| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Keiko Shimizu, Kazuo Matsubara, Ko-ichi Ohtaki, Hiroshi Shion. Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture. Neuroscience research. vol 46. issue 4. 2003-09-12. PMID:12871774. |
paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture. |
2003-09-12 |
2023-08-12 |
rat |
| Cristina Bäckman, Zhi Bing You, Thomas Perlmann, Barry J Hoffe. Elevated locomotor activity without altered striatal dopamine contents in Nurr1 heterozygous mice after acute exposure to methamphetamine. Behavioural brain research. vol 143. issue 1. 2003-09-09. PMID:12842300. |
gene targeting experiments, in which both alleles of the nurr1 gene were deleted, have shown that this molecule plays an essential role in the development of midbrain dopaminergic neurons, as shown by the loss of dopaminergic markers and the neurotransmitter dopamine (da) in the ventral mesencephalon of nurr1 null mutant mice. |
2003-09-09 |
2023-08-12 |
mouse |
| Dong-Youn Hwang, Paul Ardayfio, Un Jung Kang, Elena V Semina, Kwang-Soo Ki. Selective loss of dopaminergic neurons in the substantia nigra of Pitx3-deficient aphakia mice. Brain research. Molecular brain research. vol 114. issue 2. 2003-09-05. PMID:12829322. |
dopaminergic (da) neurons in the ventral midbrain nuclei, substantia nigra pars compacta (snc, a9) and ventral tegmental area (vta, a10), play important roles in the control of movement, emotion, cognition, and reward related behavior. |
2003-09-05 |
2023-08-12 |
mouse |
| Jun Wang, Guiquan Chen, Bai Lu, Chien-ping W. GDNF acutely potentiates Ca2+ channels and excitatory synaptic transmission in midbrain dopaminergic neurons. Neuro-Signals. vol 12. issue 2. 2003-09-04. PMID:12876402. |
gdnf acutely potentiates ca2+ channels and excitatory synaptic transmission in midbrain dopaminergic neurons. |
2003-09-04 |
2023-08-12 |
Not clear |
| Jun Wang, Guiquan Chen, Bai Lu, Chien-ping W. GDNF acutely potentiates Ca2+ channels and excitatory synaptic transmission in midbrain dopaminergic neurons. Neuro-Signals. vol 12. issue 2. 2003-09-04. PMID:12876402. |
glial cell line-derived neurotrophic factor (gdnf) is best known for its long-term survival effect on dopaminergic neurons in the ventral midbrain. |
2003-09-04 |
2023-08-12 |
Not clear |
| Jun Wang, Guiquan Chen, Bai Lu, Chien-ping W. GDNF acutely potentiates Ca2+ channels and excitatory synaptic transmission in midbrain dopaminergic neurons. Neuro-Signals. vol 12. issue 2. 2003-09-04. PMID:12876402. |
these results reveal, for the first time, an acute effect of gdnf on synaptic transmission and its potential mechanisms, and suggest that an important function of gdnf for midbrain dopaminergic neurons is the acute modulation of transmission and ion channels. |
2003-09-04 |
2023-08-12 |
Not clear |
| Hong Gao, Jianjun Wang, Wei Zhang, Yuhui Jiang, Dongbin Niu, Xiaomin Wan. [Recombinant adenovirus carrying glial cell line-derived neurotrophic factor gene protect midbrain dopaminergic neurons in mice]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. vol 35. issue 3. 2003-08-26. PMID:12914240. |
[recombinant adenovirus carrying glial cell line-derived neurotrophic factor gene protect midbrain dopaminergic neurons in mice]. |
2003-08-26 |
2023-08-12 |
mouse |
| Hong Gao, Jianjun Wang, Wei Zhang, Yuhui Jiang, Dongbin Niu, Xiaomin Wan. [Recombinant adenovirus carrying glial cell line-derived neurotrophic factor gene protect midbrain dopaminergic neurons in mice]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. vol 35. issue 3. 2003-08-26. PMID:12914240. |
to observe the protective effects of recombinant adenovirus expressing glial cell line-derived neurotrophic factor (ad-rgdnf) on the midbrain dopaminergic neurons against mptp damage. |
2003-08-26 |
2023-08-12 |
mouse |
| Long Ding, David J Perkel, Michael A Farrie. Presynaptic depression of glutamatergic synaptic transmission by D1-like dopamine receptor activation in the avian basal ganglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 14. 2003-08-07. PMID:12853427. |
it also receives dense dopaminergic innervation from the midbrain. |
2003-08-07 |
2023-08-12 |
Not clear |
| Lilla M Farkas, Nicole Dünker, Eleni Roussa, Klaus Unsicker, Kerstin Krieglstei. Transforming growth factor-beta(s) are essential for the development of midbrain dopaminergic neurons in vitro and in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832542. |
transforming growth factor-beta(s) are essential for the development of midbrain dopaminergic neurons in vitro and in vivo. |
2003-08-05 |
2023-08-12 |
rat |
| Lilla M Farkas, Nicole Dünker, Eleni Roussa, Klaus Unsicker, Kerstin Krieglstei. Transforming growth factor-beta(s) are essential for the development of midbrain dopaminergic neurons in vitro and in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832542. |
