| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Evgeniy S Potapenko, Vinicia C Biancardi, Yiqiang Zhou, Javier E Ster. Altered astrocyte glutamate transporter regulation of hypothalamic neurosecretory neurons in heart failure rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 303. issue 3. 2012-10-16. PMID:22696576. |
altered astrocyte glutamate transporter regulation of hypothalamic neurosecretory neurons in heart failure rats. |
2012-10-16 |
2023-08-12 |
rat |
| Evgeniy S Potapenko, Vinicia C Biancardi, Yiqiang Zhou, Javier E Ster. Altered astrocyte glutamate transporter regulation of hypothalamic neurosecretory neurons in heart failure rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 303. issue 3. 2012-10-16. PMID:22696576. |
patch-clamp recordings obtained from mncs in brain slices show that pharmacological blockade of astrocyte glutamate transporter 1 (glt1) function [500 μm dihydrokainate (dhk)], resulted in a persistent n-methyl-d-aspartate receptor (nmdar)-mediated inward current (tonic i(nmda)) in sham rats, an effect that was significantly smaller in mncs from hf rats. |
2012-10-16 |
2023-08-12 |
rat |
| Evgeniy S Potapenko, Vinicia C Biancardi, Yiqiang Zhou, Javier E Ster. Altered astrocyte glutamate transporter regulation of hypothalamic neurosecretory neurons in heart failure rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 303. issue 3. 2012-10-16. PMID:22696576. |
conversely, astrocyte glast expression was significantly higher in the son of hf rats, while nonselective blockade of glutamate transport activity (100 μm tboa) evoked an enhanced tonic i(nmda) activation in hf rats. |
2012-10-16 |
2023-08-12 |
rat |
| Jai-Yoon Sul, George Orosz, Richard S Givens, Philip G Haydo. Astrocytic connectivity in the hippocampus. Neuron glia biology. vol 1. issue 1. 2012-10-02. PMID:16575432. |
to explore this issue we photo-released glutamate onto a single astrocyte in murine hippocampal slices and imaged calcium responses. |
2012-10-02 |
2023-08-12 |
Not clear |
| Jai-Yoon Sul, George Orosz, Richard S Givens, Philip G Haydo. Astrocytic connectivity in the hippocampus. Neuron glia biology. vol 1. issue 1. 2012-10-02. PMID:16575432. |
photo-release of glutamate causes a metabotropic glutamate receptor (mglur)-dependent increase in internal calcium in the stimulated astrocyte and delayed calcium elevations in neighboring cells. |
2012-10-02 |
2023-08-12 |
Not clear |
| Qing-Song Liu, Qiwu Xu, Jian Kang, Maiken Nedergaar. Astrocyte activation of presynaptic metabotropic glutamate receptors modulates hippocampal inhibitory synaptic transmission. Neuron glia biology. vol 1. issue 4. 2012-10-02. PMID:16755304. |
astrocyte activation of presynaptic metabotropic glutamate receptors modulates hippocampal inhibitory synaptic transmission. |
2012-10-02 |
2023-08-12 |
Not clear |
| Paul Desjardins, Ting Du, Wenlei Jiang, Liang Peng, Roger F Butterwort. Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure: role of glutamine redefined. Neurochemistry international. vol 60. issue 7. 2012-10-01. PMID:22382077. |
moreover, the restricted transfer of glutamine from the astrocyte to the adjacent glutamatergic nerve terminal (where glutamine serves as immediate precursor for the releasable/transmitter pool of glutamate) could result in decreased excitatory transmission and excessive neuroinhibition that is characteristic of encephalopathy in alf. |
2012-10-01 |
2023-08-12 |
human |
| Helena Parfenova, Dilyara Tcheranova, Shyamali Basuroy, Alexander L Fedinec, Jianxiong Liu, Charles W Leffle. Functional role of astrocyte glutamate receptors and carbon monoxide in cerebral vasodilation response to glutamate. American journal of physiology. Heart and circulatory physiology. vol 302. issue 11. 2012-09-12. PMID:22467311. |
functional role of astrocyte glutamate receptors and carbon monoxide in cerebral vasodilation response to glutamate. |
2012-09-12 |
2023-08-12 |
Not clear |
| Helena Parfenova, Dilyara Tcheranova, Shyamali Basuroy, Alexander L Fedinec, Jianxiong Liu, Charles W Leffle. Functional role of astrocyte glutamate receptors and carbon monoxide in cerebral vasodilation response to glutamate. American journal of physiology. Heart and circulatory physiology. vol 302. issue 11. 2012-09-12. PMID:22467311. |
we addressed the hypothesis that ionotropic glutamate receptors (iglurs), including n-methyl-d-aspartic acid (nmda)- and 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl) propanoic acid (ampa)/kainate-type receptors, expressed in cortical astrocytes mediate glutamate-induced astrocyte ho activation that leads to cerebral vasodilation. |
2012-09-12 |
2023-08-12 |
Not clear |
| Helena Parfenova, Dilyara Tcheranova, Shyamali Basuroy, Alexander L Fedinec, Jianxiong Liu, Charles W Leffle. Functional role of astrocyte glutamate receptors and carbon monoxide in cerebral vasodilation response to glutamate. American journal of physiology. Heart and circulatory physiology. vol 302. issue 11. 2012-09-12. PMID:22467311. |
overall, these data indicate that the astrocyte component of the neurovascular unit is responsible for the vasodilation response of pial arterioles to topically applied glutamate via iglurs that are functionally linked to activation of constitutive ho in newborn piglets. |
2012-09-12 |
2023-08-12 |
Not clear |
