| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Darshpreet Kaur, Vivek Sharma, Rahul Deshmuk. Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer's disease. Inflammopharmacology. vol 27. issue 4. 2020-01-09. PMID:30874945. |
astrocyte dysfunctioning results in increased release of cytokines and inflammatory mediators, neurodegeneration, decreased glutamate uptake, loss of neuronal synapses, and ultimately cognitive deficits in ad. |
2020-01-09 |
2023-08-13 |
Not clear |
| B M Siemsen, C M Reichel, K C Leong, C Garcia-Keller, C D Gipson, S Spencer, J A McFaddin, K N Hooker, P W Kalivas, M D Scofiel. Effects of Methamphetamine Self-Administration and Extinction on Astrocyte Structure and Function in the Nucleus Accumbens Core. Neuroscience. vol 406. 2019-12-24. PMID:30926546. |
in order to test the impact of astrocyte activation and the induction of glial glutamate release within the nacore, we employed astrocyte-specific expression of designer receptors exclusively activated by designer drugs (dreadds). |
2019-12-24 |
2023-08-13 |
Not clear |
| Guoqiang Xing, Ming Ren, Ajay Verm. Divergent Induction of Branched-Chain Aminotransferases and Phosphorylation of Branched Chain Keto-Acid Dehydrogenase Is a Potential Mechanism Coupling Branched-Chain Keto-Acid-Mediated-Astrocyte Activation to Branched-Chain Amino Acid Depletion-Mediated Cognitive Deficit after Traumatic Brain Injury. Journal of neurotrauma. vol 35. issue 20. 2019-12-20. PMID:29764289. |
because increased pbckd would lead to increased bcka accumulation, bcka-mediated astrocyte activation, cell death, and cognitive dysfunction as found in maple syrup urine disease; thus, tbi may potentially induce cognitive deficit through diverting bcaa from glutamate production in neurons to bcka production in astrocytes through the pbckd-dependent mechanism. |
2019-12-20 |
2023-08-13 |
rat |
| Michelle Corkrum, Patrick E Rothwell, Mark J Thomas, Paulo Kofuji, Alfonso Araqu. Opioid-Mediated Astrocyte-Neuron Signaling in the Nucleus Accumbens. Cells. vol 8. issue 6. 2019-12-20. PMID:31207909. |
through the combination of calcium imaging and whole-cell patch clamp electrophysiology in brain slices, we have found that μ-opioid receptor activation in astrocytes elevates astrocyte cytoplasmic calcium and stimulates the release of the gliotransmitter glutamate, which evokes slow inward currents through the activation of neuronal n-methyl-d-aspartate (nmda) receptors. |
2019-12-20 |
2023-08-13 |
Not clear |
| Anthony D Umpierre, Peter J West, John A White, Karen S Wilco. Conditional Knock-out of mGluR5 from Astrocytes during Epilepsy Development Impairs High-Frequency Glutamate Uptake. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 4. 2019-12-16. PMID:30504280. |
astrocyte expression of metabotropic glutamate receptor 5 (mglur5) is consistently observed in resected tissue from patients with epilepsy and is equally prevalent in animal models of epilepsy. |
2019-12-16 |
2023-08-13 |
mouse |
| Anthony D Umpierre, Peter J West, John A White, Karen S Wilco. Conditional Knock-out of mGluR5 from Astrocytes during Epilepsy Development Impairs High-Frequency Glutamate Uptake. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 4. 2019-12-16. PMID:30504280. |
finally, we find that the selective and conditional knock-out of mglur5 signaling from astrocytes during epilepsy development slows the rate of glutamate clearance through astrocyte glutamate transporters under high-frequency stimulation conditions, a feature that suggests astrocyte mglur5 expression during epileptogenesis may recapitulate earlier developmental roles in regulating glutamate transporter function. |
2019-12-16 |
2023-08-13 |
mouse |
