| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chloe Delepine, Jennifer Shih, Keji Li, Pierre Gaudeaux, Mriganka Su. Differential effects of astrocyte manipulations on learned motor behavior and neuronal ensembles in the motor cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-03-09. PMID:36894315. |
mice that express decreased levels of the astrocyte glutamate transporter glt1 show impaired and variable movement trajectories, while mice with increased astrocyte gq signaling show decreased performance rates, delayed response times, and impaired trajectories. |
2023-03-09 |
2023-08-14 |
mouse |
| José Javier Miguel-Hidalg. Astrocytes as Context for the Involvement of Myelin and Nodes of Ranvier in the Pathophysiology of Depression and Stress-Related Disorders. Journal of psychiatry and brain science. vol 8. 2023-03-03. PMID:36866235. |
some of these changes involve the expression of connexins supporting astrocyte-to-oligodendrocyte gap junctions, extracellular matrix components produced by astrocytes around nodes of ranvier, specific types of astrocyte glutamate transporters, and neurotrophic factors secreted by astrocytes that are involved in the development and plasticity of myelin. |
2023-03-03 |
2023-08-14 |
human |
| Kelly M Wilson, Johnny J H. HIV Nef Expression Down-modulated GFAP Expression and Altered Glutamate Uptake and Release and Proliferation in Astrocytes. Aging and disease. vol 14. issue 1. 2023-02-23. PMID:36818564. |
lastly, we showed that nef expression led to increased glutamate uptake and decreased glutamate release by astrocytes and increased astrocyte proliferation. |
2023-02-23 |
2023-08-14 |
Not clear |
| Kelly M Wilson, Johnny J H. HIV Nef Expression Down-modulated GFAP Expression and Altered Glutamate Uptake and Release and Proliferation in Astrocytes. Aging and disease. vol 14. issue 1. 2023-02-23. PMID:36818564. |
taken together, these results indicate that nef leads to down-modulation of gfap expression and alteration of glutamate metabolism in astrocytes, and astrocyte proliferation and could be an important contributor to neurohiv. |
2023-02-23 |
2023-08-14 |
Not clear |
| Aina Badia-Soteras, Tim S Heistek, Mandy S J Kater, Aline Mak, Adrian Negrean, Michel C van den Oever, Huibert D Mansvelder, Baljit S Khakh, Rogier Min, August B Smit, Mark H G Verheije. Retraction of Astrocyte Leaflets From the Synapse Enhances Fear Memory. Biological psychiatry. 2023-01-26. PMID:36702661. |
astrocyte distal processes, known as leaflets, fine-tune synaptic activity by clearing neurotransmitters and limiting glutamate diffusion. |
2023-01-26 |
2023-08-14 |
Not clear |
| Courtney Clyburn, Kaitlin E Carson, Caleb R Smith, R Alberto Travagli, Kirsteen N Brownin. Brainstem astrocytes control homeostatic regulation of caloric intake. The Journal of physiology. 2023-01-25. PMID:36696965. |
astrocyte regulation of glutamatergic transmission to dmv neurons appears to involve release of the gliotransmitters glutamate and atp. |
2023-01-25 |
2023-08-14 |
Not clear |
| Yan Wang, Sheng Zhang, Zhaohui Lan, Vui Doan, Bokyung Kim, Sihan Liu, Meina Zhu, Vanessa L Hull, Sami Rihani, Chun-Li Zhang, John A Gray, Fuzheng Gu. SOX2 is essential for astrocyte maturation and its deletion leads to hyperactive behavior in mice. Cell reports. vol 41. issue 12. 2022-12-21. PMID:36543123. |
consistently, sox2 deficiency remarkably reduces glutamate transporter expression and compromised astrocyte function of glutamate uptake. our study provides insights into the cellular mechanisms underlying brain defects in children with sox2 mutations and suggests a link of astrocyte sox2 with extra-ocular abnormalities in sox2-mutant subjects. |
2022-12-21 |
2023-08-14 |
mouse |
