| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Horst H Simon, Lavinia Bhatt, Daniel Gherbassi, Paola Sgad\\xc3\\xb3, Lavinia Alber\\xc3\\xa. Midbrain dopaminergic neurons: determination of their developmental fate by transcription factors. Annals of the New York Academy of Sciences. vol 991. 2003-08-04. PMID:12846972.' |
in animals deficient in the two genes, the midbrain dopaminergic neurons are generated, but then fail to differentiate and disappear very rapidly. |
2003-08-04 |
2023-08-12 |
human |
| Timothy J Collier, Kathy Steece-Collier, Susan McGuire, Caryl E Sortwel. Cellular models to study dopaminergic injury responses. Annals of the New York Academy of Sciences. vol 991. 2003-08-04. PMID:12846983. |
the study of immature midbrain dopamine (da) neurons and dopaminergic cell lines in culture provides an opportunity to analyze mechanisms of cell death and avenues of potential intervention relevant to parkinson's disease (pd) in a controlled environment. |
2003-08-04 |
2023-08-12 |
Not clear |
| Mark W Barnett, Carolyn E Fisher, Georgia Perona-Wright, Jamie A Davie. Signalling by glial cell line-derived neurotrophic factor (GDNF) requires heparan sulphate glycosaminoglycan. Journal of cell science. vol 115. issue Pt 23. 2003-07-29. PMID:12414995. |
glial cell line-derived neurotrophic factor, gdnf, is vital to the development and maintenance of neural tissues; it promotes survival of sympathetic, parasympathetic and spinal motor neurons during development, protects midbrain dopaminergic neurons from apoptosis well enough to be a promising treatment for parkinson's disease, and controls renal and testicular development. |
2003-07-29 |
2023-08-12 |
Not clear |
| T Futamura, A Kakita, M Tohmi, H Sotoyama, H Takahashi, H Naw. Neonatal perturbation of neurotrophic signaling results in abnormal sensorimotor gating and social interaction in adults: implication for epidermal growth factor in cognitive development. Molecular psychiatry. vol 8. issue 1. 2003-07-29. PMID:12556905. |
epidermal growth factor (egf) and its structurally related proteins are implicated in the developmental regulation of various brain neurons, including midbrain dopaminergic neurons. |
2003-07-29 |
2023-08-12 |
rat |
| Harald Prüss, Mareike Wenzel, Dirk Eulitz, Achim Thomzig, Andreas Karschin, Rüdiger W Ve. Kir2 potassium channels in rat striatum are strategically localized to control basal ganglia function. Brain research. Molecular brain research. vol 110. issue 2. 2003-07-28. PMID:12591157. |
parkinson's disease is the most frequent movement disorder caused by loss of dopaminergic neurons in the midbrain. |
2003-07-28 |
2023-08-12 |
rat |
| Tae Eun Kim, Hack Sup Lee, Yong Beom Lee, Seung Hwan Hong, Young Seek Lee, Hiroshi Ichinose, Seung U Kim, Myung Ae Le. Sonic hedgehog and FGF8 collaborate to induce dopaminergic phenotypes in the Nurr1-overexpressing neural stem cell. Biochemical and biophysical research communications. vol 305. issue 4. 2003-07-24. PMID:12767935. |
in the present study, coordinated induction of midbrain dopaminergic phenotypes in an immortalized multipotent neural stem cell line can be achieved by both overexpression of nuclear receptor nurr1, and fibroblast growth factor-8 (fgf-8), and sonic hedgehog (shh) signals. |
2003-07-24 |
2023-08-12 |
mouse |
| Shigeyuki Nishikawa, Satoshi Goto, Kazumichi Yamada, Tadashi Hamasaki, Yukitaka Ushi. Lack of Reelin causes malpositioning of nigral dopaminergic neurons: evidence from comparison of normal and Reln(rl) mutant mice. The Journal of comparative neurology. vol 461. issue 2. 2003-07-16. PMID:12724835. |
