| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cendra Agulhon, Todd A Fiacco, Ken D McCarth. Hippocampal short- and long-term plasticity are not modulated by astrocyte Ca2+ signaling. Science (New York, N.Y.). vol 327. issue 5970. 2010-03-19. PMID:20203048. |
astrocyte release of gliotransmitters (for example, glutamate and adenosine triphosphate) is generally accepted to be a ca2+-dependent process. |
2010-03-19 |
2023-08-12 |
mouse |
| Susan M Sullivan, S Tracey Björkman, Stephanie M Miller, Paul B Colditz, David V Po. Structural remodeling of gray matter astrocytes in the neonatal pig brain after hypoxia/ischemia. Glia. vol 58. issue 2. 2010-02-19. PMID:19606499. |
d-aspartate uptake studies revealed that the h/i insult resulted in impaired astrocyte function, with significantly reduced clearance of the glutamate analog, d-aspartate. |
2010-02-19 |
2023-08-12 |
Not clear |
| Elaine S Coleman, John C Dennis, Timothy D Braden, Robert L Judd, Phil Posne. Insulin treatment prevents diabetes-induced alterations in astrocyte glutamate uptake and GFAP content in rats at 4 and 8 weeks of diabetes duration. Brain research. vol 1306. 2010-02-03. PMID:19822133. |
insulin treatment prevents diabetes-induced alterations in astrocyte glutamate uptake and gfap content in rats at 4 and 8 weeks of diabetes duration. |
2010-02-03 |
2023-08-12 |
rat |
| Elaine S Coleman, John C Dennis, Timothy D Braden, Robert L Judd, Phil Posne. Insulin treatment prevents diabetes-induced alterations in astrocyte glutamate uptake and GFAP content in rats at 4 and 8 weeks of diabetes duration. Brain research. vol 1306. 2010-02-03. PMID:19822133. |
we report here a comparison of astrocyte glutamate uptake and gfap expression in streptozotocin-induced type 1 diabetic rats and insulin-treated diabetic rats at 4 and 8 weeks following diabetes onset. |
2010-02-03 |
2023-08-12 |
rat |
| Claudia Lehmann, Stefanie Bette, Jürgen Engel. High extracellular glutamate modulates expression of glutamate transporters and glutamine synthetase in cultured astrocytes. Brain research. vol 1297. 2010-01-08. PMID:19728998. |
subjecting cultured cortical astrocytes to glutamate concentrations of 0.5-20 mm resulted in a 25% loss of glt-1 and glast protein levels after 24 h; glt-1 and glast levels maximally decreased by 40% and 75%, respectively, after 72 h. this decline was not due to astroglial cell death, since glutamate up to 50 mm did not affect the survival of cultured astrocytes within 72 h. major astrocytic cell death, however, occurred in cultures maintained under severe (4% o(2)), but not mild (9% o(2)), hypoxia, as well as in the presence of aspartate (>or=20 mm). |
2010-01-08 |
2023-08-12 |
Not clear |
| Yu-Feng Wang, Kathryn Hamilto. Chronic vs. acute interactions between supraoptic oxytocin neurons and astrocytes during lactation: role of glial fibrillary acidic protein plasticity. TheScientificWorldJournal. vol 9. 2010-01-07. PMID:19936568. |
the acute changes in astrocyte gfap levels seen during suckling likely recur periodically, accompanied by rhythmic changes in glutamate metabolism, water transport, gliotransmitter release, and spatial relationships between astrocytes and oxt neurons. |
2010-01-07 |
2023-08-12 |
Not clear |
| Grant R J Gordon, Karl J Iremonger, Srinivas Kantevari, Graham C R Ellis-Davies, Brian A MacVicar, Jaideep S Bain. Astrocyte-mediated distributed plasticity at hypothalamic glutamate synapses. Neuron. vol 64. issue 3. 2009-12-07. PMID:19914187. |
