| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jaime L Watson, Tamara J Hala, Rajarshi Putatunda, Daniel Sannie, Angelo C Lepor. Persistent at-level thermal hyperalgesia and tactile allodynia accompany chronic neuronal and astrocyte activation in superficial dorsal horn following mouse cervical contusion spinal cord injury. PloS one. vol 9. issue 9. 2015-12-21. PMID:25268642. |
following injury, an increase in the number of neurons expressing Δfosb (a marker of chronic neuronal activation), persistent astrocyte activation and proliferation (as measured by gfap and ki67 expression), and a decrease in the expression of the astrocyte glutamate transporter glt1 are observed in the ipsilateral superficial dorsal horn of cervical spinal cord. |
2015-12-21 |
2023-08-13 |
mouse |
| Ke Li, Elham Javed, Tamara J Hala, Daniel Sannie, Kathleen A Regan, Nicholas J Maragakis, Megan C Wright, David J Poulsen, Angelo C Lepor. Transplantation of glial progenitors that overexpress glutamate transporter GLT1 preserves diaphragm function following cervical SCI. Molecular therapy : the journal of the American Society of Gene Therapy. vol 23. issue 3. 2015-11-16. PMID:25492561. |
to enhance their therapeutic properties, we engineered grps with aav8 to overexpress glt1 only in astrocytes using the gfa2 promoter, resulting in significantly increased glt1 protein expression and functional glutamate uptake following astrocyte differentiation in vitro and after transplantation into c4 hemicontusion. |
2015-11-16 |
2023-08-13 |
Not clear |
| Timothy Gould, Lixin Chen, Zsuzsa Emri, Tiina Pirttimaki, Adam C Errington, Vincenzo Crunelli, H Rheinallt Parr. GABA(B) receptor-mediated activation of astrocytes by gamma-hydroxybutyric acid. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 369. issue 1654. 2015-11-05. PMID:25225100. |
in contrast, prolonged ghb and baclofen exposure caused a reduction in spontaneous astrocyte activity and glutamate release from vta astrocytes. |
2015-11-05 |
2023-08-13 |
mouse |
| Courtney Sobieski, Xiaoping Jiang, Devon C Crawford, Steven Menneric. Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 31. 2015-11-05. PMID:26245971. |
loss of local astrocyte support disrupts action potential propagation and glutamate release synchrony from unmyelinated hippocampal axon terminals in vitro. |
2015-11-05 |
2023-08-13 |
rat |
| Courtney Sobieski, Xiaoping Jiang, Devon C Crawford, Steven Menneric. Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 31. 2015-11-05. PMID:26245971. |
in conclusion, we propose that local astrocyte support has an unappreciated role in maintaining glutamate release synchrony by disturbing axonal signal propagation. |
2015-11-05 |
2023-08-13 |
rat |
| Willias Masoch. Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during paclitaxel-induced neuropathic pain in mice. PeerJ. vol 3. 2015-11-03. PMID:26528412. |
we examined glial fibrillary acidic protein (gfap; an astrocyte marker) immunoreactivity and gene expression of gfap, glutamate transporters and receptor subunits by real time pcr in the anterior cingulate cortex (acc) at 7 days post first administration of paclitaxel, a time point when mice had developed thermal hyperalgesia. |
2015-11-03 |
2023-08-13 |
mouse |
| Willias Masoch. Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during paclitaxel-induced neuropathic pain in mice. PeerJ. vol 3. 2015-11-03. PMID:26528412. |
in conclusion, during pinp there is astrocyte activation, with no change in glutamate transporter expression and differential up-regulation of glutamate receptor subunits in the acc. |
2015-11-03 |
2023-08-13 |
mouse |
| Jose L Izquierdo-Garcia, Pavithra Viswanath, Pia Eriksson, Larry Cai, Marina Radoul, Myriam M Chaumeil, Michael Blough, H Artee Luchman, Samuel Weiss, J Gregory Cairncross, Joanna J Phillips, Russell O Pieper, Sabrina M Rone. IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism. Cancer research. vol 75. issue 15. 2015-10-26. PMID:26045167. |
levels of both glutamate and pyruvate dehydrogenase (pdh) activity have been shown to be affected in u87 glioblastoma cells or normal human astrocyte (nha) cells expressing mutant idh1, as compared with cells expressing wild-type idh1. |
2015-10-26 |
2023-08-13 |
human |
| M Pérez-Domínguez, R Hernández-Benítez, C Peña Segura, H Pasantes-Morale. Thrombin-facilitated efflux of D-[3H]-aspartate from cultured astrocytes and neurons under hyponatremia and chemical ischemia. Neurochemical research. vol 39. issue 7. 2015-10-19. PMID:24706094. |
these results suggest that coincidence of swelling and thrombin during ischemia elevates extracellular glutamate prominently from astrocyte efflux, which may endanger neurons in vivo. |
2015-10-19 |
2023-08-13 |
Not clear |
| Mariko Kato Hayashi, Masato Yasu. The transmembrane transporter domain of glutamate transporters is a process tip localizer. Scientific reports. vol 5. 2015-10-16. PMID:25761899. |
