| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chiara Cervetto, Arianna Venturini, Mario Passalacqua, Diego Guidolin, Susanna Genedani, Kjell Fuxe, Dasiel O Borroto-Esquela, Pietro Cortelli, Amina Woods, Guido Maura, Manuela Marcoli, Luigi F Agnat. A2A-D2 receptor-receptor interaction modulates gliotransmitter release from striatal astrocyte processes. Journal of neurochemistry. vol 140. issue 2. 2017-07-28. PMID:27896809. |
here, we investigated the presence of d2 and a2a receptors in isolated astrocyte processes prepared from adult rat striatum by confocal imaging; the effects of receptor activation were measured on the 4-aminopyridine-evoked release of glutamate from the processes. |
2017-07-28 |
2023-08-13 |
rat |
| Moritz Armbruster, Elizabeth Hanson, Chris G Dull. Glutamate Clearance Is Locally Modulated by Presynaptic Neuronal Activity in the Cerebral Cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 40. 2017-07-24. PMID:27707974. |
interestingly, the slowing of glutamate uptake is specific to activated synapses, even within the domain of an individual astrocyte. |
2017-07-24 |
2023-08-13 |
mouse |
| Tudor Puiu, Anson E Kairys, Lynne Pauer, Tobias Schmidt-Wilcke, Eric Ichesco, Johnson P Hampson, Vitaly Napadow, Daniel J Clauw, Richard E Harri. Association of Alterations in Gray Matter Volume With Reduced Evoked-Pain Connectivity Following Short-Term Administration of Pregabalin in Patients With Fibromyalgia. Arthritis & rheumatology (Hoboken, N.J.). vol 68. issue 6. 2017-07-07. PMID:26816332. |
preclinical studies indicate that pgb may down-regulate brain glutamate release while also inhibiting astrocyte induction of glutamatergic synapse formation, and recent clinical findings support the notion that pgb modulates glutamatergic activity and functional brain connectivity in order to produce analgesia. |
2017-07-07 |
2023-08-13 |
Not clear |
| Anna Konopka, Andre Zeug, Anna Skupien, Beata Kaza, Franziska Mueller, Agnieszka Chwedorowicz, Evgeni Ponimaskin, Grzegorz M Wilczynski, Joanna Dzwone. Cleavage of Hyaluronan and CD44 Adhesion Molecule Regulate Astrocyte Morphology via Rac1 Signalling. PloS one. vol 11. issue 5. 2017-07-05. PMID:27163367. |
: glutamate clearance in the synaptic cleft, migration, astrogliosis), we investigated the influence of hyaluronan cleavage by hyaluronidase, knockdown of cd44 by specific shrna and cd44 overexpression on astrocyte morphology. |
2017-07-05 |
2023-08-13 |
Not clear |
| Danbee Ha, So Jin Bing, Ginnae Ahn, Jinhee Kim, Jinhee Cho, Areum Kim, Kalahe H I N M Herath, Hak Sun Yu, Sangmee Ahn Jo, Ik-Hyun Cho, Youngheun Je. Blocking glutamate carboxypeptidase II inhibits glutamate excitotoxicity and regulates immune responses in experimental autoimmune encephalomyelitis. The FEBS journal. vol 283. issue 18. 2017-06-26. PMID:27444540. |
despite several findings indicating possible link between glutamate and ms/eae, however, the involvement of astrocyte or gcpii on glutamate excitotoxicity has not received much attention in ms/eae. |
2017-06-26 |
2023-08-13 |
mouse |
| Lili Xu, Liumin Wang, Zhuoyu Wen, Li Wu, Yongjun Jiang, Lian Yang, Lulu Xiao, Yi Xie, Minmin Ma, Wusheng Zhu, Ruidong Ye, Xinfeng Li. Caveolin-1 is a checkpoint regulator in hypoxia-induced astrocyte apoptosis via Ras/Raf/ERK pathway. American journal of physiology. Cell physiology. vol 310. issue 11. 2017-05-30. PMID:27009876. |
downregulation of cav-1 using cav-1 small interfering rna dramatically worsened astrocyte cell damage and impaired cellular glutamate uptake after ogd, whereas overexpression of cav-1 with cav-1 scaffolding domain peptide attenuated ogd-induced cell apoptosis. |
2017-05-30 |
2023-08-13 |
human |
| Jacqueline A Hubbard, Jenny I Szu, Jennifer M Yonan, Devin K Binde. Regulation of astrocyte glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) expression in a model of epilepsy. Experimental neurology. vol 283. issue Pt A. 2017-05-05. PMID:27155358. |
