| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meng Yu, Fengjiao Sun, Guo Xiang, Yuhan Zhang, Xuejun Wang, Xia Liu, Bin Huang, Xingang Li, Di Zhan. Liver kinase B-1 modulates the activity of dopamine neurons in the ventral tegmental area and regulates social memory formation. Frontiers in molecular neuroscience. vol 17. 2024-04-22. PMID:38646099. |
the dopaminergic system, originating from the midbrain ventral tegmental area (vta), is a key modulator of cognitive function. |
2024-04-22 |
2024-04-24 |
mouse |
| Sang Hui Yong, Sang-Mi Kim, Gyeong Woon Kong, Seung Hwan Ko, Eun-Hye Lee, Yohan Oh, Sang Hui Yon. ASCL1-mediated direct reprogramming: converting ventral midbrain astrocytes into dopaminergic neurons for Parkinson's disease therapy. BMB reports. 2024-04-22. PMID:38649147. |
ascl1-mediated direct reprogramming: converting ventral midbrain astrocytes into dopaminergic neurons for parkinson's disease therapy. |
2024-04-22 |
2024-04-26 |
Not clear |
| Hye-Yeon Park, Ga Seul Lee, Jun Go, Young-Kyoung Ryu, Chul-Ho Lee, Jeong Hee Moon, Kyoung-Shim Ki. Angiotensin-converting enzyme inhibition prevents L-dopa-induced dyskinesia in a 6-OHDA-induced mouse model of Parkinson's disease. European journal of pharmacology. 2024-04-20. PMID:38642669. |
parkinson's disease (pd) is characterised by severe movement defects and the degeneration of dopaminergic neurones in the midbrain. |
2024-04-20 |
2024-04-23 |
mouse |
| In-Beom Jin, Nam-Heon Kim, Jung-Soo Ha. Emerging role of the lateral habenula in conditioned inhibition and depression. Behavioral neuroscience. 2024-04-18. PMID:38635178. |
recent research has shed light on the lateral habenula (lhb) engagement in conditioned inhibition, along with the midbrain dopaminergic neurons. |
2024-04-18 |
2024-04-20 |
Not clear |
| Adrian Romero, Armando Sanchez, Jocelyn D Jones, Kristel Ledesma, Medhat S El-Halawany, Ayman K Hamouda, Brent R Bil. Optimization of Zebrafish Larvae 6-OHDA Exposure for Neurotoxin Induced Dopaminergic Marker Reduction. Zebrafish. 2024-04-12. PMID:38608227. |
parkinson's disease (pd) is a neurodegenerative disorder that is clinically assessed by motor symptoms associated with the loss of midbrain dopaminergic neurons affecting the quality of life for over 8.5 million people worldwide. |
2024-04-12 |
2024-04-15 |
zebrafish |
| Chiara Prodani, Elaine E Irvine, Alessandro Sardini, Hannah J Gleneadie, Andrew Dimond, Mathew Van de Pette, Rosalind John, Michelle Kokkinou, Oliver Howes, Dominic J Withers, Mark A Ungless, Matthias Merkenschlager, Amanda G Fishe. Protein restriction during pregnancy alters Cdkn1c silencing, dopamine circuitry and offspring behaviour without changing expression of key neuronal marker genes. Scientific reports. vol 14. issue 1. 2024-04-12. PMID:38609446. |
exposure to lpd in utero resulted in significantly more tyrosine hydroxylase positive (dopaminergic) neurons in the midbrain of adult offspring as compared to age-matched, control-diet equivalents. |
2024-04-12 |
2024-04-15 |
mouse |
| Riccardo Avvisati, Anna-Kristin Kaufmann, Callum J Young, Gabriella E Portlock, Sophie Cancemi, Rui Ponte Costa, Peter J Magill, Paul D Dodso. Distributional coding of associative learning in discrete populations of midbrain dopamine neurons. Cell reports. vol 43. issue 4. 2024-04-06. PMID:38581677. |
here, we investigated the organizational logic of dopaminergic signaling by recording and labeling individual midbrain dopamine neurons during associative behavior. |
2024-04-06 |
2024-04-10 |
Not clear |
| Jean-Louis A Parmasad, Konrad M Ricke, Benjamin Nguyen, Morgan G Stykel, Brodie Buchner-Duby, Amanda Bruce, Haley M Geertsma, Eric Lian, Nathalie A Lengacher, Steve M Callaghan, Alvin Joselin, Julianna J Tomlinson, Michael G Schlossmacher, William L Stanford, Jiyan Ma, Patrik Brundin, Scott D Ryan, Maxime W C Rousseau. Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy. Cell death & disease. vol 15. issue 4. 2024-04-04. PMID:38575601. |
parkinson's disease (pd) is a debilitating neurodegenerative disease characterized by the loss of midbrain dopaminergic neurons (dans) and the abnormal accumulation of α-synuclein (α-syn) protein. |
2024-04-04 |
2024-04-07 |
mouse |
| Malú Gámez Tansey, Jake Boles, Jenny Holt, Cassandra Cole, Noelle Neighbarger, Nikhil Urs, Oihane Uriarte-Huart. Locus coeruleus injury modulates ventral midbrain neuroinflammation during DSS-induced colitis. Research square. 2024-04-01. PMID:38559083. |
in all, this study supports the growing appreciation for the lc as neuroprotective against inflammation-induced brain injury and draws attention to the potential for neergic interventions to exert disease-modifying effects under conditions where peripheral inflammation may compromise ventral midbrain dopaminergic neurons and increase the risk for development of pd. |
2024-04-01 |
2024-04-04 |
mouse |
| Aggeliki Dimopoulou, Vasiliki Panagiotakopoulou, Theodora Mourtzi, Ilias Kazanis, Fevronia Angelato. Alpha-synuclein pathology in the "weaver" mouse, a genetic model of dopaminergic denervation. microPublication biology. vol 2024. 2024-03-29. PMID:38550606. |
