| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Víctor Naranjo, Ana Contreras, Beatriz Merino, Adrián Plaza, María P Lorenzo, Cristina García-Cáceres, Antonia García, Julie A Chowen, Mariano Ruiz-Gayo, Nuria Del Olmo, Victoria Can. Specific Deletion of the Astrocyte Leptin Receptor Induces Changes in Hippocampus Glutamate Metabolism, Synaptic Transmission and Plasticity. Neuroscience. vol 447. 2021-05-14. PMID:31705891. |
specific deletion of the astrocyte leptin receptor induces changes in hippocampus glutamate metabolism, synaptic transmission and plasticity. |
2021-05-14 |
2023-08-13 |
mouse |
| Aditi Vian Varma-Doyle, Walter J Lukiw, Yuhai Zhao, Jesus Lovera, Deidre Devie. A hypothesis-generating scoping review of miRs identified in both multiple sclerosis and dementia, their protein targets, and miR signaling pathways. Journal of the neurological sciences. vol 420. 2021-05-14. PMID:33183778. |
these overlapping mirs are involved in pathways related to apoptosis, neuroinflammation, glutamate toxicity, astrocyte activation, microglial burst activity, synaptic dysfunction, and remyelination. |
2021-05-14 |
2023-08-13 |
Not clear |
| Xueqin Wang, Zan Xu, Fangli Zhao, Kuanhung J Lin, Joshua B Foster, Tianqi Xiao, Nydia Kung, Candice C Askwith, John P Bruno, Valentina Valentini, Kevin J Hodgetts, Chien-Liang Glenn Li. Restoring tripartite glutamatergic synapses: A potential therapy for mood and cognitive deficits in Gulf War illness. Neurobiology of stress. vol 13. 2021-05-14. PMID:33344696. |
they exhibited the following pathological changes in hippocampi: elevated extracellular glutamate levels, impaired glutamatergic synapses, astrocyte atrophy, loss of interneurons, and decreased neurogenesis. |
2021-05-14 |
2023-08-13 |
mouse |
| Ali Sepehrinezhad, Asadollah Zarifkar, Gholamreza Namvar, Ali Shahbazi, Roger William. Astrocyte swelling in hepatic encephalopathy: molecular perspective of cytotoxic edema. Metabolic brain disease. vol 35. issue 4. 2021-05-11. PMID:32146658. |
this article discusses the possible mechanisms of astrocyte swelling which related to hyperammonia, including the possible roles of molecules like glutamine, lactate, aquaporin-4 water channel, 18 kda translocator protein, glial fibrillary acidic protein, alanine, glutathione, toll-like receptor 4, epidermal growth factor receptor, glutamate, and manganese, as well as inflammation, oxidative stress, mitochondrial permeability transition, atp depletion, and astrocyte senescence. |
2021-05-11 |
2023-08-13 |
Not clear |
| Michel K Herde, Kirsten Bohmbach, Cátia Domingos, Natascha Vana, Joanna A Komorowska-Müller, Stefan Passlick, Inna Schwarz, Colin J Jackson, Dirk Dietrich, Martin K Schwarz, Christian Henneberge. Local Efficacy of Glutamate Uptake Decreases with Synapse Size. Cell reports. vol 32. issue 12. 2021-05-05. PMID:32966786. |
synaptically released glutamate is largely cleared by glutamate transporters localized on perisynaptic astrocyte processes. |
2021-05-05 |
2023-08-13 |
Not clear |
| Michel K Herde, Kirsten Bohmbach, Cátia Domingos, Natascha Vana, Joanna A Komorowska-Müller, Stefan Passlick, Inna Schwarz, Colin J Jackson, Dirk Dietrich, Martin K Schwarz, Christian Henneberge. Local Efficacy of Glutamate Uptake Decreases with Synapse Size. Cell reports. vol 32. issue 12. 2021-05-05. PMID:32966786. |
therefore, the substantial variability of astrocyte coverage of individual hippocampal synapses implies that the efficacy of local glutamate uptake and thus the spatial fidelity of synaptic transmission is synapse dependent. |
2021-05-05 |
2023-08-13 |
Not clear |
| Mark F McCarty, James J DiNicolantonio, Aaron Lerne. A Fundamental Role for Oxidants and Intracellular Calcium Signals in Alzheimer's Pathogenesis-And How a Comprehensive Antioxidant Strategy May Aid Prevention of This Disorder. International journal of molecular sciences. vol 22. issue 4. 2021-04-13. PMID:33669995. |