regulation of astrocyte glutamate transporter-1 (glt1) and aquaporin-4 (aqp4) expression in a model of epilepsy. |
2017-05-05 |
2023-08-13 |
mouse |
| Jacqueline A Hubbard, Jenny I Szu, Jennifer M Yonan, Devin K Binde. Regulation of astrocyte glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) expression in a model of epilepsy. Experimental neurology. vol 283. issue Pt A. 2017-05-05. PMID:27155358. |
our findings suggest that specific molecular changes in astrocyte glutamate transporters and water channels occur during epileptogenesis in this model, and suggest the novel therapeutic strategy of restoring glutamate and water homeostasis. |
2017-05-05 |
2023-08-13 |
mouse |
| Yong-Ku Kim, Kyoung-Sae N. Role of glutamate receptors and glial cells in the pathophysiology of treatment-resistant depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 70. 2017-04-12. PMID:27046518. |
an appropriate reuptake of glutamate at the astrocyte is crucial for preventing 'spill-over' of synaptic glutamate and binding to the extrasynaptic nmda receptor. |
2017-04-12 |
2023-08-13 |
Not clear |
| Patrícia Nardin, Caroline Zanotto, Fernanda Hansen, Cristiane Batassini, Manuela Sangalli Gasparin, Patrícia Sesterheim, Carlos-Alberto Gonçalve. Peripheral Levels of AGEs and Astrocyte Alterations in the Hippocampus of STZ-Diabetic Rats. Neurochemical research. vol 41. issue 8. 2017-03-03. PMID:27084774. |
herein, we investigate specific astrocyte changes in the rat hippocampus in a model of dm induced by stz, particularly looking at glial fibrillary acidic protein (gfap), s100b protein and glutamate uptake, as well as the content of advanced glycated end products (ages) in serum and cerebrospinal fluid (csf), as a consequence of elevated hyperglycemia and the content of receptor for ages in the hippocampus. |
2017-03-03 |
2023-08-13 |
rat |
| Milos Kostic, Nikola Zivkovic, Ana Cvetanovic, Ivana Stojanovic, Miodrag Coli. IL-17 signalling in astrocytes promotes glutamate excitotoxicity: Indications for the link between inflammatory and neurodegenerative events in multiple sclerosis. Multiple sclerosis and related disorders. vol 11. 2017-02-27. PMID:28104249. |
accordingly, the objective of our study was to assess il-17a effect on astrocyte ability to metabolize and release glutamate, considering that astrocytes had the central role in glutamate homeostasis. |
2017-02-27 |
2023-08-13 |
Not clear |
| Stephanie N Blandford, William H Baldridg. The Effect of Glutamate Receptor Agonists on Mouse Retinal Astrocyte [Ca(2+)]i. BioMed research international. vol 2016. 2017-02-22. PMID:27413752. |
the effect of glutamate receptor agonists on mouse retinal astrocyte [ca(2+)]i. calcium-imaging techniques were used to determine if mouse retinal astrocytes in situ respond to agonists of ionotropic (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, ampa; n-methyl-d-aspartate, nmda) and metabotropic (s-3,5-dihydroxyphenylglycine, dhpg; trans-1-amino-1,3-cyclopentanedicarboxylic acid, acpd) glutamate receptors. |
2017-02-22 |
2023-08-13 |
mouse |
| Stephanie N Blandford, William H Baldridg. The Effect of Glutamate Receptor Agonists on Mouse Retinal Astrocyte [Ca(2+)]i. BioMed research international. vol 2016. 2017-02-22. PMID:27413752. |
in most cases we found no evidence that retinal astrocyte intracellular calcium ion concentration ([ca(2+)]i) increased in response to these glutamate agonists. |
2017-02-22 |
2023-08-13 |
mouse |
| Esther Fuente-Martín, Cristina García-Cáceres, Pilar Argente-Arizón, Francisca Díaz, Miriam Granado, Alejandra Freire-Regatillo, David Castro-González, María L Ceballos, Laura M Frago, Suzanne L Dickson, Jesús Argente, Julie A Chowe. Ghrelin Regulates Glucose and Glutamate Transporters in Hypothalamic Astrocytes. Scientific reports. vol 6. 2017-02-17. PMID:27026049. |
