| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jinhua Xue, Yanning Li, Yue Qi, Ziwei Zhang, Xiaolu Tan. Exogenous Otx2 protects midbrain dopaminergic neurons from MPP Neurotoxicology. 2022-06-01. PMID:35644505. |
exogenous otx2 protects midbrain dopaminergic neurons from mpp mitochondrial dysfunction is the main pathological mechanism responsible for the death of midbrain dopaminergic (mda) neurons. |
2022-06-01 |
2023-08-13 |
Not clear |
| Shiyan Chen, Jiamei Lian, Yueqing Su, Chao Den. Effects of Risperidone and Prenatal Poly I:C Exposure on GABA Biomolecules. vol 12. issue 5. 2022-05-28. PMID:35625659. |
effects of risperidone and prenatal poly i:c exposure on gaba the ventral tegmental area (vta) in the ventral midbrain is the origin of the dopaminergic neurotransmission pathways. |
2022-05-28 |
2023-08-13 |
Not clear |
| Mayank Patel, Shamsher Sing. Apigenin Attenuates Functional and Structural Alterations via Targeting NF-kB/Nrf2 Signaling Pathway in LPS-Induced Parkinsonism in Experimental Rats : Apigenin Attenuates LPS-Induced Parkinsonism in Experimental Rats. Neurotoxicity research. 2022-05-24. PMID:35608813. |
parkinson's disease (pd) is a progressive hypokinetic movement disorder caused by selective degeneration of dopaminergic neurons in striatum and dopamine deficiency in a region of the midbrain. |
2022-05-24 |
2023-08-13 |
rat |
| Niamh Moriarty, Jessica A Kauhausen, Chiara Pavan, Cameron Pj Hunt, Isabelle R de Luzy, Vanessa Penna, Charlotte M Ermine, Lachlan H Thompson, Clare L Paris. Understanding the influence of target acquisition on survival, integration and phenotypic maturation of dopamine neurons within stem cell-derived neural grafts in a Parkinson's disease model. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-05-24. PMID:35610045. |
midbrain dopaminergic neurons include many subtypes characterised by their location, connectivity and function. |
2022-05-24 |
2023-08-13 |
mouse |
| Iro Boura, Kallol Ray Chaudhur. Coronavirus Disease 2019 and Related Parkinsonism: The Clinical Evidence Thus Far. Movement disorders clinical practice. 2022-05-23. PMID:35601258. |
this theory is further augmented by reports of a pathogenic effect of the severe acute respiratory syndrome coronavirus-2 (sars-cov-2) on the central nervous system with specific impact on the dopaminergic pathway, as well as the possibility of the virus to selectively bind to angiotensin-converting enzyme-2 (ace-2); these molecules are expressed abundantly in the midbrain dopamine neurons and, are likely involved in several cellular mechanisms cited in parkinson's disease (pd) pathophysiology. |
2022-05-23 |
2023-08-13 |
Not clear |
| Francesca Montarolo, Serena Martire, Francesco Chiara, Sarah Allegra, Silvia De Francia, Eriola Hoxha, Filippo Tempia, Marco Alfonso Capobianco, Antonio Bertolott. NURR1-deficient mice have age- and sex-specific behavioral phenotypes. Journal of neuroscience research. 2022-05-20. PMID:35593070. |
the transcription factor nurr1 is essential to the generation and maintenance of midbrain dopaminergic (mda) neurons and its deregulation is involved in the development of dopamine (da)-associated brain disorders, such as parkinson's disease (pd). |
2022-05-20 |
2023-08-13 |
mouse |
| Tapan Behl, Piyush Madaan, Aayush Sehgal, Sukhbir Singh, Hafiz A Makeen, Mohammed Albratty, Hassan A Alhazmi, Abdulkarim M Meraya, Simona Bunga. Demystifying the Neuroprotective Role of Neuropeptides in Parkinson's Disease: A Newfangled and Eloquent Therapeutic Perspective. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35562956. |
