| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nancy Y A Sey, Benxia Hu, Marina Iskhakova, Sool Lee, Huaigu Sun, Neda Shokrian, Gabriella Ben Hutta, Jesse A Marks, Bryan C Quach, Eric O Johnson, Dana B Hancock, Schahram Akbarian, Hyejung Wo. Chromatin architecture in addiction circuitry identifies risk genes and potential biological mechanisms underlying cigarette smoking and alcohol use traits. Molecular psychiatry. 2022-04-15. PMID:35422469. |
risk genes were highly expressed in cortical glutamatergic, midbrain dopaminergic, gabaergic, and serotonergic neurons, suggesting them as relevant cell types in understanding the mechanisms by which genetic risk factors influence cigarette smoking and alcohol use. |
2022-04-15 |
2023-08-13 |
Not clear |
| Silvia Arber, Rui M Cost. Networking brainstem and basal ganglia circuits for movement. Nature reviews. Neuroscience. 2022-04-15. PMID:35422525. |
important networking components include broadcasting neurons in the cortex, cerebellar output neurons and midbrain dopaminergic neurons. |
2022-04-15 |
2023-08-13 |
Not clear |
| Amanda R Burmeister, Juozas Gordevicius, Emmanuel N Paul, Christina Houck, Sonia George, Martha L Escobar Galvis, Qiong Sha, Patrik Brundin, J Andrew Pospisilik, Karen Racicot, Lena Brundi. Maternal Herpesviridae infection during pregnancy alters midbrain dopaminergic signatures in adult offspring. Neurobiology of disease. 2022-04-13. PMID:35417751. |
maternal herpesviridae infection during pregnancy alters midbrain dopaminergic signatures in adult offspring. |
2022-04-13 |
2023-08-13 |
mouse |
| Xin Liu, Zhong Rui Du, Xiong Wang, Xiang Rong Sun, Qing Zhao, Fang Zhao, Wing Tak Wong, Ka Hing Wong, Xiao-Li Don. Polymannuronic acid prebiotic plus Lacticaseibacillus rhamnosus GG probiotic as a novel synbiotic promoted their separate neuroprotection against Parkinson's disease. Food research international (Ottawa, Ont.). vol 155. 2022-04-11. PMID:35400445. |
our results found oral administration of prebiotic pm or lgg separately or in combination for 5 weeks could prevent dopaminergic neuronal loss via improving reduced walking distance and activity or weakened muscle strength in behavior tests by enhancing tyrosine hydroxylase (th) gene and/or protein expressions in the midbrain and striatum of pd mice. |
2022-04-11 |
2023-08-13 |
mouse |
| Aleksandar Rakovic, Dorothea Voß, Franca Vulinovic, Britta Meier, Ann-Katrin Hellberg, Carla Nau, Christine Klein, Enrico Leipol. Electrophysiological Properties of Induced Pluripotent Stem Cell-Derived Midbrain Dopaminergic Neurons Correlate With Expression of Tyrosine Hydroxylase. Frontiers in cellular neuroscience. vol 16. 2022-04-11. PMID:35401116. |
electrophysiological properties of induced pluripotent stem cell-derived midbrain dopaminergic neurons correlate with expression of tyrosine hydroxylase. |
2022-04-11 |
2023-08-13 |
Not clear |
| F Gubinelli, G Cazzolla, M Negrini, I Kulacz, A Mehrdadian, G Tomasello, C Venuti, L Sarauskyte, F Jacobs, F P Manfredsson, M Davidsson, A Heue. Lateralized deficits after unilateral AAV-vector based overexpression of alpha-synuclein in the midbrain of rats on drug-free behavioural tests. Behavioural brain research. 2022-04-11. PMID:35405174. |
preclinical rodent models of parkinson's aim to recapitulate some of the hallmarks of the disease as it presents in humans, including the progressive neuronal loss of dopaminergic neurons in the midbrain as well as the development of a behavioural phenotype. |
2022-04-11 |
2023-08-13 |
rat |
| b' Alice Adiletta, Alessandra Pross, Nicol\\xc3\\xb2 Taricco, Paola Sgad\\xc3\\xb. Embryonic Valproate Exposure Alters Mesencephalic Dopaminergic Neurons Distribution and Septal Dopaminergic Gene Expression in Domestic Chicks. Frontiers in integrative neuroscience. vol 16. 2022-04-04. PMID:35369647.' |
