| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Wang, Sheng Zhang, Zhaohui Lan, Vui Doan, Bokyung Kim, Sihan Liu, Meina Zhu, Vanessa L Hull, Sami Rihani, Chun-Li Zhang, John A Gray, Fuzheng Gu. SOX2 is essential for astrocyte maturation and its deletion leads to hyperactive behavior in mice. Cell reports. vol 41. issue 12. 2022-12-21. PMID:36543123. |
consistently, sox2 deficiency remarkably reduces glutamate transporter expression and compromised astrocyte function of glutamate uptake. our study provides insights into the cellular mechanisms underlying brain defects in children with sox2 mutations and suggests a link of astrocyte sox2 with extra-ocular abnormalities in sox2-mutant subjects. |
2022-12-21 |
2023-08-14 |
mouse |
| Bethany A Freel, Benjamin A Kelvington, Sonali Sengupta, Malini Mukherjee, Kevin R Franci. Sterol dysregulation in Smith-Lemli-Opitz syndrome causes astrocyte immune reactivity through microglia crosstalk. Disease models & mechanisms. vol 15. issue 12. 2022-12-16. PMID:36524414. |
transcript analyses demonstrate extensive dhcr7 astrocyte immune activation, hyper-responsiveness to glutamate stimulation and altered calcium flux. |
2022-12-16 |
2023-08-14 |
mouse |
| Osamu Nozawa, Muneaki Miyata, Hajime Shiotani, Takeshi Kameyama, Ryouhei Komaki, Tatsuhiro Shimizu, Toshihiko Kuriu, Yutaro Kashiwagi, Yuka Sato, Michinori Koebisu, Atsu Aiba, Shigeo Okabe, Kiyohito Mizutani, Yoshimi Taka. A novel Necl-2/3-mediated mechanism for tripartite synapse formation. Development (Cambridge, England). 2022-12-02. PMID:36458527. |
co-cultured neurons were required for astrocyte ramifications in a neuronal activity-dependent manner and synaptically released glutamate and activation of astrocytic mglur5 metabotropic glutamate receptor were likely involved in astrocyte ramifications. |
2022-12-02 |
2023-08-14 |
mouse |
| Osamu Nozawa, Muneaki Miyata, Hajime Shiotani, Takeshi Kameyama, Ryouhei Komaki, Tatsuhiro Shimizu, Toshihiko Kuriu, Yutaro Kashiwagi, Yuka Sato, Michinori Koebisu, Atsu Aiba, Shigeo Okabe, Kiyohito Mizutani, Yoshimi Taka. A novel Necl-2/3-mediated mechanism for tripartite synapse formation. Development (Cambridge, England). 2022-12-02. PMID:36458527. |
astrocytic necl-2/cadm1 trans-interacted with axonal necl-3/cadm2, inducing astrocyte-synapse interactions and astrocyte functional polarization by recruiting eaat1/2 glutamate transporters and kir4.1 k+ channel to the paps, without affecting astrocyte ramifications. |
2022-12-02 |
2023-08-14 |
mouse |
| Julian Karpf, Petr Unichenko, Nicholas Chalmers, Felix Beyer, Marie-Theres Wittmann, Julia Schneider, Elif Fidan, Andre Reis, Jan Beckervordersandforth, Sebastian Brandner, Stefan Liebner, Sven Falk, Andreas Sagner, Christian Henneberger, Ruth Beckervordersandfort. Dentate gyrus astrocytes exhibit layer-specific molecular, morphological and physiological features. Nature neuroscience. 2022-11-28. PMID:36443610. |
astrocyte subtypes differentially express glutamate transporters, which is associated with different amplitudes of glutamate transporter-mediated currents. |
2022-11-28 |
2023-08-14 |
mouse |
| Mi Li, Jingmei Yu, Huan Deng, Shansha Xie, Qiuling Li, Yuping Zhao, Shubin Yin, Yi-Fei J. Upregulation of glutamate transporter 1 by mTOR/Akt pathway in astrocyte culture during oxygen-glucose deprivation and reoxygenation. Experimental brain research. 2022-11-27. PMID:36436003. |
upregulation of glutamate transporter 1 by mtor/akt pathway in astrocyte culture during oxygen-glucose deprivation and reoxygenation. |
2022-11-27 |
2023-08-14 |
Not clear |
| Julián Henao-Restrepo, Carolina López-Murillo, Pablo Valderrama-Carmona, Natalia Orozco-Santa, Johana Gomez, Johanna Gutiérrez-Vargas, Renato Moraga, Jorge Toledo, Jessica Lisa Littau, Steffen Härtel, Joseph F Arboleda-Velásquez, Diego Sepulveda-Falla, Francisco Lopera, Gloria Patricia Cardona-Gómez, Andrés Villegas, Rafael Posada-Duqu. Gliovascular alterations in sporadic and familial Alzheimer's disease: APOE3 Christchurch homozygote glioprotection. Brain pathology (Zurich, Switzerland). 2022-09-21. PMID:36130084. |
