| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jacqueline P Garcia, Moritz Armbruster, Mary Sommer, Aliana Nunez-Beringer, Chris G Dull. Glutamate uptake is transiently compromised in the perilesional cortex following controlled cortical impact. Cerebral cortex (New York, N.Y. : 1991). vol 35. issue 2. 2025-02-26. PMID:40007051. |
the astrocyte k+ channel, kir4.1, regulates activity-dependent slowing of glutamate uptake. |
2025-02-26 |
2025-02-28 |
Not clear |
| Zila Martinez-Lozada, Alain M Guillem, Isabella Song, Michael V Gonzalez, Hajime Takano, Esha Parikh, Jeffrey D Rothstein, Mary E Putt, Michael B Robinso. Identification of a Subpopulation of Astrocyte Progenitor Cells in the Neonatal Subventricular Zone: Evidence that Migration is Regulated by Glutamate Signaling. Neurochemical research. vol 50. issue 1. 2025-01-10. PMID:39789409. |
identification of a subpopulation of astrocyte progenitor cells in the neonatal subventricular zone: evidence that migration is regulated by glutamate signaling. |
2025-01-10 |
2025-01-13 |
mouse |
| Duo Li, Qiang Li, Rui Zhan. Dynamical modeling and analysis of epileptic discharges transition caused by glutamate release with metabolism processes regulation from astrocyte. Chaos (Woodbury, N.Y.). vol 34. issue 12. 2024-12-24. PMID:39718810. |
dynamical modeling and analysis of epileptic discharges transition caused by glutamate release with metabolism processes regulation from astrocyte. |
2024-12-24 |
2024-12-26 |
Not clear |
| Henry Liu, Adelie Y S Tan, Nasim F Mehrabi, Clinton P Turner, Maurice A Curtis, Richard L M Faull, Mike Dragunow, Malvindar K Singh-Bains, Amy M Smit. Astrocytic proteins involved in regulation of the extracellular environment are increased in the Alzheimer's disease middle temporal gyrus. Neurobiology of disease. 2024-11-27. PMID:39603277. |
we have investigated changes to key astrocyte proteins involved in the regulation of cns extracellular environment in the human ad middle temporal gyrus (mtg): aquaporin-4 (aqp-4), glutamate transporter-1 (glt-1) and inwardly-rectifying potassium channel 4.1 (kir4.1). |
2024-11-27 |
2024-11-30 |
human |
| Heng Li, Yuqing Zhao, Ruicheng Dai, Peiyao Geng, Danwei Weng, Wenting Wu, Fengting Yu, Rui Lin, Zhaofa Wu, Yulong Li, Minmin Lu. Astrocytes release ATP/ADP and glutamate in flashes via vesicular exocytosis. Molecular psychiatry. 2024-11-23. PMID:39578520. |
here, we visualized atp/adp and glutamate response following astrocyte activation and investigated their mechanisms in vivo. |
2024-11-23 |
2024-11-25 |
Not clear |
| Zizheng Suo, Ting Xiao, Yinyin Qu, Yuxiang Zheng, Wenjie Xu, Bowen Zhou, Jing Yang, Jie Yu, Hui Zheng, Cheng N. Aged hippocampal single-cell atlas screening unveils disrupted neuroglial system in postoperative cognitive impairment. Aging cell. 2024-11-14. PMID:39540334. |
reactive microglia also aggravated astrocyte and oligodendrocyte cytotoxicity through the pgd2/dp and complement pathways, altering glutamate level and synaptic function via the "tripartite synapses" model, and affecting neuronal myelination. |
2024-11-14 |
2024-11-17 |
mouse |
| Eric Guedj, Alexandre Cionca, Julie A Péron, Cyrus Ayubcha, Frédéric Assal, Tatiana Horowitz, Abass Alav. Long Coronavirus Disease and the Brain: Molecular Neuroimaging Insights into Neurologic and Psychiatric Sequelae. PET clinics. 2024-10-31. PMID:39482218. |