development of midbrain dopaminergic neurons is known to depend on inductive signals derived from the ventral midline, including sonic hedgehog (shh) as one of the identified molecules. |
2003-08-05 |
2023-08-12 |
rat |
| Lilla M Farkas, Nicole Dünker, Eleni Roussa, Klaus Unsicker, Kerstin Krieglstei. Transforming growth factor-beta(s) are essential for the development of midbrain dopaminergic neurons in vitro and in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832542. |
here we show that in addition to shh, transforming growth factor (tgf)-beta is required for both induction and survival of ventrally located midbrain dopaminergic neurons. |
2003-08-05 |
2023-08-12 |
rat |
| Lilla M Farkas, Nicole Dünker, Eleni Roussa, Klaus Unsicker, Kerstin Krieglstei. Transforming growth factor-beta(s) are essential for the development of midbrain dopaminergic neurons in vitro and in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832542. |
like shh, tgf-beta is expressed in early embryonic structures such as notochord and floor plate, as well as in the area where midbrain dopaminergic neurons are developing. |
2003-08-05 |
2023-08-12 |
rat |
| Lilla M Farkas, Nicole Dünker, Eleni Roussa, Klaus Unsicker, Kerstin Krieglstei. Transforming growth factor-beta(s) are essential for the development of midbrain dopaminergic neurons in vitro and in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832542. |
treatment of cells dissociated from the rat embryonic day (e) 12 midbrain floor with tgf-beta significantly increases the number of tyrosine hydroxylase (th)-positive dopaminergic neurons within 24 hr. |
2003-08-05 |
2023-08-12 |
rat |
| Lilla M Farkas, Nicole Dünker, Eleni Roussa, Klaus Unsicker, Kerstin Krieglstei. Transforming growth factor-beta(s) are essential for the development of midbrain dopaminergic neurons in vitro and in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832542. |
furthermore, neutralization of tgf-beta in vivo during chick e2-7 but not e4-7 resulted in a significant reduction in th-positive neurons in the ventral midbrain floor but not in the locus coeruleus or diencephalon, which suggests that the tgf-beta is required for the induction of mesencephalic dopaminergic neurons with a critical time period at e2/e3. |
2003-08-05 |
2023-08-12 |
rat |
| Lilla M Farkas, Nicole Dünker, Eleni Roussa, Klaus Unsicker, Kerstin Krieglstei. Transforming growth factor-beta(s) are essential for the development of midbrain dopaminergic neurons in vitro and in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832542. |
furthermore, neutralization of tgf-beta between e6 and 10, a time period during maturation of mesencephalic dopaminergic neurons when no further inductive cues are required, also resulted in a significant loss of dopaminergic neurons, suggesting that tgf-beta is required for the promotion of survival of ventral midbrain dopaminergic neurons as well. |
2003-08-05 |
2023-08-12 |
rat |
| Lilla M Farkas, Nicole Dünker, Eleni Roussa, Klaus Unsicker, Kerstin Krieglstei. Transforming growth factor-beta(s) are essential for the development of midbrain dopaminergic neurons in vitro and in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832542. |
together, our results identify tgf-beta as an essential mediator for the induction and maintenance of midbrain dopaminergic neurons. |
2003-08-05 |
2023-08-12 |
rat |
| b' Horst H Simon, Lavinia Bhatt, Daniel Gherbassi, Paola Sgad\\xc3\\xb3, Lavinia Alber\\xc3\\xa. Midbrain dopaminergic neurons: determination of their developmental fate by transcription factors. Annals of the New York Academy of Sciences. vol 991. 2003-08-04. PMID:12846972.' |
midbrain dopaminergic neurons: determination of their developmental fate by transcription factors. |
2003-08-04 |
2023-08-12 |
human |
| b' Horst H Simon, Lavinia Bhatt, Daniel Gherbassi, Paola Sgad\\xc3\\xb3, Lavinia Alber\\xc3\\xa. Midbrain dopaminergic neurons: determination of their developmental fate by transcription factors. Annals of the New York Academy of Sciences. vol 991. 2003-08-04. PMID:12846972.' |
midbrain dopaminergic neurons are the main source of dopamine in the mammalian central nervous system and are associated with one of the most prominent human neurological disorders, parkinson's disease. |
2003-08-04 |
2023-08-12 |
human |
| b' Horst H Simon, Lavinia Bhatt, Daniel Gherbassi, Paola Sgad\\xc3\\xb3, Lavinia Alber\\xc3\\xa. Midbrain dopaminergic neurons: determination of their developmental fate by transcription factors. Annals of the New York Academy of Sciences. vol 991. 2003-08-04. PMID:12846972.' |
this requirement is specific to the midbrain dopaminergic neurons, since other populations of the same neurotransmitter phenotype develop normally in absence of the gene. |
2003-08-04 |
2023-08-12 |
human |