parkinson's disease (pd) refers to one of the eminently grievous, preponderant, tortuous nerve-cell-devastating ailments that markedly impacts the dopaminergic (dargic) nerve cells of the midbrain region, namely the substantia nigra pars compacta (sn-pc). |
2022-05-14 |
2023-08-13 |
human |
| Namrata Kumari, Nagarjuna Daram, Md Sabir Alam, Anita Kamra Verm. Rationalizing the Use of Polyphenol Nano-formulations in the Therapy of Neurodegenerative Diseases. CNS & neurological disorders drug targets. 2022-05-13. PMID:35549866. |
dopaminergic neuronal death in the midbrain and accumulation of β- synuclein in the neurons are the hallmark of parkinson's disease. |
2022-05-13 |
2023-08-13 |
Not clear |
| Emily E Anderson, Carl T Ash, Amy E Moritz, Patricia Dranchak, R Benjamin Free, James Inglese, Joseph P Steiner, David R Sibley, Emmanuel O Akan. Establishing an RNA interference (RNAi) screen for neuroprotection of dopaminergic neurons in Caenorhabditis elegans models of Parkinson's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35553997. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by the selective death of dopaminergic neurons in the substantia nigra of the midbrain, resulting in bradykinesia, tremors, muscle rigidity, and other motor and non-motor deficits. |
2022-05-13 |
2023-08-13 |
human |
| Amanda Grassel, Carris Borland, Federica Bertolotti, Ryan Osselborn, Tracey Nassuna, Bryce Zabat, Shubhik DebBurma. Insight into Parkinson's Disease From a Yeast Model: How Three Alpha-Synuclein Mutants (A18T, A29S, & A53V) Generate Toxicity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554149. |
parkinson's disease (pd) is a fatal and incurable neurodegenerative disorder linked to the loss of dopaminergic neurons in the midbrain. |
2022-05-13 |
2023-08-13 |
Not clear |
| Xing Cai, Hailan Liu, Bing Feng, Meng Yu, Yang He, Hesong Liu, Chen Liang, Yongjie Yang, Longlong Tu, Nan Zhang, Lina Wang, Na Yin, Junying Han, Zili Yan, Chunmei Wang, Pingwen Xu, Qi Wu, Qingchun Tong, Yanlin He, Yong X. A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice. Nature neuroscience. 2022-05-02. PMID:35501380. |
a d2 to d1 shift in dopaminergic inputs to midbrain 5-ht neurons causes anorexia in mice. |
2022-05-02 |
2023-08-13 |
mouse |
| Sreekanth Rajan, Hui Ting Toh, Hong Ye, Ziyin Wang, Adeline Henry Basil, Tanvi Parnaik, Jun Yeob Yoo, Kah-Leong Lim, Ho Sup Yoo. Prostaglandin A2 Interacts with Nurr1 and Ameliorates Behavioral Deficits in Parkinson's Disease Fly Model. Neuromolecular medicine. 2022-04-28. PMID:35482177. |
the orphan nuclear receptor nurr1 is critical for the development, maintenance, and protection of midbrain dopaminergic neurons. |
2022-04-28 |
2023-08-13 |
Not clear |
| Ana Chegão, Mariana Guarda, Bruno M Alexandre, Liana Shvachiy, Mariana Temido-Ferreira, Inês Marques-Morgado, Bárbara Fernandes Gomes, Rune Matthiesen, Luísa V Lopes, Pedro R Florindo, Ricardo A Gomes, Patrícia Gomes-Alves, Joana E Coelho, Tiago Fleming Outeiro, Hugo Vicente Mirand. Glycation modulates glutamatergic signaling and exacerbates Parkinson's disease-like phenotypes. NPJ Parkinson's disease. vol 8. issue 1. 2022-04-26. PMID:35468899. |
the glycated proteins in the midbrain of mgo-injected thy1-asyn mice strongly correlate with pd and dopaminergic pathways. |
2022-04-26 |
2023-08-13 |
mouse |
| Anurupa A Ghosh, Dinesh Kumar Verma, Gabriela Cabrera, Kwadwo Ofori, Karina Hernandez-Quijada, Jae-Kwan Kim, Joo Hee Chung, Michael Moore, Sung Hwan Moon, Jong Bok Seo, Yong-Hwan Ki. A Novel NOX Inhibitor Treatment Attenuates Parkinson's Disease-Related Pathology in Mouse Models. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35457082. |