| Kiyoshi Oomagari, Bruno Buisson, Aline Dumuis, Joël Bockaert, Jean-Philippe Pi. Effect of Glutamate and Ionomycin on the Release of Arachidonic Acid, Prostaglandins and HETEs from Cultured Neurons and Astrocytes. The European journal of neuroscience. vol 3. issue 10. 2019-11-20. PMID:12106250. |
in contrast, in astrocyte cultures, ionomycin (but not glutamate) strongly stimulated the release of pgs and hetes as well as ara. |
2019-11-20 |
2023-08-12 |
mouse |
| Victoria Cano, Ismael Valladolid-Acebes, Francisco Hernández-Nuño, Beatriz Merino, Nuria Del Olmo, Julie A Chowen, Mariano Ruiz-Gay. Morphological changes in glial fibrillary acidic protein immunopositive astrocytes in the hippocampus of dietary-induced obese mice. Neuroreport. vol 25. issue 11. 2019-11-20. PMID:24911388. |
we have analyzed astrocyte morphology and density by glial fibrillary acidic protein immunohistochemistry, as well as the expression of the glutamate transporters, glt-1 (glutamate transporter type-1), and glast (astrocyte glutamate transporter), in the ca3 area of the hippocampus. |
2019-11-20 |
2023-08-13 |
mouse |
| Gaëlle Champeil-Potokar, Marie Hennebelle, Alizée Latour, Sylvie Vancassel, Isabelle Deni. Docosahexaenoic acid (DHA) prevents corticosterone-induced changes in astrocyte morphology and function. Journal of neurochemistry. vol 136. issue 6. 2019-11-20. PMID:26709611. |
corticosterone stimulated astrocyte glutamate recycling by increasing glutamate uptake and glutamine synthetase (gs), and altered the astrocyte cytoskeleton. |
2019-11-20 |
2023-08-13 |
rat |
| Elisabeth Hansso. Long-term pain, neuroinflammation and glial activation. Scandinavian journal of pain. vol 1. issue 2. 2019-11-20. PMID:29913949. |
increased release of glutamate and atp leads to disturbances in ca2+ signalling, increased production of cytokines and free radicals, attenuation of the astrocyte glutamate transport capacity, and conformational changes in the astrocytic cytoskeleton, the actin filaments, which can lead to formation and rebuilding of new synapses. |
2019-11-20 |
2023-08-13 |
Not clear |
| Simone Pelassa, Diego Guidolin, Arianna Venturini, Monica Averna, Giulia Frumento, Letizia Campanini, Rosa Bernardi, Pietro Cortelli, Giovanna Calandra Buonaura, Guido Maura, Luigi F Agnati, Chiara Cervetto, Manuela Marcol. A2A-D2 Heteromers on Striatal Astrocytes: Biochemical and Biophysical Evidence. International journal of molecular sciences. vol 20. issue 10. 2019-11-12. PMID:31109007. |
our previous findings indicate that a2a and d2 receptors are co-expressed on adult rat striatal astrocytes and on the astrocyte processes, and that a2a-d2 receptor⁻receptor interaction can control the release of glutamate from the processes. |
2019-11-12 |
2023-08-13 |
rat |
| Chun-Shu Piao, Ashley L Holloway, Sue Hong-Routson, Mark S Wainwrigh. Depression following traumatic brain injury in mice is associated with down-regulation of hippocampal astrocyte glutamate transporters by thrombin. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 39. issue 1. 2019-11-04. PMID:29135354. |
depression following traumatic brain injury in mice is associated with down-regulation of hippocampal astrocyte glutamate transporters by thrombin. |
2019-11-04 |
2023-08-13 |
mouse |
| Chun-Shu Piao, Ashley L Holloway, Sue Hong-Routson, Mark S Wainwrigh. Depression following traumatic brain injury in mice is associated with down-regulation of hippocampal astrocyte glutamate transporters by thrombin. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 39. issue 1. 2019-11-04. PMID:29135354. |
these results identify a novel mechanism by which tbi results in down-regulation of astrocyte glutamate transporters and implicate astrocyte and glutamate transporter dysfunction in depression following tbi. |