we found that vpa affected the rostro-caudal distribution of da neurons, without changing the expression levels of several dopaminergic markers in the mesencephalon. |
2022-04-04 |
2023-08-13 |
chicken |
| Gabriela Novak, Steven Finkbeiner, Gaia Skibinski, Michela Bernini, Cristina Donato, Alexander Skupi. Generation of two human induced pluripotent stem cell lines from fibroblasts of Parkinson's disease patients carrying the ILE368ASN mutation in PINK1 (LCSBi002) and the R275W mutation in Parkin (LCSBI004). Stem cell research. vol 61. 2022-04-04. PMID:35378365. |
the cell lines were successfully used to generate midbrain dopaminergic neurons, the neuron type primarily affected in pd. |
2022-04-04 |
2023-08-13 |
human |
| Jinchuan Zhao, Xin Gao, Liangyou Zhao, Yiqing Wang, Jingbo Zhang, Shumin Li. Effects of Cannabidiol on Parkinson's Disease in a Transgenic Mouse Model by Gut-Brain Metabolic Analysis. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-04-01. PMID:35360659. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by a disorder of the dopaminergic system in the midbrain, causing classical pd motor symptoms. |
2022-04-01 |
2023-08-13 |
mouse |
| Yingchun Su, Yanting Liu, Dewei He, Guiqiu Hu, Hefei Wang, Bojian Ye, Yuan He, Xiyu Gao, Dianfeng Li. Hordenine inhibits neuroinflammation and exerts neuroprotective effects via inhibiting NF-κB and MAPK signaling pathways in vivo and in vitro. International immunopharmacology. vol 108. 2022-03-29. PMID:35349959. |
parkinson's disease (pd) is a usual disease caused by degeneration of the central nervous system, which features the denaturation and death of dopaminergic neurons in the substantia nigra compact (snc) of the midbrain. |
2022-03-29 |
2023-08-13 |
rat |
| Adrianne F Pike, Ildikò Szabò, Robert Veerhuis, Luigi Bubacc. The potential convergence of NLRP3 inflammasome, potassium, and dopamine mechanisms in Parkinson's disease. NPJ Parkinson's disease. vol 8. issue 1. 2022-03-25. PMID:35332154. |
potassium conductance also influences dopamine release from midbrain dopaminergic neurons. |
2022-03-25 |
2023-08-13 |
Not clear |
| Anjie Ni, Carl Erns. Evidence That Substantia Nigra Pars Compacta Dopaminergic Neurons Are Selectively Vulnerable to Oxidative Stress Because They Are Highly Metabolically Active. Frontiers in cellular neuroscience. vol 16. 2022-03-21. PMID:35308118. |
we further provide evidence to support the hypothesis that transcription factors (tfs) required to drive induction, differentiation, and maintenance of midbrain dopaminergic neural progenitor cells which give rise to terminally differentiated snpc neurons are uniquely involved in both developmental patterning and metabolism, a dual function unlike other tfs that program neurons in other brain regions. |
2022-03-21 |
2023-08-13 |
human |
| Federico Miozzo, Eva P Valencia-Alarcón, Luca Stickley, Michaëla Majcin Dorcikova, Francesco Petrelli, Damla Tas, Nicolas Loncle, Irina Nikonenko, Peter Bou Dib, Emi Nagosh. Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor. Nature communications. vol 13. issue 1. 2022-03-18. PMID:35301315. |
maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor. |
2022-03-18 |
2023-08-13 |
mouse |
| Chen Yang, Yuzheng Hu, Aleksandr D Talishinsky, Christian T Potter, Coleman B Calva, Leslie A Ramsey, Andrew J Kesner, Reuben F Don, Sue Junn, Aaron Tan, Anne F Pierce, Céline Nicolas, Yosuke Arima, Seung-Chan Lee, Conghui Su, Jensine M Coudriet, Carlos A Mejia-Aponte, Dong V Wang, Hanbing Lu, Yihong Yang, Satoshi Ikemot. Medial prefrontal cortex and anteromedial thalamus interaction regulates goal-directed behavior and dopaminergic neuron activity. Nature communications. vol 13. issue 1. 2022-03-17. PMID:35296648. |