our results revealed increased serine 129 phosphorylation in the midbrain, striatum, and cortex at a phase of established dopaminergic degeneration on postnatal day 100. |
2024-03-29 |
2024-03-31 |
mouse |
| Jennifer Sally Samson, Anuradha Ramesh, Venkatachalam Deepa Parvath. Development of midbrain dopaminergic neurons and the advantage of using hiPSCs as a model system to study Parkinson's disease. Neuroscience. 2024-03-24. PMID:38522661. |
development of midbrain dopaminergic neurons and the advantage of using hipscs as a model system to study parkinson's disease. |
2024-03-24 |
2024-03-27 |
Not clear |
| Jennifer Sally Samson, Anuradha Ramesh, Venkatachalam Deepa Parvath. Development of midbrain dopaminergic neurons and the advantage of using hiPSCs as a model system to study Parkinson's disease. Neuroscience. 2024-03-24. PMID:38522661. |
midbrain dopaminergic (mda) neurons are significantly impaired in patients inflicted with parkinson's disease (pd), subsequently affecting a variety of motor functions. |
2024-03-24 |
2024-03-27 |
Not clear |
| Lizett Ortiz de Ora, Julia M Balsamo, Kylie S Uyeda, Elizabeth N Bes. Discovery of a Gut Bacterial Metabolic Pathway that Drives α-Synuclein Aggregation. ACS chemical biology. 2024-03-22. PMID:38517270. |
parkinson's disease (pd) etiology is associated with aggregation and accumulation of α-synuclein (α-syn) proteins in midbrain dopaminergic neurons. |
2024-03-22 |
2024-03-24 |
Not clear |
| Y Li, J Xu, C Jiang, Z Chen, Y Chen, M Ying, A Wang, C Ma, C Wang, Y Guo, C Li. [Rho kinase inhibitor Y27632 promotes survival of human induced pluripotent stem cells during differentiation into functional midbrain dopaminergic progenitor cells in Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 44. issue 2. 2024-03-19. PMID:38501408. |
[rho kinase inhibitor y27632 promotes survival of human induced pluripotent stem cells during differentiation into functional midbrain dopaminergic progenitor cells in to improve the efficiency of induced differentiation of primitive neural epithelial cells derived from human induced pluripotent stem cells (hipscs-necs) into functional midbrain dopaminergic progenitor cells (daps). |
2024-03-19 |
2024-03-21 |
human |
| Ana Araújo, Isabel Catarina Duarte, Teresa Sousa, Joana Oliveira, Ana Telma Pereira, António Macedo, Miguel Castelo-Branc. Neural inhibition as implemented by an actor-critic model involves the human dorsal striatum and ventral tegmental area. Scientific reports. vol 14. issue 1. 2024-03-17. PMID:38493169. |
rodent and computational studies show that midbrain regions play crucial roles during errors by sending dopaminergic learning signals to the basal ganglia for behavioural adjustment. |
2024-03-17 |
2024-03-19 |
human |
| Fuyuki Karube, Yang Yang, Kenta Kobayashi, Fumino Fujiyam. Anterograde trans-neuronal labeling of striatal interneurons in relation to dopamine neurons in the substantia nigra pars compacta. Frontiers in neuroanatomy. vol 18. 2024-03-14. PMID:38482378. |
dopaminergic (da) neurons in the midbrain are highly heterogeneous in terms of gene and protein expression and axonal projections. |
2024-03-14 |
2024-03-16 |
Not clear |
| Zijian Zheng, Shushan Zhang, Xinjie Liu, Xiangrong Wang, Cheng Xue, Xiao Wu, Xinran Zhang, Xinping Xu, Zheng Liu, Longping Yao, Guohui L. LRRK2 regulates ferroptosis through the system Xc-GSH-GPX4 pathway in the neuroinflammatory mechanism of Parkinson's disease. Journal of cellular physiology. 2024-03-13. PMID:38477420. |
neuroinflammation mediated by activated microglia and apoptosis of dopaminergic (da) neurons in the midbrain are its primary pathological manifestations. |
2024-03-13 |
2024-03-15 |
mouse |
| Liqing Lin, Jie Deng, Junhui Peng, Jing Cui, Lei Wang, Min Zhang, Jia Gao, Fudong Li, Yunyu Shi, Mengqi L. Structural insights into the recognition of the A/T-rich motif in target gene promoters by the LMX1a homeobox domain. The FEBS journal. 2024-03-11. PMID:38465368. |
lim homeodomain transcription factor 1-alpha (lmx1a) is a neuronal lineage-specific transcription activator that plays an essential role during the development of midbrain dopaminergic (mda) neurons. |
2024-03-11 |
2024-03-14 |
Not clear |
| Ruotong Li, Guoyi Tang, Jie Yang, Shasha Gao, Yixuan Wang, Xiang Wu, Yihua Bai, Jian Li. The avBNST Neurochemistry international. 2024-03-08. PMID:38458538. |
the vta and drn contain dopaminergic and serotonergic cell groups in the midbrain which regulate anxiety-like behaviors. |
2024-03-08 |
2024-03-11 |
rat |
| Min Seong Kim, Subeen Yoon, Jiwoo Choi, Yong Jun Kim, Gabsang Le. Stem Cell-Based Approaches in Parkinson's Disease Research. International journal of stem cells. 2024-03-07. PMID:38449089. |
parkinson's disease (pd) is a neurodegenerative condition characterized by the loss of midbrain dopaminergic neurons, leading to motor symptoms. |
2024-03-07 |
2024-03-09 |
Not clear |