| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masaki Oya, Kiwamu Matsuoka, Manabu Kubota, Junya Fujino, Shisei Tei, Keisuke Takahata, Kenji Tagai, Yasuharu Yamamoto, Hitoshi Shimada, Chie Seki, Takashi Itahashi, Yuta Y Aoki, Haruhisa Ohta, Ryu-Ichiro Hashimoto, Genichi Sugihara, Takayuki Obata, Ming-Rong Zhang, Tetsuya Suhara, Motoaki Nakamura, Nobumasa Kato, Yuhei Takado, Hidehiko Takahashi, Makoto Higuch. Increased glutamate and glutamine levels and their relationship to astrocytes and dopaminergic transmissions in the brains of adults with autism. Scientific reports. vol 13. issue 1. 2023-07-19. PMID:37468523. |
the amplified glutamate signals may arise from enhanced glutamatergic circuits, which can be affected by astrocyte activation and suppressive signaling of dopamine neurotransmission. |
2023-07-19 |
2023-08-14 |
Not clear |
| Roon Banerjee, Aishwarya Raj, Chandrakanta Potdar, Pramod Kumar Pal, Ravi Yadav, Nitish Kamble, Vikram Holla, Indrani Datt. Astrocytes Differentiated from LRRK2-I1371V Parkinson's-Disease-Induced Pluripotent Stem Cells Exhibit Similar Yield but Cell-Intrinsic Dysfunction in Glutamate Uptake and Metabolism, ATP Generation, and Nrf2-Mediated Glutathione Machinery. Cells. vol 12. issue 12. 2023-06-28. PMID:37371062. |
here, we aimed to assess the cell-intrinsic effect of the lrrk2-i1371v mutant variant, prevalent in east asian populations, on astrocyte yield and biology, involving nrf2-mediated glutathione machinery, glutamate uptake and metabolism, and atp generation in astrocytes derived from lrrk2-i1371v pd patient ipscs and independently confirmed in lrrk2-i1371v-overexpressed u87 cells. |
2023-06-28 |
2023-08-14 |
Not clear |
| Roon Banerjee, Aishwarya Raj, Chandrakanta Potdar, Pramod Kumar Pal, Ravi Yadav, Nitish Kamble, Vikram Holla, Indrani Datt. Astrocytes Differentiated from LRRK2-I1371V Parkinson's-Disease-Induced Pluripotent Stem Cells Exhibit Similar Yield but Cell-Intrinsic Dysfunction in Glutamate Uptake and Metabolism, ATP Generation, and Nrf2-Mediated Glutathione Machinery. Cells. vol 12. issue 12. 2023-06-28. PMID:37371062. |
our data demonstrate for the first time that the mutation in the lrrk2-i1371v allele causes significant astrocytic dysfunction with respect to nrf2-mediated antioxidant machinery, at -generation, and glutamate metabolism, even with comparable astrocyte yields. |
2023-06-28 |
2023-08-14 |
Not clear |
| Vanessa Sovrani, Larissa Daniele Bobermin, Patrícia Sesterheim, Ester Rezena, Matheus Sinhorelli Cioccari, Carlos Alexandre Netto, Carlos-Alberto Gonçalves, Guilhian Leipnitz, André Quincozes-Santo. Glioprotective effects of resveratrol in hypothalamic astrocyte cultures obtained from interferon receptor knockout (IFNα/βR In vitro cellular & developmental biology. Animal. 2023-06-23. PMID:37353697. |
glioprotective effects of resveratrol in hypothalamic astrocyte cultures obtained from interferon receptor knockout (ifnα/βr astrocytes play essential roles in the central nervous system (cns), such as the regulation of glutamate metabolism, antioxidant defenses, and inflammatory/immune responses. |
2023-06-23 |
2023-08-14 |
mouse |
| Carmen Muñoz-Ballester, Stefanie Robe. Astrocyte-mediated mechanisms contribute to traumatic brain injury pathology. WIREs mechanisms of disease. 2023-06-18. PMID:37332001. |
we address the astrocyte response to focal versus diffuse tbi and heterogeneity of reactive astrocytes within the same brain, the role of intermediate filament upregulation, functional changes to astrocyte function including potassium and glutamate homeostasis, blood-brain barrier maintenance and repair, metabolism, and reactive oxygen species detoxification, sex differences, and factors influencing astrocyte proliferation after tbi. |
2023-06-18 |
2023-08-14 |
Not clear |
| Chiara Cervetto, Guido Maura, Diego Guidolin, Sarah Amato, Cristina Ceccoli, Luigi F Agnati, Manuela Marcol. Striatal astrocytic A2A-D2 receptor-receptor interactions and their role in neuropsychiatric disorders. Neuropharmacology. 2023-06-15. PMID:37321323. |
