| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shi Di, Ion R Popescu, Jeffrey G Taske. Glial control of endocannabinoid heterosynaptic modulation in hypothalamic magnocellular neuroendocrine cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 46. 2014-01-06. PMID:24227742. |
therefore, depolarization- and glucocorticoid-evoked 2-arachidonoylglycerol release from magnocellular neurons is spatially restricted to glutamate synapses by astrocytes, but spills over onto gaba synapses under conditions of reduced astrocyte buffering; tonic endocannabinoid modulation of gaba release, in contrast, is likely mediated by anandamide and is insensitive to astrocytic buffering. |
2014-01-06 |
2023-08-12 |
rat |
| Yongjie Yang, Haruki Higashimori, Lydie More. Developmental maturation of astrocytes and pathogenesis of neurodevelopmental disorders. Journal of neurodevelopmental disorders. vol 5. issue 1. 2013-11-12. PMID:23988237. |
in this review, we discuss our perspectives about how astrocyte developmental maturation is regulated, and how disruption of the astrocyte functional maturation process, especially alterations in their ability to regulate glutamate homeostasis, may alter synaptic physiology and contribute to the pathogenesis of neurodevelopmental disorders. |
2013-11-12 |
2023-08-12 |
Not clear |
| Chunxing Liu, Wenjie Wu, Bin Zhang, Jie Xiang, Jian Zo. Temporospatial expression and cellular localization of glutamine synthetase following traumatic spinal cord injury in adult rats. Molecular medicine reports. vol 7. issue 5. 2013-11-05. PMID:23525248. |
glutamine synthetase (gs) is an enzyme involved in an endogenous mechanism of protection against glutamate neurotoxicity and is important in the regulation of astrocyte migration. |
2013-11-05 |
2023-08-12 |
rat |
| Chun-Jung Chen, Yen-Chuan Ou, Cheng-Yi Chang, Hung-Chuan Pan, Su-Lan Liao, Shih-Yun Chen, Shue-Ling Raung, Ching-Yi La. Glutamate released by Japanese encephalitis virus-infected microglia involves TNF-α signaling and contributes to neuronal death. Glia. vol 60. issue 3. 2013-11-01. PMID:22144112. |
infection with jev was found to elicit the extracellular glutamate accumulation from microglia but not from neuron and astrocyte cultures. |
2013-11-01 |
2023-08-12 |
Not clear |
| Haruki Higashimori, Lydie Morel, James Huth, Lothar Lindemann, Chris Dulla, Amaro Taylor, Mike Freeman, Yongjie Yan. Astroglial FMRP-dependent translational down-regulation of mGluR5 underlies glutamate transporter GLT1 dysregulation in the fragile X mouse. Human molecular genetics. vol 22. issue 10. 2013-11-01. PMID:23396537. |
using mismatched astrocyte and neuron co-cultures, we demonstrate that the loss of astroglial (but not neuronal) fmrp particularly reduces neuron-dependent glt1 expression and glutamate uptake in co-cultures. |
2013-11-01 |
2023-08-12 |
mouse |
| Thomas Koeglsperger, Shaomin Li, Christian Brenneis, Jessica L Saulnier, Lior Mayo, Yijun Carrier, Dennis J Selkoe, Howard L Weine. Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS. Glia. vol 61. issue 6. 2013-10-29. PMID:23536313. |
we found that depletion of tgf-β1 in the cns resulted in a loss of the astrocyte glutamate transporter (glut) proteins glt-1 (eaat2) and glast (eaat1) and decreased glutamate uptake in the mouse hippocampus. |
2013-10-29 |
2023-08-12 |
mouse |
| Cora H Nijboer, Cobi J Heijnen, Vincent Degos, Hanneke L D M Willemen, Pierre Gressens, Annemieke Kavelaar. Astrocyte GRK2 as a novel regulator of glutamate transport and brain damage. Neurobiology of disease. vol 54. 2013-10-21. PMID:23313319. |
