| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vedrana Montana, Daniel Flint, Helle S Waagepetersen, Arne Schousboe, Vladimir Parpur. Two Metabolic Fuels, Glucose and Lactate, Differentially Modulate Exocytotic Glutamate Release from Cultured Astrocytes. Neurochemical research. vol 46. issue 10. 2021-09-14. PMID:34057673. |
astrocytes synthesize glutamate de novo owing to the pyruvate entry to the citric/tricarboxylic acid cycle via pyruvate carboxylase, an astrocyte specific enzyme. |
2021-09-14 |
2023-08-13 |
Not clear |
| Zhong-Fang Shi, Qing Fang, Ye Chen, Li-Xin Xu, Min Wu, Mei Jia, Yi Lu, Xiao-Xuan Wang, Yu-Jiao Wang, Xu Yan, Li-Ping Dong, Fang Yua. Methylene blue ameliorates brain edema in rats with experimental ischemic stroke via inhibiting aquaporin 4 expression. Acta pharmacologica Sinica. vol 42. issue 3. 2021-09-09. PMID:32665706. |
in a cell swelling model established in cultured rat astrocyte exposed to glutamate (1 mm), we consistently found that mb (10 μm) attenuated cell swelling, aqp4 increases and erk1/2 activation. |
2021-09-09 |
2023-08-13 |
rat |
| Grayson O Sipe, Jeremy Petravicz, Rajeev V Rikhye, Rodrigo Garcia, Nikolaos Mellios, Mriganka Su. Astrocyte glutamate uptake coordinates experience-dependent, eye-specific refinement in developing visual cortex. Glia. vol 69. issue 7. 2021-09-04. PMID:33675674. |
astrocyte glutamate uptake coordinates experience-dependent, eye-specific refinement in developing visual cortex. |
2021-09-04 |
2023-08-13 |
mouse |
| Vered Kellner, Calvin J Kersbergen, Sally Li, Travis A Babola, Gesine Saher, Dwight E Bergle. Dual metabotropic glutamate receptor signaling enables coordination of astrocyte and neuron activity in developing sensory domains. Neuron. vol 109. issue 16. 2021-09-02. PMID:34245686. |
dual metabotropic glutamate receptor signaling enables coordination of astrocyte and neuron activity in developing sensory domains. |
2021-09-02 |
2023-08-13 |
mouse |
| Vered Kellner, Calvin J Kersbergen, Sally Li, Travis A Babola, Gesine Saher, Dwight E Bergle. Dual metabotropic glutamate receptor signaling enables coordination of astrocyte and neuron activity in developing sensory domains. Neuron. vol 109. issue 16. 2021-09-02. PMID:34245686. |
astrocyte responses were restricted to the pre-hearing period and induced by synergistic activation of two metabotropic glutamate receptors, mglur5 and mglur3, which promoted ip3r2-dependent calcium release from intracellular stores. |
2021-09-02 |
2023-08-13 |
mouse |
| James Ak Lee, Benjamin Hall, Jessica Allsop, Razan Alqarni, Scott P Alle. Lipid metabolism in astrocytic structure and function. Seminars in cell & developmental biology. vol 112. 2021-08-20. PMID:32773177. |
astrocytes are the main storage point of glycogen in the brain and it is well established that astrocyte uptake of glutamate and release of lactate prevents neuronal excitability and supports neuronal metabolic function. |
2021-08-20 |
2023-08-13 |
Not clear |
| Benjamin K Lau, Ciaran Murphy-Royal, Manpreet Kaur, Min Qiao, Jaideep S Bains, Grant R Gordon, Stephanie L Borglan. Obesity-induced astrocyte dysfunction impairs heterosynaptic plasticity in the orbitofrontal cortex. Cell reports. vol 36. issue 7. 2021-08-18. PMID:34407401. |
here, we show that extended access to a cafeteria diet impairs astrocyte glutamate clearance, which leads to a heterosynaptic depression of gaba transmission onto pyramidal neurons of the ofc. |
2021-08-18 |
2023-08-13 |
Not clear |