astrocytic a2a-d2 heteromers were found able to control the release of glutamate from the striatal astrocyte processes. |
2023-06-15 |
2023-08-14 |
Not clear |
| Mathieu Letellier, Yukiko God. Astrocyte calcium signaling shifts the polarity of presynaptic plasticity. Neuroscience. 2023-06-09. PMID:37295597. |
upon preventing astrocyte calcium signaling or blocking l-type vgccs, nmda+glycine application triggers an increase, rather than a decrease, in the rate of spontaneous glutamate release, thereby shifting the presynaptic plasticity to promote an increase in strength. |
2023-06-09 |
2023-08-14 |
Not clear |
| Rosanna Tarkany Basting, Marcelo Henrique Napimoga, Carlos Antônio Trindade Silva, Henrique Ballassini Abdalla, Braz Campos Durso, Leopoldo Henrique Barboza Martins, Herbert de Abreu Cavalcanti, Bruce D Hammock, Juliana Trindade Clemente-Napimog. Soluble epoxide hydrolase inhibitor blockage microglial cell activation in subnucleus caudalis in a persistent model of arthritis. International immunopharmacology. vol 120. 2023-05-25. PMID:37230034. |
in tsc, tppu reduces the cytokine storm and attenuates the microglia activated p2x7/cathepsin s/fractalkine pathway and reduces the astrocyte activation and glutamate levels. |
2023-05-25 |
2023-08-14 |
rat |
| Yi-Wen Bai, Qi-Hao Yang, Pei-Jie Chen, Xue-Qiang Wan. Repetitive transcranial magnetic stimulation regulates neuroinflammation in neuropathic pain. Frontiers in immunology. vol 14. 2023-05-14. PMID:37180127. |
in addition, rtms reduces the expression of glutamate receptors (mglur5 and nmdar2b) and microglia and astrocyte markers (iba1 and gfap). |
2023-05-14 |
2023-08-14 |
Not clear |
| Rafael Short Ferreira, Paulo Roberto Ribeiro, Juliana Helena Castro E Silva, Juliana Bender Hoppe, Monique Marylin Alves de Almeida, Beatriz Correia de Lima Ferreira, Gustavo Borges Andrade, Suzana Braga de Souza, Luzimar Gonzaga Ferdandez, Maria de Fátima Dias Costa, Christianne Gazzana Salbego, Andrea Domenico Rivera, Aline Longoni, Adriano Martimbianco de Assis, Francesca Pieropan, José Cláudio Fonseca Moreira, Silvia Lima Costa, Arthur Morgan Butt, Victor Diogenes Amaral da Silv. Amburana cearensis seed extract stimulates astrocyte glutamate homeostatic mechanisms in hippocampal brain slices and protects oligodendrocytes against ischemia. BMC complementary medicine and therapies. vol 23. issue 1. 2023-05-11. PMID:37170258. |
amburana cearensis seed extract stimulates astrocyte glutamate homeostatic mechanisms in hippocampal brain slices and protects oligodendrocytes against ischemia. |
2023-05-11 |
2023-08-14 |
Not clear |
| Ke-Xin Li, Meng Lu, Meng-Xu Cui, Xiao-Ming Wang, Yang Zhen. Astrocyte-neuron communication mediated by the Notch signaling pathway: focusing on glutamate transport and synaptic plasticity. Neural regeneration research. vol 18. issue 10. 2023-04-14. PMID:37056149. |
maintaining glutamate homeostasis after hypoxic ischemia is important for synaptic function and neural cell activity, and regulation of glutamate transport between astrocyte and neuron is one of the important modalities for reducing glutamate accumulation. |
2023-04-14 |
2023-08-14 |
Not clear |
| Michał Seweryn Karbownik, Paulina Sokołowska, Edward Kowalczy. Gut Microbiota Metabolites Differentially Release Gliotransmitters from the Cultured Human Astrocytes: A Preliminary Report. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047602. |
in order to test this mechanism, a human astrocyte cell-line culture was treated with the compounds or without them, and the supernatants were collected for the analysis of atp and glutamate gliotransmitter release with the use of luminescent and fluorescent methods, respectively. |
2023-04-13 |
2023-08-14 |
human |
| Linda-Isabell Schmitt, Christina David, Rebecca Steffen, Stefanie Hezel, Andreas Roos, Ulrike Schara-Schmidt, Christoph Kleinschnitz, Markus Leo, Tim Hagenacke. Spinal astrocyte dysfunction drives motor neuron loss in late-onset spinal muscular atrophy. Acta neuropathologica. 2023-03-17. PMID:36930296. |
