| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Shouta Serizawa, Fumiko Kihara-Negishi, Koichi J Homma, Shinji Yamaguch. Dopaminergic nuclei in the chick midbrain express serotonin receptor subfamily genes. Frontiers in physiology. vol 13. 2022-11-25. PMID:36425295. |
another important neural modulatory system exists in the midbrain, the dopaminergic system, which is associated to reward processing and motivation control. |
2022-11-25 |
2023-08-14 |
chicken |
| Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Shouta Serizawa, Fumiko Kihara-Negishi, Koichi J Homma, Shinji Yamaguch. Dopaminergic nuclei in the chick midbrain express serotonin receptor subfamily genes. Frontiers in physiology. vol 13. 2022-11-25. PMID:36425295. |
recently, midbrain dopaminergic neurons were shown to be innervated by serotonergic neurons and modulated by 5-ht, with the crosstalk between serotonergic and dopaminergic systems attracting increased attention. |
2022-11-25 |
2023-08-14 |
chicken |
| Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Shouta Serizawa, Fumiko Kihara-Negishi, Koichi J Homma, Shinji Yamaguch. Dopaminergic nuclei in the chick midbrain express serotonin receptor subfamily genes. Frontiers in physiology. vol 13. 2022-11-25. PMID:36425295. |
in birds, previous studies revealed that midbrain dopaminergic neurons are located in the a8-a10 homologous clusters. |
2022-11-25 |
2023-08-14 |
chicken |
| Gurvir S Virdi, Minee L Choi, James R Evans, Zhi Yao, Dilan Athauda, Stephanie Strohbuecker, Raja S Nirujogi, Anna I Wernick, Noelia Pelegrina-Hidalgo, Craig Leighton, Rebecca S Saleeb, Olga Kopach, Haya Alrashidi, Daniela Melandri, Jimena Perez-Lloret, Plamena R Angelova, Sergiy Sylantyev, Simon Eaton, Simon Heales, Dmitri A Rusakov, Dario R Alessi, Tilo Kunath, Mathew H Horrocks, Andrey Y Abramov, Rickie Patani, Sonia Gandh. Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons. NPJ Parkinson's disease. vol 8. issue 1. 2022-11-24. PMID:36424392. |
protein aggregation and calcium dysregulation are hallmarks of familial parkinson's disease in midbrain dopaminergic neurons. |
2022-11-24 |
2023-08-14 |
human |
| Gurvir S Virdi, Minee L Choi, James R Evans, Zhi Yao, Dilan Athauda, Stephanie Strohbuecker, Raja S Nirujogi, Anna I Wernick, Noelia Pelegrina-Hidalgo, Craig Leighton, Rebecca S Saleeb, Olga Kopach, Haya Alrashidi, Daniela Melandri, Jimena Perez-Lloret, Plamena R Angelova, Sergiy Sylantyev, Simon Eaton, Simon Heales, Dmitri A Rusakov, Dario R Alessi, Tilo Kunath, Mathew H Horrocks, Andrey Y Abramov, Rickie Patani, Sonia Gandh. Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons. NPJ Parkinson's disease. vol 8. issue 1. 2022-11-24. PMID:36424392. |
our small molecule-based protocol generates highly enriched midbrain dopaminergic (mda) neurons: molecular identity was confirmed using single-cell rna sequencing and proteomics, and functional identity was established through dopamine synthesis, and measures of electrophysiological activity. |
2022-11-24 |
2023-08-14 |
human |
| Zhiqian Yu, Kazuko Ueno, Ryo Funayama, Mai Sakai, Naoki Nariai, Kaname Kojima, Yoshie Kikuchi, Xue Li, Chiaki Ono, Junpei Kanatani, Jiro Ono, Kazuya Iwamoto, Kenji Hashimoto, Kengo Kinoshita, Keiko Nakayama, Masao Nagasaki, Hiroaki Tomit. Sex-Specific Differences in the Transcriptome of the Human Dorsolateral Prefrontal Cortex in Schizophrenia. Molecular neurobiology. 2022-11-22. PMID:36414910. |
an ingenuity pathway analysis revealed that the differentially expressed genes related to schizophrenia in the female group were involved in midbrain dopaminergic and γ-aminobutyric acid (gaba)-ergic neurons and microglia. |
2022-11-22 |
2023-08-14 |
human |