the transmembrane transporter domain fragments of glutamate transporters also localized to astrocyte process tips in cultured hippocampal slice. |
2015-10-16 |
2023-08-13 |
Not clear |
| Marta A Tarczyluk, David A Nagel, H Rhein Parri, Erin H Y Tse, James E Brown, Michael D Coleman, Eric J Hil. Amyloid β 1-42 induces hypometabolism in human stem cell-derived neuron and astrocyte networks. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 8. 2015-10-15. PMID:25853906. |
in this study, we show that human stem cell-derived neuron and astrocyte cultures treated with oligomers of amyloid beta 1-42 (aβ1-42) also display a clear hypometabolism, particularly with regard to utilization of substrates such as glucose, pyruvate, lactate, and glutamate. |
2015-10-15 |
2023-08-13 |
human |
| U Skupio, M Tertil, M Sikora, S Golda, A Wawrzczak-Bargiela, R Przewlock. Behavioral and molecular alterations in mice resulting from chronic treatment with dexamethasone: relevance to depression. Neuroscience. vol 286. 2015-09-14. PMID:25433240. |
furthermore, our results indicate a decrease in the mrna expression of glutamate aspartate transporter (glast, slc1a3), an astroglial cell marker, in the hippocampus and prefrontal cortex. |
2015-09-14 |
2023-08-13 |
mouse |
| Zhi-Gang Ji, Hongxia Wan. Optogenetic control of astrocytes: is it possible to treat astrocyte-related epilepsy? Brain research bulletin. vol 110. 2015-09-09. PMID:25451697. |
here, we discuss the possibility that an optogenetic approach could be used to control the release of gliotransmitters and improve astrocyte function such as glutamate and k(+) uptake, and thereby offer a potential strategy to investigate and treat astrocyte-related epilepsy. |
2015-09-09 |
2023-08-13 |
Not clear |
| R Martín, R Bajo-Grañeras, R Moratalla, G Perea, A Araqu. Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways. Science (New York, N.Y.). vol 349. issue 6249. 2015-09-04. PMID:26273054. |
likewise, astrocyte subpopulations selectively regulated homotypic synapses through metabotropic glutamate receptor activation. |
2015-09-04 |
2023-08-13 |
Not clear |
| Amélie O Dumont, Stéphanie Goursaud, Nathalie Desmet, Emmanuel Herman. Differential regulation of glutamate transporter subtypes by pro-inflammatory cytokine TNF-α in cortical astrocytes from a rat model of amyotrophic lateral sclerosis. PloS one. vol 9. issue 5. 2015-08-31. PMID:24836816. |
considering the putative link between inflammation and excitotoxicity, we have here characterized the influence of tnf-α on glutamate transporters in cerebral cortical astrocyte cultures from wild-type rats and from a rat model of als (hsod1g93a). |
2015-08-31 |
2023-08-13 |
rat |
| Hans-Gert Bernstein, Johann Steiner, Paul C Guest, Henrik Dobrowolny, Bernhard Bogert. Glial cells as key players in schizophrenia pathology: recent insights and concepts of therapy. Schizophrenia research. vol 161. issue 1. 2015-08-24. PMID:24948484. |
since astrocytes play a key role in the synaptic metabolism of glutamate, gaba, monoamines and purines, astrocyte dysfunction may contribute to certain aspects of disturbed neurotransmission in schizophrenia. |
2015-08-24 |
2023-08-13 |
Not clear |
| Nina B Illarionova, Nina B Illarionava, Hjalmar Brismar, Anita Aperia, Eli Gunnarso. Role of Na,K-ATPase α1 and α2 isoforms in the support of astrocyte glutamate uptake. PloS one. vol 9. issue 6. 2015-08-05. PMID:24901986. |
role of na,k-atpase α1 and α2 isoforms in the support of astrocyte glutamate uptake. |
2015-08-05 |
2023-08-13 |
rat |
| N S Kolomeet. [Role of astrocytes in alterations of glutamatergic neurotransmission in schizophrenia]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 115. issue 1. 2015-07-07. PMID:25945378. |
the literature on the astrocyte ability to regulate glutamate neurotransmission is reviewed. |
2015-07-07 |
2023-08-13 |
Not clear |
| N S Kolomeet. [Role of astrocytes in alterations of glutamatergic neurotransmission in schizophrenia]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 115. issue 1. 2015-07-07. PMID:25945378. |
astrocyte abnormalities in schizophrenia include the disturbances of glutamate reuptake, recycling and turnover of endogenous nmda-r ligands. |
2015-07-07 |
2023-08-13 |
Not clear |
| Laurentiu Mogoanta, Marius Ciurea, Ionica Pirici, Claudiu Margaritescu, Cristiana Simionescu, Daniela A Ion, Daniel Piric. Different dynamics of aquaporin 4 and glutamate transporter-1 distribution in the perineuronal and perivascular compartments during ischemic stroke. Brain pathology (Zurich, Switzerland). vol 24. issue 5. 2015-06-29. PMID:24571080. |
aquaporin-4 (aqp4) and glutamate transporter-1 (glt-1) represent the major water and glutamate astrocyte buffering gateways in the brain. |
2015-06-29 |
2023-08-12 |
human |