results from the normal mice show that, at the midembryonic stage, reelin identified with cr-50 is highly concentrated in the ventral mesencephalon, where nigral dopaminergic neurons are in progress to migrate laterally to their eventual position of the adult brain. |
2003-07-16 |
2023-08-12 |
mouse |
| Pepijn van den Munckhof, Kelvin C Luk, Line Ste-Marie, Jane Montgomery, Pierre J Blanchet, Abbas F Sadikot, Jacques Droui. Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons. Development (Cambridge, England). vol 130. issue 11. 2003-07-11. PMID:12702666. |
pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons. |
2003-07-11 |
2023-08-12 |
mouse |
| Ju-Yeon Kim, Hyun Chul Koh, Ji-Yeon Lee, Mi-Yoon Chang, You-Chan Kim, Hee-Yong Chung, Hyeon Son, Yong-Sung Lee, Lorenz Studer, Ron McKay, Sang-Hun Le. Dopaminergic neuronal differentiation from rat embryonic neural precursors by Nurr1 overexpression. Journal of neurochemistry. vol 85. issue 6. 2003-07-10. PMID:12787064. |
here we demonstrate the ability of nurr1, a nuclear orphan receptor essential for midbrain da neuron development in vivo, to induce dopaminergic differentiation in naïve cns precursors in vitro. |
2003-07-10 |
2023-08-12 |
rat |
| Paul N Deslandes, David M Pache, Paul Buckland, Robert D E Sewel. Morphine, cocaine and antidepressant induced motivational activity and midbrain dopaminergic neurotransmission. European journal of pharmacology. vol 453. issue 2-3. 2003-07-08. PMID:12398908. |
morphine, cocaine and antidepressant induced motivational activity and midbrain dopaminergic neurotransmission. |
2003-07-08 |
2023-08-12 |
human |
| Claude Brodski, Daniela M Vogt Weisenhorn, Massimo Signore, Inge Sillaber, Matthias Oesterheld, Vania Broccoli, Dario Acampora, Antonio Simeone, Wolfgang Wurs. Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 10. 2003-06-25. PMID:12764108. |
midbrain dopaminergic and hindbrain serotonergic neurons play an important role in the modulation of behavior and are involved in a series of neuropsychiatric disorders. |
2003-06-25 |
2023-08-12 |
mouse |
| Claude Brodski, Daniela M Vogt Weisenhorn, Massimo Signore, Inge Sillaber, Matthias Oesterheld, Vania Broccoli, Dario Acampora, Antonio Simeone, Wolfgang Wurs. Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 10. 2003-06-25. PMID:12764108. |
during embryogenesis, midbrain dopaminergic neurons are specified rostral to the midbrain-hindbrain organizer (mho), and hindbrain serotonergic neurons are specified caudal to it. |
2003-06-25 |
2023-08-12 |
mouse |
| Claude Brodski, Daniela M Vogt Weisenhorn, Massimo Signore, Inge Sillaber, Matthias Oesterheld, Vania Broccoli, Dario Acampora, Antonio Simeone, Wolfgang Wurs. Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 10. 2003-06-25. PMID:12764108. |
we report that in transgenic mice in which otx2 and accordingly the mho are shifted caudally, the midbrain dopaminergic neuronal population expands to the ectopically positioned mho and is enlarged. |
2003-06-25 |
2023-08-12 |
mouse |
| Claude Brodski, Daniela M Vogt Weisenhorn, Massimo Signore, Inge Sillaber, Matthias Oesterheld, Vania Broccoli, Dario Acampora, Antonio Simeone, Wolfgang Wurs. Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 10. 2003-06-25. PMID:12764108. |
together, we provide evidence that the position of the mho determines the location and size of midbrain dopaminergic and hindbrain serotonergic cell populations in vivo. |