here, we characterized astrocyte properties related to reactivity, glutamate homeostasis, and structural integrity of the gliovascular unit (gvu), as factors that could underlie the pathogenesis or protection of ad. |
2022-09-21 |
2023-08-14 |
human |
| Maryvonne Ardourel, Arnaud Pâris, Chloé Felgerolle, Fabien Lesne, Isabelle Ranchon-Cole, Sylvain Briault, Olivier Perch. FMRP-related retinal phenotypes: Evidence of glutamate-glutamine metabolic cycle impairment. Experimental eye research. 2022-09-06. PMID:36067823. |
indeed, glutamate homeostasis deficit has been observed in absence of fmrp in-vivo in cortex and hippocampus structures as well as in vitro on astroglial cell culture. |
2022-09-06 |
2023-08-14 |
human |
| Stephan Schacke, Joanna Kirkpatrick, Amy Stocksdale, Reinhard Bauer, Christian Hagel, Lars Björn Riecken, Helen Morriso. Ezrin deficiency triggers glial fibrillary acidic protein upregulation and a distinct reactive astrocyte phenotype. Glia. 2022-08-05. PMID:35929192. |
astrocytes engage in glia-synaptic interactions through peripheral astrocyte processes, thus modulating synaptic signaling, for example, by handling glutamate removal from the synaptic cleft and (re)provision to axonal terminals. |
2022-08-05 |
2023-08-14 |
mouse |
| Daniel Báez Castellanos, Cynthia A Martín-Jiménez, Andrés Pinzón, George E Barreto, Guillermo Federico Padilla-González, Andrés Aristizábal, Martha Zuluaga, Janneth González Santo. Metabolomic Analysis of Human Astrocytes in Lipotoxic Condition: Potential Biomarker Identification by Machine Learning Modeling. Biomolecules. vol 12. issue 7. 2022-07-27. PMID:35883542. |
in this work, we propose that dysregulation in seleno-amino acid metabolism, urea cycle, and glutamate metabolism pathways are major triggers in astrocyte lipotoxic scenarios, while increased metabolites such as alanine, adenosine, and glutamate are suggested as potential biomarkers, which, to our knowledge, have not been identified in human astrocytes and are proposed as candidates for further research and validation. |
2022-07-27 |
2023-08-14 |
human |
| Asami Ikeda, Chiharu Yamasaki, Yurina Kubo, Yudai Doi, Mayu Komamizu, Masaharu Komatsu, Kazuhiro Shiozak. Alteration of the neuronal and glial cell profiles in Neu1-deficient zebrafish. Glycoconjugate journal. 2022-07-25. PMID:35877057. |
additionally, neu1-ko zebrafish induced the hyperactivation of astrocytes accompanied by an increase in gfap and phosphorylated erk levels, while the mrna levels of astrocyte glutamate transporters (eaat1a, eaat1c, and eaat2) were downregulated. |
2022-07-25 |
2023-08-14 |
zebrafish |
| M Neus Fullana, Verónica Paz, Francesc Artigas, Analia Bortolozz. Ketamine triggers rapid antidepressant effects by modulating synaptic plasticity in a new depressive-like mouse model based on astrocyte glutamate transporter GLT-1 knockdown in infralimbic cortex. Revista de psiquiatria y salud mental. vol 15. issue 2. 2022-07-15. PMID:35840289. |
ketamine triggers rapid antidepressant effects by modulating synaptic plasticity in a new depressive-like mouse model based on astrocyte glutamate transporter glt-1 knockdown in infralimbic cortex. |
2022-07-15 |
2023-08-14 |
mouse |
| Jessica Proulx, Satomi Stacy, In-Woo Park, Kathleen Borgman. A Non-Canonical Role for IRE1α Links ER and Mitochondria as Key Regulators of Astrocyte Dysfunction: Implications in Methamphetamine use and HIV-Associated Neurocognitive Disorders. Frontiers in neuroscience. vol 16. 2022-07-05. PMID:35784841. |
overall, our findings confirm ire1α modulates astrocyte mitochondrial respiration, glycolytic function, morphological activation, inflammation, and glutamate uptake, highlighting a novel potential target for regulating astrocyte dysfunction. |
2022-07-05 |
2023-08-14 |
human |