| Odia Osemwegie, Landon Butler, Seenivasan Subbiah, Ernest Smit. Effects of in vitro exposure of perfluorooctanoic acid and monocrotophos on astroglia SVG p12 cells. Journal of applied toxicology : JAT. vol 41. issue 9. 2021-08-16. PMID:33569802. |
the endpoints evaluated include cell viability, intracellular glutamate levels as a marker of astrocyte homeostasis function, differential gene expression for selected proteins, which include inflammatory markers (tachykinin), astrocytosis (nestin), s100b, and metabolism enzymes (cyp1a1). |
2021-08-16 |
2023-08-13 |
Not clear |
| Leonid P Savtchenko, Kaiyu Zheng, Dmitri A Rusako. Buffering by Transporters Can Spare Geometric Hindrance in Controlling Glutamate Escape. Frontiers in cellular neuroscience. vol 15. 2021-08-10. PMID:34366791. |
the surface of astrocyte processes that often surround excitatory synapses is packed with high-affinity glutamate transporters, largely preventing extrasynaptic glutamate escape. |
2021-08-10 |
2023-08-13 |
Not clear |
| Luan Pereira Diniz, Ana Paula Bérgamo Araujo, Isadora Matias, Matheus N Garcia, Fernanda G Q Barros-Aragão, Ricardo Augusto de Melo Reis, Débora Foguel, Carolina Braga, Cláudia P Figueiredo, Luciana Romão, Flávia Carvalho Alcantara Gome. Astrocyte glutamate transporters are increased in an early sporadic model of synucleinopathy. Neurochemistry international. vol 138. 2021-07-30. PMID:32439533. |
astrocyte glutamate transporters are increased in an early sporadic model of synucleinopathy. |
2021-07-30 |
2023-08-13 |
mouse |
| Irma E Cisneros, Anuja Ghorpade, Kathleen Borgman. Methamphetamine Activates Trace Amine Associated Receptor 1 to Regulate Astrocyte Excitatory Amino Acid Transporter-2 via Differential CREB Phosphorylation During HIV-Associated Neurocognitive Disorders. Frontiers in neurology. vol 11. 2021-07-28. PMID:33324330. |
astrocyte excitatory amino acid transporter (eaat)-2 is responsible for >90% of glutamate uptake from the synaptic environment and is significantly decreased with meth and hiv-1. |
2021-07-28 |
2023-08-13 |
human |
| Ravi Kumar, Yu-Ting Huang, Chun-Chung Chen, Shun-Fen Tzeng, Chi-Keung Cha. Astrocytic Regulation of Synchronous Bursting in Cortical Cultures: From Local to Global. Cerebral cortex communications. vol 1. issue 1. 2021-07-24. PMID:34296118. |
an understanding of glutamate trafficking dynamics is of general application to explain how astrocyte malfunction can result in pathological seizure-like phenomena in neuronal systems. |
2021-07-24 |
2023-08-13 |
Not clear |
| Ni-Hsuan Lin, Ai-Wen Yang, Chih-Hsuan Chang, Ming-Der Pern. Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 5. 2021-07-19. PMID:33908669. |
in conclusion, our findings provide evidence that links elevated gfap isoform expression with gfap aggregation and impaired glutamate transport, and suggest a potential non-cell-autonomous mechanism underlying neurodegeneration through astrocyte dysfunction. |
2021-07-19 |
2023-08-13 |
mouse |
| Alessandra Carion, Angèle Markey, Julie Hétru, Camille Carpentier, Victoria Suarez-Ulloa, Mathieu Denoël, Ryan L Earley, Frédéric Silvestr. Behavior and gene expression in the brain of adult self-fertilizing mangrove rivulus fish (Kryptolebias marmoratus) after early life exposure to the neurotoxin β-N-methylamino-l-alanine (BMAA). Neurotoxicology. vol 79. 2021-07-13. PMID:32380192. |
our results suggest disruption of glutamate turnover, intracellular dopamine depletion and activation of astrocyte protective mechanisms, indicating that bmaa might be excitotoxic. |
2021-07-13 |
2023-08-13 |
Not clear |