we also confirmed that the compound treatment reduced the levels of protein aggregation, along with phosphorylated-α-synuclein, in the striatum and ventral midbrain and further dopaminergic neuronal loss. |
2022-04-23 |
2023-08-13 |
mouse |
| Alcmène Chalazonitis, Meenakshi Rao, David Sulze. Similarities and differences between nigral and enteric dopaminergic neurons unravel distinctive involvement in Parkinson's disease. NPJ Parkinson's disease. vol 8. issue 1. 2022-04-23. PMID:35459867. |
in addition to the well-known degeneration of midbrain dopaminergic neurons, enteric neurons can also be affected in neurodegenerative disorders such as parkinson's disease (pd). |
2022-04-23 |
2023-08-13 |
mouse |
| Alcmène Chalazonitis, Meenakshi Rao, David Sulze. Similarities and differences between nigral and enteric dopaminergic neurons unravel distinctive involvement in Parkinson's disease. NPJ Parkinson's disease. vol 8. issue 1. 2022-04-23. PMID:35459867. |
although their cellular sources and developmental times of origin differ, midbrain and ens dopaminergic neurons express many transcription factors in common and their respective environments express similar neurotrophic molecules. |
2022-04-23 |
2023-08-13 |
mouse |
| Benjamin M Hiller, David J Marmion, Cayla A Thompson, Nathaniel A Elliott, Howard Federoff, Patrik Brundin, Virginia B Mattis, Christopher W McMahon, Jeffrey H Kordowe. Optimizing maturity and dose of iPSC-derived dopamine progenitor cell therapy for Parkinson's disease. NPJ Regenerative medicine. vol 7. issue 1. 2022-04-22. PMID:35449132. |
in pursuit of treating parkinson's disease with cell replacement therapy, differentiated induced pluripotent stem cells (ipsc) are an ideal source of midbrain dopaminergic (mda) cells. |
2022-04-22 |
2023-08-13 |
human |
| Liang Gao, Qiang Xue, Shun Gong, Gaoyi Li, Wusong Tong, Mingxia Fan, Xianzhen Chen, Jia Yin, Yu Song, Songyu Chen, Jingrong Huang, Chengbin Wang, Yan Don. Structural and Functional Alterations of Substantia Nigra and Associations With Anxiety and Depressive Symptoms Following Traumatic Brain Injury. Frontiers in neurology. vol 13. 2022-04-22. PMID:35449518. |
in the midbrain, dopaminergic neurons are mainly situated in the substantia nigra (sn) and the ventral tegmental area (vta). |
2022-04-22 |
2023-08-13 |
Not clear |
| Silke Nuber, Chee Yeun Chung, Daniel F Tardiff, Pascal A Bechade, Thomas D McCaffery, Kazuma Shimanaka, Jeonghoon Choi, Belle Chang, Waseem Raja, Esther Neve, Christopher Burke, Xin Jiang, Ping Xu, Vikram Khurana, Ulf Dettmer, Saranna Fanning, Kenneth J Rhodes, Dennis J Selkoe, Robert H Scannevi. A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2022-04-21. PMID:35445353. |
increasing evidence has shown that parkinson's disease (pd) impairs midbrain dopaminergic, cortical and other neuronal subtypes in large part due to the build-up of lipid- and vesicle-rich α-synuclein (αsyn) cytotoxic inclusions. |
2022-04-21 |
2023-08-13 |
mouse |
| Nancy Y A Sey, Benxia Hu, Marina Iskhakova, Sool Lee, Huaigu Sun, Neda Shokrian, Gabriella Ben Hutta, Jesse A Marks, Bryan C Quach, Eric O Johnson, Dana B Hancock, Schahram Akbarian, Hyejung Wo. Chromatin architecture in addiction circuitry identifies risk genes and potential biological mechanisms underlying cigarette smoking and alcohol use traits. Molecular psychiatry. 2022-04-15. PMID:35422469. |
to investigate the functional impact of common variants associated with cigarette smoking and alcohol use traits, we applied hi-c coupled magma (h-magma) built upon cortical and newly generated midbrain dopaminergic neuronal hi-c datasets to gwas summary statistics of nicotine dependence, cigarettes per day, problematic alcohol use, and drinks per week. |
2022-04-15 |
2023-08-13 |
Not clear |