2019-11-04 |
2023-08-13 |
mouse |
| Megan E Bosch, Tammy Kielia. Astrocytes in juvenile neuronal ceroid lipofuscinosis (CLN3) display metabolic and calcium signaling abnormalities. Journal of neurochemistry. vol 148. issue 5. 2019-10-28. PMID:29964296. |
neuronal loss is thought to occur, in part, via glutamate excitotoxicity; however, little is known about astrocyte glutamate regulation in jncl. |
2019-10-28 |
2023-08-13 |
Not clear |
| Hyun Geun Shim, Sung-Soo Jang, Seung Ha Kim, Eun Mi Hwang, Joo Ok Min, Hye Yun Kim, Yoo Sung Kim, Changhyeon Ryu, Geehoon Chung, YoungSoo Kim, Bo-Eun Yoon, Sang Jeong Ki. TNF-α increases the intrinsic excitability of cerebellar Purkinje cells through elevating glutamate release in Bergmann Glia. Scientific reports. vol 8. issue 1. 2019-10-21. PMID:30072733. |
in addition, we measured the concentration of glutamate derived from dissociated cerebellar cortical astrocyte cultures treated with tnf-α and observed a progressive increase of glutamate in a time-dependent manner. |
2019-10-21 |
2023-08-13 |
human |
| Michael D Scofiel. Exploring the Role of Astroglial Glutamate Release and Association With Synapses in Neuronal Function and Behavior. Biological psychiatry. vol 84. issue 11. 2019-10-08. PMID:29258653. |
however, data from animal models of addiction demonstrate that a variety of drug-induced molecular adaptations responsible for relapse vulnerability take place in astrocyte systems that regulate glutamate uptake and release. |
2019-10-08 |
2023-08-13 |
Not clear |
| Michael D Scofiel. Exploring the Role of Astroglial Glutamate Release and Association With Synapses in Neuronal Function and Behavior. Biological psychiatry. vol 84. issue 11. 2019-10-08. PMID:29258653. |
further, i compile evidence regarding astrocyte glutamate release as well as astrocyte association with synapses with respect to the impact of these cellular phenomena in shaping synaptic transmission. |
2019-10-08 |
2023-08-13 |
Not clear |
| Theresa S Rimmele, Haissa de Castro Abrantes, Joel Wellbourne-Wood, Sylvain Lengacher, Jean-Yves Chatto. Extracellular Potassium and Glutamate Interact To Modulate Mitochondria in Astrocytes. ACS chemical neuroscience. vol 9. issue 8. 2019-10-03. PMID:29741354. |
whereas astrocyte glutamate uptake causes cytosolic and mitochondrial acidification, extracellular potassium induces bicarbonate-dependent cellular alkalinization. |
2019-10-03 |
2023-08-13 |
Not clear |
| Philippine C Geiszler, Aslihan Ugun-Klusek, Karen Lawler, Marie-Christine Pardon, Ding Yuchun, Li Bai, Clare A Daykin, Dorothee P Auer, Lynn Bedfor. Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons. Scientific reports. vol 8. issue 1. 2019-09-23. PMID:29555943. |
our results extend the limited understanding of metabolite changes associated with gliosis and provide evidence that changes in glutamate homeostasis and lactate may correlate with astrocyte activation and have biomarker potential for tracking neuroinflammation. |
2019-09-23 |
2023-08-13 |
mouse |
| Caroline Zanotto, Fernanda Hansen, Fabiana Galland, Cristiane Batassini, Bárbara Carolina Federhen, Vanessa Fernanda da Silva, Marina Concli Leite, Patrícia Nardin, Carlos-Alberto Gonçalve. Glutamatergic Alterations in STZ-Induced Diabetic Rats Are Reversed by Exendin-4. Molecular neurobiology. vol 56. issue 5. 2019-08-13. PMID:30145785. |
ex-4 abrogated the decrease in glutamate uptake and glun1 content caused by methylglyoxal (mg) in hippocampal slices, in addition to leading to an increase in glutamate uptake in astrocyte culture cells and hippocampal slices under basal conditions. |
2019-08-13 |
2023-08-13 |
rat |