| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gehua Wen, Xiaoni Zhan, Xiaoming Xu, Xi Xia, Shukun Jiang, Xinghua Ren, Weishu Ren, Haoyang Lou, Lei Lu, Anca Hermenean, Jun Yao, Lina Gao, Baoman Li, Yan Lu, Xu W. Ketamine Improves the Glymphatic Pathway by Reducing the Pyroptosis of Hippocampal Astrocytes in the Chronic Unpredictable Mild Stress Model. Molecular neurobiology. 2023-10-15. PMID:37840071. |
depression is associated with elevated levels of glutamate and astrocyte loss in the brain; the exploration of the relationships between ketamine's antidepressant effect and astrocytes has drawn great attention. |
2023-10-15 |
2023-11-08 |
mouse |
| Iain J Hartnell, Declan Woodhouse, William Jasper, Luke Mason, Pavan Marwaha, Manon Graffeuil, Laurie C Lau, Jeanette L Norman, David S Chatelet, Luc Buee, James A R Nicoll, David Blum, Guillaume Dorothee, Delphine Boch. Glial reactivity and T cell infiltration in frontotemporal lobar degeneration with tau pathology. Brain : a journal of neurology. 2023-09-13. PMID:37703311. |
markers of astrocyte glutamate cycling function were reduced in ftld-tau (p = 0.0075; pid: p < 0.0400) implying astrocyte reactivity associated with a decreased glutamate cycling activity which was further associated with ptau expression. |
2023-09-13 |
2023-10-07 |
mouse |
| Benjamin M Siemsen, Adam R Denton, Jeffrey Parrila-Carrero, Kaylee N Hooker, Eilish A Carpenter, Meagan E Prescot, Ashley G Brock, Annaka M Westphal, Mary-Nan Leath, John A McFaddin, Thomas C Jhou, Jacqueline F McGinty, Michael D Scofiel. Heroin Self-Administration and Extinction Increase Prelimbic Cortical Astrocyte-Synapse Proximity and Alter Dendritic Spine Morphometrics That Are Reversed by N-Acetylcysteine. Cells. vol 12. issue 14. 2023-07-29. PMID:37508477. |
normalizing astrocyte glutamate homeostasis with drugs like the antioxidant n-acetylcysteine (nac) prevents cue-induced heroin seeking. |
2023-07-29 |
2023-08-14 |
rat |
| Benjamin M Siemsen, Adam R Denton, Jeffrey Parrila-Carrero, Kaylee N Hooker, Eilish A Carpenter, Meagan E Prescot, Ashley G Brock, Annaka M Westphal, Mary-Nan Leath, John A McFaddin, Thomas C Jhou, Jacqueline F McGinty, Michael D Scofiel. Heroin Self-Administration and Extinction Increase Prelimbic Cortical Astrocyte-Synapse Proximity and Alter Dendritic Spine Morphometrics That Are Reversed by N-Acetylcysteine. Cells. vol 12. issue 14. 2023-07-29. PMID:37508477. |
here, we observe functional adaptations in the prl cortical astrocyte following heroin self-administration (sa) and extinction as measured by the electrophysiologically evoked plasmalemmal glutamate transporter 1 (glt-1)-dependent current. |
2023-07-29 |
2023-08-14 |
rat |
| Sijie Shirley Yang, Svetlana Simtchouk, Julien Gibon, Andis Klegeri. Regulation of the phagocytic activity of astrocytes by neuroimmune mediators endogenous to the central nervous system. PloS one. vol 18. issue 7. 2023-07-27. PMID:37498903. |
by monitoring other functions of astrocytes, we concluded there were no correlations between the effects of the mediators studied on astrocyte phagocytic activity and their secretion of cytokines, cytotoxins, or glutamate. |
2023-07-27 |
2023-08-14 |
human |
| Dongqing Jing, Xiaoli Hou, Xiao Guo, Xin Zhao, Kexin Zhang, Jingwen Zhang, Chengxia Kan, Fang Han, Junling Liu, Xiaodong Su. Astrocytes in Post-Stroke Depression: Roles in Inflammation, Neurotransmission, and Neurotrophin Signaling. Cellular and molecular neurobiology. 2023-07-20. PMID:37470888. |
this review summarizes the latest evidence of astrocyte involvement in psd from human and animal studies, focusing on the alterations of astrocyte markers and functions in relation to monoamine neurotransmitters, inflammatory cytokines, brain-derived neurotrophic factor, and glutamate excitotoxicity. |
2023-07-20 |
2023-08-14 |
human |
| Masaki Oya, Kiwamu Matsuoka, Manabu Kubota, Junya Fujino, Shisei Tei, Keisuke Takahata, Kenji Tagai, Yasuharu Yamamoto, Hitoshi Shimada, Chie Seki, Takashi Itahashi, Yuta Y Aoki, Haruhisa Ohta, Ryu-Ichiro Hashimoto, Genichi Sugihara, Takayuki Obata, Ming-Rong Zhang, Tetsuya Suhara, Motoaki Nakamura, Nobumasa Kato, Yuhei Takado, Hidehiko Takahashi, Makoto Higuch. Increased glutamate and glutamine levels and their relationship to astrocytes and dopaminergic transmissions in the brains of adults with autism. Scientific reports. vol 13. issue 1. 2023-07-19. PMID:37468523. |