astrocyte grk2 as a novel regulator of glutamate transport and brain damage. |
2013-10-21 |
2023-08-12 |
mouse |
| Boris Görg, Freimut Schliess, Dieter Häussinge. Osmotic and oxidative/nitrosative stress in ammonia toxicity and hepatic encephalopathy. Archives of biochemistry and biophysics. vol 536. issue 2. 2013-09-30. PMID:23567841. |
astrocyte swelling triggers a complex signaling cascade which relies on nmda receptor activation, elevation of intracellular ca(2+) concentration and prostanoid-driven glutamate exocytosis, which result in increased formation of reactive nitrogen and oxygen species (rnos) through activation of nadph oxidase and nitric oxide synthase. |
2013-09-30 |
2023-08-12 |
human |
| Vera Lachmann, Boris Görg, Hans Jürgen Bidmon, Verena Keitel, Dieter Häussinge. Precipitants of hepatic encephalopathy induce rapid astrocyte swelling in an oxidative stress dependent manner. Archives of biochemistry and biophysics. vol 536. issue 2. 2013-09-30. PMID:23707757. |
in line with a nmda receptor-, prostanoid- and ca(2+)-dependence of nh4cl-induced rnos formation, ca(2+) chelation and inhibition of nmda receptors or cyclooxygenase suppressed nh4cl-induced astrocyte swelling, whereas the ca(2+)-ionophore ionomycin, nmda, glutamate and prostanoids induced rapid astrocyte swelling. |
2013-09-30 |
2023-08-12 |
Not clear |
| Alexandra E Schreiner, Eric Berlinger, Julia Langer, Karl W Kafitz, Christine R Ros. Lesion-induced alterations in astrocyte glutamate transporter expression and function in the hippocampus. ISRN neurology. vol 2013. 2013-09-30. PMID:24078881. |
lesion-induced alterations in astrocyte glutamate transporter expression and function in the hippocampus. |
2013-09-30 |
2023-08-12 |
Not clear |
| Juliana Kleinkauf-Rocha, Larissa Daniele Bobermin, Priscila de Mattos Machado, Carlos-Alberto Gonçalves, Carmem Gottfried, André Quincozes-Santo. Lipoic acid increases glutamate uptake, glutamine synthetase activity and glutathione content in C6 astrocyte cell line. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 31. issue 3. 2013-08-30. PMID:23286972. |
lipoic acid increases glutamate uptake, glutamine synthetase activity and glutathione content in c6 astrocyte cell line. |
2013-08-30 |
2023-08-12 |
Not clear |
| Juliana Kleinkauf-Rocha, Larissa Daniele Bobermin, Priscila de Mattos Machado, Carlos-Alberto Gonçalves, Carmem Gottfried, André Quincozes-Santo. Lipoic acid increases glutamate uptake, glutamine synthetase activity and glutathione content in C6 astrocyte cell line. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 31. issue 3. 2013-08-30. PMID:23286972. |
we show here that la modulates specific glial parameters in c6 astrocyte cell line, such as glutamate uptake, glutamine synthetase (gs) activity and glutathione content, commonly associated with the protective role of glial cells. |
2013-08-30 |
2023-08-12 |
Not clear |
| Nicole M Ashpole, Aarti R Chawla, Matthew P Martin, Tatiana Brustovetsky, Nickolay Brustovetsky, Andy Hudmo. Loss of calcium/calmodulin-dependent protein kinase II activity in cortical astrocytes decreases glutamate uptake and induces neurotoxic release of ATP. The Journal of biological chemistry. vol 288. issue 20. 2013-08-06. PMID:23543737. |
when extracellular glutamate and atp levels are measured after camkii inhibition within our enriched astrocyte cultures, no alterations in glutamate levels are observed, whereas atp levels in the extracellular environment significantly increase. |
2013-08-06 |
2023-08-12 |
Not clear |