| Inês Belo do Nascimento, Marie Verfaillie, Gamze Ates, Pauline Beckers, Virginie Joris, Nathalie Desmet, Ann Massie, Emmanuel Herman. AMPK Modulates the Metabolic Adaptation of C6 Glioma Cells in Glucose-Deprived Conditions without Affecting Glutamate Transport. Cells. vol 11. issue 11. 2022-06-10. PMID:35681495. |
together, these results indicate that ampk contributes to the adaptation of astrocyte metabolism triggered by metabolic stress, but not to the regulation of glutamate transport. |
2022-06-10 |
2023-08-14 |
Not clear |
| Jessica M Proulx, Kathleen Borgman. Inositol-requiring enzyme 1 alpha (IRE1α) regulates astrocyte metabolic and inflammatory phenotypes: Implications in (METH)amphetamine use disorder and HIV-associated neurocognitive disorders. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555709. |
manipulation of ire1α using both pharmacological inhibitors and an overexpression plasmid, confirms ire1α modulates astrocyte calcium signaling, metabolic activity, glutamate clearance, and cytokine release. |
2022-05-13 |
2023-08-13 |
human |
| Swati Gupta, Narges Bazargani, James Drew, Jack H Howden, Souvik Modi, Sana Al Awabdh, Hélène Marie, David Attwell, Josef T Kittle. The non-adrenergic imidazoline-1 receptor protein nischarin is a key regulator of astrocyte glutamate uptake. iScience. vol 25. issue 4. 2022-04-18. PMID:35434559. |
the non-adrenergic imidazoline-1 receptor protein nischarin is a key regulator of astrocyte glutamate uptake. |
2022-04-18 |
2023-08-13 |
Not clear |
| Lorenzo Di Cesare Mannelli, Laura Micheli, Chiara Cervetto, Alessandra Toti, Elena Lucarini, Carmen Parisio, Manuela Marcoli, Carla Ghelardin. Neuronal alarmin IL-1α evokes astrocyte-mediated protective signals: Effectiveness in chemotherapy-induced neuropathic pain. Neurobiology of disease. 2022-04-03. PMID:35367629. |
ex vivo analysis on spinal purified astrocyte processes (gliosomes) and nerve terminals (synaptosomes) revealed the property of il-1α to reduce the endogenous glutamate release induced by oxaliplatin. |
2022-04-03 |
2023-08-13 |
rat |
| Lorenzo Di Cesare Mannelli, Laura Micheli, Chiara Cervetto, Alessandra Toti, Elena Lucarini, Carmen Parisio, Manuela Marcoli, Carla Ghelardin. Neuronal alarmin IL-1α evokes astrocyte-mediated protective signals: Effectiveness in chemotherapy-induced neuropathic pain. Neurobiology of disease. 2022-04-03. PMID:35367629. |
exogenously administered in rats, il-1α prevents neuropathic pain in the presence of spinal glutamate decrease and astrocyte activation. |
2022-04-03 |
2023-08-13 |
rat |
| Stefan Hirschberg, Anton Dvorzhak, Seyed M A Rasooli-Nejad, Svilen Angelov, Marieluise Kirchner, Philipp Mertins, Gilla Lättig-Tünnemann, Christoph Harms, Dietmar Schmitz, Rosemarie Granty. Uncoupling the Excitatory Amino Acid Transporter 2 From Its C-Terminal Interactome Restores Synaptic Glutamate Clearance at Corticostriatal Synapses and Alleviates Mutant Huntingtin-Induced Hypokinesia. Frontiers in cellular neuroscience. vol 15. 2022-02-17. PMID:35173582. |
it was found that the presence of a c-terminal-modified eaat2 transgene (i) increased the level of native eaat2 protein in striatal lysates and perisynaptic astrocyte processes, (ii) enhanced the glutamate uptake of transduced astrocytes, (iii) stimulated glutamate clearance at individual corticostriatal synapses, (iv) increased the glutamate uptake of striatal astrocytes and (iv) alleviated the mhtt-related hypokinesia (open field indicators of movement initiation). |
2022-02-17 |
2023-08-13 |
mouse |
| Xiaokang Zeng, Xinhuai Dong, Qiang Xiao, Jie Ya. Vitamin C Inhibits Ubiquitination of Glutamate Transporter 1 (GLT-1) in Astrocytes by Downregulating HECTD1. ACS chemical neuroscience. 2022-02-11. PMID:35148069. |
astrocyte glutamate transporter 1 (glt-1) is the main transporter responsible for transporting glutamate, and investigations toward the regulation of glt-1 in astrocytes can reveal important insights. |
2022-02-11 |
2023-08-13 |
Not clear |