the amplified glutamate signals may arise from enhanced glutamatergic circuits, which can be affected by astrocyte activation and suppressive signaling of dopamine neurotransmission. |
2023-07-19 |
2023-08-14 |
Not clear |
| Roon Banerjee, Aishwarya Raj, Chandrakanta Potdar, Pramod Kumar Pal, Ravi Yadav, Nitish Kamble, Vikram Holla, Indrani Datt. Astrocytes Differentiated from LRRK2-I1371V Parkinson's-Disease-Induced Pluripotent Stem Cells Exhibit Similar Yield but Cell-Intrinsic Dysfunction in Glutamate Uptake and Metabolism, ATP Generation, and Nrf2-Mediated Glutathione Machinery. Cells. vol 12. issue 12. 2023-06-28. PMID:37371062. |
here, we aimed to assess the cell-intrinsic effect of the lrrk2-i1371v mutant variant, prevalent in east asian populations, on astrocyte yield and biology, involving nrf2-mediated glutathione machinery, glutamate uptake and metabolism, and atp generation in astrocytes derived from lrrk2-i1371v pd patient ipscs and independently confirmed in lrrk2-i1371v-overexpressed u87 cells. |
2023-06-28 |
2023-08-14 |
Not clear |
| Roon Banerjee, Aishwarya Raj, Chandrakanta Potdar, Pramod Kumar Pal, Ravi Yadav, Nitish Kamble, Vikram Holla, Indrani Datt. Astrocytes Differentiated from LRRK2-I1371V Parkinson's-Disease-Induced Pluripotent Stem Cells Exhibit Similar Yield but Cell-Intrinsic Dysfunction in Glutamate Uptake and Metabolism, ATP Generation, and Nrf2-Mediated Glutathione Machinery. Cells. vol 12. issue 12. 2023-06-28. PMID:37371062. |
our data demonstrate for the first time that the mutation in the lrrk2-i1371v allele causes significant astrocytic dysfunction with respect to nrf2-mediated antioxidant machinery, at -generation, and glutamate metabolism, even with comparable astrocyte yields. |
2023-06-28 |
2023-08-14 |
Not clear |
| Vanessa Sovrani, Larissa Daniele Bobermin, Patrícia Sesterheim, Ester Rezena, Matheus Sinhorelli Cioccari, Carlos Alexandre Netto, Carlos-Alberto Gonçalves, Guilhian Leipnitz, André Quincozes-Santo. Glioprotective effects of resveratrol in hypothalamic astrocyte cultures obtained from interferon receptor knockout (IFNα/βR In vitro cellular & developmental biology. Animal. 2023-06-23. PMID:37353697. |
glioprotective effects of resveratrol in hypothalamic astrocyte cultures obtained from interferon receptor knockout (ifnα/βr astrocytes play essential roles in the central nervous system (cns), such as the regulation of glutamate metabolism, antioxidant defenses, and inflammatory/immune responses. |
2023-06-23 |
2023-08-14 |
mouse |
| Carmen Muñoz-Ballester, Stefanie Robe. Astrocyte-mediated mechanisms contribute to traumatic brain injury pathology. WIREs mechanisms of disease. 2023-06-18. PMID:37332001. |
we address the astrocyte response to focal versus diffuse tbi and heterogeneity of reactive astrocytes within the same brain, the role of intermediate filament upregulation, functional changes to astrocyte function including potassium and glutamate homeostasis, blood-brain barrier maintenance and repair, metabolism, and reactive oxygen species detoxification, sex differences, and factors influencing astrocyte proliferation after tbi. |
2023-06-18 |
2023-08-14 |
Not clear |
| Chiara Cervetto, Guido Maura, Diego Guidolin, Sarah Amato, Cristina Ceccoli, Luigi F Agnati, Manuela Marcol. Striatal astrocytic A2A-D2 receptor-receptor interactions and their role in neuropsychiatric disorders. Neuropharmacology. 2023-06-15. PMID:37321323. |
astrocytic a2a-d2 heteromers were found able to control the release of glutamate from the striatal astrocyte processes. |
2023-06-15 |
2023-08-14 |
Not clear |
| Mathieu Letellier, Yukiko God. Astrocyte calcium signaling shifts the polarity of presynaptic plasticity. Neuroscience. 2023-06-09. PMID:37295597. |
upon preventing astrocyte calcium signaling or blocking l-type vgccs, nmda+glycine application triggers an increase, rather than a decrease, in the rate of spontaneous glutamate release, thereby shifting the presynaptic plasticity to promote an increase in strength. |
2023-06-09 |
2023-08-14 |
Not clear |