the pre-emptive administration of arundic acid (aa), as an inhibitor of astrocyte activation, to sma mice prior to the loss of motor neurons (p28) resulted in elevated eaat1 protein levels compared to vehicle-treated sma mice and prevented the increase of glutamate in the spinal cord and the loss of spinal mns. |
2023-03-17 |
2023-08-14 |
mouse |
| Sarah Amato, Monica Averna, Diego Guidolin, Cristina Ceccoli, Elena Gatta, Simona Candiani, Marco Pedrazzi, Michela Capraro, Guido Maura, Luigi F Agnati, Chiara Cervetto, Manuela Marcol. Heteromerization of Dopamine D2 and Oxytocin Receptor in Adult Striatal Astrocytes. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36902106. |
we found that both d2 and otr were expressed on the same astrocyte processes and controlled the release of glutamate, showing a facilitatory receptor-receptor interaction in the d2-otr heteromers. |
2023-03-11 |
2023-08-14 |
rat |
| Chloe Delepine, Jennifer Shih, Keji Li, Pierre Gaudeaux, Mriganka Su. Differential effects of astrocyte manipulations on learned motor behavior and neuronal ensembles in the motor cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-03-09. PMID:36894315. |
mice that express decreased levels of the astrocyte glutamate transporter glt1 show impaired and variable movement trajectories, while mice with increased astrocyte gq signaling show decreased performance rates, delayed response times, and impaired trajectories. |
2023-03-09 |
2023-08-14 |
mouse |
| José Javier Miguel-Hidalg. Astrocytes as Context for the Involvement of Myelin and Nodes of Ranvier in the Pathophysiology of Depression and Stress-Related Disorders. Journal of psychiatry and brain science. vol 8. 2023-03-03. PMID:36866235. |
some of these changes involve the expression of connexins supporting astrocyte-to-oligodendrocyte gap junctions, extracellular matrix components produced by astrocytes around nodes of ranvier, specific types of astrocyte glutamate transporters, and neurotrophic factors secreted by astrocytes that are involved in the development and plasticity of myelin. |
2023-03-03 |
2023-08-14 |
human |
| Kelly M Wilson, Johnny J H. HIV Nef Expression Down-modulated GFAP Expression and Altered Glutamate Uptake and Release and Proliferation in Astrocytes. Aging and disease. vol 14. issue 1. 2023-02-23. PMID:36818564. |
lastly, we showed that nef expression led to increased glutamate uptake and decreased glutamate release by astrocytes and increased astrocyte proliferation. |
2023-02-23 |
2023-08-14 |
Not clear |
| Kelly M Wilson, Johnny J H. HIV Nef Expression Down-modulated GFAP Expression and Altered Glutamate Uptake and Release and Proliferation in Astrocytes. Aging and disease. vol 14. issue 1. 2023-02-23. PMID:36818564. |
taken together, these results indicate that nef leads to down-modulation of gfap expression and alteration of glutamate metabolism in astrocytes, and astrocyte proliferation and could be an important contributor to neurohiv. |
2023-02-23 |
2023-08-14 |
Not clear |
| Aina Badia-Soteras, Tim S Heistek, Mandy S J Kater, Aline Mak, Adrian Negrean, Michel C van den Oever, Huibert D Mansvelder, Baljit S Khakh, Rogier Min, August B Smit, Mark H G Verheije. Retraction of Astrocyte Leaflets From the Synapse Enhances Fear Memory. Biological psychiatry. 2023-01-26. PMID:36702661. |
astrocyte distal processes, known as leaflets, fine-tune synaptic activity by clearing neurotransmitters and limiting glutamate diffusion. |
2023-01-26 |
2023-08-14 |
Not clear |
| Courtney Clyburn, Kaitlin E Carson, Caleb R Smith, R Alberto Travagli, Kirsteen N Brownin. Brainstem astrocytes control homeostatic regulation of caloric intake. The Journal of physiology. 2023-01-25. PMID:36696965. |
astrocyte regulation of glutamatergic transmission to dmv neurons appears to involve release of the gliotransmitters glutamate and atp. |
2023-01-25 |
2023-08-14 |
Not clear |