this review also explores the pathophysiological mechanisms of these results, including astrocyte dysfunction and glutamate dysregulation, as well as the multimodal comparison to mr imaging findings. |
2024-10-31 |
2024-11-03 |
Not clear |
| Roberta Amoriello, Clara Ballerin. Immunofluorescence Staining of Murine Spinal Cord Sections to Evaluate Microglial Activation and Astrogliosis. Methods in molecular biology (Clifton, N.J.). vol 2857. 2024-09-30. PMID:39348064. |
aging impacts microglia and astrocytes by promoting the production of pro-inflammatory cytokines, impairing microglial phagocytosis and motility and astrocyte glutamate uptake. |
2024-09-30 |
2024-10-02 |
mouse |
| Anze Testen, Jonathan W VanRyzin, Tania J Bellinger, Ronald Kim, Han Wang, Matthew J Gastinger, Emily A Witt, Janay P Franklin, Haley A Vecchiarelli, Katherine Picard, Marie-Ève Tremblay, Kathryn J Reissne. Abstinence from cocaine self-administration promotes microglia pruning of astrocytes which drives cocaine-seeking behavior. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345569. |
rodent drug self-administration leads to compromised ability of astrocytes to maintain glutamate homeostasis within the brain's reward circuitry, as well as reductions in surface area, volume, and synaptic colocalization of astrocyte membranes. |
2024-09-30 |
2024-10-02 |
Not clear |
| Xiangyang Zang, Jingting Zhang, Jingping Hu, Xingying Mo, Tingwei Zheng, Jiaming Ji, Jibin Xing, Chaojin Chen, Shaoli Zho. Electroconvulsive therapy combined with esketamine improved depression through PI3K/AKT/GLT-1 pathway. Journal of affective disorders. 2024-09-12. PMID:39265873. |
glutamate transporter-1 (glt-1) expressed in astrocyte is responsible for glutamate clearance to maintain glutamate balance. |
2024-09-12 |
2024-09-15 |
rat |
| Xin-Hao Jiao, Jie Wan, Wei-Feng Wu, Lin-Hui Ma, Chen Chen, Wei Dong, Yi-Qi Liu, Chun-Hui Jin, Ao Sun, Yue Zhou, Zi-Yi Li, Qiang Liu, Yu-Qing Wu, Cheng-Hua Zho. GLT-1 downregulation in hippocampal astrocytes induced by type 2 diabetes contributes to postoperative cognitive dysfunction in adult mice. CNS neuroscience & therapeutics. vol 30. issue 9. 2024-09-02. PMID:39218798. |
astrocyte glutamate transporter 1 (glt-1) plays a crucial role in regulating neuron excitability. |
2024-09-02 |
2024-09-04 |
mouse |
| Henri Chahinian, Nouara Yahi, Jacques Fantin. Glutamate, Gangliosides, and the Synapse: Electrostatics at Work in the Brain. International journal of molecular sciences. vol 25. issue 16. 2024-08-29. PMID:39201269. |
this electric field controls the flow of glutamate in the tripartite synapse involving pre- and post-synaptic neurons and the astrocyte. |
2024-08-29 |
2024-09-01 |
Not clear |
| Sarah Amato, Monica Averna, Elisa Farsetti, Diego Guidolin, Marco Pedrazzi, Elena Gatta, Simona Candiani, Guido Maura, Luigi Francesco Agnati, Chiara Cervetto, Manuela Marcol. Control of Dopamine Signal in High-Order Receptor Complex on Striatal Astrocytes. International journal of molecular sciences. vol 25. issue 16. 2024-08-29. PMID:39201299. |
by biophysical and functional approaches, we focused our attention on the existence of an a2a-d2-otr high-order receptor complex and its role in modulating cytosolic calcium levels and endogenous glutamate release, when striatal astrocyte processes were stimulated with 4-aminopyridine. |
2024-08-29 |
2024-09-01 |
Not clear |
