| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun Fan, Mei-Chuan Chou, Yen-Chin Liu, Ching-Kuan Liu, Chu-Huang Chen, Shiou-Lan Che. Intermittent Hypoxia Activates N-Methyl-D-Aspartate Receptors to Induce Anxiety Behaviors in a Mouse Model of Sleep-Associated Apnea. Molecular neurobiology. vol 58. issue 7. 2021-07-06. PMID:33660202. |
increased glutamate n-methyl-d-aspartate (nmda) receptor subunits 2b (glun2b) and phosphorylated-erk1/2 were seen in the mpfc, striatum, and hippocampus of ih mice, but no significant microglial and astrocyte activation was found in these brain areas. |
2021-07-06 |
2023-08-13 |
mouse |
| Mengqi Zhang, Haojun Yang, Zhuohui Chen, Xinhang Hu, Tong Wu, Weiping Li. Long Noncoding RNA X-Inactive-Specific Transcript Promotes the Secretion of Inflammatory Cytokines in LPS Stimulated Astrocyte Cell Via Sponging miR-29c-3p and Regulating Nuclear Factor of Activated T cell 5 Expression. Frontiers in endocrinology. vol 12. 2021-06-15. PMID:33776905. |
astrocyte activation promotes glutamate accumulation and secretion of inflammatory factors, mainly responsible for epilepsy. |
2021-06-15 |
2023-08-13 |
Not clear |
| Qing Li, Haifang Zhang, Zhen Jia, Linlin Zhang, Yize Li, Rubin Xu, Chunyan Wang, Yonghao Y. Hydrogen enriched saline alleviates morphine tolerance via inhibiting neuroinflammation, GLT-1, GS nitration and NMDA receptor trafficking and functioning in the spinal cord of rats. Neuroscience letters. vol 755. 2021-06-08. PMID:33774150. |
the pro-inflammatory cytokine expressions [tumor necrosis factor-alpha (tnf-α), interleukin-1β (il-1β), il-6)] (by western blotting), astrocyte activation (by immunofluorescence and western blotting), and nitration of glutamate transporter-1 (glt-1) and glutamine synthetase (gs) (by immunoprecipitation), membrane and total expression of n-methyl-d-aspartic acid (nmda) receptor nr1 and nr2b subunits were carried out in the spinal dorsal horns. |
2021-06-08 |
2023-08-13 |
rat |
| Usha Kant Misra, Sandeep Kumar Singh, Jayantee Kalita, Alok Kuma. Astrocyte activation following nitrous oxide exposure is related to oxidative stress and glutamate excitotoxicity. Brain research. vol 1730. 2021-06-07. PMID:31911167. |
astrocyte activation following nitrous oxide exposure is related to oxidative stress and glutamate excitotoxicity. |
2021-06-07 |
2023-08-13 |
Not clear |
| Lifu Sheng, Tessandra Stewart, Dishun Yang, Eric Thorland, David Soltys, Patrick Aro, Tarek Khrisat, Zhiying Xie, Na Li, Zongran Liu, Chen Tian, Matthew Bercow, Junichi Matsumoto, Cyrus P Zabetian, Elaine Peskind, Joseph F Quinn, Min Shi, Jing Zhan. Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson's disease pathogenesis. Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32641150. |
these evs accumulated in astrocyte endfeet, a component of the bbb, where they impaired glutamate uptake, likely via interaction between excitatory amino acid transporter 2 (eaat2) and oligomeric α-syn. |
2021-05-31 |
2023-08-13 |
mouse |
| Isidro Ferrer, Pol Andrés-Benito, Maria Victoria Zelaya, Maria Elena Erro Aguirre, Margarita Carmona, Karina Ausín, Mercedes Lachén-Montes, Joaquín Fernández-Irigoyen, Enrique Santamaría, José Antonio Del Ri. Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy. Acta neuropathologica. vol 139. issue 4. 2021-05-17. PMID:31907603. |
in ggt cases linked to mapt p301t mutation, astrocyte markers gfap, aldh1l1, ykl40 mrna and protein, gja1 mrna, and aq4 protein are significantly increased; glutamate transporter glt1 (eaat2) and glucose transporter (slc2a1) decreased; mitochondrial pyruvate carrier 1 (mpc1) increased, and mitochondrial uncoupling protein 5 (ucp5) almost absent in gais in frontal cortex (fc). |
2021-05-17 |
2023-08-13 |
mouse |
