| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeremy Petravicz, Todd A Fiacco, Ken D McCarth. Loss of IP3 receptor-dependent Ca2+ increases in hippocampal astrocytes does not affect baseline CA1 pyramidal neuron synaptic activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 19. 2008-06-13. PMID:18463250. |
these data show that ip(3)r2 is the key functional ip(3)r driving g(q)-linked gpcr-mediated ca(2+) increases in hippocampal astrocytes and that removal of astrocyte ca(2+) increases does not significantly affect excitatory neuronal synaptic activity or ambient glutamate levels. |
2008-06-13 |
2023-08-12 |
mouse |
| Natalie A Prow, David N Iran. The inflammatory cytokine, interleukin-1 beta, mediates loss of astroglial glutamate transport and drives excitotoxic motor neuron injury in the spinal cord during acute viral encephalomyelitis. Journal of neurochemistry. vol 105. issue 4. 2008-06-06. PMID:18194440. |
together, these data show that il-1beta inhibits astrocyte glutamate transport in the spinal cord during viral encephalomyelitis. |
2008-06-06 |
2023-08-12 |
mouse |
| Jia Newcombe, Alim Uddin, Rosamund Dove, Bela Patel, Lechoslaw Turski, Yukio Nishizawa, Terence Smit. Glutamate receptor expression in multiple sclerosis lesions. Brain pathology (Zurich, Switzerland). vol 18. issue 1. 2008-06-02. PMID:17924980. |
astrocyte and macrophage populations expressed glutamate metabolizing enzymes and unexpectedly the eaac1 transporter, which may play a role in glutamate uptake in lesions. |
2008-06-02 |
2023-08-12 |
Not clear |
| Minjie Xie, Wei Wang, Harold K Kimelberg, Min Zho. Oxygen and glucose deprivation-induced changes in astrocyte membrane potential and their underlying mechanisms in acute rat hippocampal slices. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 28. issue 3. 2008-04-30. PMID:17713462. |
oxygen and glucose deprivation-induced astrocyte v(m) depolarization was only marginally inhibited, approximately 10%, by inhibition of ionotropic glutamate, gamma-aminobutyric acid, purinergic receptors, and glutamate transporters presumed to be present on astrocytes in situ, suggesting increase in extracellular [k(+)] was primarily responsible for the astrocytic v(m) change. |
2008-04-30 |
2023-08-12 |
rat |
| Lizhen Li, Andrea Lundkvist, Daniel Andersson, Ulrika Wilhelmsson, Nobuo Nagai, Andrea C Pardo, Christina Nodin, Anders Ståhlberg, Karina Aprico, Kerstin Larsson, Takeshi Yabe, Lieve Moons, Andrew Fotheringham, Ioan Davies, Peter Carmeliet, Joan P Schwartz, Marcela Pekna, Mikael Kubista, Fredrik Blomstrand, Nicholas Maragakis, Michael Nilsson, Milos Pekn. Protective role of reactive astrocytes in brain ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 28. issue 3. 2008-04-30. PMID:17726492. |
thus, reactive astrocytes have a protective role in brain ischemia, and the absence of astrocyte ifs is linked to changes in glutamate transport, et(b)r-mediated control of gap junctions, and pai-1 expression. |
2008-04-30 |
2023-08-12 |
mouse |
| Jun-Chih Lo, Wei-Chi Huang, Yun-Chia Chou, Chun-Hsien Tseng, Wei-Li Lee, Synthia H Su. Activation of P2X(7) receptors decreases glutamate uptake and glutamine synthetase activity in RBA-2 astrocytes via distinct mechanisms. Journal of neurochemistry. vol 105. issue 1. 2008-04-28. PMID:18067549. |
here we report that treatment of rba-2 cells, a type-2-like astrocyte cell line, with atp and the p2x(7) receptor selective agonist 3'-o-(4-benzoylbenzoyl) adenosine 5'-triphosphate (bzatp) decreased the na+-dependent [3h]glutamate uptake within minutes. |
2008-04-28 |
2023-08-12 |
Not clear |
| Marta Navarrete, Alfonso Araqu. Endocannabinoids mediate neuron-astrocyte communication. Neuron. vol 57. issue 6. 2008-04-28. PMID:18367089. |
these receptors are activated by endocannabinoids released by neurons, increasing astrocyte ca2+ levels, which stimulate glutamate release that activates nmda receptors in pyramidal neurons. |
2008-04-28 |
2023-08-12 |
Not clear |
| R Padmashri, S K Sikda. Glutamate transporter blockade affects Ca(2+) responses in astrocytes. Neuroscience. vol 151. issue 1. 2008-04-22. PMID:18037246. |
to test the hypothesis we pretreated astrocytes in culture (primary rat astrocyte cultures) with glutamate (500 microm) and glutamate transport inhibitor, threo-beta-hydroxy-aspartate (200 microm, tbha) or glutamate (500 microm) in na(+) free extracellular solution for 20 min. |
