| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lilla M Farkas, Nicole Dünker, Eleni Roussa, Klaus Unsicker, Kerstin Krieglstei. Transforming growth factor-beta(s) are essential for the development of midbrain dopaminergic neurons in vitro and in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832542. |
like shh, tgf-beta is expressed in early embryonic structures such as notochord and floor plate, as well as in the area where midbrain dopaminergic neurons are developing. |
2003-08-05 |
2023-08-12 |
rat |
| Lilla M Farkas, Nicole Dünker, Eleni Roussa, Klaus Unsicker, Kerstin Krieglstei. Transforming growth factor-beta(s) are essential for the development of midbrain dopaminergic neurons in vitro and in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832542. |
treatment of cells dissociated from the rat embryonic day (e) 12 midbrain floor with tgf-beta significantly increases the number of tyrosine hydroxylase (th)-positive dopaminergic neurons within 24 hr. |
2003-08-05 |
2023-08-12 |
rat |
| Lilla M Farkas, Nicole Dünker, Eleni Roussa, Klaus Unsicker, Kerstin Krieglstei. Transforming growth factor-beta(s) are essential for the development of midbrain dopaminergic neurons in vitro and in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832542. |
furthermore, neutralization of tgf-beta in vivo during chick e2-7 but not e4-7 resulted in a significant reduction in th-positive neurons in the ventral midbrain floor but not in the locus coeruleus or diencephalon, which suggests that the tgf-beta is required for the induction of mesencephalic dopaminergic neurons with a critical time period at e2/e3. |
2003-08-05 |
2023-08-12 |
rat |
| Lilla M Farkas, Nicole Dünker, Eleni Roussa, Klaus Unsicker, Kerstin Krieglstei. Transforming growth factor-beta(s) are essential for the development of midbrain dopaminergic neurons in vitro and in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832542. |
furthermore, neutralization of tgf-beta between e6 and 10, a time period during maturation of mesencephalic dopaminergic neurons when no further inductive cues are required, also resulted in a significant loss of dopaminergic neurons, suggesting that tgf-beta is required for the promotion of survival of ventral midbrain dopaminergic neurons as well. |
2003-08-05 |
2023-08-12 |
rat |
| Lilla M Farkas, Nicole Dünker, Eleni Roussa, Klaus Unsicker, Kerstin Krieglstei. Transforming growth factor-beta(s) are essential for the development of midbrain dopaminergic neurons in vitro and in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 12. 2003-08-05. PMID:12832542. |
together, our results identify tgf-beta as an essential mediator for the induction and maintenance of midbrain dopaminergic neurons. |
2003-08-05 |
2023-08-12 |
rat |
| b' Horst H Simon, Lavinia Bhatt, Daniel Gherbassi, Paola Sgad\\xc3\\xb3, Lavinia Alber\\xc3\\xa. Midbrain dopaminergic neurons: determination of their developmental fate by transcription factors. Annals of the New York Academy of Sciences. vol 991. 2003-08-04. PMID:12846972.' |
midbrain dopaminergic neurons: determination of their developmental fate by transcription factors. |
2003-08-04 |
2023-08-12 |
human |
| b' Horst H Simon, Lavinia Bhatt, Daniel Gherbassi, Paola Sgad\\xc3\\xb3, Lavinia Alber\\xc3\\xa. Midbrain dopaminergic neurons: determination of their developmental fate by transcription factors. Annals of the New York Academy of Sciences. vol 991. 2003-08-04. PMID:12846972.' |
midbrain dopaminergic neurons are the main source of dopamine in the mammalian central nervous system and are associated with one of the most prominent human neurological disorders, parkinson's disease. |
2003-08-04 |
2023-08-12 |
human |
| b' Horst H Simon, Lavinia Bhatt, Daniel Gherbassi, Paola Sgad\\xc3\\xb3, Lavinia Alber\\xc3\\xa. Midbrain dopaminergic neurons: determination of their developmental fate by transcription factors. Annals of the New York Academy of Sciences. vol 991. 2003-08-04. PMID:12846972.' |
this requirement is specific to the midbrain dopaminergic neurons, since other populations of the same neurotransmitter phenotype develop normally in absence of the gene. |
2003-08-04 |
2023-08-12 |
human |
| b' Horst H Simon, Lavinia Bhatt, Daniel Gherbassi, Paola Sgad\\xc3\\xb3, Lavinia Alber\\xc3\\xa. Midbrain dopaminergic neurons: determination of their developmental fate by transcription factors. Annals of the New York Academy of Sciences. vol 991. 2003-08-04. PMID:12846972.' |
in animals deficient in the two genes, the midbrain dopaminergic neurons are generated, but then fail to differentiate and disappear very rapidly. |
2003-08-04 |
2023-08-12 |
human |
| Timothy J Collier, Kathy Steece-Collier, Susan McGuire, Caryl E Sortwel. Cellular models to study dopaminergic injury responses. Annals of the New York Academy of Sciences. vol 991. 2003-08-04. PMID:12846983. |
the study of immature midbrain dopamine (da) neurons and dopaminergic cell lines in culture provides an opportunity to analyze mechanisms of cell death and avenues of potential intervention relevant to parkinson's disease (pd) in a controlled environment. |
2003-08-04 |
2023-08-12 |
Not clear |
| Mark W Barnett, Carolyn E Fisher, Georgia Perona-Wright, Jamie A Davie. Signalling by glial cell line-derived neurotrophic factor (GDNF) requires heparan sulphate glycosaminoglycan. Journal of cell science. vol 115. issue Pt 23. 2003-07-29. PMID:12414995. |
glial cell line-derived neurotrophic factor, gdnf, is vital to the development and maintenance of neural tissues; it promotes survival of sympathetic, parasympathetic and spinal motor neurons during development, protects midbrain dopaminergic neurons from apoptosis well enough to be a promising treatment for parkinson's disease, and controls renal and testicular development. |
2003-07-29 |
2023-08-12 |
Not clear |
| T Futamura, A Kakita, M Tohmi, H Sotoyama, H Takahashi, H Naw. Neonatal perturbation of neurotrophic signaling results in abnormal sensorimotor gating and social interaction in adults: implication for epidermal growth factor in cognitive development. Molecular psychiatry. vol 8. issue 1. 2003-07-29. PMID:12556905. |
epidermal growth factor (egf) and its structurally related proteins are implicated in the developmental regulation of various brain neurons, including midbrain dopaminergic neurons. |
2003-07-29 |
2023-08-12 |
rat |
| Harald Prüss, Mareike Wenzel, Dirk Eulitz, Achim Thomzig, Andreas Karschin, Rüdiger W Ve. Kir2 potassium channels in rat striatum are strategically localized to control basal ganglia function. Brain research. Molecular brain research. vol 110. issue 2. 2003-07-28. PMID:12591157. |
parkinson's disease is the most frequent movement disorder caused by loss of dopaminergic neurons in the midbrain. |
2003-07-28 |
2023-08-12 |
rat |
| Tae Eun Kim, Hack Sup Lee, Yong Beom Lee, Seung Hwan Hong, Young Seek Lee, Hiroshi Ichinose, Seung U Kim, Myung Ae Le. Sonic hedgehog and FGF8 collaborate to induce dopaminergic phenotypes in the Nurr1-overexpressing neural stem cell. Biochemical and biophysical research communications. vol 305. issue 4. 2003-07-24. PMID:12767935. |
in the present study, coordinated induction of midbrain dopaminergic phenotypes in an immortalized multipotent neural stem cell line can be achieved by both overexpression of nuclear receptor nurr1, and fibroblast growth factor-8 (fgf-8), and sonic hedgehog (shh) signals. |
2003-07-24 |
2023-08-12 |
mouse |
| Shigeyuki Nishikawa, Satoshi Goto, Kazumichi Yamada, Tadashi Hamasaki, Yukitaka Ushi. Lack of Reelin causes malpositioning of nigral dopaminergic neurons: evidence from comparison of normal and Reln(rl) mutant mice. The Journal of comparative neurology. vol 461. issue 2. 2003-07-16. PMID:12724835. |
results from the normal mice show that, at the midembryonic stage, reelin identified with cr-50 is highly concentrated in the ventral mesencephalon, where nigral dopaminergic neurons are in progress to migrate laterally to their eventual position of the adult brain. |
2003-07-16 |
2023-08-12 |
mouse |
| Pepijn van den Munckhof, Kelvin C Luk, Line Ste-Marie, Jane Montgomery, Pierre J Blanchet, Abbas F Sadikot, Jacques Droui. Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons. Development (Cambridge, England). vol 130. issue 11. 2003-07-11. PMID:12702666. |
pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons. |
2003-07-11 |
2023-08-12 |
mouse |
| Ju-Yeon Kim, Hyun Chul Koh, Ji-Yeon Lee, Mi-Yoon Chang, You-Chan Kim, Hee-Yong Chung, Hyeon Son, Yong-Sung Lee, Lorenz Studer, Ron McKay, Sang-Hun Le. Dopaminergic neuronal differentiation from rat embryonic neural precursors by Nurr1 overexpression. Journal of neurochemistry. vol 85. issue 6. 2003-07-10. PMID:12787064. |
here we demonstrate the ability of nurr1, a nuclear orphan receptor essential for midbrain da neuron development in vivo, to induce dopaminergic differentiation in naïve cns precursors in vitro. |
2003-07-10 |
2023-08-12 |
rat |
| Paul N Deslandes, David M Pache, Paul Buckland, Robert D E Sewel. Morphine, cocaine and antidepressant induced motivational activity and midbrain dopaminergic neurotransmission. European journal of pharmacology. vol 453. issue 2-3. 2003-07-08. PMID:12398908. |
morphine, cocaine and antidepressant induced motivational activity and midbrain dopaminergic neurotransmission. |
2003-07-08 |
2023-08-12 |
human |
| Claude Brodski, Daniela M Vogt Weisenhorn, Massimo Signore, Inge Sillaber, Matthias Oesterheld, Vania Broccoli, Dario Acampora, Antonio Simeone, Wolfgang Wurs. Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 10. 2003-06-25. PMID:12764108. |
midbrain dopaminergic and hindbrain serotonergic neurons play an important role in the modulation of behavior and are involved in a series of neuropsychiatric disorders. |
2003-06-25 |
2023-08-12 |
mouse |
| Claude Brodski, Daniela M Vogt Weisenhorn, Massimo Signore, Inge Sillaber, Matthias Oesterheld, Vania Broccoli, Dario Acampora, Antonio Simeone, Wolfgang Wurs. Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 10. 2003-06-25. PMID:12764108. |
during embryogenesis, midbrain dopaminergic neurons are specified rostral to the midbrain-hindbrain organizer (mho), and hindbrain serotonergic neurons are specified caudal to it. |
2003-06-25 |
2023-08-12 |
mouse |