| Rosanna Tarkany Basting, Marcelo Henrique Napimoga, Carlos Antônio Trindade Silva, Henrique Ballassini Abdalla, Braz Campos Durso, Leopoldo Henrique Barboza Martins, Herbert de Abreu Cavalcanti, Bruce D Hammock, Juliana Trindade Clemente-Napimog. Soluble epoxide hydrolase inhibitor blockage microglial cell activation in subnucleus caudalis in a persistent model of arthritis. International immunopharmacology. vol 120. 2023-05-25. PMID:37230034. |
in tsc, tppu reduces the cytokine storm and attenuates the microglia activated p2x7/cathepsin s/fractalkine pathway and reduces the astrocyte activation and glutamate levels. |
2023-05-25 |
2023-08-14 |
rat |
| Yi-Wen Bai, Qi-Hao Yang, Pei-Jie Chen, Xue-Qiang Wan. Repetitive transcranial magnetic stimulation regulates neuroinflammation in neuropathic pain. Frontiers in immunology. vol 14. 2023-05-14. PMID:37180127. |
in addition, rtms reduces the expression of glutamate receptors (mglur5 and nmdar2b) and microglia and astrocyte markers (iba1 and gfap). |
2023-05-14 |
2023-08-14 |
Not clear |
| Rafael Short Ferreira, Paulo Roberto Ribeiro, Juliana Helena Castro E Silva, Juliana Bender Hoppe, Monique Marylin Alves de Almeida, Beatriz Correia de Lima Ferreira, Gustavo Borges Andrade, Suzana Braga de Souza, Luzimar Gonzaga Ferdandez, Maria de Fátima Dias Costa, Christianne Gazzana Salbego, Andrea Domenico Rivera, Aline Longoni, Adriano Martimbianco de Assis, Francesca Pieropan, José Cláudio Fonseca Moreira, Silvia Lima Costa, Arthur Morgan Butt, Victor Diogenes Amaral da Silv. Amburana cearensis seed extract stimulates astrocyte glutamate homeostatic mechanisms in hippocampal brain slices and protects oligodendrocytes against ischemia. BMC complementary medicine and therapies. vol 23. issue 1. 2023-05-11. PMID:37170258. |
amburana cearensis seed extract stimulates astrocyte glutamate homeostatic mechanisms in hippocampal brain slices and protects oligodendrocytes against ischemia. |
2023-05-11 |
2023-08-14 |
Not clear |
| Ke-Xin Li, Meng Lu, Meng-Xu Cui, Xiao-Ming Wang, Yang Zhen. Astrocyte-neuron communication mediated by the Notch signaling pathway: focusing on glutamate transport and synaptic plasticity. Neural regeneration research. vol 18. issue 10. 2023-04-14. PMID:37056149. |
maintaining glutamate homeostasis after hypoxic ischemia is important for synaptic function and neural cell activity, and regulation of glutamate transport between astrocyte and neuron is one of the important modalities for reducing glutamate accumulation. |
2023-04-14 |
2023-08-14 |
Not clear |
| Michał Seweryn Karbownik, Paulina Sokołowska, Edward Kowalczy. Gut Microbiota Metabolites Differentially Release Gliotransmitters from the Cultured Human Astrocytes: A Preliminary Report. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047602. |
in order to test this mechanism, a human astrocyte cell-line culture was treated with the compounds or without them, and the supernatants were collected for the analysis of atp and glutamate gliotransmitter release with the use of luminescent and fluorescent methods, respectively. |
2023-04-13 |
2023-08-14 |
human |
| Linda-Isabell Schmitt, Christina David, Rebecca Steffen, Stefanie Hezel, Andreas Roos, Ulrike Schara-Schmidt, Christoph Kleinschnitz, Markus Leo, Tim Hagenacke. Spinal astrocyte dysfunction drives motor neuron loss in late-onset spinal muscular atrophy. Acta neuropathologica. 2023-03-17. PMID:36930296. |
the pre-emptive administration of arundic acid (aa), as an inhibitor of astrocyte activation, to sma mice prior to the loss of motor neurons (p28) resulted in elevated eaat1 protein levels compared to vehicle-treated sma mice and prevented the increase of glutamate in the spinal cord and the loss of spinal mns. |
2023-03-17 |
2023-08-14 |
mouse |
| Sarah Amato, Monica Averna, Diego Guidolin, Cristina Ceccoli, Elena Gatta, Simona Candiani, Marco Pedrazzi, Michela Capraro, Guido Maura, Luigi F Agnati, Chiara Cervetto, Manuela Marcol. Heteromerization of Dopamine D2 and Oxytocin Receptor in Adult Striatal Astrocytes. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36902106. |
we found that both d2 and otr were expressed on the same astrocyte processes and controlled the release of glutamate, showing a facilitatory receptor-receptor interaction in the d2-otr heteromers. |
2023-03-11 |
2023-08-14 |
rat |