| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amélie O Dumont, Stéphanie Goursaud, Nathalie Desmet, Emmanuel Herman. Differential regulation of glutamate transporter subtypes by pro-inflammatory cytokine TNF-α in cortical astrocytes from a rat model of amyotrophic lateral sclerosis. PloS one. vol 9. issue 5. 2015-08-31. PMID:24836816. |
considering the putative link between inflammation and excitotoxicity, we have here characterized the influence of tnf-α on glutamate transporters in cerebral cortical astrocyte cultures from wild-type rats and from a rat model of als (hsod1g93a). |
2015-08-31 |
2023-08-13 |
rat |
| Hans-Gert Bernstein, Johann Steiner, Paul C Guest, Henrik Dobrowolny, Bernhard Bogert. Glial cells as key players in schizophrenia pathology: recent insights and concepts of therapy. Schizophrenia research. vol 161. issue 1. 2015-08-24. PMID:24948484. |
since astrocytes play a key role in the synaptic metabolism of glutamate, gaba, monoamines and purines, astrocyte dysfunction may contribute to certain aspects of disturbed neurotransmission in schizophrenia. |
2015-08-24 |
2023-08-13 |
Not clear |
| Nina B Illarionova, Nina B Illarionava, Hjalmar Brismar, Anita Aperia, Eli Gunnarso. Role of Na,K-ATPase α1 and α2 isoforms in the support of astrocyte glutamate uptake. PloS one. vol 9. issue 6. 2015-08-05. PMID:24901986. |
role of na,k-atpase α1 and α2 isoforms in the support of astrocyte glutamate uptake. |
2015-08-05 |
2023-08-13 |
rat |
| N S Kolomeet. [Role of astrocytes in alterations of glutamatergic neurotransmission in schizophrenia]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 115. issue 1. 2015-07-07. PMID:25945378. |
the literature on the astrocyte ability to regulate glutamate neurotransmission is reviewed. |
2015-07-07 |
2023-08-13 |
Not clear |
| N S Kolomeet. [Role of astrocytes in alterations of glutamatergic neurotransmission in schizophrenia]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 115. issue 1. 2015-07-07. PMID:25945378. |
astrocyte abnormalities in schizophrenia include the disturbances of glutamate reuptake, recycling and turnover of endogenous nmda-r ligands. |
2015-07-07 |
2023-08-13 |
Not clear |
| Laurentiu Mogoanta, Marius Ciurea, Ionica Pirici, Claudiu Margaritescu, Cristiana Simionescu, Daniela A Ion, Daniel Piric. Different dynamics of aquaporin 4 and glutamate transporter-1 distribution in the perineuronal and perivascular compartments during ischemic stroke. Brain pathology (Zurich, Switzerland). vol 24. issue 5. 2015-06-29. PMID:24571080. |
aquaporin-4 (aqp4) and glutamate transporter-1 (glt-1) represent the major water and glutamate astrocyte buffering gateways in the brain. |
2015-06-29 |
2023-08-12 |
human |
| Sofya Abazyan, Eun Ju Yang, Bagrat Abazyan, Meng Xia, Chunxia Yang, Camilo Rojas, Barbara Slusher, Rita Sattler, Mikhail Pletniko. Mutant disrupted-in-schizophrenia 1 in astrocytes: focus on glutamate metabolism. Journal of neuroscience research. vol 92. issue 12. 2015-06-19. PMID:25131692. |
although mutant disc1 had no significant effects on astrocyte proliferation, glu reuptake, glutaminase, or glutamate carboxypeptidase ii activity, expression of mutant disc1 was associated with increased levels of alanine-serine-cysteine transporter 2, vesicular glutamate transporters 1 and 3 in primary astrocytes and in the hippocampus, and elevated expression of the nr1 subunit and diminished expression of the nr2a subunit of n-methyl-d-aspartate (nmda) receptors in the hippocampus, at postnatal day 21. |
2015-06-19 |
2023-08-13 |
mouse |