| Silke D Honsek, Corinna Walz, Karl W Kafitz, Christine R Ros. Astrocyte calcium signals at Schaffer collateral to CA1 pyramidal cell synapses correlate with the number of activated synapses but not with synaptic strength. Hippocampus. vol 22. issue 1. 2012-09-06. PMID:20882545. |
astrocyte calcium transients upon this three-pulse stimulation could be evoked repetitively, increased in amplitude with increasing stimulation intensity and were dependent on activation of metabotropic glutamate receptors. |
2012-09-06 |
2023-08-12 |
Not clear |
| Melanie Jungblut, Marie Catherine Tiveron, Serena Barral, Bjarke Abrahamsen, Sebastian Knöbel, Sandra Pennartz, Jürgen Schmitz, Martine Perraut, Frank W Pfrieger, Wilhelm Stoffel, Harold Cremer, Andreas Bosi. Isolation and characterization of living primary astroglial cells using the new GLAST-specific monoclonal antibody ACSA-1. Glia. vol 60. issue 6. 2012-08-10. PMID:22374709. |
binding of the antibody to glast and subsequent sorting of glast-positive cells neither interfered with cellular glutamate transport nor compromised astrocyte viability in vitro. |
2012-08-10 |
2023-08-12 |
mouse |
| Marica Carbone, Susan Duty, Marcus Rattra. Riluzole neuroprotection in a Parkinson's disease model involves suppression of reactive astrocytosis but not GLT-1 regulation. BMC neuroscience. vol 13. 2012-08-10. PMID:22480308. |
recent evidence suggests that riluzole can up-regulate the expression and activity of the astrocyte glutamate transporter, glt-1. |
2012-08-10 |
2023-08-12 |
rat |
| Linea F Obel, Karen M H Andersen, Lasse K Bak, Arne Schousboe, Helle S Waagepeterse. Effects of adrenergic agents on intracellular Ca2+ homeostasis and metabolism of glucose in astrocytes with an emphasis on pyruvate carboxylation, oxidative decarboxylation and recycling: implications for glutamate neurotransmission and excitotoxicity. Neurotoxicity research. vol 21. issue 4. 2012-07-23. PMID:22194159. |
the metabolism of glycogen, the location of which is confined to astrocytes, is affected by norepinephrine (ne), and hence, adrenergic signaling in the astrocyte might affect glutamate homeostasis with implications for excitatory neurotransmission and possibly excitotoxic neurodegeneration. |
2012-07-23 |
2023-08-12 |
Not clear |
| Aven Lee, Ashley R Anderson, Shannon J Beasley, Nigel L Barnett, Philip Poronnik, David V Po. A new splice variant of the glutamate-aspartate transporter: cloning and immunolocalization of GLAST1c in rat, pig and human brains. Journal of chemical neuroanatomy. vol 43. issue 1. 2012-07-19. PMID:22026960. |
we conclude that glast1c may represent an astrocyte and oligodendrocyte glutamate transporter, though this could not be formally validated by d-aspartate uptake studies, due to the low transfection efficiency of constructs into cos 7 cells. |
2012-07-19 |
2023-08-12 |
human |
| Rogier Min, Thomas Nevia. Astrocyte signaling controls spike timing-dependent depression at neocortical synapses. Nature neuroscience. vol 15. issue 5. 2012-06-21. PMID:22446881. |
following activation, astrocytes released glutamate, which activated presynaptic nmda receptors to induce t-ltd. astrocyte stimulation coincident with afferent activity resulted in long-term depression, indicating that astrocyte activation is sufficient for the induction of synaptic depression. |
2012-06-21 |
2023-08-12 |
rat |
| Marica Carbone, Susan Duty, Marcus Rattra. Riluzole elevates GLT-1 activity and levels in striatal astrocytes. Neurochemistry international. vol 60. issue 1. 2012-06-20. PMID:22080156. |
drugs which upregulate astrocyte glutamate transport may be useful neuroprotective compounds by preventing excitotoxicity. |
2012-06-20 |
2023-08-12 |
mouse |
| Marta Navarrete, Gertrudis Perea, David Fernandez de Sevilla, Marta Gómez-Gonzalo, Angel Núñez, Eduardo D Martín, Alfonso Araqu. Astrocytes mediate in vivo cholinergic-induced synaptic plasticity. PLoS biology. vol 10. issue 2. 2012-06-06. PMID:22347811. |
therefore, cholinergic-induced ltp requires astrocyte ca²⁺ elevations, which stimulate astrocyte glutamate release that activates mglurs. |
2012-06-06 |
2023-08-12 |
mouse |
| Jana Benesova, Vendula Rusnakova, Pavel Honsa, Helena Pivonkova, David Dzamba, Mikael Kubista, Miroslava Anderov. Distinct expression/function of potassium and chloride channels contributes to the diverse volume regulation in cortical astrocytes of GFAP/EGFP mice. PloS one. vol 7. issue 1. 2012-05-29. PMID:22253765. |
using three-dimensional confocal morphometry, which enables quantification of the total astrocytic volume, the effects of selected inhibitors of k⁺ and cl⁻ channels/transporters or glutamate transporters on astrocyte volume changes were determined during 20 minute-ogd in situ. |
2012-05-29 |
2023-08-12 |
mouse |
| Tiffany M Fleming, Victoria Scott, Krishna Naskar, Natalie Joe, Colin H Brown, Javier E Ster. State-dependent changes in astrocyte regulation of extrasynaptic NMDA receptor signalling in neurosecretory neurons. The Journal of physiology. vol 589. issue Pt 16. 2012-05-24. PMID:21690192. |
pharmacological blockade of glt1 astrocyte glutamate transporters, as well as the gliotoxin α-aminodadipic acid, enhanced tonic i(nmda) and neuronal activity, supporting an astrocyte regulation of tonic i(nmda) strength. |
2012-05-24 |
2023-08-12 |
Not clear |