| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ramesh Pariyar, Tonking Bastola, Dae Ho Lee, Jungwon Se. Neuroprotective Effects of the DPP4 Inhibitor Vildagliptin in In Vivo and In Vitro Models of Parkinson's Disease. International journal of molecular sciences. vol 23. issue 4. 2022-02-26. PMID:35216503. |
parkinson's disease (pd) is characterized by loss of dopaminergic neurons in the substantia nigra pars compacta (snpc) of the midbrain. |
2022-02-26 |
2023-08-13 |
mouse |
| Haley M Geertsma, Terry R Suk, Konrad M Ricke, Kyra Horsthuis, Jean-Louis A Parmasad, Zoe A Fisk, Steve M Callaghan, Maxime W C Rousseau. Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor impairment and cortical dysfunction, independent of protein aggregation. Human molecular genetics. 2022-02-18. PMID:35179202. |
through histological analyses, we observed motor cortex atrophy in the absence of midbrain dopaminergic neurodegeneration. |
2022-02-18 |
2023-08-13 |
mouse |
| Erin McCarthy, Aaron Barron, Noelia Morales-Prieto, Martina Mazzocchi, Cathal M McCarthy, Louise M Collins, Aideen M Sullivan, Gerard W O'Keeff. Gene Co-expression Analysis of the Human Substantia Nigra Identifies ZNHIT1 as an SNCA Co-expressed Gene that Protects Against α-Synuclein-Induced Impairments in Neurite Growth and Mitochondrial Dysfunction in SH-SY5Y Cells. Molecular neurobiology. 2022-02-17. PMID:35175558. |
parkinson's disease (pd) is neurodegenerative disorder with the pathological hallmarks of progressive degeneration of midbrain dopaminergic neurons from the substantia nigra (sn), and accumulation and spread of inclusions of aggregated α-synuclein (α-syn). |
2022-02-17 |
2023-08-13 |
human |
| Michele Salemi, Giuseppe Lanza, Maria Paola Mogavero, Filomena I I Cosentino, Eugenia Borgione, Roberta Iorio, Giovanna Maria Ventola, Giovanna Marchese, Maria Grazia Salluzzo, Maria Ravo, Raffaele Ferr. A Transcriptome Analysis of mRNAs and Long Non-Coding RNAs in Patients with Parkinson's Disease. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163455. |
clinical symptoms include the progressive loss of dopaminergic neurons in the substantia nigra of the midbrain, which leads to striatal dopamine deficiency and, subsequently, causes motor dysfunction. |
2022-02-15 |
2023-08-13 |
human |
| Lukas Seebauer, Yanni Schneider, Alice Drobny, Sonja Plötz, Tomas Koudelka, Andreas Tholey, Iryna Prots, Beate Winner, Friederike Zunke, Jürgen Winkler, Wei Xian. Interaction of Alpha Synuclein and Microtubule Organization Is Linked to Impaired Neuritic Integrity in Parkinson's Patient-Derived Neuronal Cells. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163733. |
in this study, we investigate the impact of asyn on microtubule organization in asyn overexpressing h4 neuroglioma cells and midbrain dopaminergic neuronal cells (mdans) generated from pd patient-derived human induced pluripotent stem cells (hipscs) carrying an asyn gene duplication ( |
2022-02-15 |
2023-08-13 |
human |
| Stephano J Chang, Ruth Mitchell, Juliette Hukin, Ash Singha. Treatment-responsive Holmes tremor in a child with low-pressure hydrocephalus: video case report and systematic review of the literature. Journal of neurosurgery. Pediatrics. 2022-02-11. PMID:35148507. |
mechanistically, the combined rest and action tremor is thought to require a double lesion of both the dopaminergic nigrostriatal system and the dentatorubrothalamic pathways, often near the midbrain where both pathways converge. |
2022-02-11 |
2023-08-13 |
Not clear |
| Qiang Miao, Zhi Chai, Li-Juan Song, Qing Wang, Guo-Bin Song, Jing Wang, Jie-Zhong Yu, Bao-Guo Xiao, Cun-Gen M. The neuroprotective effects and transdifferentiation of astrocytes into dopaminergic neurons of Ginkgolide K on Parkinson' disease mice. Journal of neuroimmunology. vol 364. 2022-02-05. PMID:35121334. |
parkinson's disease (pd) is a chronic and progressive movement disorder caused by the selective loss of midbrain dopaminergic neurons of unknown etiology. |
2022-02-05 |
2023-08-13 |
mouse |
| Pik-Shan Lo, Vladimir V Rymar, Timothy E Kennedy, Abbas F Sadiko. The Netrin-1 Receptor DCC Promotes the Survival of a Subpopulation of Midbrain Dopaminergic Neurons: Relevance for Ageing and Parkinson's Disease. Journal of neurochemistry. 2022-02-04. PMID:35118677. |
the netrin-1 receptor dcc promotes the survival of a subpopulation of midbrain dopaminergic neurons: relevance for ageing and parkinson's disease. |
2022-02-04 |
2023-08-13 |
mouse |
| Pik-Shan Lo, Vladimir V Rymar, Timothy E Kennedy, Abbas F Sadiko. The Netrin-1 Receptor DCC Promotes the Survival of a Subpopulation of Midbrain Dopaminergic Neurons: Relevance for Ageing and Parkinson's Disease. Journal of neurochemistry. 2022-02-04. PMID:35118677. |
mechanisms that determine the survival of midbrain dopaminergic (mda) neurons in the adult central nervous system (cns) are not fully understood. |
2022-02-04 |
2023-08-13 |
mouse |
| Camilo A Sanchez, Jackson Brougher, Deepika G Krishnan, Catherine A Thor. Longitudinal Assessment of Skilled Forelimb Motor Impairments in DJ-1 Knockout Rats. Behavioural brain research. 2022-02-01. PMID:35101457. |
50% loss of midbrain dopaminergic neurons appearing around 6-8 months of age. |
2022-02-01 |
2023-08-13 |
rat |
| Benjamin D Hobson, Se Joon Choi, Eugene V Mosharov, Rajesh K Soni, David Sulzer, Peter Sim. Subcellular proteomics of dopamine neurons in the mouse brain. eLife. vol 11. 2022-01-31. PMID:35098924. |
by combining apex2 biotinylation with mass spectrometry, we mapped the somatodendritic and axonal proteomes of midbrain dopaminergic neurons. |
2022-01-31 |
2023-08-13 |
mouse |
| Javed Ahmed Ujjan, William Morani, Naz Memon, Sugumar Mohanasundaram, Shibili Nuhmani, Bhupesh Kumar Sing. Force Platform-Based Intervention Program for Individuals Suffering with Neurodegenerative Diseases like Parkinson. Computational and mathematical methods in medicine. vol 2022. 2022-01-27. PMID:35082910. |
substantia nigra (a midbrain dopaminergic nucleus) with lack of hormone called dopamine causes parkinson's disease (pd), a neurological disorder. |
2022-01-27 |
2023-08-13 |
human |
| Adriana Trapani, Stefania Cometa, Elvira De Giglio, Filomena Corbo, Roberta Cassano, Maria Luisa Di Gioia, Sonia Trombino, Md Niamat Hossain, Sante Di Gioia, Giuseppe Trapani, Massimo Cones. Novel Nanoparticles Based on Pharmaceutics. vol 14. issue 1. 2022-01-21. PMID:35057043. |
as for parkinson's disease (pd), characterized by dopaminergic midbrain neurons degeneration, currently there is no disease modifying therapy. |
2022-01-21 |
2023-08-13 |
Not clear |
| Muhammad O Chohan, Jared M Kopelman, Hannah Yueh, Zeinab Fazlali, Natasha Greene, Alexander Z Harris, Peter D Balsam, E David Leonardo, Edgar R Kramer, Jeremy Veenstra-VanderWeele, Susanne E Ahmar. Developmental impact of glutamate transporter overexpression on dopaminergic neuron activity and stereotypic behavior. Molecular psychiatry. 2022-01-21. PMID:35058566. |
in mice, midbrain slc1a1 expression supports repetitive behavior in response to dopaminergic agonists, aligning with neuroimaging and pharmacologic challenge studies that have implicated the dopaminergic system in ocd. |
2022-01-21 |
2023-08-13 |
mouse |