moreover, nutraceutical antioxidant strategies may oppose the adverse impact of amyloid β oligomers on astrocyte clearance of glutamate, and on the ability of brain capillaries to export amyloid β monomers/oligomers from the brain. |
2021-04-13 |
2023-08-13 |
Not clear |
| Maria Meyer, Maria Sol Kruse, Laura Garay, Analia Lima, Paulina Roig, Hazel Hunt, Joseph Belanoff, E Ronald de Kloet, Maria Claudia Gonzalez Deniselle, Alejandro F De Nicol. Long-term effects of the glucocorticoid receptor modulator CORT113176 in murine motoneuron degeneration. Brain research. vol 1727. 2021-04-05. PMID:31726042. |
there was a moderate positive effect on glutamine synthase and astrocyte glutamate transporters, suggesting decreased glutamate excitotoxicity. |
2021-04-05 |
2023-08-13 |
mouse |
| Neus Fullana, Júlia Gasull-Camós, Mireia Tarrés-Gatius, Anna Castañé, Analía Bortolozzi, Francesc Artiga. Astrocyte control of glutamatergic activity: Downstream effects on serotonergic function and emotional behavior. Neuropharmacology. vol 166. 2021-04-02. PMID:32045742. |
further, astrocytes regulate excitatory synapse activity via glutamate reuptake through astrocytic transporters eaat1 and eaat2 (glast and glt-1 in rodents), and alterations of astrocyte number/function have been reported in mdd patients and suicide victims. |
2021-04-02 |
2023-08-13 |
mouse |
| Patrick D Parker, Pratyush Suryavanshi, Marcello Melone, Punam A Sawant-Pokam, Katelyn M Reinhart, Dan Kaufmann, Jeremy J Theriot, Arianna Pugliese, Fiorenzo Conti, C William Shuttleworth, Daniela Pietrobon, K C Brenna. Non-canonical glutamate signaling in a genetic model of migraine with aura. Neuron. vol 109. issue 4. 2021-03-10. PMID:33321071. |
glutamatergic plumes overlapped anatomically with a reduced density of glt-1a-positive astrocyte processes and were mimicked in wild-type animals by inhibiting glutamate clearance. |
2021-03-10 |
2023-08-13 |
mouse |
| Mika Takarada-Iemat. Roles of N-myc downstream-regulated gene 2 in the central nervous system: molecular basis and relevance to pathophysiology. Anatomical science international. vol 96. issue 1. 2021-03-08. PMID:33174183. |
these studies demonstrate that ndrg2 plays diverse roles in the regulation of astrocyte reactivity, blood-brain barrier integrity, and glutamate excitotoxicity. |
2021-03-08 |
2023-08-13 |
mouse |
| James K Nolan, Tran N H Nguyen, Khanh Vy H Le, Luke E DeLong, Hyowon Le. Simple Fabrication of Flexible Biosensor Arrays Using Direct Writing for Multianalyte Measurement from Human Astrocytes. SLAS technology. vol 25. issue 1. 2021-02-12. PMID:31766939. |
the biosensors simultaneously measured glucose, glutamate, and lactate from astrocyte cultures. |
2021-02-12 |
2023-08-13 |
human |
| Jiang Wu, Bihua Bie, Joseph F Foss, Mohamed Nagui. Amyloid Fibril-Induced Astrocytic Glutamate Transporter Disruption Contributes to Complement C1q-Mediated Microglial Pruning of Glutamatergic Synapses. Molecular neurobiology. vol 57. issue 5. 2021-02-03. PMID:32008166. |
activation of astrocyte and reduction glutamate transporter 1 (glt1) were noted after bilateral microinjection of amyloid-beta (aβ |
2021-02-03 |
2023-08-13 |
rat |
| Maurício Dos Santos Pereira, Gabriel Henrique Dias Abreu, Jeremy Rocca, Sabah Hamadat, Rita Raisman-Vozari, Patrick Pierre Michel, Elaine Del Be. Contributive Role of TNF-α to L-DOPA-Induced Dyskinesia in a Unilateral 6-OHDA Lesion Model of Parkinson's Disease. Frontiers in pharmacology. vol 11. 2021-01-30. PMID:33510643. |
to possibly reproduce the neuroinflammatory component of lid, we exposed astrocyte and microglial cells in culture to candidate molecules that might operate as inflammatory cues during lid development, i.e., l-dopa, dopamine, or glutamate. |