2003-06-25 |
2023-08-12 |
mouse |
| M Matsumoto, C Shannon Weickert, M Akil, B K Lipska, T M Hyde, M M Herman, J E Kleinman, D R Weinberge. Catechol O-methyltransferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function. Neuroscience. vol 116. issue 1. 2003-06-24. PMID:12535946. |
in the midbrain, comt mrna was detected in dopaminergic neurons in both species, albeit at low levels. |
2003-06-24 |
2023-08-12 |
human |
| Xi-Bin Liang, Xian-Yu Liu, Feng-Qiao Li, Yong Luo, Jun Lu, Wang-Ming Zhang, Xiao-Min Wang, Ji-Sheng Ha. Long-term high-frequency electro-acupuncture stimulation prevents neuronal degeneration and up-regulates BDNF mRNA in the substantia nigra and ventral tegmental area following medial forebrain bundle axotomy. Brain research. Molecular brain research. vol 108. issue 1-2. 2003-06-16. PMID:12480178. |
after 24 sessions of ea stimulation (28 days after mfb transection), dopaminergic neurons in the ventral midbrain were examined by immunohistochemical staining, and brain-derived neurotrophic factor (bdnf) mrna levels in ventral midbrain were measured by in situ hybridization. |
2003-06-16 |
2023-08-12 |
rat |
| Xi-Bin Liang, Xian-Yu Liu, Feng-Qiao Li, Yong Luo, Jun Lu, Wang-Ming Zhang, Xiao-Min Wang, Ji-Sheng Ha. Long-term high-frequency electro-acupuncture stimulation prevents neuronal degeneration and up-regulates BDNF mRNA in the substantia nigra and ventral tegmental area following medial forebrain bundle axotomy. Brain research. Molecular brain research. vol 108. issue 1-2. 2003-06-16. PMID:12480178. |
our results suggest that long-term high-frequency ea is effective in halting the degeneration of dopaminergic neurons in the sn and up-regulating the levels of bdnf mrna in the subfields of the ventral midbrain. |
2003-06-16 |
2023-08-12 |
rat |
| R Geracitano, E Paolucci, S Prisco, E Guatteo, C Zona, P Longone, M Ammassari-Teule, G Bernardi, N Berretta, N B Mercur. Altered long-term corticostriatal synaptic plasticity in transgenic mice overexpressing human CU/ZN superoxide dismutase (GLY(93)-->ALA) mutation. Neuroscience. vol 118. issue 2. 2003-06-16. PMID:12699776. |
apart from the extensive loss of motor neurons, degeneration of midbrain dopaminergic cells has been described in both familial and sporadic forms of amyotrophic lateral sclerosis (als). |
2003-06-16 |
2023-08-12 |
mouse |
| I A Moroz, H Rajabi, D Rodaros, J Stewar. Effects of sex and hormonal status on astrocytic basic fibroblast growth factor-2 and tyrosine hydroxylase immunoreactivity after medial forebrain bundle 6-hydroxydopamine lesions of the midbrain dopamine neurons. Neuroscience. vol 118. issue 2. 2003-06-16. PMID:12699782. |
we examined astrocytic basic fibroblast growth factor immunoreactivity (fgf-2-ir) and tyrosine hydroxylase immunoreactivity (th-ir) in the cell-body region of midbrain dopaminergic neurons after unilateral infusions of the neurotoxin 6-hydroxydopamine into the medial forebrain bundle in male and female rats. |
2003-06-16 |
2023-08-12 |
rat |
| Shigeki Ohmachi, Tadahisa Mikami, Morichika Konishi, Ayumi Miyake, Nobuyuki Ito. Preferential neurotrophic activity of fibroblast growth factor-20 for dopaminergic neurons through fibroblast growth factor receptor-1c. Journal of neuroscience research. vol 72. issue 4. 2003-06-06. PMID:12704805. |
fibroblast growth factor (fgf)-20 preferentially expressed in the substantia nigra pars compacta (snpc) of the rat brain significantly enhanced the survival of midbrain dopaminergic neurons. |
2003-06-06 |
2023-08-12 |
rat |