| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ceriel H J Asbreuk, Christina F Vogelaar, Anita Hellemons, Marten P Smidt, J Peter H Burbac. CNS expression pattern of Lmx1b and coexpression with ptx genes suggest functional cooperativity in the development of forebrain motor control systems. Molecular and cellular neurosciences. vol 21. issue 3. 2003-03-31. PMID:12498783. |
noteworthy, the lmx1b expression domain is shared by ptx2 in posterior hypothalamic regions and by ptx3 in the dopaminergic neurons of the ventral midbrain. |
2003-03-31 |
2023-08-12 |
Not clear |
| John Y Lin, Ratna Dubey, Greg D Funk, Janusz Lipsk. Receptor subtype-specific modulation by dopamine of glutamatergic responses in striatal medium spiny neurons. Brain research. vol 959. issue 2. 2003-03-28. PMID:12493613. |
the output of gabaergic medium-sized spiny neurons in the dorsal striatum is controlled in part by glutamatergic input from the neocortex and the thalamus, and dopaminergic input from ventral midbrain. |
2003-03-28 |
2023-08-12 |
rat |
| Sangmi Chung, Kai-C Sonntag, Therese Andersson, Lars M Bjorklund, Jae-Joon Park, Dong-Wook Kim, Un Jung Kang, Ole Isacson, Kwang-Soo Ki. Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons. The European journal of neuroscience. vol 16. issue 10. 2003-03-05. PMID:12453046. |
nurr1 is a transcription factor critical for the development of midbrain dopaminergic (da) neurons. |
2003-03-05 |
2023-08-12 |
mouse |
| Claudia Kappen, Paul J Yaworsk. Mutation of a putative nuclear receptor binding site abolishes activity of the nestin midbrain enhancer. Biochimica et biophysica acta. vol 1625. issue 1. 2003-03-05. PMID:12527431. |
the ventral midbrain is the prominent source of dopaminergic neurons, which are affected in parkinson's disease. |
2003-03-05 |
2023-08-12 |
mouse |
| Hardy J Rideout, Paula Dietrich, Magali Savalle, William T Dauer, Leonidas Stefani. Regulation of alpha-synuclein by bFGF in cultured ventral midbrain dopaminergic neurons. Journal of neurochemistry. vol 84. issue 4. 2003-03-05. PMID:12562524. |
regulation of alpha-synuclein by bfgf in cultured ventral midbrain dopaminergic neurons. |
2003-03-05 |
2023-08-12 |
rat |
| Hardy J Rideout, Paula Dietrich, Magali Savalle, William T Dauer, Leonidas Stefani. Regulation of alpha-synuclein by bFGF in cultured ventral midbrain dopaminergic neurons. Journal of neurochemistry. vol 84. issue 4. 2003-03-05. PMID:12562524. |
e18 rat cortical neurons and dopaminergic neurons of e14 rat ventral midbrain showed an induction of alpha-synuclein protein levels with maturation in culture. |
2003-03-05 |
2023-08-12 |
rat |
| Hardy J Rideout, Paula Dietrich, Magali Savalle, William T Dauer, Leonidas Stefani. Regulation of alpha-synuclein by bFGF in cultured ventral midbrain dopaminergic neurons. Journal of neurochemistry. vol 84. issue 4. 2003-03-05. PMID:12562524. |
we conclude that bfgf promotes alpha-synuclein expression in cultured ventral midbrain dopaminergic neurons through a direct transcriptional effect. |
2003-03-05 |
2023-08-12 |
rat |
| Hardy J Rideout, Paula Dietrich, Magali Savalle, William T Dauer, Leonidas Stefani. Regulation of alpha-synuclein by bFGF in cultured ventral midbrain dopaminergic neurons. Journal of neurochemistry. vol 84. issue 4. 2003-03-05. PMID:12562524. |
these results suggest that distinct growth factors may thus mediate plasticity responses or influence disease states in ventral midbrain dopaminergic neurons. |
2003-03-05 |
2023-08-12 |
rat |
| V P Chekhonin, S V Lebedev, T B Dmitrieva, V P Baklaushev, E A Savchenko, I P Lazarenko, O I Gurina, V V Belopaso. [Criteria of efficiency of transplantation of embryonic nervous tissue preparations in rats with 6-OHDA-impaired dopaminergic nigrostriatal system]. Patologicheskaia fiziologiia i eksperimental'naia terapiia. issue 3. 2003-02-24. PMID:12462177. |
effectiveness of transplantation of cells from embryonal nervous tissue of the ventral mesencephalon (vm ent) and striatum (str ent) by apomorphin-induced motor asymmetry (apo-test), consolidation of the transplant (the degree of glyal reaction and amount of dopaminergic neurons) and blood serum levels of gfap was studied for 3 months in wistar rats with 6-ohda-impaired dopaminergic nigrostriatal system. |
2003-02-24 |
2023-08-12 |
rat |
| J N Joyce, H L Ryoo, T B Beach, J N Caviness, Mark Stacy, E V Gurevich, Mark Reiser, C H Adle. Loss of response to levodopa in Parkinson's disease and co-occurrence with dementia: role of D3 and not D2 receptors. Brain research. vol 955. issue 1-2. 2003-01-31. PMID:12419530. |
all pd cases (+/-dementia), regardless of response to dopaminergic drugs, exhibited a significant and similar degree and pattern of loss of tyrosine hydroxylase immunocytochemistry and da transporter binding in striatum, and loss of tyrosine hydroxylase-immunoreactive neurons and brain-derived neurotrophic-immunoreactive neurons from the ventral midbrain. |
2003-01-31 |
2023-08-12 |
Not clear |
| Janusz Lipski, John Lin, Min-Yau Teo, Michiel van Wy. The network vs. pacemaker theory of the activity of RVL presympathetic neurons--a comparison with another putative pacemaker system. Autonomic neuroscience : basic & clinical. vol 98. issue 1-2. 2003-01-27. PMID:12144048. |
