here, we examined whether exposure to methamphetamine affects the morphogenesis and diversity of ventral midbrain dopaminergic neurons (vmdns). |
2023-03-29 |
2023-08-14 |
mouse |
| Chang Li, Natalie B Saliba, Hannah Martin, Nicole A Losurdo, Kian Kolahdouzan, Riyan Siddiqui, Destynie Medeiros, Wei L. Purkinje cell dopaminergic inputs to astrocytes regulate cerebellar-dependent behavior. Nature communications. vol 14. issue 1. 2023-03-24. PMID:36959176. |
the dopaminergic pathways originating from the midbrain have received the most attention; however, the relevance of the cerebellar dopaminergic system is largely undiscovered. |
2023-03-24 |
2023-08-14 |
Not clear |
| Rebeka Popovic, Amrita Mukherjee, Nuno Santos Leal, Lydia Morris, Yizhou Yu, Samantha H Y Loh, L Miguel Martin. Blocking dPerk in the intestine suppresses neurodegeneration in a Drosophila model of Parkinson's disease. Cell death & disease. vol 14. issue 3. 2023-03-23. PMID:36949073. |
parkinson's disease (pd) is characterised by selective death of dopaminergic (da) neurons in the midbrain and motor function impairment. |
2023-03-23 |
2023-08-14 |
drosophila_melanogaster |
| J Xu, Y Li, G Zhong, Z Fang, C Liu, C Ma, C Wang, Y Guo, C Li. [Directed differentiation of human induced pluripotent stem cells into midbrain]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 43. issue 2. 2023-03-22. PMID:36946035. |
to establish an efficient protocol for directed differentiation of human induced pluripotent stem cells (hipscs) into functional midbrain dopaminergic progenitor cells (daps) |
2023-03-22 |
2023-08-14 |
human |
| Meng-Nan Liu, Xiao-Yu Tian, Ting Fang, Ning Wu, Hong Li, Jin L. Insights into the Involvement and Therapeutic Target Potential of the Dopamine System in the Posttraumatic Stress Disorder. Molecular neurobiology. 2023-03-18. PMID:36933147. |
while the midbrain dopamine system can affect physiological processes such as aversive fear memory learning, consolidation, persistence, and extinction, by altering the functions of the dopaminergic neurons, our viewpoint is that the dopamine system plays a considerable role in the ptsd occurrence and acts as a potential therapeutic target of the disorder. |
2023-03-18 |
2023-08-14 |
Not clear |
| Zhiwen You, Luyue Wang, Hui He, Ziyan Wu, Xinyue Zhang, Shuaixiang Xue, Peibo Xu, Yanhong Hong, Man Xiong, Wu Wei, Yuejun Che. Mapping of clonal lineages across developmental stages in human neural differentiation. Cell stem cell. 2023-03-18. PMID:36933556. |
specifically, we uncovered a ventral midbrain progenitor cluster as the common clonal origin of midbrain dopaminergic (mda) neurons, midbrain glutamatergic neurons, and vascular and leptomeningeal cells and identified a surface marker that can improve graft outcomes. |
2023-03-18 |
2023-08-14 |
human |
| Xiaoyi Chen, Yunjiang Feng, Ronald J Quinn, Dean L Pountney, Des R Richardson, George D Mellick, Linlin M. Pharmacological reviews. 2023-03-14. PMID:36918260. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by selective loss of dopaminergic neurons in the substantia nigra pars compacta (snpc) region of the midbrain. |
2023-03-14 |
2023-08-14 |
Not clear |
| Yu Shikano, Sho Yagishita, Kenji F Tanaka, Norio Takat. Slow-rising and fast-falling dopaminergic dynamics jointly adjust negative prediction error in the ventral striatum. The European journal of neuroscience. 2023-02-27. PMID:36843200. |
although it is well-documented that better-than-expected outcomes are encoded quantitatively via midbrain dopaminergic (da) activity, it has been less addressed experimentally whether worse-than-expected outcomes are expressed quantitatively as well. |
2023-02-27 |
2023-08-14 |
mouse |