2021-01-30 |
2023-08-13 |
mouse |
| Maurício Dos Santos Pereira, Gabriel Henrique Dias Abreu, Jeremy Rocca, Sabah Hamadat, Rita Raisman-Vozari, Patrick Pierre Michel, Elaine Del Be. Contributive Role of TNF-α to L-DOPA-Induced Dyskinesia in a Unilateral 6-OHDA Lesion Model of Parkinson's Disease. Frontiers in pharmacology. vol 11. 2021-01-30. PMID:33510643. |
however, glutamate enhanced tnf-α secretion and gfap expression in astrocyte cultures and promoted iba-1 expression in microglial cultures. |
2021-01-30 |
2023-08-13 |
mouse |
| Kati L Healey, Sandra Kibble, Sierra Hodges, Kathryn J Reissner, Anze Testen, Tiffany A Wills, Shawn K Acheson, Benjamin M Siemsen, John A McFaddin, Michael D Scofield, H Scott Swartzwelde. Enduring alterations in hippocampal astrocytesynaptic proximity following adolescent alcohol exposure: reversal by gabapentin. Neural regeneration research. vol 15. issue 8. 2021-01-24. PMID:31997814. |
additionally, we assessed the colocalization of astrocyte plasma membrane labeling with immunoreactivity for ampa-(α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) glutamate receptor 1, an ampa receptor subunit and established neuronal marker of excitatory synapses, as a metric of astrocyte-synapse proximity. |
2021-01-24 |
2023-08-13 |
human |
| Yujiao Lu, Gangadhara R Sareddy, Jing Wang, Quanguang Zhang, Fu-Lei Tang, Uday P Pratap, Rajeshwar R Tekmal, Ratna K Vadlamudi, Darrell W Bran. Neuron-Derived Estrogen Is Critical for Astrocyte Activation and Neuroprotection of the Ischemic Brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 38. 2021-01-15. PMID:32817249. |
the compromised astrocyte activation in fbn-aro-ko mice was associated with robust downregulation of the astrocyte-derived neurotrophic factors, bdnf and igf-1, as well as the astrocytic glutamate transporter, glt-1. |
2021-01-15 |
2023-08-13 |
mouse |
| Chin-Tsang Yang, Shih-Ya Hung, Sheng-Feng Hsu, Iona MacDonald, Jaung-Geng Lin, Sih-Ting Luo, Pei-Lin Lin, Yi-Hung Che. Inhibiting the LPS-induced enhancement of mEPSC frequency in superficial dorsal horn neurons may serve as an electrophysiological model for alleviating pain. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:31690742. |
microglial inhibitors minocycline and paeonol, as well as an astrocyte inhibitor, a p2y1 receptor (p2y1r) antagonist, and a metabotropic glutamate receptor 5 (mglur5) antagonist, all prevented lps-induced enhancement of mepsc frequency. |
2020-10-27 |
2023-08-13 |
mouse |
| Chin-Tsang Yang, Shih-Ya Hung, Sheng-Feng Hsu, Iona MacDonald, Jaung-Geng Lin, Sih-Ting Luo, Pei-Lin Lin, Yi-Hung Che. Inhibiting the LPS-induced enhancement of mEPSC frequency in superficial dorsal horn neurons may serve as an electrophysiological model for alleviating pain. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:31690742. |
these results indicate that lps-activated microglia release atp, which stimulates astrocyte p2y1rs to release glutamate, triggering presynaptic mglur5 receptors and increasing presynaptic glutamate release, leading to an increase in mepsc frequency and enhancement of nociceptive transmission in sdh neurons. |
2020-10-27 |
2023-08-13 |
mouse |
| Ekaterina Savchenko, Gabriel N Teku, Antonio Boza-Serrano, Kaspar Russ, Manon Berns, Tomas Deierborg, Nuno J Lamas, Hynek Wichterle, Jeffrey Rothstein, Christopher E Henderson, Mauno Vihinen, Laurent Roybo. FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes. Scientific reports. vol 9. issue 1. 2020-10-26. PMID:31270389. |
the glutamate transporter 1 (glt1) is upregulated during astrocyte development and maturation in vivo and is vital for astrocyte function. |
2020-10-26 |
2023-08-13 |
mouse |