interestingly, there is an analogy between the contrasting views on the role of the network vs. pacemakers in the generation of sympathetic tone, and a debate regarding the relative role of such mechanisms in other types of 'spontaneously' active neurons, including dopaminergic neurons of the substantia nigra/ventral tegmental area (in ventral mesencephalon). |
2003-01-27 |
2023-08-12 |
rat |
| Rebecca Elliott, Jana L Newman, Olivia A Longe, J F William Deaki. Differential response patterns in the striatum and orbitofrontal cortex to financial reward in humans: a parametric functional magnetic resonance imaging study. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 1. 2003-01-27. PMID:12514228. |
amygdala, striatum, and dopaminergic midbrain responded to the presence of rewards, regardless of value. |
2003-01-27 |
2023-08-12 |
human |
| Kenji Sakai, Eisuke Furui, Kiyonobu Komai, Masako Notoya, Masahito Yamad. [Acquired stuttering as an early symptom in a patient with progressive supranuclear palsy]. Rinsho shinkeigaku = Clinical neurology. vol 42. issue 2. 2003-01-10. PMID:12424973. |
these symptoms may be caused by the disturbance of dopaminergic system from midbrain to limbic system and frontal cortex as reported in psp. |
2003-01-10 |
2023-08-12 |
Not clear |
| Myung Ae Lee, Hye-Souk Lee, Hyun Soo Lee, Kyung G Cho, Byung Kwan Jin, Seonghyang Sohn, Young Seek Lee, Hiroshi Ichinose, Seung Up Ki. Overexpression of midbrain-specific transcription factor Nurr1 modifies susceptibility of mouse neural stem cells to neurotoxins. Neuroscience letters. vol 333. issue 1. 2002-12-26. PMID:12401563. |
nurr1 is a member of the nuclear receptor superfamily of transcription factors that is highly expressed in midbrain dopaminergic (da) neurons, the cells primarily lost in human parkinson's disease (pd), and in nurr1-null mice selective agenesis of midbrain da neurons is found. |
2002-12-26 |
2023-08-12 |
mouse |
| David G Le Couteur, Michael Muller, Maria C Yang, George D Mellick, Allan J McLea. Age-environment and gene-environment interactions in the pathogenesis of Parkinson's disease. Reviews on environmental health. vol 17. issue 1. 2002-12-24. PMID:12088093. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by dopaminergic cell death and deposition of lewy bodies within the substantia nigra of the midbrain. |
2002-12-24 |
2023-08-12 |
Not clear |
| Wenzhen Duan, Xiaoxiang Zhu, Bruce Ladenheim, Qian-sheng Yu, Zhihong Guo, Jon Oyler, Roy G Cutler, Jean Lud Cadet, Nigel H Greig, Mark P Mattso. p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism. Annals of neurology. vol 52. issue 5. 2002-12-03. PMID:12402257. |
we report that two novel synthetic inhibitors of the tumor suppressor protein p53, pifithrin-alpha (pft-alpha) and z-1-117, are highly effective in protecting midbrain dopaminergic neurons and improving behavioral outcome in a mouse model of parkinson's disease. |
2002-12-03 |
2023-08-12 |
mouse |
| Cecilia Flores, Jane Stewart, Natalina Salmaso, Ying Zhang, Patricia Boks. Astrocytic basic fibroblast growth factor expression in dopaminergic regions after perinatal anoxia. Biological psychiatry. vol 52. issue 4. 2002-11-22. PMID:12208644. |
because astrocytic basic fibroblast growth factor (bfgf) activity in the midbrain dopaminergic cell body region is required for the development of enduring changes in dopaminergic function induced by stimulant drugs, we investigated the effects of intrauterine anoxia on astrocytic bfgf expression in dopaminergic regions at 2 weeks of age and after a stress manipulation in adults. |
2002-11-22 |
2023-08-12 |
Not clear |
| Scott E Counts, Susan O McGuire, Caryl E Sortwell, Jacqueline N Crawley, Timothy J Collier, Elliott J Mufso. Galanin inhibits tyrosine hydroxylase expression in midbrain dopaminergic neurons. Journal of neurochemistry. vol 83. issue 2. 2002-11-20. PMID:12423254. |
galanin inhibits tyrosine hydroxylase expression in midbrain dopaminergic neurons. |
2002-11-20 |
2023-08-12 |
rat |
| Scott E Counts, Susan O McGuire, Caryl E Sortwell, Jacqueline N Crawley, Timothy J Collier, Elliott J Mufso. Galanin inhibits tyrosine hydroxylase expression in midbrain dopaminergic neurons. Journal of neurochemistry. vol 83. issue 2. 2002-11-20. PMID:12423254. |
gal inhibition of midbrain da activity may involve a galr1- mediated reduction of th in midbrain dopaminergic neurons. |
2002-11-20 |
2023-08-12 |
rat |
| Susanne Petri, Klaus Krampfl, Reinhard Dengler, Johannes Bufler, Adolf Weindl, Thomas Arzberge. Human GABA A receptors on dopaminergic neurons in the pars compacta of the substantia nigra. The Journal of comparative neurology. vol 452. issue 4. 2002-11-15. PMID:12355418. |
we used a combination of in situ hybridization histochemistry (ish) and immunohistochemistry (ihc) on sections of human postmortem mesencephalon to investigate the expression of gaba(a) receptor subunit messenger rnas (mrnas) and of the receptor protein in dopaminergic sn cells. |
2002-11-15 |
2023-08-12 |
human |