2008-04-22 |
2023-08-12 |
rat |
| R Padmashri, S K Sikda. Glutamate transporter blockade affects Ca(2+) responses in astrocytes. Neuroscience. vol 151. issue 1. 2008-04-22. PMID:18037246. |
when the experiments were done on astrocyte pairs that were pretreated with glutamate and tbha, we observed attenuated ca(2+) responses in the adjoining cell when compared with the depolarized cell. |
2008-04-22 |
2023-08-12 |
rat |
| R Padmashri, S K Sikda. Glutamate transporter blockade affects Ca(2+) responses in astrocytes. Neuroscience. vol 151. issue 1. 2008-04-22. PMID:18037246. |
the results were contrary to our earlier observation of heightened responses in the adjoining cell of the astrocyte pair, in cells pretreated with glutamate alone. |
2008-04-22 |
2023-08-12 |
rat |
| Miguel Salazar, José Antonio Pariente, Ginés María Salido, Antonio Gonzále. Ebselen increases cytosolic free Ca2+ concentration, stimulates glutamate release and increases GFAP content in rat hippocampal astrocytes. Toxicology. vol 244. issue 2-3. 2008-04-09. PMID:18237838. |
our results show that ebselen (1-20microm) dose dependently increases [ca2+](c), stimulates glutamate release and increases gfap content, a hallmark of astrocyte reactivity. |
2008-04-09 |
2023-08-12 |
rat |
| Lúcia Maria Vieira de Almeida, Cristopher Celintano Piñeiro, Marina Concli Leite, Giovana Brolese, Rodrigo Bainy Leal, Carmem Gottfried, Carlos-Alberto Gonçalve. Protective effects of resveratrol on hydrogen peroxide induced toxicity in primary cortical astrocyte cultures. Neurochemical research. vol 33. issue 1. 2008-04-01. PMID:17594518. |
the aim of this study is to evaluate the putative protective effect of resveratrol against acute h2o2-induced oxidative stress in astrocyte cultures, evaluating ros production, glutamate uptake activity, glutathione content and s100b secretion. |
2008-04-01 |
2023-08-12 |
Not clear |
| Anlong Li, Qi Xi, Edward S Umstot, Lars Bellner, Michal L Schwartzman, Jonathan H Jaggar, Charles W Leffle. Astrocyte-derived CO is a diffusible messenger that mediates glutamate-induced cerebral arteriolar dilation by activating smooth muscle Cell KCa channels. Circulation research. vol 102. issue 2. 2008-03-27. PMID:17991880. |
brain slice arteriole dilation to glutamate was also blocked by l-2-alpha aminoadipic acid, a selective astrocyte toxin, and paxilline, a k(ca) channel blocker. |
2008-03-27 |
2023-08-12 |
Not clear |
| M R Bennett, L Farnell, W G Gibso. Origins of blood volume change due to glutamatergic synaptic activity at astrocytes abutting on arteriolar smooth muscle cells. Journal of theoretical biology. vol 250. issue 1. 2008-03-19. PMID:17920632. |
coupling from glutamatergic synapses to smooth muscle cells of arterioles is effected by astrocytes releasing epoxyeicosatrienoic acids (eets) onto them, following glutamate stimulation of the astrocyte. |
2008-03-19 |
2023-08-12 |
Not clear |
| Tore Eid, Anne Williamson, Tih-Shih W Lee, Ognen A Petroff, Nihal C de Laneroll. Glutamate and astrocytes--key players in human mesial temporal lobe epilepsy? Epilepsia. vol 49 Suppl 2. 2008-03-14. PMID:18226171. |
moreover, it appears that glial cells, particularly the astrocyte, may play a key role in the glutamate overflow in mtle. |
2008-03-14 |
2023-08-12 |
human |
| Yanrong Shi, Xiaoguang Liu, Debebe Gebremedhin, John R Falck, David R Harder, Raymond C Koehle. Interaction of mechanisms involving epoxyeicosatrienoic acids, adenosine receptors, and metabotropic glutamate receptors in neurovascular coupling in rat whisker barrel cortex. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 28. issue 1. 2008-03-10. PMID:17519974. |
adenosine, astrocyte metabotropic glutamate receptors (mglurs), and epoxyeicosatrienoic acids (eets) have been implicated in neurovascular coupling. |
2008-03-10 |
2023-08-12 |
rat |
| Lúcia Maria Vieira de Almeida, Cristopher Celintano Piñeiro, Marina Concli Leite, Giovanna Brolese, Francine Tramontina, Ana Maria Feoli, Carmen Gottfried, Carlos-Alberto Gonçalve. Resveratrol increases glutamate uptake, glutathione content, and S100B secretion in cortical astrocyte cultures. Cellular and molecular neurobiology. vol 27. issue 5. 2008-01-22. PMID:17554623. |
resveratrol increases glutamate uptake, glutathione content, and s100b secretion in cortical astrocyte cultures. |
2008-01-22 |
2023-08-12 |
rat |
| Lúcia Maria Vieira de Almeida, