| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shota Nakagawa, Yasuhiko Izumi, Yuki Takada-Takatori, Akinori Akaike, Toshiaki Kum. Increased CCL6 expression in astrocytes and neuronal protection from neuron-astrocyte interactions. Biochemical and biophysical research communications. vol 519. issue 4. 2020-06-22. PMID:31551151. |
furthermore, glutamate neurotoxicity in mixed neuron and astrocyte cultures was enhanced by pretreatments with the ccr1 antagonist. |
2020-06-22 |
2023-08-13 |
Not clear |
| Yatao Liu, Wei Liu, Xiaoqing Wang, Zhanhai Wan, Fengxian Gu, Li Ma, Yufang Len. Hippocampal astrocyte dysfunction contributes to etomidate-induced long-lasting synaptic inhibition. Biochemical and biophysical research communications. vol 519. issue 4. 2020-06-22. PMID:31558319. |
using microdialysis and magnetic-activated cell-sorting techniques, we found that astrocyte secretion of glutamate, d-serine, and atp, as well as astrocyte function, were depressed in the hippocampus following treatment with etomidate. |
2020-06-22 |
2023-08-13 |
mouse |
| Xin-Shang Wang, Jiao Yue, Li-Ning Hu, Zhen Tian, Kun Zhang, Le Yang, Hui-Nan Zhang, Yan-Yan Guo, Bin Feng, Hai-Yan Liu, Yu-Mei Wu, Ming-Gao Zhao, Shui-Bing Li. Activation of G protein-coupled receptor 30 protects neurons by regulating autophagy in astrocytes. Glia. vol 68. issue 1. 2020-06-04. PMID:31429156. |
in cultured primary astrocytes, glutamate exposure induced astrocyte proliferation and decreased astrocyte autophagy by activating mammalian target of rapamycin (mtor) and c-jun n-terminal kinase (jnk) and inhibiting p38 mitogen-activated protein kinase (mapk) pathway. |
2020-06-04 |
2023-08-13 |
mouse |
| Vicki L Maha. Neurointegrity and neurophysiology: astrocyte, glutamate, and carbon monoxide interactions. Medical gas research. vol 9. issue 1. 2020-05-22. PMID:30950417. |
neurointegrity and neurophysiology: astrocyte, glutamate, and carbon monoxide interactions. |
2020-05-22 |
2023-08-13 |
Not clear |
| Vicki L Maha. Neurointegrity and neurophysiology: astrocyte, glutamate, and carbon monoxide interactions. Medical gas research. vol 9. issue 1. 2020-05-22. PMID:30950417. |
the effect of carbon monoxide, an intrinsic central nervous system gasotransmitter, in the complex astrocyte homeostasis of glutamate may offer insights to normal brain development, protection, and its use as a neuromodulator and neurotherapeutic. |
2020-05-22 |
2023-08-13 |
Not clear |
| Vicki L Maha. Neurointegrity and neurophysiology: astrocyte, glutamate, and carbon monoxide interactions. Medical gas research. vol 9. issue 1. 2020-05-22. PMID:30950417. |
in this article, we will review the effects of carbon monoxide on astrocyte homeostasis of glutamate. |
2020-05-22 |
2023-08-13 |
Not clear |
| Chandani Limbad, Tal Ronnen Oron, Fatouma Alimirah, Albert R Davalos, Tara E Tracy, Li Gan, Pierre-Yves Desprez, Judith Campis. Astrocyte senescence promotes glutamate toxicity in cortical neurons. PloS one. vol 15. issue 1. 2020-04-17. PMID:31945125. |
astrocyte senescence promotes glutamate toxicity in cortical neurons. |
2020-04-17 |
2023-08-13 |
human |
| Daniel Ziemens, Franziska Oschmann, Niklas J Gerkau, Christine R Ros. Heterogeneity of Activity-Induced Sodium Transients between Astrocytes of the Mouse Hippocampus and Neocortex: Mechanisms and Consequences. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 14. 2020-04-03. PMID:30737311. |
activity-related sodium transients induced by glutamate uptake represent a special form of astrocyte excitability. |
2020-04-03 |
2023-08-13 |
mouse |
| Yi-Min Kuo, Pei-Chien Hsu, Chia-Chi Hung, Ya-Yu Hu, Yu-Jie Huang, Yu-Ling Gan, Chun-Hua Lin, Feng-Shiun Shie, Wen-Kuei Chang, Lung-Sen Kao, Mei-Yung Tsou, Yi-Hsuan Le. Soluble Epoxide Hydrolase Inhibition Attenuates Excitotoxicity Involving 14,15-Epoxyeicosatrienoic Acid-Mediated Astrocytic Survival and Plasticity to Preserve Glutamate Homeostasis. Molecular neurobiology. vol 56. issue 12. 2020-04-02. PMID:31257558. |
the anti-excitotoxic effects of 14,15-eet and auda were both blocked by the group 1 mglur5 antagonist 2-methyl-6-(phenylethynyl)pyridine (mpep), as were their protective effects against nmda-disrupted perineuronal astrocyte processes expressing glutamate transporter-1 (glt-1) and subsequent glutamate uptake. |
2020-04-02 |
2023-08-13 |
rat |
| Hamid M Abdolmaleky, Adam C Gower, Chen-Khuan Wong, Jiayi W Cox, Xiaoling Zhang, Arunthathi Thiagalingam, Rahim Shafa, Vadivelu Sivaraman, Jin-Rong Zhou, Sam Thiagalinga. Aberrant transcriptomes and DNA methylomes define pathways that drive pathogenesis and loss of brain laterality/asymmetry in schizophrenia and bipolar disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 180. issue 2. 2020-03-09. PMID:30468562. |
gene set enrichment analysis (gsea) demonstrated that bmp signaling and astrocyte and cerebral cortex development are significantly (fdr q < 0.25) coordinately upregulated in both scz and bd[+], and glutamate signaling and tgfβ signaling are significantly coordinately upregulated in scz. |
2020-03-09 |
2023-08-13 |
human |
| Peter Bedner, Christian Steinhäuse. TNFα-Driven Astrocyte Purinergic Signaling during Epileptogenesis. Trends in molecular medicine. vol 25. issue 2. 2020-03-02. PMID:30581052. |
glia 2018; https://doi.org/10.1002/glia.23519) revealed that pathologically elevated tumor necrosis factor α contributes to epileptogenesis, by boosting hyperexcitation through an autocrine mechanism involving purinergic signaling, astrocyte glutamate release, and modulation of neuronal transmitter release. |
2020-03-02 |
2023-08-13 |
Not clear |
| Sara Murru, Simon Hess, Esther Barth, Eva R Almajan, Désirée Schatton, Steffen Hermans, Susanne Brodesser, Thomas Langer, Peter Kloppenburg, Elena I Rugarl. Astrocyte-specific deletion of the mitochondrial m-AAA protease reveals glial contribution to neurodegeneration. Glia. vol 67. issue 8. 2020-02-10. PMID:30989755. |
we propose that astrocyte dysfunction amplifies both neuroinflammation and glutamate excitotoxicity in patients carrying mutations in afg3l2, leading to a vicious circle that contributes to neuronal death. |
2020-02-10 |
2023-08-13 |
mouse |
| Tomosuke Nakano, Toshiki Hasegawa, Dai Suzuki, Eishi Motomura, Motohiro Okad. Amantadine Combines Astroglial System Xc Biomolecules. vol 9. issue 5. 2020-01-31. PMID:31108896. |
the findings of microdialysis and cultured astrocyte studies suggest that a combination of sxc activation with inhibitions of ionotropic glutamate receptors contributes to neuroprotective, neuro-reparative and cognitive-enhancing activities that can mitigate several neuropsychiatric disorders. |
2020-01-31 |
2023-08-13 |
rat |
| Angela María Barrera-Sandoval, Edison Osorio, Gloria Patricia Cardona-Góme. Microglial-targeting induced by intranasal linalool during neurological protection postischemia. European journal of pharmacology. vol 857. 2020-01-14. PMID:31136761. |
in astrocyte and microglial cultures, linalool reduced pro-inflammation and had a potent effect on microglial cells, generating nrf2 subcellular redistribution under glutamate excitotoxicity conditions. |
2020-01-14 |
2023-08-13 |
rat |
| Darshpreet Kaur, Vivek Sharma, Rahul Deshmuk. Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer's disease. Inflammopharmacology. vol 27. issue 4. 2020-01-09. PMID:30874945. |
astrocyte dysfunctioning results in increased release of cytokines and inflammatory mediators, neurodegeneration, decreased glutamate uptake, loss of neuronal synapses, and ultimately cognitive deficits in ad. |
2020-01-09 |
2023-08-13 |
Not clear |
| B M Siemsen, C M Reichel, K C Leong, C Garcia-Keller, C D Gipson, S Spencer, J A McFaddin, K N Hooker, P W Kalivas, M D Scofiel. Effects of Methamphetamine Self-Administration and Extinction on Astrocyte Structure and Function in the Nucleus Accumbens Core. Neuroscience. vol 406. 2019-12-24. PMID:30926546. |
in order to test the impact of astrocyte activation and the induction of glial glutamate release within the nacore, we employed astrocyte-specific expression of designer receptors exclusively activated by designer drugs (dreadds). |
2019-12-24 |
2023-08-13 |
Not clear |
| Guoqiang Xing, Ming Ren, Ajay Verm. Divergent Induction of Branched-Chain Aminotransferases and Phosphorylation of Branched Chain Keto-Acid Dehydrogenase Is a Potential Mechanism Coupling Branched-Chain Keto-Acid-Mediated-Astrocyte Activation to Branched-Chain Amino Acid Depletion-Mediated Cognitive Deficit after Traumatic Brain Injury. Journal of neurotrauma. vol 35. issue 20. 2019-12-20. PMID:29764289. |
because increased pbckd would lead to increased bcka accumulation, bcka-mediated astrocyte activation, cell death, and cognitive dysfunction as found in maple syrup urine disease; thus, tbi may potentially induce cognitive deficit through diverting bcaa from glutamate production in neurons to bcka production in astrocytes through the pbckd-dependent mechanism. |
2019-12-20 |
2023-08-13 |
rat |
| Michelle Corkrum, Patrick E Rothwell, Mark J Thomas, Paulo Kofuji, Alfonso Araqu. Opioid-Mediated Astrocyte-Neuron Signaling in the Nucleus Accumbens. Cells. vol 8. issue 6. 2019-12-20. PMID:31207909. |
through the combination of calcium imaging and whole-cell patch clamp electrophysiology in brain slices, we have found that μ-opioid receptor activation in astrocytes elevates astrocyte cytoplasmic calcium and stimulates the release of the gliotransmitter glutamate, which evokes slow inward currents through the activation of neuronal n-methyl-d-aspartate (nmda) receptors. |
2019-12-20 |
2023-08-13 |
Not clear |
| Anthony D Umpierre, Peter J West, John A White, Karen S Wilco. Conditional Knock-out of mGluR5 from Astrocytes during Epilepsy Development Impairs High-Frequency Glutamate Uptake. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 4. 2019-12-16. PMID:30504280. |
astrocyte expression of metabotropic glutamate receptor 5 (mglur5) is consistently observed in resected tissue from patients with epilepsy and is equally prevalent in animal models of epilepsy. |
2019-12-16 |
2023-08-13 |
mouse |
| Anthony D Umpierre, Peter J West, John A White, Karen S Wilco. Conditional Knock-out of mGluR5 from Astrocytes during Epilepsy Development Impairs High-Frequency Glutamate Uptake. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 4. 2019-12-16. PMID:30504280. |
finally, we find that the selective and conditional knock-out of mglur5 signaling from astrocytes during epilepsy development slows the rate of glutamate clearance through astrocyte glutamate transporters under high-frequency stimulation conditions, a feature that suggests astrocyte mglur5 expression during epileptogenesis may recapitulate earlier developmental roles in regulating glutamate transporter function. |
2019-12-16 |
2023-08-13 |
mouse |