| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chunshu Piao, Hantamalala Ralay Ranaivo, Allison Rusie, Nitin Wadhwani, Sookyong Koh, Mark S Wainwrigh. Thrombin decreases expression of the glutamate transporter GLAST and inhibits glutamate uptake in primary cortical astrocytes via the Rho kinase pathway. Experimental neurology. vol 273. 2016-02-18. PMID:26391563. |
we tested the hypothesis that exposure of astrocytes to high levels of thrombin, as may occur after a compromise of the blood-brain barrier, would reduce astrocyte glutamate transporter levels. |
2016-02-18 |
2023-08-13 |
human |
| Claudia Karus, Miguel A Mondragão, Daniel Ziemens, Christine R Ros. Astrocytes restrict discharge duration and neuronal sodium loads during recurrent network activity. Glia. vol 63. issue 6. 2016-01-08. PMID:25639699. |
the gliotoxin nafac (sodium-fluoroacetate) resulted in elevation of astrocyte sodium concentration and reduced glial uptake of glutamate and potassium uptake through na(+) /k(+)-atpase. |
2016-01-08 |
2023-08-13 |
mouse |
| C R Robinson, P M Doughert. Spinal astrocyte gap junction and glutamate transporter expression contributes to a rat model of bortezomib-induced peripheral neuropathy. Neuroscience. vol 285. 2015-12-31. PMID:25446343. |
spinal astrocyte gap junction and glutamate transporter expression contributes to a rat model of bortezomib-induced peripheral neuropathy. |
2015-12-31 |
2023-08-13 |
rat |
| Elisabeth Hansso. Actin filament reorganization in astrocyte networks is a key functional step in neuroinflammation resulting in persistent pain: novel findings on network restoration. Neurochemical research. vol 40. issue 2. 2015-12-30. PMID:24952067. |
in addition, ca(2+) signaling systems are altered, na(+)- and glutamate transporters are downregulated, and pro-inflammatory cytokines, particularly il-1β, are released in dysfunctional astrocyte networks. |
2015-12-30 |
2023-08-13 |
Not clear |
| Eman Abdou, Alan S Hazel. Thiamine deficiency: an update of pathophysiologic mechanisms and future therapeutic considerations. Neurochemical research. vol 40. issue 2. 2015-12-30. PMID:25297573. |
the consequences of this include oxidative stress, excitotoxicity, inflammatory responses, decreased neurogenesis, blood-brain barrier disruption, lactic acidosis and a reduction in astrocyte functional integrity involving a loss of glutamate transporters and other astrocyte-specific proteins which together contribute in a major way to the resulting neurodegeneration. |
2015-12-30 |
2023-08-13 |
Not clear |
| Theresa S Rimmele, Jean-Yves Chatto. A novel optical intracellular imaging approach for potassium dynamics in astrocytes. PloS one. vol 9. issue 10. 2015-12-22. PMID:25275375. |
we then found that glutamate superfusion caused a reversible drop of [k+]i that depended on the glutamate concentration with an apparent ec50 of 11.1±1.4 µm, corresponding to the affinity of astrocyte glutamate transporters. |
2015-12-22 |
2023-08-13 |
mouse |
| Jaime L Watson, Tamara J Hala, Rajarshi Putatunda, Daniel Sannie, Angelo C Lepor. Persistent at-level thermal hyperalgesia and tactile allodynia accompany chronic neuronal and astrocyte activation in superficial dorsal horn following mouse cervical contusion spinal cord injury. PloS one. vol 9. issue 9. 2015-12-21. PMID:25268642. |
following injury, an increase in the number of neurons expressing Δfosb (a marker of chronic neuronal activation), persistent astrocyte activation and proliferation (as measured by gfap and ki67 expression), and a decrease in the expression of the astrocyte glutamate transporter glt1 are observed in the ipsilateral superficial dorsal horn of cervical spinal cord. |
2015-12-21 |
2023-08-13 |
mouse |
| Ke Li, Elham Javed, Tamara J Hala, Daniel Sannie, Kathleen A Regan, Nicholas J Maragakis, Megan C Wright, David J Poulsen, Angelo C Lepor. Transplantation of glial progenitors that overexpress glutamate transporter GLT1 preserves diaphragm function following cervical SCI. Molecular therapy : the journal of the American Society of Gene Therapy. vol 23. issue 3. 2015-11-16. PMID:25492561. |
to enhance their therapeutic properties, we engineered grps with aav8 to overexpress glt1 only in astrocytes using the gfa2 promoter, resulting in significantly increased glt1 protein expression and functional glutamate uptake following astrocyte differentiation in vitro and after transplantation into c4 hemicontusion. |
2015-11-16 |
2023-08-13 |
Not clear |
| Timothy Gould, Lixin Chen, Zsuzsa Emri, Tiina Pirttimaki, Adam C Errington, Vincenzo Crunelli, H Rheinallt Parr. GABA(B) receptor-mediated activation of astrocytes by gamma-hydroxybutyric acid. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 369. issue 1654. 2015-11-05. PMID:25225100. |
in contrast, prolonged ghb and baclofen exposure caused a reduction in spontaneous astrocyte activity and glutamate release from vta astrocytes. |
2015-11-05 |
2023-08-13 |
mouse |
