| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sofya Abazyan, Eun Ju Yang, Bagrat Abazyan, Meng Xia, Chunxia Yang, Camilo Rojas, Barbara Slusher, Rita Sattler, Mikhail Pletniko. Mutant disrupted-in-schizophrenia 1 in astrocytes: focus on glutamate metabolism. Journal of neuroscience research. vol 92. issue 12. 2015-06-19. PMID:25131692. |
although mutant disc1 had no significant effects on astrocyte proliferation, glu reuptake, glutaminase, or glutamate carboxypeptidase ii activity, expression of mutant disc1 was associated with increased levels of alanine-serine-cysteine transporter 2, vesicular glutamate transporters 1 and 3 in primary astrocytes and in the hippocampus, and elevated expression of the nr1 subunit and diminished expression of the nr2a subunit of n-methyl-d-aspartate (nmda) receptors in the hippocampus, at postnatal day 21. |
2015-06-19 |
2023-08-13 |
mouse |
| Chan Yuan, Junying Gao, Jichao Guo, Lei Bai, Charles Marshall, Zhiyou Cai, Linmei Wang, Ming Xia. Dimethyl sulfoxide damages mitochondrial integrity and membrane potential in cultured astrocytes. PloS one. vol 9. issue 9. 2015-06-16. PMID:25238609. |
the present study showed that exposure of astrocyte cultures to 1% dmso for 24 h did not significantly affect cell survival, but decreased cell viability and glial glutamate transporter expression, and caused mitochondrial swelling, membrane potential impairment and reactive oxygen species production, and subsequent cytochrome c release and caspase-3 activation. |
2015-06-16 |
2023-08-13 |
Not clear |
| Dan Song, Junnan Xu, Qiufang Bai, Liping Cai, Leif Hertz, Liang Pen. Role of the intracellular nucleoside transporter ENT3 in transmitter and high K+ stimulation of astrocytic ATP release investigated using siRNA against ENT3. ASN neuro. vol 6. issue 4. 2015-06-11. PMID:25298788. |
the present study has confirmed and quantitated stimulated atp release in response to glutamate, adenosine, or an elevated k(+) concentration from well-differentiated astrocyte cultures, measured by a luciferin-luciferase reaction. |
2015-06-11 |
2023-08-13 |
Not clear |
| R C Roberts, J K Roche, R E McCullumsmit. Localization of excitatory amino acid transporters EAAT1 and EAAT2 in human postmortem cortex: a light and electron microscopic study. Neuroscience. vol 277. 2015-06-08. PMID:25064059. |
the process of glutamate release, activity, and reuptake involves the astrocyte, the presynaptic and postsynaptic neurons. |
2015-06-08 |
2023-08-13 |
human |
| Yao Shen, Yueyang Tian, Xiaojie Shi, Jianbo Yang, Li Ouyang, Jieqiong Gao, Jianxin L. Exposure to high glutamate concentration activates aerobic glycolysis but inhibits ATP-linked respiration in cultured cortical astrocytes. Cell biochemistry and function. vol 32. issue 6. 2015-06-03. PMID:25077445. |
the glutamate-induced astrocyte damage can be mimicked by the non-metabolized substrate d-aspartate but reversed by the non-selective glutamate transporter inhibitor tboa. |
2015-06-03 |
2023-08-13 |
Not clear |
| Agata Campisi, Rosaria Acquaviva, Roberta Bonfanti, Giuseppina Raciti, Andrea Amodeo, Silvana Mastrojeni, Salvatore Ragusa, Liliana Iau. Antioxidant properties of Berberis aetnensis C. Presl (Berberidaceae) roots extract and protective effects on astroglial cell cultures. TheScientificWorldJournal. vol 2014. 2015-05-26. PMID:25177720. |
we demonstrated that the alkaloid extract of roots of b. aetnensis c. presl contains prevalently berberine and berbamine, possesses antimicrobial properties, and was able to counteract the upregulation evoked by glutamate of tissue transglutaminase in primary rat astroglial cell cultures. |