| Víctor Naranjo, Ana Contreras, Beatriz Merino, Adrián Plaza, María P Lorenzo, Cristina García-Cáceres, Antonia García, Julie A Chowen, Mariano Ruiz-Gayo, Nuria Del Olmo, Victoria Can. Specific Deletion of the Astrocyte Leptin Receptor Induces Changes in Hippocampus Glutamate Metabolism, Synaptic Transmission and Plasticity. Neuroscience. vol 447. 2021-05-14. PMID:31705891. |
specific deletion of the astrocyte leptin receptor induces changes in hippocampus glutamate metabolism, synaptic transmission and plasticity. |
2021-05-14 |
2023-08-13 |
mouse |
| Aditi Vian Varma-Doyle, Walter J Lukiw, Yuhai Zhao, Jesus Lovera, Deidre Devie. A hypothesis-generating scoping review of miRs identified in both multiple sclerosis and dementia, their protein targets, and miR signaling pathways. Journal of the neurological sciences. vol 420. 2021-05-14. PMID:33183778. |
these overlapping mirs are involved in pathways related to apoptosis, neuroinflammation, glutamate toxicity, astrocyte activation, microglial burst activity, synaptic dysfunction, and remyelination. |
2021-05-14 |
2023-08-13 |
Not clear |
| Xueqin Wang, Zan Xu, Fangli Zhao, Kuanhung J Lin, Joshua B Foster, Tianqi Xiao, Nydia Kung, Candice C Askwith, John P Bruno, Valentina Valentini, Kevin J Hodgetts, Chien-Liang Glenn Li. Restoring tripartite glutamatergic synapses: A potential therapy for mood and cognitive deficits in Gulf War illness. Neurobiology of stress. vol 13. 2021-05-14. PMID:33344696. |
they exhibited the following pathological changes in hippocampi: elevated extracellular glutamate levels, impaired glutamatergic synapses, astrocyte atrophy, loss of interneurons, and decreased neurogenesis. |
2021-05-14 |
2023-08-13 |
mouse |
| Ali Sepehrinezhad, Asadollah Zarifkar, Gholamreza Namvar, Ali Shahbazi, Roger William. Astrocyte swelling in hepatic encephalopathy: molecular perspective of cytotoxic edema. Metabolic brain disease. vol 35. issue 4. 2021-05-11. PMID:32146658. |
this article discusses the possible mechanisms of astrocyte swelling which related to hyperammonia, including the possible roles of molecules like glutamine, lactate, aquaporin-4 water channel, 18 kda translocator protein, glial fibrillary acidic protein, alanine, glutathione, toll-like receptor 4, epidermal growth factor receptor, glutamate, and manganese, as well as inflammation, oxidative stress, mitochondrial permeability transition, atp depletion, and astrocyte senescence. |
2021-05-11 |
2023-08-13 |
Not clear |
| Michel K Herde, Kirsten Bohmbach, Cátia Domingos, Natascha Vana, Joanna A Komorowska-Müller, Stefan Passlick, Inna Schwarz, Colin J Jackson, Dirk Dietrich, Martin K Schwarz, Christian Henneberge. Local Efficacy of Glutamate Uptake Decreases with Synapse Size. Cell reports. vol 32. issue 12. 2021-05-05. PMID:32966786. |
synaptically released glutamate is largely cleared by glutamate transporters localized on perisynaptic astrocyte processes. |
2021-05-05 |
2023-08-13 |
Not clear |
| Michel K Herde, Kirsten Bohmbach, Cátia Domingos, Natascha Vana, Joanna A Komorowska-Müller, Stefan Passlick, Inna Schwarz, Colin J Jackson, Dirk Dietrich, Martin K Schwarz, Christian Henneberge. Local Efficacy of Glutamate Uptake Decreases with Synapse Size. Cell reports. vol 32. issue 12. 2021-05-05. PMID:32966786. |
therefore, the substantial variability of astrocyte coverage of individual hippocampal synapses implies that the efficacy of local glutamate uptake and thus the spatial fidelity of synaptic transmission is synapse dependent. |
2021-05-05 |
2023-08-13 |
Not clear |
| Mark F McCarty, James J DiNicolantonio, Aaron Lerne. A Fundamental Role for Oxidants and Intracellular Calcium Signals in Alzheimer's Pathogenesis-And How a Comprehensive Antioxidant Strategy May Aid Prevention of This Disorder. International journal of molecular sciences. vol 22. issue 4. 2021-04-13. PMID:33669995. |
