| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Morris H Baslo. The astrocyte surface NAAG receptor and NAAG peptidase signaling complex as a therapeutic target. Drug news & perspectives. vol 21. issue 5. 2008-10-23. PMID:18596989. |
naag is a peptide neurotransmitter released by stimulated neurons and specifically targeted to the group ii metabotropic glutamate receptor 3 (mglu(3)), activation of which initiates astrocyte ca(2+) waves responsible for astrocyte-astrocyte and astrocyte-vascular system signaling and induction of vascular hyperemic responses that increase energy supplies to stimulated neurons. |
2008-10-23 |
2023-08-12 |
human |
| Luciana Ferreira Romão, Vivian de Oliveira Sousa, Vivaldo Moura Neto, Flávia Carvalho Alcantara Gome. Glutamate activates GFAP gene promoter from cultured astrocytes through TGF-beta1 pathways. Journal of neurochemistry. vol 106. issue 2. 2008-09-16. PMID:18419760. |
here, we evaluated the role of the excitatory neurotransmitter, glutamate, in astrocyte differentiation. |
2008-09-16 |
2023-08-12 |
mouse |
| Luciana Ferreira Romão, Vivian de Oliveira Sousa, Vivaldo Moura Neto, Flávia Carvalho Alcantara Gome. Glutamate activates GFAP gene promoter from cultured astrocytes through TGF-beta1 pathways. Journal of neurochemistry. vol 106. issue 2. 2008-09-16. PMID:18419760. |
together, our results suggest that glial metabotropic glutamate 2/3 receptor activation by neurons induces tgf-beta1 secretion, leading to gfap gene activation and astrocyte differentiation and involves smad and mapk/pi3k pathways. |
2008-09-16 |
2023-08-12 |
mouse |
| Tammy Kielia. Glial connexins and gap junctions in CNS inflammation and disease. Journal of neurochemistry. vol 106. issue 3. 2008-09-15. PMID:18410504. |
of paramount importance to cns homeostasis are astrocyte networks formed by gap junctions, which play a critical role in maintaining the homeostatic regulation of extracellular ph, k+, and glutamate levels. |
2008-09-15 |
2023-08-12 |
Not clear |
| V L Tawfik, M R Regan, C Haenggeli, M L Lacroix-Fralish, N Nutile-McMenemy, N Perez, J D Rothstein, J A DeLe. Propentofylline-induced astrocyte modulation leads to alterations in glial glutamate promoter activation following spinal nerve transection. Neuroscience. vol 152. issue 4. 2008-08-07. PMID:18358622. |
propentofylline-induced astrocyte modulation leads to alterations in glial glutamate promoter activation following spinal nerve transection. |
2008-08-07 |
2023-08-12 |
mouse |
| Alessandra Swarowsky, Letícia Rodrigues, Regina Biasibetti, Marina C Leite, Lucas Fürstenau de Oliveira, Lucia M V de Almeida, Carmem Gottfried, Jorge A Quillfeldt, Matilde Achaval, Carlos-Alberto Gonçalve. Glial alterations in the hippocampus of rats submitted to ibotenic-induced lesion of the nucleus basalis magnocellularis. Behavioural brain research. vol 190. issue 2. 2008-07-30. PMID:18395808. |
in this study, we investigated possible specific astrocyte alterations in the hippocampi of wistar rats submitted to nbm damage with ibotenic acid, investigating the content and immunohistochemistry of glial fibrillary acidic protein (gfap), as well as s100b protein content, glutamate uptake and glutamine synthetase activity on the 7th and 28th post-lesion days. |
2008-07-30 |
2023-08-12 |
rat |
| Nuria de Vera, Emili Martínez, Coral Sanfeli. Spermine induces cell death in cultured human embryonic cerebral cortical neurons through N-methyl-D-aspartate receptor activation. Journal of neuroscience research. vol 86. issue 4. 2008-07-08. PMID:17941054. |