2015-05-26 |
2023-08-13 |
rat |
| Agata Campisi, Rosaria Acquaviva, Roberta Bonfanti, Giuseppina Raciti, Andrea Amodeo, Silvana Mastrojeni, Salvatore Ragusa, Liliana Iau. Antioxidant properties of Berberis aetnensis C. Presl (Berberidaceae) roots extract and protective effects on astroglial cell cultures. TheScientificWorldJournal. vol 2014. 2015-05-26. PMID:25177720. |
in primary rat astroglial cell cultures, exposed to glutamate, we evaluated the effect of the extract on glutathione levels and on intracellular production of reactive oxygen species generated by glutamate. |
2015-05-26 |
2023-08-13 |
rat |
| Rajarshi Putatunda, Tamara J Hala, Jeannie Chin, Angelo C Lepor. Chronic at-level thermal hyperalgesia following rat cervical contusion spinal cord injury is accompanied by neuronal and astrocyte activation and loss of the astrocyte glutamate transporter, GLT1, in superficial dorsal horn. Brain research. vol 1581. 2015-05-21. PMID:24833066. |
chronic at-level thermal hyperalgesia following rat cervical contusion spinal cord injury is accompanied by neuronal and astrocyte activation and loss of the astrocyte glutamate transporter, glt1, in superficial dorsal horn. |
2015-05-21 |
2023-08-13 |
rat |
| Rajarshi Putatunda, Tamara J Hala, Jeannie Chin, Angelo C Lepor. Chronic at-level thermal hyperalgesia following rat cervical contusion spinal cord injury is accompanied by neuronal and astrocyte activation and loss of the astrocyte glutamate transporter, GLT1, in superficial dorsal horn. Brain research. vol 1581. 2015-05-21. PMID:24833066. |
furthermore, dysregulation of extracellular glutamate homeostasis and chronic astrocyte activation play important underlying roles in persistent hyperexcitability of these superficial dorsal horn neurons. |
2015-05-21 |
2023-08-13 |
rat |
| Rajarshi Putatunda, Tamara J Hala, Jeannie Chin, Angelo C Lepor. Chronic at-level thermal hyperalgesia following rat cervical contusion spinal cord injury is accompanied by neuronal and astrocyte activation and loss of the astrocyte glutamate transporter, GLT1, in superficial dorsal horn. Brain research. vol 1581. 2015-05-21. PMID:24833066. |
finally, persistent astrocyte activation and significantly reduced expression of the major cns glutamate transporter, glt1, in superficial dorsal horn astrocytes are associated with both excitability changes in stt neurons and the neuropathic pain behavioral phenotype. |
2015-05-21 |
2023-08-13 |
rat |
| Rajarshi Putatunda, Tamara J Hala, Jeannie Chin, Angelo C Lepor. Chronic at-level thermal hyperalgesia following rat cervical contusion spinal cord injury is accompanied by neuronal and astrocyte activation and loss of the astrocyte glutamate transporter, GLT1, in superficial dorsal horn. Brain research. vol 1581. 2015-05-21. PMID:24833066. |
in conclusion, we have characterized clinically-relevant rodent models of cervical contusion-induced neuropathic pain that result in chronic activation of both stt neurons and astrocytes, as well as compromise in astrocyte glutamate transporter expression. |
2015-05-21 |
2023-08-13 |
rat |
| Helena Domin, Bernadeta Szewczyk, Monika Woźniak, Anika Wawrzak-Wleciał, Maria Śmiałowsk. Antidepressant-like effect of the mGluR5 antagonist MTEP in an astroglial degeneration model of depression. Behavioural brain research. vol 273. 2015-05-11. PMID:25043733. |
such imbalance may be induced by astrocyte ablation which reduces glutamate uptake and increases glutamate level in the synaptic cleft. |
2015-05-11 |
2023-08-13 |
rat |