| Kaneyasu Nishimura, Shanzheng Yang, Ka Wai Lee, Emilía Sif Ásgrímsdóttir, Kasra Nikouei, Wojciech Paslawski, Sabine Gnodde, Guochang Lyu, Lijuan Hu, Carmen Saltó, Per Svenningsson, Jens Hjerling-Leffler, Sten Linnarsson, Ernest Arena. Single-cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation. Stem cell reports. 2022-11-18. PMID:36400027. |
in this study, we identify developmental factors important for the differentiation of human embryonic stem cells (hescs) into functional midbrain dopaminergic (mda) neurons. |
2022-11-18 |
2023-08-14 |
human |
| Zohra Rahmani, Satya Surabhi, Francisca Rojo-Cortés, Amina Dulac, Andreas Jenny, Serge Birma. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36361864. |
parkinson disease (pd) is a common neurodegenerative condition affecting people predominantly at old age that is characterized by a progressive loss of midbrain dopaminergic neurons and by the accumulation of α-synuclein-containing intraneuronal inclusions known as lewy bodies. |
2022-11-11 |
2023-08-14 |
Not clear |
| Els F Halff, Grazia Rutigliano, Anna Garcia-Hidalgo, Oliver D Howe. Trace amine-associated receptor 1 (TAAR1) agonism as a new treatment strategy for schizophrenia and related disorders. Trends in neurosciences. 2022-11-11. PMID:36369028. |
studies in rodents using taar1 knockout (taar1-ko) and overexpression models show that taar1 agonism inhibits midbrain dopaminergic and serotonergic activity, and enhances prefrontal glutamatergic function. |
2022-11-11 |
2023-08-14 |
Not clear |
| Talia Krainc, Mariana H G Monje, Morgan Kinsinger, Bernabe I Bustos, Steven J Lubb. Melanin and Neuromelanin: Linking Skin Pigmentation and Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. 2022-11-09. PMID:36350228. |
because neuromelanin and melanin share many functional characteristics and overlapping biosynthetic pathways, it has been postulated that genes involved in skin pigmentation and melanin formation may play a role in the susceptibility of vulnerable midbrain dopaminergic neurons to neurodegeneration. |
2022-11-09 |
2023-08-14 |
mouse |
| Junichi Yoshida, Maritza Oñate, Leila Khatami, Jorge Vera, Farzan Nadim, Kamran Khodakha. Cerebellar Contributions to the Basal Ganglia Influence Motor Coordination, Reward Processing, and Movement Vigor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 42. issue 45. 2022-11-09. PMID:36351826. |
we review two sets of such connections: disynaptic projections through the thalamus and direct monosynaptic projections to the midbrain dopaminergic nuclei, the vta and the snc. |
2022-11-09 |
2023-08-14 |
Not clear |
| Ziba Asadpoordezaki, Andrew N Coogan, Beverley M Henle. Chronobiology of Parkinson's Disease: Past, Present and Future. The European journal of neuroscience. 2022-11-07. PMID:36342744. |
parkinson's disease is a neurodegenerative disorder predominately affecting midbrain dopaminergic neurons that results in a broad range of motor and non-motor symptoms. |
2022-11-07 |
2023-08-14 |
Not clear |
| Jia-Hou Poh, Mai-Anh T Vu, Jessica K Stanek, Abigail Hsiung, Tobias Egner, R Alison Adcoc. Hippocampal convergence during anticipatory midbrain activation promotes subsequent memory formation. Nature communications. vol 13. issue 1. 2022-11-07. PMID:36344524. |
crucially, anticipatory hippocampal pattern typicality increased with dopaminergic midbrain activation and uniquely accounted for the association between midbrain activation and subsequent recall. |
2022-11-07 |
2023-08-14 |
human |
| Blake L Elliott, Kimberlee D'Ardenne, Vishnu P Murty, Gene A Brewer, Samuel M McClur. Midbrain-Hippocampus Structural Connectivity Selectively Predicts Motivated Memory Encoding. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-11-04. PMID:36332978. |
functional mri studies show that interactions between the dopaminergic midbrain (sn/vta), hippocampus, and nucleus accumbens (nac) are critical for motivated memory encoding. |