| Chan Yuan, Junying Gao, Jichao Guo, Lei Bai, Charles Marshall, Zhiyou Cai, Linmei Wang, Ming Xia. Dimethyl sulfoxide damages mitochondrial integrity and membrane potential in cultured astrocytes. PloS one. vol 9. issue 9. 2015-06-16. PMID:25238609. |
the present study showed that exposure of astrocyte cultures to 1% dmso for 24 h did not significantly affect cell survival, but decreased cell viability and glial glutamate transporter expression, and caused mitochondrial swelling, membrane potential impairment and reactive oxygen species production, and subsequent cytochrome c release and caspase-3 activation. |
2015-06-16 |
2023-08-13 |
Not clear |
| Dan Song, Junnan Xu, Qiufang Bai, Liping Cai, Leif Hertz, Liang Pen. Role of the intracellular nucleoside transporter ENT3 in transmitter and high K+ stimulation of astrocytic ATP release investigated using siRNA against ENT3. ASN neuro. vol 6. issue 4. 2015-06-11. PMID:25298788. |
the present study has confirmed and quantitated stimulated atp release in response to glutamate, adenosine, or an elevated k(+) concentration from well-differentiated astrocyte cultures, measured by a luciferin-luciferase reaction. |
2015-06-11 |
2023-08-13 |
Not clear |
| R C Roberts, J K Roche, R E McCullumsmit. Localization of excitatory amino acid transporters EAAT1 and EAAT2 in human postmortem cortex: a light and electron microscopic study. Neuroscience. vol 277. 2015-06-08. PMID:25064059. |
the process of glutamate release, activity, and reuptake involves the astrocyte, the presynaptic and postsynaptic neurons. |
2015-06-08 |
2023-08-13 |
human |
| Yao Shen, Yueyang Tian, Xiaojie Shi, Jianbo Yang, Li Ouyang, Jieqiong Gao, Jianxin L. Exposure to high glutamate concentration activates aerobic glycolysis but inhibits ATP-linked respiration in cultured cortical astrocytes. Cell biochemistry and function. vol 32. issue 6. 2015-06-03. PMID:25077445. |
the glutamate-induced astrocyte damage can be mimicked by the non-metabolized substrate d-aspartate but reversed by the non-selective glutamate transporter inhibitor tboa. |
2015-06-03 |
2023-08-13 |
Not clear |
| Agata Campisi, Rosaria Acquaviva, Roberta Bonfanti, Giuseppina Raciti, Andrea Amodeo, Silvana Mastrojeni, Salvatore Ragusa, Liliana Iau. Antioxidant properties of Berberis aetnensis C. Presl (Berberidaceae) roots extract and protective effects on astroglial cell cultures. TheScientificWorldJournal. vol 2014. 2015-05-26. PMID:25177720. |
we demonstrated that the alkaloid extract of roots of b. aetnensis c. presl contains prevalently berberine and berbamine, possesses antimicrobial properties, and was able to counteract the upregulation evoked by glutamate of tissue transglutaminase in primary rat astroglial cell cultures. |
2015-05-26 |
2023-08-13 |
rat |
| Agata Campisi, Rosaria Acquaviva, Roberta Bonfanti, Giuseppina Raciti, Andrea Amodeo, Silvana Mastrojeni, Salvatore Ragusa, Liliana Iau. Antioxidant properties of Berberis aetnensis C. Presl (Berberidaceae) roots extract and protective effects on astroglial cell cultures. TheScientificWorldJournal. vol 2014. 2015-05-26. PMID:25177720. |
in primary rat astroglial cell cultures, exposed to glutamate, we evaluated the effect of the extract on glutathione levels and on intracellular production of reactive oxygen species generated by glutamate. |
2015-05-26 |
2023-08-13 |
rat |
| Rajarshi Putatunda, Tamara J Hala, Jeannie Chin, Angelo C Lepor. Chronic at-level thermal hyperalgesia following rat cervical contusion spinal cord injury is accompanied by neuronal and astrocyte activation and loss of the astrocyte glutamate transporter, GLT1, in superficial dorsal horn. Brain research. vol 1581. 2015-05-21. PMID:24833066. |