another effect observed is that glutamate, but not spermine, induced astrocyte swelling. |
2008-07-08 |
2023-08-12 |
human |
| James Schummers, Hongbo Yu, Mriganka Su. Tuned responses of astrocytes and their influence on hemodynamic signals in the visual cortex. Science (New York, N.Y.). vol 320. issue 5883. 2008-07-03. PMID:18566287. |
furthermore, blocking astrocyte glutamate transporters influenced the magnitude and duration of adjacent visually driven neuronal responses. |
2008-07-03 |
2023-08-12 |
Not clear |
| Wei Wang, Wen Wang, Yayun Wang, Jing Huang, Shengxi Wu, Yun-Qing L. Temporal changes of astrocyte activation and glutamate transporter-1 expression in the spinal cord after spinal nerve ligation-induced neuropathic pain. Anatomical record (Hoboken, N.J. : 2007). vol 291. issue 5. 2008-06-23. PMID:18384122. |
temporal changes of astrocyte activation and glutamate transporter-1 expression in the spinal cord after spinal nerve ligation-induced neuropathic pain. |
2008-06-23 |
2023-08-12 |
Not clear |
| Wei Wang, Wen Wang, Yayun Wang, Jing Huang, Shengxi Wu, Yun-Qing L. Temporal changes of astrocyte activation and glutamate transporter-1 expression in the spinal cord after spinal nerve ligation-induced neuropathic pain. Anatomical record (Hoboken, N.J. : 2007). vol 291. issue 5. 2008-06-23. PMID:18384122. |
as a glutamate scavenger, the glutamate transporter-1 (glt-1) is exclusively expressed on the astrocytes and probably correlates with astrocyte activation. |
2008-06-23 |
2023-08-12 |
Not clear |
| Renata T Abib, André Quincozes-Santos, Patricia Nardin, Susana T Wofchuk, Marcos L Perry, Carlos-Alberto Gonçalves, Carmem Gottfrie. Epicatechin gallate increases glutamate uptake and S100B secretion in C6 cell lineage. Molecular and cellular biochemistry. vol 310. issue 1-2. 2008-06-20. PMID:18066651. |
here, we evaluated cell morphology and integrity and specific astrocyte activities; glutamate uptake and secretion of s100b in the presence of 0.1, 1 and 10 microm ecg. |
2008-06-20 |
2023-08-12 |
Not clear |
| Eli Gunnarson, Marina Zelenina, Gustav Axehult, Yutong Song, Alexander Bondar, Patrik Krieger, Hjalmar Brismar, Sergey Zelenin, Anita Aperi. Identification of a molecular target for glutamate regulation of astrocyte water permeability. Glia. vol 56. issue 6. 2008-06-20. PMID:18286643. |
identification of a molecular target for glutamate regulation of astrocyte water permeability. |
2008-06-20 |
2023-08-12 |
rat |
| Eli Gunnarson, Marina Zelenina, Gustav Axehult, Yutong Song, Alexander Bondar, Patrik Krieger, Hjalmar Brismar, Sergey Zelenin, Anita Aperi. Identification of a molecular target for glutamate regulation of astrocyte water permeability. Glia. vol 56. issue 6. 2008-06-20. PMID:18286643. |
here, we report that glutamate increases astrocyte water permeability and that the molecular target for this effect is the aquaporin-4 (aqp4) serine 111 residue, which is in a strategic position for control of the water channel gating. |
2008-06-20 |
2023-08-12 |
rat |
| Jeremy Petravicz, Todd A Fiacco, Ken D McCarth. Loss of IP3 receptor-dependent Ca2+ increases in hippocampal astrocytes does not affect baseline CA1 pyramidal neuron synaptic activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 19. 2008-06-13. PMID:18463250. |
astrocyte ca(2+) has been deemed necessary and sufficient to trigger the release of gliotransmitters, such as atp and glutamate, from astrocytes to modulate neuronal activity. |
2008-06-13 |
2023-08-12 |
mouse |