| Yun Fan, Mei-Chuan Chou, Yen-Chin Liu, Ching-Kuan Liu, Chu-Huang Chen, Shiou-Lan Che. Intermittent Hypoxia Activates N-Methyl-D-Aspartate Receptors to Induce Anxiety Behaviors in a Mouse Model of Sleep-Associated Apnea. Molecular neurobiology. vol 58. issue 7. 2021-07-06. PMID:33660202. |
increased glutamate n-methyl-d-aspartate (nmda) receptor subunits 2b (glun2b) and phosphorylated-erk1/2 were seen in the mpfc, striatum, and hippocampus of ih mice, but no significant microglial and astrocyte activation was found in these brain areas. |
2021-07-06 |
2023-08-13 |
mouse |
| Mengqi Zhang, Haojun Yang, Zhuohui Chen, Xinhang Hu, Tong Wu, Weiping Li. Long Noncoding RNA X-Inactive-Specific Transcript Promotes the Secretion of Inflammatory Cytokines in LPS Stimulated Astrocyte Cell Via Sponging miR-29c-3p and Regulating Nuclear Factor of Activated T cell 5 Expression. Frontiers in endocrinology. vol 12. 2021-06-15. PMID:33776905. |
astrocyte activation promotes glutamate accumulation and secretion of inflammatory factors, mainly responsible for epilepsy. |
2021-06-15 |
2023-08-13 |
Not clear |
| Qing Li, Haifang Zhang, Zhen Jia, Linlin Zhang, Yize Li, Rubin Xu, Chunyan Wang, Yonghao Y. Hydrogen enriched saline alleviates morphine tolerance via inhibiting neuroinflammation, GLT-1, GS nitration and NMDA receptor trafficking and functioning in the spinal cord of rats. Neuroscience letters. vol 755. 2021-06-08. PMID:33774150. |
the pro-inflammatory cytokine expressions [tumor necrosis factor-alpha (tnf-α), interleukin-1β (il-1β), il-6)] (by western blotting), astrocyte activation (by immunofluorescence and western blotting), and nitration of glutamate transporter-1 (glt-1) and glutamine synthetase (gs) (by immunoprecipitation), membrane and total expression of n-methyl-d-aspartic acid (nmda) receptor nr1 and nr2b subunits were carried out in the spinal dorsal horns. |
2021-06-08 |
2023-08-13 |
rat |
| Usha Kant Misra, Sandeep Kumar Singh, Jayantee Kalita, Alok Kuma. Astrocyte activation following nitrous oxide exposure is related to oxidative stress and glutamate excitotoxicity. Brain research. vol 1730. 2021-06-07. PMID:31911167. |
astrocyte activation following nitrous oxide exposure is related to oxidative stress and glutamate excitotoxicity. |
2021-06-07 |
2023-08-13 |
Not clear |
| Lifu Sheng, Tessandra Stewart, Dishun Yang, Eric Thorland, David Soltys, Patrick Aro, Tarek Khrisat, Zhiying Xie, Na Li, Zongran Liu, Chen Tian, Matthew Bercow, Junichi Matsumoto, Cyrus P Zabetian, Elaine Peskind, Joseph F Quinn, Min Shi, Jing Zhan. Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson's disease pathogenesis. Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32641150. |
these evs accumulated in astrocyte endfeet, a component of the bbb, where they impaired glutamate uptake, likely via interaction between excitatory amino acid transporter 2 (eaat2) and oligomeric α-syn. |
2021-05-31 |
2023-08-13 |
mouse |
| Isidro Ferrer, Pol Andrés-Benito, Maria Victoria Zelaya, Maria Elena Erro Aguirre, Margarita Carmona, Karina Ausín, Mercedes Lachén-Montes, Joaquín Fernández-Irigoyen, Enrique Santamaría, José Antonio Del Ri. Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy. Acta neuropathologica. vol 139. issue 4. 2021-05-17. PMID:31907603. |
in ggt cases linked to mapt p301t mutation, astrocyte markers gfap, aldh1l1, ykl40 mrna and protein, gja1 mrna, and aq4 protein are significantly increased; glutamate transporter glt1 (eaat2) and glucose transporter (slc2a1) decreased; mitochondrial pyruvate carrier 1 (mpc1) increased, and mitochondrial uncoupling protein 5 (ucp5) almost absent in gais in frontal cortex (fc). |
2021-05-17 |
2023-08-13 |
mouse |