chronic at-level thermal hyperalgesia following rat cervical contusion spinal cord injury is accompanied by neuronal and astrocyte activation and loss of the astrocyte glutamate transporter, glt1, in superficial dorsal horn. |
2015-05-21 |
2023-08-13 |
rat |
| Rajarshi Putatunda, Tamara J Hala, Jeannie Chin, Angelo C Lepor. Chronic at-level thermal hyperalgesia following rat cervical contusion spinal cord injury is accompanied by neuronal and astrocyte activation and loss of the astrocyte glutamate transporter, GLT1, in superficial dorsal horn. Brain research. vol 1581. 2015-05-21. PMID:24833066. |
furthermore, dysregulation of extracellular glutamate homeostasis and chronic astrocyte activation play important underlying roles in persistent hyperexcitability of these superficial dorsal horn neurons. |
2015-05-21 |
2023-08-13 |
rat |
| Rajarshi Putatunda, Tamara J Hala, Jeannie Chin, Angelo C Lepor. Chronic at-level thermal hyperalgesia following rat cervical contusion spinal cord injury is accompanied by neuronal and astrocyte activation and loss of the astrocyte glutamate transporter, GLT1, in superficial dorsal horn. Brain research. vol 1581. 2015-05-21. PMID:24833066. |
finally, persistent astrocyte activation and significantly reduced expression of the major cns glutamate transporter, glt1, in superficial dorsal horn astrocytes are associated with both excitability changes in stt neurons and the neuropathic pain behavioral phenotype. |
2015-05-21 |
2023-08-13 |
rat |
| Rajarshi Putatunda, Tamara J Hala, Jeannie Chin, Angelo C Lepor. Chronic at-level thermal hyperalgesia following rat cervical contusion spinal cord injury is accompanied by neuronal and astrocyte activation and loss of the astrocyte glutamate transporter, GLT1, in superficial dorsal horn. Brain research. vol 1581. 2015-05-21. PMID:24833066. |
in conclusion, we have characterized clinically-relevant rodent models of cervical contusion-induced neuropathic pain that result in chronic activation of both stt neurons and astrocytes, as well as compromise in astrocyte glutamate transporter expression. |
2015-05-21 |
2023-08-13 |
rat |
| Helena Domin, Bernadeta Szewczyk, Monika Woźniak, Anika Wawrzak-Wleciał, Maria Śmiałowsk. Antidepressant-like effect of the mGluR5 antagonist MTEP in an astroglial degeneration model of depression. Behavioural brain research. vol 273. 2015-05-11. PMID:25043733. |
such imbalance may be induced by astrocyte ablation which reduces glutamate uptake and increases glutamate level in the synaptic cleft. |
2015-05-11 |
2023-08-13 |
rat |
| Jianxiong Liu, Alexander L Fedinec, Charles W Leffler, Helena Parfenov. Enteral supplements of a carbon monoxide donor CORM-A1 protect against cerebrovascular dysfunction caused by neonatal seizures. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 2. 2015-04-10. PMID:25370858. |
the postictal responses of pial arterioles to bradykinin, glutamate, the ampa receptor agonist quisqualic acid, adp, and heme were greatly reduced, suggesting that seizures cause injury to endothelial and astrocyte components of the neurovascular unit. |
2015-04-10 |
2023-08-13 |
Not clear |
| Christopher S Casley, Viktor Lakics, Hyoung-gon Lee, Lisa M Broad, Theresa A Day, Tricia Cluett, Mark A Smith, Michael J O'Neill, Ann E Kingsto. Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-β peptide. Brain research. vol 1260. 2015-03-30. PMID:19401173. |
up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-β peptide. |
2015-03-30 |
2023-08-12 |
human |