| Courtney Sobieski, Xiaoping Jiang, Devon C Crawford, Steven Menneric. Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 31. 2015-11-05. PMID:26245971. |
loss of local astrocyte support disrupts action potential propagation and glutamate release synchrony from unmyelinated hippocampal axon terminals in vitro. |
2015-11-05 |
2023-08-13 |
rat |
| Courtney Sobieski, Xiaoping Jiang, Devon C Crawford, Steven Menneric. Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 31. 2015-11-05. PMID:26245971. |
in conclusion, we propose that local astrocyte support has an unappreciated role in maintaining glutamate release synchrony by disturbing axonal signal propagation. |
2015-11-05 |
2023-08-13 |
rat |
| Willias Masoch. Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during paclitaxel-induced neuropathic pain in mice. PeerJ. vol 3. 2015-11-03. PMID:26528412. |
we examined glial fibrillary acidic protein (gfap; an astrocyte marker) immunoreactivity and gene expression of gfap, glutamate transporters and receptor subunits by real time pcr in the anterior cingulate cortex (acc) at 7 days post first administration of paclitaxel, a time point when mice had developed thermal hyperalgesia. |
2015-11-03 |
2023-08-13 |
mouse |
| Willias Masoch. Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during paclitaxel-induced neuropathic pain in mice. PeerJ. vol 3. 2015-11-03. PMID:26528412. |
in conclusion, during pinp there is astrocyte activation, with no change in glutamate transporter expression and differential up-regulation of glutamate receptor subunits in the acc. |
2015-11-03 |
2023-08-13 |
mouse |
| Jose L Izquierdo-Garcia, Pavithra Viswanath, Pia Eriksson, Larry Cai, Marina Radoul, Myriam M Chaumeil, Michael Blough, H Artee Luchman, Samuel Weiss, J Gregory Cairncross, Joanna J Phillips, Russell O Pieper, Sabrina M Rone. IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism. Cancer research. vol 75. issue 15. 2015-10-26. PMID:26045167. |
levels of both glutamate and pyruvate dehydrogenase (pdh) activity have been shown to be affected in u87 glioblastoma cells or normal human astrocyte (nha) cells expressing mutant idh1, as compared with cells expressing wild-type idh1. |
2015-10-26 |
2023-08-13 |
human |
| M Pérez-Domínguez, R Hernández-Benítez, C Peña Segura, H Pasantes-Morale. Thrombin-facilitated efflux of D-[3H]-aspartate from cultured astrocytes and neurons under hyponatremia and chemical ischemia. Neurochemical research. vol 39. issue 7. 2015-10-19. PMID:24706094. |
these results suggest that coincidence of swelling and thrombin during ischemia elevates extracellular glutamate prominently from astrocyte efflux, which may endanger neurons in vivo. |
2015-10-19 |
2023-08-13 |
Not clear |
| Mariko Kato Hayashi, Masato Yasu. The transmembrane transporter domain of glutamate transporters is a process tip localizer. Scientific reports. vol 5. 2015-10-16. PMID:25761899. |
the transmembrane transporter domain fragments of glutamate transporters also localized to astrocyte process tips in cultured hippocampal slice. |
2015-10-16 |
2023-08-13 |
Not clear |
| Marta A Tarczyluk, David A Nagel, H Rhein Parri, Erin H Y Tse, James E Brown, Michael D Coleman, Eric J Hil. Amyloid β 1-42 induces hypometabolism in human stem cell-derived neuron and astrocyte networks. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 8. 2015-10-15. PMID:25853906. |
in this study, we show that human stem cell-derived neuron and astrocyte cultures treated with oligomers of amyloid beta 1-42 (aβ1-42) also display a clear hypometabolism, particularly with regard to utilization of substrates such as glucose, pyruvate, lactate, and glutamate. |
2015-10-15 |
2023-08-13 |
human |
| U Skupio, M Tertil, M Sikora, S Golda, A Wawrzczak-Bargiela, R Przewlock. Behavioral and molecular alterations in mice resulting from chronic treatment with dexamethasone: relevance to depression. Neuroscience. vol 286. 2015-09-14. PMID:25433240. |
furthermore, our results indicate a decrease in the mrna expression of glutamate aspartate transporter (glast, slc1a3), an astroglial cell marker, in the hippocampus and prefrontal cortex. |
2015-09-14 |
2023-08-13 |
mouse |
| Zhi-Gang Ji, Hongxia Wan. Optogenetic control of astrocytes: is it possible to treat astrocyte-related epilepsy? Brain research bulletin. vol 110. 2015-09-09. PMID:25451697. |
here, we discuss the possibility that an optogenetic approach could be used to control the release of gliotransmitters and improve astrocyte function such as glutamate and k(+) uptake, and thereby offer a potential strategy to investigate and treat astrocyte-related epilepsy. |
2015-09-09 |
2023-08-13 |
Not clear |
| R Martín, R Bajo-Grañeras, R Moratalla, G Perea, A Araqu. Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways. Science (New York, N.Y.). vol 349. issue 6249. 2015-09-04. PMID:26273054. |
likewise, astrocyte subpopulations selectively regulated homotypic synapses through metabotropic glutamate receptor activation. |
2015-09-04 |
2023-08-13 |
Not clear |