| Bethany A Freel, Benjamin A Kelvington, Sonali Sengupta, Malini Mukherjee, Kevin R Franci. Sterol dysregulation in Smith-Lemli-Opitz syndrome causes astrocyte immune reactivity through microglia crosstalk. Disease models & mechanisms. vol 15. issue 12. 2022-12-16. PMID:36524414. |
transcript analyses demonstrate extensive dhcr7 astrocyte immune activation, hyper-responsiveness to glutamate stimulation and altered calcium flux. |
2022-12-16 |
2023-08-14 |
mouse |
| Osamu Nozawa, Muneaki Miyata, Hajime Shiotani, Takeshi Kameyama, Ryouhei Komaki, Tatsuhiro Shimizu, Toshihiko Kuriu, Yutaro Kashiwagi, Yuka Sato, Michinori Koebisu, Atsu Aiba, Shigeo Okabe, Kiyohito Mizutani, Yoshimi Taka. A novel Necl-2/3-mediated mechanism for tripartite synapse formation. Development (Cambridge, England). 2022-12-02. PMID:36458527. |
co-cultured neurons were required for astrocyte ramifications in a neuronal activity-dependent manner and synaptically released glutamate and activation of astrocytic mglur5 metabotropic glutamate receptor were likely involved in astrocyte ramifications. |
2022-12-02 |
2023-08-14 |
mouse |
| Osamu Nozawa, Muneaki Miyata, Hajime Shiotani, Takeshi Kameyama, Ryouhei Komaki, Tatsuhiro Shimizu, Toshihiko Kuriu, Yutaro Kashiwagi, Yuka Sato, Michinori Koebisu, Atsu Aiba, Shigeo Okabe, Kiyohito Mizutani, Yoshimi Taka. A novel Necl-2/3-mediated mechanism for tripartite synapse formation. Development (Cambridge, England). 2022-12-02. PMID:36458527. |
astrocytic necl-2/cadm1 trans-interacted with axonal necl-3/cadm2, inducing astrocyte-synapse interactions and astrocyte functional polarization by recruiting eaat1/2 glutamate transporters and kir4.1 k+ channel to the paps, without affecting astrocyte ramifications. |
2022-12-02 |
2023-08-14 |
mouse |
| Julian Karpf, Petr Unichenko, Nicholas Chalmers, Felix Beyer, Marie-Theres Wittmann, Julia Schneider, Elif Fidan, Andre Reis, Jan Beckervordersandforth, Sebastian Brandner, Stefan Liebner, Sven Falk, Andreas Sagner, Christian Henneberger, Ruth Beckervordersandfort. Dentate gyrus astrocytes exhibit layer-specific molecular, morphological and physiological features. Nature neuroscience. 2022-11-28. PMID:36443610. |
astrocyte subtypes differentially express glutamate transporters, which is associated with different amplitudes of glutamate transporter-mediated currents. |
2022-11-28 |
2023-08-14 |
mouse |
| Mi Li, Jingmei Yu, Huan Deng, Shansha Xie, Qiuling Li, Yuping Zhao, Shubin Yin, Yi-Fei J. Upregulation of glutamate transporter 1 by mTOR/Akt pathway in astrocyte culture during oxygen-glucose deprivation and reoxygenation. Experimental brain research. 2022-11-27. PMID:36436003. |
upregulation of glutamate transporter 1 by mtor/akt pathway in astrocyte culture during oxygen-glucose deprivation and reoxygenation. |
2022-11-27 |
2023-08-14 |
Not clear |
| Julián Henao-Restrepo, Carolina López-Murillo, Pablo Valderrama-Carmona, Natalia Orozco-Santa, Johana Gomez, Johanna Gutiérrez-Vargas, Renato Moraga, Jorge Toledo, Jessica Lisa Littau, Steffen Härtel, Joseph F Arboleda-Velásquez, Diego Sepulveda-Falla, Francisco Lopera, Gloria Patricia Cardona-Gómez, Andrés Villegas, Rafael Posada-Duqu. Gliovascular alterations in sporadic and familial Alzheimer's disease: APOE3 Christchurch homozygote glioprotection. Brain pathology (Zurich, Switzerland). 2022-09-21. PMID:36130084. |
here, we characterized astrocyte properties related to reactivity, glutamate homeostasis, and structural integrity of the gliovascular unit (gvu), as factors that could underlie the pathogenesis or protection of ad. |
2022-09-21 |
2023-08-14 |
human |
| Maryvonne Ardourel, Arnaud Pâris, Chloé Felgerolle, Fabien Lesne, Isabelle Ranchon-Cole, Sylvain Briault, Olivier Perch. FMRP-related retinal phenotypes: Evidence of glutamate-glutamine metabolic cycle impairment. Experimental eye research. 2022-09-06. PMID:36067823. |