| Jeremy Petravicz, Todd A Fiacco, Ken D McCarth. Loss of IP3 receptor-dependent Ca2+ increases in hippocampal astrocytes does not affect baseline CA1 pyramidal neuron synaptic activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 19. 2008-06-13. PMID:18463250. |
these data show that ip(3)r2 is the key functional ip(3)r driving g(q)-linked gpcr-mediated ca(2+) increases in hippocampal astrocytes and that removal of astrocyte ca(2+) increases does not significantly affect excitatory neuronal synaptic activity or ambient glutamate levels. |
2008-06-13 |
2023-08-12 |
mouse |
| Natalie A Prow, David N Iran. The inflammatory cytokine, interleukin-1 beta, mediates loss of astroglial glutamate transport and drives excitotoxic motor neuron injury in the spinal cord during acute viral encephalomyelitis. Journal of neurochemistry. vol 105. issue 4. 2008-06-06. PMID:18194440. |
together, these data show that il-1beta inhibits astrocyte glutamate transport in the spinal cord during viral encephalomyelitis. |
2008-06-06 |
2023-08-12 |
mouse |
| Jia Newcombe, Alim Uddin, Rosamund Dove, Bela Patel, Lechoslaw Turski, Yukio Nishizawa, Terence Smit. Glutamate receptor expression in multiple sclerosis lesions. Brain pathology (Zurich, Switzerland). vol 18. issue 1. 2008-06-02. PMID:17924980. |
astrocyte and macrophage populations expressed glutamate metabolizing enzymes and unexpectedly the eaac1 transporter, which may play a role in glutamate uptake in lesions. |
2008-06-02 |
2023-08-12 |
Not clear |
| Minjie Xie, Wei Wang, Harold K Kimelberg, Min Zho. Oxygen and glucose deprivation-induced changes in astrocyte membrane potential and their underlying mechanisms in acute rat hippocampal slices. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 28. issue 3. 2008-04-30. PMID:17713462. |
oxygen and glucose deprivation-induced astrocyte v(m) depolarization was only marginally inhibited, approximately 10%, by inhibition of ionotropic glutamate, gamma-aminobutyric acid, purinergic receptors, and glutamate transporters presumed to be present on astrocytes in situ, suggesting increase in extracellular [k(+)] was primarily responsible for the astrocytic v(m) change. |
2008-04-30 |
2023-08-12 |
rat |
| Lizhen Li, Andrea Lundkvist, Daniel Andersson, Ulrika Wilhelmsson, Nobuo Nagai, Andrea C Pardo, Christina Nodin, Anders Ståhlberg, Karina Aprico, Kerstin Larsson, Takeshi Yabe, Lieve Moons, Andrew Fotheringham, Ioan Davies, Peter Carmeliet, Joan P Schwartz, Marcela Pekna, Mikael Kubista, Fredrik Blomstrand, Nicholas Maragakis, Michael Nilsson, Milos Pekn. Protective role of reactive astrocytes in brain ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 28. issue 3. 2008-04-30. PMID:17726492. |
thus, reactive astrocytes have a protective role in brain ischemia, and the absence of astrocyte ifs is linked to changes in glutamate transport, et(b)r-mediated control of gap junctions, and pai-1 expression. |
2008-04-30 |
2023-08-12 |
mouse |
| Jun-Chih Lo, Wei-Chi Huang, Yun-Chia Chou, Chun-Hsien Tseng, Wei-Li Lee, Synthia H Su. Activation of P2X(7) receptors decreases glutamate uptake and glutamine synthetase activity in RBA-2 astrocytes via distinct mechanisms. Journal of neurochemistry. vol 105. issue 1. 2008-04-28. PMID:18067549. |
here we report that treatment of rba-2 cells, a type-2-like astrocyte cell line, with atp and the p2x(7) receptor selective agonist 3'-o-(4-benzoylbenzoyl) adenosine 5'-triphosphate (bzatp) decreased the na+-dependent [3h]glutamate uptake within minutes. |
2008-04-28 |
2023-08-12 |
Not clear |