| Sophie Schröder, Ulrike Fuchs, Verena Gisa, Tonatiuh Pena, Dennis M Krüger, Nina Hempel, Susanne Burkhardt, Gabriela Salinas, Anna-Lena Schütz, Ivana Delalle, Farahnaz Sananbenesi, Andre Fische. PRDM16-DT is a novel lncRNA that regulates astrocyte function in Alzheimer's disease. Acta neuropathologica. vol 148. issue 1. 2024-08-29. PMID:39207536. |
in line with this, knockdown of prdm16-dt and prdm16os revealed its critical role in maintaining astrocyte homeostasis and supporting neuronal function by regulating genes essential for glutamate uptake, lactate release, and neuronal spine density through interactions with the re1-silencing transcription factor (rest) and polycomb repressive complex 2 (prc2). |
2024-08-29 |
2024-09-04 |
human |
| Sen Shang, Leilei Wang, Xiaoyun L. β-Hydroxybutyrate enhances astrocyte glutamate uptake through EAAT1 expression regulation. Molecular and cellular neurosciences. 2024-08-23. PMID:39179164. |
β-hydroxybutyrate enhances astrocyte glutamate uptake through eaat1 expression regulation. |
2024-08-23 |
2024-08-27 |
mouse |
| Sam S Critzer, Taylor J Bosch, Kelene A Fercho, Jamie L Scholl, Lee A Baug. Water and Brain Function - Effects of Hydration Status on Neurostimulation with Transcranial Magnetic Stimulation. Journal of neurophysiology. 2024-07-31. PMID:39081213. |
compared to dehydration, we expected rehydration to show signs of macroscopic and microscopic volume changes including decreased scalp-cortex distance (brain closer to stimulator) and astrocyte swelling-induced glutamate release. |
2024-07-31 |
2024-08-02 |
Not clear |
| Cheng-Lin Lu, Jing Ren, Xiong Ca. An astroglial basis of major depressive disorder: Molecular, Cellular, and Circuit Features. Biological psychiatry. 2024-07-31. PMID:39084500. |
accumulated evidence indicates that the astrocyte is an important contributor to the pathophysiology of mdd including blood-brain barrier (bbb) integrity, gap junctions, gliotransmission, glutamate homeostasis, and energy metabolism. |
2024-07-31 |
2024-08-03 |
Not clear |
| Rong Luo, Xiaojun Hu, Xin Li, Fan Lei, Ping Liao, Limei Yi, Xia Zhang, Bin Zhou, Ruotian Jian. Dysfunctional astrocyte glutamate uptake in the hypothalamic paraventricular nucleus contributes to visceral pain and anxiety-like behavior in mice with chronic pancreatitis. Glia. 2024-07-24. PMID:39046219. |
dysfunctional astrocyte glutamate uptake in the hypothalamic paraventricular nucleus contributes to visceral pain and anxiety-like behavior in mice with chronic pancreatitis. |
2024-07-24 |
2024-07-26 |
mouse |
| Ana Isabel Silva, Renato Socodato, Carolina Pinto, Ana Filipa Terceiro, Teresa Canedo, João Bettencourt Relvas, Margarida Saraiva, Teresa Summaviell. IL-10 and Cdc42 modulate astrocyte-mediated microglia activation in methamphetamine-induced neuroinflammation. Glia. 2024-05-23. PMID:38780232. |
our findings reveal that the presence of recombinant il-10 (ril-10) counteracts meth-induced excessive glutamate release in astrocyte cultures, which significantly reduces microglial activation. |
2024-05-23 |
2024-05-27 |
Not clear |
| Lu Chen, Wenqian Yang, Fei Yang, Tingwan Xu, Yanying Yu, Qian Wu, Yanbing Ha. Astrocyte mitochondria: Potential therapeutic targets for epilepsy. Heliyon. vol 10. issue 9. 2024-05-18. PMID:38756598. |
in this review, we mainly summarize the regulatory role of astrocyte mitochondria in glutamate, calcium ion, and adenosine triphosphate (atp) homeostasis and outline the protective role of astrocyte mitochondria in nervous system diseases, revealing a new target for epilepsy treatment. |
2024-05-18 |
2024-05-27 |
Not clear |