| Markus Westphal, Paolo Panza, Edda Kastenhuber, Johanna Wehrle, Wolfgang Drieve. Wnt/β-catenin signaling promotes neurogenesis in the diencephalospinal dopaminergic system of embryonic zebrafish. Scientific reports. vol 12. issue 1. 2022-01-20. PMID:35046434. |
wnt/β-catenin signaling is important for mammalian midbrain dopaminergic neurogenesis, while little is known about its role in ventral forebrain dopaminergic development. |
2022-01-20 |
2023-08-13 |
zebrafish |
| Francesca Garretti, Connor Monahan, Alessandro Sette, Dritan Agalliu, David Sulze. T cells, α-synuclein and Parkinson disease. Handbook of clinical neurology. vol 184. 2022-01-17. PMID:35034753. |
the notion that autoimmune responses to α-synuclein may be involved in the pathogenesis of this disorder stems from reports that mutations in α-synuclein or certain alleles of the major histocompatibility complex (mhc) are associated with the disease and that dopaminergic and norepinephrinergic neurons in the midbrain can present antigenic epitopes. |
2022-01-17 |
2023-08-13 |
Not clear |
| Gabriela Novak, Dimitrios Kyriakis, Kamil Grzyb, Michela Bernini, Sophie Rodius, Gunnar Dittmar, Steven Finkbeiner, Alexander Skupi. Single-cell transcriptomics of human iPSC differentiation dynamics reveal a core molecular network of Parkinson's disease. Communications biology. vol 5. issue 1. 2022-01-14. PMID:35027645. |
parkinson's disease (pd) is the second-most prevalent neurodegenerative disorder, characterized by the loss of dopaminergic neurons (mda) in the midbrain. |
2022-01-14 |
2023-08-13 |
human |
| Benjamin D Hobson, Linghao Kong, Maria Florencia Angelo, Ori J Lieberman, Eugene V Mosharov, Etienne Herzog, David Sulzer, Peter A Sim. Subcellular and regional localization of mRNA translation in midbrain dopamine neurons. Cell reports. vol 38. issue 2. 2022-01-12. PMID:35021090. |
midbrain dopaminergic (mda) neurons exhibit extensive dendritic and axonal arborizations, but local protein synthesis is not characterized in these neurons. |
2022-01-12 |
2023-08-13 |
Not clear |
| Fubo Cheng, Wenxu Zheng, Peter Antony Barbuti, Paola Bonsi, Change Liu, Nicolas Casadei, Giulia Ponterio, Maria Meringolo, Jakob Admard, Claire Marie Dording, Libo Yu-Taeger, Huu Phuc Nguyen, Kathrin Grundmann-Hauser, Thomas Ott, Henry Houlden, Antonio Pisani, Rejko Krüger, Olaf Ries. DYT6 mutated THAP1 is a cell type dependent regulator of the SP1 family. Brain : a journal of neurology. 2022-01-11. PMID:35015830. |
in this study we used epigenetic and transcriptomic approaches combined with multiple model systems (thap1 patients' frontal cortex, thap1 patients' ipscs derived midbrain dopaminergic neurons, thap1 heterozygous knock-out rat model, and thap1 heterozygous knock-out sh-sy5y cell lines) to uncover a novel function of thap1 and the potential pathogenesis of dyt6 dystonia. |
2022-01-11 |
2023-08-13 |
mouse |
| Fubo Cheng, Wenxu Zheng, Peter Antony Barbuti, Paola Bonsi, Change Liu, Nicolas Casadei, Giulia Ponterio, Maria Meringolo, Jakob Admard, Claire Marie Dording, Libo Yu-Taeger, Huu Phuc Nguyen, Kathrin Grundmann-Hauser, Thomas Ott, Henry Houlden, Antonio Pisani, Rejko Krüger, Olaf Ries. DYT6 mutated THAP1 is a cell type dependent regulator of the SP1 family. Brain : a journal of neurology. 2022-01-11. PMID:35015830. |
comparing global differentially expressed genes detected in thap1 patients' ipscs derived midbrain dopaminergic neurons and thap1 heterozygous knock-out rat striatum, we observed many common dysregulated genes and 61 of them are involved in dystonic syndromes related pathways, like synaptic transmission, nervous system development, and locomotor behavior. |
2022-01-11 |
2023-08-13 |
mouse |