moreover, nutraceutical antioxidant strategies may oppose the adverse impact of amyloid β oligomers on astrocyte clearance of glutamate, and on the ability of brain capillaries to export amyloid β monomers/oligomers from the brain. |
2021-04-13 |
2023-08-13 |
Not clear |
| Maria Meyer, Maria Sol Kruse, Laura Garay, Analia Lima, Paulina Roig, Hazel Hunt, Joseph Belanoff, E Ronald de Kloet, Maria Claudia Gonzalez Deniselle, Alejandro F De Nicol. Long-term effects of the glucocorticoid receptor modulator CORT113176 in murine motoneuron degeneration. Brain research. vol 1727. 2021-04-05. PMID:31726042. |
there was a moderate positive effect on glutamine synthase and astrocyte glutamate transporters, suggesting decreased glutamate excitotoxicity. |
2021-04-05 |
2023-08-13 |
mouse |
| Neus Fullana, Júlia Gasull-Camós, Mireia Tarrés-Gatius, Anna Castañé, Analía Bortolozzi, Francesc Artiga. Astrocyte control of glutamatergic activity: Downstream effects on serotonergic function and emotional behavior. Neuropharmacology. vol 166. 2021-04-02. PMID:32045742. |
further, astrocytes regulate excitatory synapse activity via glutamate reuptake through astrocytic transporters eaat1 and eaat2 (glast and glt-1 in rodents), and alterations of astrocyte number/function have been reported in mdd patients and suicide victims. |
2021-04-02 |
2023-08-13 |
mouse |
| Patrick D Parker, Pratyush Suryavanshi, Marcello Melone, Punam A Sawant-Pokam, Katelyn M Reinhart, Dan Kaufmann, Jeremy J Theriot, Arianna Pugliese, Fiorenzo Conti, C William Shuttleworth, Daniela Pietrobon, K C Brenna. Non-canonical glutamate signaling in a genetic model of migraine with aura. Neuron. vol 109. issue 4. 2021-03-10. PMID:33321071. |
glutamatergic plumes overlapped anatomically with a reduced density of glt-1a-positive astrocyte processes and were mimicked in wild-type animals by inhibiting glutamate clearance. |
2021-03-10 |
2023-08-13 |
mouse |
| Mika Takarada-Iemat. Roles of N-myc downstream-regulated gene 2 in the central nervous system: molecular basis and relevance to pathophysiology. Anatomical science international. vol 96. issue 1. 2021-03-08. PMID:33174183. |
these studies demonstrate that ndrg2 plays diverse roles in the regulation of astrocyte reactivity, blood-brain barrier integrity, and glutamate excitotoxicity. |
2021-03-08 |
2023-08-13 |
mouse |
| James K Nolan, Tran N H Nguyen, Khanh Vy H Le, Luke E DeLong, Hyowon Le. Simple Fabrication of Flexible Biosensor Arrays Using Direct Writing for Multianalyte Measurement from Human Astrocytes. SLAS technology. vol 25. issue 1. 2021-02-12. PMID:31766939. |
the biosensors simultaneously measured glucose, glutamate, and lactate from astrocyte cultures. |
2021-02-12 |
2023-08-13 |
human |
| Jiang Wu, Bihua Bie, Joseph F Foss, Mohamed Nagui. Amyloid Fibril-Induced Astrocytic Glutamate Transporter Disruption Contributes to Complement C1q-Mediated Microglial Pruning of Glutamatergic Synapses. Molecular neurobiology. vol 57. issue 5. 2021-02-03. PMID:32008166. |
activation of astrocyte and reduction glutamate transporter 1 (glt1) were noted after bilateral microinjection of amyloid-beta (aβ |
2021-02-03 |
2023-08-13 |
rat |
| Maurício Dos Santos Pereira, Gabriel Henrique Dias Abreu, Jeremy Rocca, Sabah Hamadat, Rita Raisman-Vozari, Patrick Pierre Michel, Elaine Del Be. Contributive Role of TNF-α to L-DOPA-Induced Dyskinesia in a Unilateral 6-OHDA Lesion Model of Parkinson's Disease. Frontiers in pharmacology. vol 11. 2021-01-30. PMID:33510643. |
to possibly reproduce the neuroinflammatory component of lid, we exposed astrocyte and microglial cells in culture to candidate molecules that might operate as inflammatory cues during lid development, i.e., l-dopa, dopamine, or glutamate. |
2021-01-30 |
2023-08-13 |
mouse |