| Gerald Seifert, Christian Steinhäuse. Neuron-astrocyte signaling and epilepsy. Experimental neurology. vol 244. 2013-08-02. PMID:21925173. |
moreover, malfunction of glutamate transporters and the astrocytic glutamate-converting enzyme, glutamine synthetase, as observed in epileptic tissue suggested that astrocyte dysfunction is causative of hyperexcitation, seizure spread and neurotoxicity. |
2013-08-02 |
2023-08-12 |
Not clear |
| Maryse Paquet, Fabiola M Ribeiro, Jennifer Guadagno, Jessica L Esseltine, Stephen S G Ferguson, Sean P Crega. Role of metabotropic glutamate receptor 5 signaling and homer in oxygen glucose deprivation-mediated astrocyte apoptosis. Molecular brain. vol 6. 2013-07-10. PMID:23406666. |
role of metabotropic glutamate receptor 5 signaling and homer in oxygen glucose deprivation-mediated astrocyte apoptosis. |
2013-07-10 |
2023-08-12 |
Not clear |
| Angelo C Lepore, John O'Donnell, Andrew S Kim, Eun Ju Yang, Alisha Tuteja, Amanda Haidet-Phillips, Colin P O'Banion, Nicholas J Maragaki. Reduction in expression of the astrocyte glutamate transporter, GLT1, worsens functional and histological outcomes following traumatic spinal cord injury. Glia. vol 59. issue 12. 2013-07-08. PMID:21882244. |
reduction in expression of the astrocyte glutamate transporter, glt1, worsens functional and histological outcomes following traumatic spinal cord injury. |
2013-07-08 |
2023-08-12 |
mouse |
| Angelo C Lepore, John O'Donnell, Andrew S Kim, Eun Ju Yang, Alisha Tuteja, Amanda Haidet-Phillips, Colin P O'Banion, Nicholas J Maragaki. Reduction in expression of the astrocyte glutamate transporter, GLT1, worsens functional and histological outcomes following traumatic spinal cord injury. Glia. vol 59. issue 12. 2013-07-08. PMID:21882244. |
the astrocyte glutamate transporter, glt1, is responsible for the vast majority of glutamate uptake in the adult central nervous system (cns), thereby regulating extracellular glutamate homeostasis and preventing excitotoxicity. |
2013-07-08 |
2023-08-12 |
mouse |
| Angelo C Lepore, John O'Donnell, Andrew S Kim, Eun Ju Yang, Alisha Tuteja, Amanda Haidet-Phillips, Colin P O'Banion, Nicholas J Maragaki. Reduction in expression of the astrocyte glutamate transporter, GLT1, worsens functional and histological outcomes following traumatic spinal cord injury. Glia. vol 59. issue 12. 2013-07-08. PMID:21882244. |
to determine the role of glt1 in secondary cell loss following sci, mice heterozygous for the glt1 astrocyte glutamate transporter (glt1+/-) and wild-type mice received thoracic crush sci. |
2013-07-08 |
2023-08-12 |
mouse |
| Vincent Degos, Tifenn Le Charpentier, Vibol Chhor, Olivier Brissaud, Sophie Lebon, Leslie Schwendimann, Nathalie Bednareck, Sandrine Passemard, Jean Mantz, Pierre Gressen. Neuroprotective effects of dexmedetomidine against glutamate agonist-induced neuronal cell death are related to increased astrocyte brain-derived neurotrophic factor expression. Anesthesiology. vol 118. issue 5. 2013-06-18. PMID:23353792. |
neuroprotective effects of dexmedetomidine against glutamate agonist-induced neuronal cell death are related to increased astrocyte brain-derived neurotrophic factor expression. |
2013-06-18 |
2023-08-12 |
mouse |
| Francesca Galeffi, Dennis A Turne. Exploiting metabolic differences in glioma therapy. Current drug discovery technologies. vol 9. issue 4. 2013-06-04. PMID:22339075. |
astrocyte functions include buffering the extracellular space, providing substrates to neurons, interchanging glutamate and glutamine for synaptic transmission with neurons, and facilitating access to blood vessels. |
2013-06-04 |
2023-08-12 |
Not clear |