2022-11-04 |
2023-08-14 |
human |
| Wei-Li Kuan, Maha Alfaidi, Catherine B Horne, Benjamin Vallin, Sarah Fox, Shaline V Fazal, Caroline H Williams-Gray, Roger A Barke. Selective neurodegeneration generated by intravenous α-synuclein pre-formed fibril administration is not associated with endogenous α-synuclein levels in the rat brain. Brain pathology (Zurich, Switzerland). 2022-11-02. PMID:36321260. |
our data demonstrated that a non-selective, transvascular delivery of α-synuclein pffs led to a time-dependent loss of specific populations of midbrain (but not olfactory) dopaminergic neurons, medullary (but not pontine) cholinergic neurons, and brainstem serotonergic neurons. |
2022-11-02 |
2023-08-14 |
rat |
| Marcella Birtele, Petter Storm, Yogita Sharma, Janko Kajtez, Jenny Nelander Wahlestedt, Edoardo Sozzi, Fredrik Nilsson, Simon Stott, Xiaoling L He, Bengt Mattsson, Daniella Rylander Ottosson, Roger A Barker, Alessandro Fiorenzano, Malin Parma. Single-cell transcriptional and functional analysis of dopaminergic neurons in organoid-like cultures derived from human fetal midbrain. Development (Cambridge, England). 2022-10-28. PMID:36305490. |
single-cell transcriptional and functional analysis of dopaminergic neurons in organoid-like cultures derived from human fetal midbrain. |
2022-10-28 |
2023-08-14 |
human |
| Walaa F Alsanie, Sherin Abdelrahman, Majid Alhomrani, Ahmed Gaber, Ebtisam Abdulah Alosimi, Hamza Habeeballah, Heba A Alkhatabi, Raed I Felimban, Charlotte A E Hauser, Hossam H Tayeb, Abdulhakeem S Alamri, Abdulwahab Alamri, Bassem M Raafat, Khaled A Alswat, Yusuf S Althobaiti, Yousif A Asir. The Influence of Prenatal Exposure to Quetiapine Fumarate on the Development of Dopaminergic Neurons in the Ventral Midbrain of Mouse Embryos. International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36293205. |
the influence of prenatal exposure to quetiapine fumarate on the development of dopaminergic neurons in the ventral midbrain of mouse embryos. |
2022-10-27 |
2023-08-14 |
mouse |
| Md Mominur Rahman, Xiaoyan Wang, Md Rezaul Islam, Shopnil Akash, Fatema Akter Supti, Mohona Islam Mitu, Md Harun-Or-Rashid, Most Nazmin Aktar, Most Sumaiya Khatun Kali, Farhana Israt Jahan, Rajeev K Singla, Bairong Shen, Abdur Rauf, Rohit Sharm. Multifunctional role of natural products for the treatment of Parkinson's disease: At a glance. Frontiers in pharmacology. vol 13. 2022-10-27. PMID:36299886. |
the deterioration and subsequent cognitive impairments of the midbrain nigral dopaminergic neurons distinguish by this characteristic. |
2022-10-27 |
2023-08-14 |
Not clear |
| Xiaochen Bai, Jinghui Wang, Xiaoshuang Zhang, Yilin Tang, Yongtao He, Jiayin Zhao, Linlin Han, Rong Fang, Zhaolin Liu, Hongtian Dong, Qing Li, Jingyu Ge, Yuanyuan Ma, Mei Yu, Ruilin Sun, Jian Wang, Jian Fei, Fang Huan. Deficiency of miR-29a/b1 leads to premature aging and dopaminergic neuroprotection in mice. Frontiers in molecular neuroscience. vol 15. 2022-10-24. PMID:36277485. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by progressive degeneration of midbrain dopaminergic neurons. |
2022-10-24 |
2023-08-14 |
mouse |
| Angelo Iannielli, Mirko Luoni, Serena Gea Giannelli, Rosangela Ferese, Gabriele Ordazzo, Matteo Fossati, Andrea Raimondi, Felipe Opazo, Olga Corti, Jochen H M Prehn, Stefano Gambardella, Ronald Melki, Vania Broccol. Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplications. Cell death & disease. vol 13. issue 10. 2022-10-19. PMID:36261424. |
we differentiated these ipsc lines in midbrain dopaminergic (da) neuronal cultures to characterize αsyn aggregation in native and seeded conditions and evaluate its associated cellular dysfunctions. |
2022-10-19 |
2023-08-14 |
Not clear |