this effect requires a metabotropic glutamate receptor-mediated rise in ca(2+) in the astrocyte processes surrounding the neuron and the release of the gliotransmitter atp, which acts on postsynaptic purinergic receptors. |
2009-12-07 |
2023-08-12 |
Not clear |
| Pennelope K Blakely, Bette K Kleinschmidt-DeMasters, Kenneth L Tyler, David N Iran. Disrupted glutamate transporter expression in the spinal cord with acute flaccid paralysis caused by West Nile virus infection. Journal of neuropathology and experimental neurology. vol 68. issue 10. 2009-12-04. PMID:19918118. |
these findings suggest that wnv infection results in local immune activation within the spinal cord that in turn causes a failure of astrocyte glutamate reuptake even as the number of astrocytes increases; rising extracellular glutamate levels may then drive excitotoxic injury of both infected and uninfected anterior horn cells. |
2009-12-04 |
2023-08-12 |
human |
| Morris H Baslow, David N Guilfoyl. Are astrocytes the missing link between lack of brain aspartoacylase activity and the spongiform leukodystrophy in Canavan disease? Neurochemical research. vol 34. issue 9. 2009-10-19. PMID:19319678. |
we also hypothesize that naa is not directly liberated by neurons in wm as it is in gray matter, and that its source in wm ecf is solely as a product of the catabolism of axon-released naag at nodes of ranvier by astrocyte naag peptidase after it has docked with the astrocyte surface metabotropic glutamate receptor 3. |
2009-10-19 |
2023-08-12 |
Not clear |
| Hans-Gert Bernstein, Johann Steiner, Bernhard Bogert. Glial cells in schizophrenia: pathophysiological significance and possible consequences for therapy. Expert review of neurotherapeutics. vol 9. issue 7. 2009-09-21. PMID:19589054. |
since astrocytes play a key role in the synaptic metabolism of glutamate and monamines, astrocyte dysfunction may well be related to the current transmitter theories of schizophrenia. |
2009-09-21 |
2023-08-12 |
Not clear |
| Letícia Carina Ribeiro, André Quincozes-Santos, Marina Concli Leite, Renata Torres Abib, Juliana Kleinkauf-Rocha, Regina Biasibetti, Liane Nanci Rotta, Susana T Wofchuk, Marcos Luiz Santos Perry, Carlos-Alberto Gonçalves, Carmem Gottfrie. Caloric restriction increases hippocampal glutamate uptake and glutamine synthetase activity in Wistar rats. Neuroscience research. vol 64. issue 3. 2009-08-20. PMID:19376166. |
the impairment of astroglial cell function, including glutamate uptake, glutamine synthetase (gs) activity and s100b secretion, may contribute to the progression of neurological disorders. |
2009-08-20 |
2023-08-12 |
rat |
| Letícia Carina Ribeiro, André Quincozes-Santos, Marina Concli Leite, Renata Torres Abib, Juliana Kleinkauf-Rocha, Regina Biasibetti, Liane Nanci Rotta, Susana T Wofchuk, Marcos Luiz Santos Perry, Carlos-Alberto Gonçalves, Carmem Gottfrie. Caloric restriction increases hippocampal glutamate uptake and glutamine synthetase activity in Wistar rats. Neuroscience research. vol 64. issue 3. 2009-08-20. PMID:19376166. |
in summary, the present study indicates that cr also modulates astrocyte functions by increasing glutamate uptake and gs activity, suggesting that cr might exert its neuroprotective effects against brain illness by modulation of astrocytic functions. |
2009-08-20 |
2023-08-12 |
rat |
| Barbara Grintal, Gaëlle Champeil-Potokar, Monique Lavialle, Sylvie Vancassel, Sylvie Breton, Isabelle Deni. Inhibition of astroglial glutamate transport by polyunsaturated fatty acids: evidence for a signalling role of docosahexaenoic acid. Neurochemistry international. vol 54. issue 8. 2009-07-15. PMID:19428799. |
therefore, dha reduces glutamate uptake through a signal-like effect but not through changes in the pufa composition of the astrocyte membranes. |
2009-07-15 |
2023-08-12 |
rat |
| K S Panickar, A R Jayakumar, K V Rama Rao, M D Norenber. Ammonia-induced activation of p53 in cultured astrocytes: role in cell swelling and glutamate uptake. Neurochemistry international. vol 55. issue 1-3. 2009-07-15. PMID:19428812. |
our results indicate that a potentially important downstream target of ammonia neurotoxicity is p53, whose activation contributes to astrocyte swelling and glutamate uptake inhibition, processes likely a consequence of ons derived from the mpt and activation of nf-kappab. |
2009-07-15 |
2023-08-12 |
Not clear |
| Zhaobao Yin, Jan Albrecht, Tore Syversen, Haiyan Jiang, Marshall Summar, Joao B T Rocha, Marcelo Farina, Michael Aschne. Comparison of alterations in amino acids content in cultured astrocytes or neurons exposed to methylmercury separately or in co-culture. Neurochemistry international. vol 55. issue 1-3. 2009-07-15. PMID:19428818. |
the results showed that glutamate concentrations significantly decreased in neurons, but not in astrocyte cultures exposed to 10 microm mehg. |
2009-07-15 |
2023-08-12 |
Not clear |
| Zhen Yu Xu, Hua Dong Liu, Lok Ting Lau, Zhang Yingge, Rui Zhao, Geng Lei Tong, Pak Hoo Chan, Albert Cheung Hoi Y. Responses of astrocyte to simultaneous glutamate and arachidonic acid treatment. Neurochemistry international. vol 55. issue 1-3. 2009-07-15. PMID:19428819. |
responses of astrocyte to simultaneous glutamate and arachidonic acid treatment. |
2009-07-15 |
2023-08-12 |
Not clear |
| M D Norenberg, K V Rama Rao, A R Jayakuma. Signaling factors in the mechanism of ammonia neurotoxicity. Metabolic brain disease. vol 24. issue 1. 2009-07-06. PMID:19104923. |
this article reviews the role of these factors in the mechanism of he and ammonia toxicity with a focus on astrocyte swelling and glutamate uptake, which are important consequences of ammonia neurotoxicity. |
2009-07-06 |
2023-08-12 |
Not clear |
| Jessica Carmen, Jeffrey D Rothstein, Douglas A Ker. Tumor necrosis factor-alpha modulates glutamate transport in the CNS and is a critical determinant of outcome from viral encephalomyelitis. Brain research. vol 1263. 2009-06-24. PMID:19368827. |
treatment of organotypic slice cultures with nsv results in viral replication, cell death, altered astrocyte morphology, and the downregulation of the astrocytic glutamate transporter, glt-1. |
2009-06-24 |
2023-08-12 |
mouse |
| Alexander N Silchenko, Peter A Tas. Computational modeling of paroxysmal depolarization shifts in neurons induced by the glutamate release from astrocytes. Biological cybernetics. vol 98. issue 1. 2009-05-18. PMID:18064484. |
the timing of glutamate release from the astrocyte is studied by means of a combined modeling of a vesicle cycle and the dynamics of snare-proteins. |
2009-05-18 |
2023-08-12 |
Not clear |
| Anna K Andersson, Louise Adermark, Mikael Persson, Anna Westerlund, Torsten Olsson, Elisabeth Hansso. Lactate contributes to ammonia-mediated astroglial dysfunction during hyperammonemia. Neurochemical research. vol 34. issue 3. 2009-05-11. PMID:18716864. |
the data presented here show that nh4cl (5 mm) mediates astroglial cell swelling, and that treatment with nh4cl or lactate (25 mm) causes rearrangements of actin filaments and reduces astroglial glutamate uptake capacity. |
2009-05-11 |
2023-08-12 |
Not clear |