| Jianxiong Liu, Alexander L Fedinec, Charles W Leffler, Helena Parfenov. Enteral supplements of a carbon monoxide donor CORM-A1 protect against cerebrovascular dysfunction caused by neonatal seizures. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 2. 2015-04-10. PMID:25370858. |
the postictal responses of pial arterioles to bradykinin, glutamate, the ampa receptor agonist quisqualic acid, adp, and heme were greatly reduced, suggesting that seizures cause injury to endothelial and astrocyte components of the neurovascular unit. |
2015-04-10 |
2023-08-13 |
Not clear |
| Christopher S Casley, Viktor Lakics, Hyoung-gon Lee, Lisa M Broad, Theresa A Day, Tricia Cluett, Mark A Smith, Michael J O'Neill, Ann E Kingsto. Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-β peptide. Brain research. vol 1260. 2015-03-30. PMID:19401173. |
up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-β peptide. |
2015-03-30 |
2023-08-12 |
human |
| Irma E Cisneros, Anuja Ghorpad. Methamphetamine and HIV-1-induced neurotoxicity: role of trace amine associated receptor 1 cAMP signaling in astrocytes. Neuropharmacology. vol 85. 2015-03-30. PMID:24950453. |
in the present study, we investigated the effects of meth and hiv-1 on primary human astrocyte taar1 expression, function and glutamate clearance. |
2015-03-30 |
2023-08-13 |
human |
| Ahmad Ghanizadeh, Michael Ber. Beta-lactam antibiotics as a possible novel therapy for managing epilepsy and autism, a case report and review of literature. Iranian journal of child neurology. vol 9. issue 1. 2015-03-13. PMID:25767546. |
it is hypothesized that modulating astrocyte glutamate transporter expression by ceftriaxone or cefixime might improve some symptoms of autism. |
2015-03-13 |
2023-08-13 |
Not clear |
| Tadahiro Numakawa, Shingo Nakajima, Noriko Yamamoto, Yoshiko Ooshima, Haruki Odaka, Kazuo Hashido, Naoki Adachi, Hiroshi Kunug. Basic fibroblast growth factor induces miR-134 upregulation in astrocyte for cell maturation. Biochemical and biophysical research communications. vol 456. issue 1. 2015-03-10. PMID:25482448. |
we also found upregulation of glial fibrillary acidic protein (astrocyte marker) and decreased extracellular concentration of glutamate after mir-134 overexpression and bfgf application, suggesting that astroglial cell maturation is enhanced by bfgf through induction of mir-134. |
2015-03-10 |
2023-08-13 |
Not clear |
| Krishna Naskar, Javier E Ster. A functional coupling between extrasynaptic NMDA receptors and A-type K+ channels under astrocyte control regulates hypothalamic neurosecretory neuronal activity. The Journal of physiology. vol 592. issue 13. 2015-02-21. PMID:24835172. |
we found that activation of nmdars by extracellular glutamate levels influenced by astrocyte glutamate transporters resulted in a significant inhibition of ia. |
2015-02-21 |
2023-08-13 |
rat |
| Blanca Fernández-López, Silvia María Valle-Maroto, Antón Barreiro-Iglesias, María Celina Rodici. Neuronal release and successful astrocyte uptake of aminoacidergic neurotransmitters after spinal cord injury in lampreys. Glia. vol 62. issue 8. 2015-02-04. PMID:24733772. |
the main aim of our study was to investigate, in the sea lamprey, the release of aminoacidergic neurotransmitters and the subsequent astrocyte uptake of these neurotransmitters during the first week following a complete sci by detecting glutamate, gaba, glycine, hu and cytokeratin immunoreactivities. |
2015-02-04 |
2023-08-13 |
Not clear |
| Susan L Campbell, John J Hablitz, Michelle L Olse. Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia. Frontiers in cellular neuroscience. vol 8. 2015-01-08. PMID:25565960. |
functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia. |
2015-01-08 |
2023-08-13 |
rat |