indeed, glutamate homeostasis deficit has been observed in absence of fmrp in-vivo in cortex and hippocampus structures as well as in vitro on astroglial cell culture. |
2022-09-06 |
2023-08-14 |
human |
| Stephan Schacke, Joanna Kirkpatrick, Amy Stocksdale, Reinhard Bauer, Christian Hagel, Lars Björn Riecken, Helen Morriso. Ezrin deficiency triggers glial fibrillary acidic protein upregulation and a distinct reactive astrocyte phenotype. Glia. 2022-08-05. PMID:35929192. |
astrocytes engage in glia-synaptic interactions through peripheral astrocyte processes, thus modulating synaptic signaling, for example, by handling glutamate removal from the synaptic cleft and (re)provision to axonal terminals. |
2022-08-05 |
2023-08-14 |
mouse |
| Daniel Báez Castellanos, Cynthia A Martín-Jiménez, Andrés Pinzón, George E Barreto, Guillermo Federico Padilla-González, Andrés Aristizábal, Martha Zuluaga, Janneth González Santo. Metabolomic Analysis of Human Astrocytes in Lipotoxic Condition: Potential Biomarker Identification by Machine Learning Modeling. Biomolecules. vol 12. issue 7. 2022-07-27. PMID:35883542. |
in this work, we propose that dysregulation in seleno-amino acid metabolism, urea cycle, and glutamate metabolism pathways are major triggers in astrocyte lipotoxic scenarios, while increased metabolites such as alanine, adenosine, and glutamate are suggested as potential biomarkers, which, to our knowledge, have not been identified in human astrocytes and are proposed as candidates for further research and validation. |
2022-07-27 |
2023-08-14 |
human |
| Asami Ikeda, Chiharu Yamasaki, Yurina Kubo, Yudai Doi, Mayu Komamizu, Masaharu Komatsu, Kazuhiro Shiozak. Alteration of the neuronal and glial cell profiles in Neu1-deficient zebrafish. Glycoconjugate journal. 2022-07-25. PMID:35877057. |
additionally, neu1-ko zebrafish induced the hyperactivation of astrocytes accompanied by an increase in gfap and phosphorylated erk levels, while the mrna levels of astrocyte glutamate transporters (eaat1a, eaat1c, and eaat2) were downregulated. |
2022-07-25 |
2023-08-14 |
zebrafish |
| M Neus Fullana, Verónica Paz, Francesc Artigas, Analia Bortolozz. Ketamine triggers rapid antidepressant effects by modulating synaptic plasticity in a new depressive-like mouse model based on astrocyte glutamate transporter GLT-1 knockdown in infralimbic cortex. Revista de psiquiatria y salud mental. vol 15. issue 2. 2022-07-15. PMID:35840289. |
ketamine triggers rapid antidepressant effects by modulating synaptic plasticity in a new depressive-like mouse model based on astrocyte glutamate transporter glt-1 knockdown in infralimbic cortex. |
2022-07-15 |
2023-08-14 |
mouse |
| Jessica Proulx, Satomi Stacy, In-Woo Park, Kathleen Borgman. A Non-Canonical Role for IRE1α Links ER and Mitochondria as Key Regulators of Astrocyte Dysfunction: Implications in Methamphetamine use and HIV-Associated Neurocognitive Disorders. Frontiers in neuroscience. vol 16. 2022-07-05. PMID:35784841. |
overall, our findings confirm ire1α modulates astrocyte mitochondrial respiration, glycolytic function, morphological activation, inflammation, and glutamate uptake, highlighting a novel potential target for regulating astrocyte dysfunction. |
2022-07-05 |
2023-08-14 |
human |
| Inês Belo do Nascimento, Marie Verfaillie, Gamze Ates, Pauline Beckers, Virginie Joris, Nathalie Desmet, Ann Massie, Emmanuel Herman. AMPK Modulates the Metabolic Adaptation of C6 Glioma Cells in Glucose-Deprived Conditions without Affecting Glutamate Transport. Cells. vol 11. issue 11. 2022-06-10. PMID:35681495. |
together, these results indicate that ampk contributes to the adaptation of astrocyte metabolism triggered by metabolic stress, but not to the regulation of glutamate transport. |
2022-06-10 |
2023-08-14 |
Not clear |