axonal terminal stimulation of mpfc neurons in downstream regions, including the anteromedial thalamic nucleus (am), reinforced behavior and activated midbrain dopaminergic neurons. |
2022-03-17 |
2023-08-13 |
mouse |
| Amritha Chakkittukandiyil, Deepak Vasudevan Sajini, Arjunan Karuppaiah, Divakar Selvara. The principal molecular mechanisms behind the activation of Keap1/Nrf2/ARE pathway leading to neuroprotective action in Parkinson's disease. Neurochemistry international. 2022-03-12. PMID:35278519. |
pd is associated with the loss of dopaminergic neurons in the substantia nigra pars compacta region of the midbrain. |
2022-03-12 |
2023-08-13 |
human |
| Paulla Vieira Rodrigues, João Vitor Pereira de Godoy, Beatriz Pelegrini Bosque, Dionísio Pedro Amorim Neto, Katiane Tostes, Soledad Palameta, Sheila Garcia-Rosa, Celisa Caldana Costa Tonoli, Hernandes Faustino de Carvalho, Matheus de Castro Fonsec. Transcellular propagation of fibrillar α-synuclein from enteroendocrine to neuronal cells requires cell-to-cell contact and is Rab35-dependent. Scientific reports. vol 12. issue 1. 2022-03-10. PMID:35264710. |
parkinson's disease (pd) is a neurodegenerative condition featured by motor dysfunction, death of midbrain dopaminergic neurons and accumulation of α-synuclein (αsyn) aggregates. |
2022-03-10 |
2023-08-13 |
Not clear |
| Walaa F Alsanie, Majid Alhomrani, Ahmed Gaber, Hamza Habeeballah, Heba A Alkhatabi, Raed I Felimban, Sherin Abdelrahman, Charlotte A E Hauser, Adeel G Chaudhary, Abdulhakeem S Alamri, Bassem M Raafat, Abdulwahab Alamri, Sirajudheen Anwar, Khaled A Alswat, Yusuf S Althobaiti, Yousif A Asir. The Effects of Prenatal Exposure to Pregabalin on the Development of Ventral Midbrain Dopaminergic Neurons. Cells. vol 11. issue 5. 2022-03-10. PMID:35269474. |
the effects of prenatal exposure to pregabalin on the development of ventral midbrain dopaminergic neurons. |
2022-03-10 |
2023-08-13 |
mouse |
| Walaa F Alsanie, Majid Alhomrani, Ahmed Gaber, Hamza Habeeballah, Heba A Alkhatabi, Raed I Felimban, Sherin Abdelrahman, Charlotte A E Hauser, Adeel G Chaudhary, Abdulhakeem S Alamri, Bassem M Raafat, Abdulwahab Alamri, Sirajudheen Anwar, Khaled A Alswat, Yusuf S Althobaiti, Yousif A Asir. The Effects of Prenatal Exposure to Pregabalin on the Development of Ventral Midbrain Dopaminergic Neurons. Cells. vol 11. issue 5. 2022-03-10. PMID:35269474. |
this study focused on ventral midbrain dopaminergic neurons, as they are responsible for cognition, movement, and behavior. |
2022-03-10 |
2023-08-13 |
mouse |
| Melissa L Caras, Max F K Happel, Bharath Chandrasekaran, Pablo Ripollés, Sarah M Keesom, Laura M Hurley, Luke Remage-Healey, Lori L Holt, Beverly A Wrigh. Non-sensory Influences on Auditory Learning and Plasticity. Journal of the Association for Research in Otolaryngology : JARO. 2022-03-02. PMID:35235100. |
we begin by presenting evidence that reward signals from the dopaminergic midbrain act on cortico-subcortical networks to shape sound-evoked responses of auditory cortical neurons, facilitate auditory category learning, and modulate the long-term storage of new words and their meanings. |
2022-03-02 |
2023-08-13 |
human |
| Ian M O'Shea, Haroon S Popal, Ingrid R Olson, Vishnu P Murty, David V Smit. Distinct alterations in cerebellar connectivity with substantia nigra and ventral tegmental area in Parkinson's disease. Scientific reports. vol 12. issue 1. 2022-03-01. PMID:35228561. |
in parkinson's disease (pd), neurodegeneration of dopaminergic neurons occurs in the midbrain, specifically targeting the substantia nigra (sn), while leaving the ventral tegmental area (vta) relatively spared in early phases of the disease. |
2022-03-01 |
2023-08-13 |
Not clear |