moreover, primary astrocyte cultures from ghsr-1a knock-out mice do not change glutamate transporter or glut2 levels in response to acyl-ghrelin. |
2017-02-17 |
2023-08-13 |
mouse |
| Esther Fuente-Martín, Cristina García-Cáceres, Pilar Argente-Arizón, Francisca Díaz, Miriam Granado, Alejandra Freire-Regatillo, David Castro-González, María L Ceballos, Laura M Frago, Suzanne L Dickson, Jesús Argente, Julie A Chowe. Ghrelin Regulates Glucose and Glutamate Transporters in Hypothalamic Astrocytes. Scientific reports. vol 6. 2017-02-17. PMID:27026049. |
our results indicate that acyl-ghrelin may mediate part of its metabolic actions through modulation of hypothalamic astrocytes and that this effect could involve astrocyte mediated changes in local glucose and glutamate metabolism that alter the signals/nutrients reaching neighboring neurons. |
2017-02-17 |
2023-08-13 |
mouse |
| Maurizio De Pittà, Nicolas Brune. Modulation of Synaptic Plasticity by Glutamatergic Gliotransmission: A Modeling Study. Neural plasticity. vol 2016. 2016-12-30. PMID:27195153. |
glutamatergic gliotransmission, that is, the release of glutamate from perisynaptic astrocyte processes in an activity-dependent manner, has emerged as a potentially crucial signaling pathway for regulation of synaptic plasticity, yet its modes of expression and function in vivo remain unclear. |
2016-12-30 |
2023-08-13 |
Not clear |
| Chiara Cervetto, Laura Vergani, Mario Passalacqua, Milena Ragazzoni, Arianna Venturini, Francesco Cecconi, Nicola Berretta, Nicola Mercuri, Marcello D'Amelio, Guido Maura, Paolo Mariottini, Adriana Voci, Manuela Marcoli, Manuela Cervell. Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse. Neuromolecular medicine. vol 18. issue 1. 2016-12-28. PMID:26530396. |
to investigate the mechanisms by which smo overexpression leads to increased susceptibility to kainate excitotoxicity and seizure, in the cerebral cortex of dach-smo and control mice we assessed markers for astrocyte proliferation and neuron loss, and the ability of kainate to evoke glutamate release from nerve terminals and astrocyte processes. |
2016-12-28 |
2023-08-13 |
mouse |
| Chiara Cervetto, Laura Vergani, Mario Passalacqua, Milena Ragazzoni, Arianna Venturini, Francesco Cecconi, Nicola Berretta, Nicola Mercuri, Marcello D'Amelio, Guido Maura, Paolo Mariottini, Adriana Voci, Manuela Marcoli, Manuela Cervell. Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse. Neuromolecular medicine. vol 18. issue 1. 2016-12-28. PMID:26530396. |
we conclude that reactive astrocytosis and activation of glutamate release from astrocyte processes might contribute, together with increased reactive oxygen species production, to the vulnerability to kainate excitotoxicity in dach-smo mice. |
2016-12-28 |
2023-08-13 |
mouse |
| Elizabeth Hanson, Niels Christian Danbolt, Chris G Dull. Astrocyte membrane properties are altered in a rat model of developmental cortical malformation but single-cell astrocytic glutamate uptake is robust. Neurobiology of disease. vol 89. 2016-12-13. PMID:26875663. |
astrocyte membrane properties are altered in a rat model of developmental cortical malformation but single-cell astrocytic glutamate uptake is robust. |
2016-12-13 |
2023-08-13 |
human |
| Elizabeth Hanson, Niels Christian Danbolt, Chris G Dull. Astrocyte membrane properties are altered in a rat model of developmental cortical malformation but single-cell astrocytic glutamate uptake is robust. Neurobiology of disease. vol 89. 2016-12-13. PMID:26875663. |
additionally, recent studies examining astrocyte glutamate uptake in dcms have reported conflicting results, adding confusion to the field. |
2016-12-13 |
2023-08-13 |
human |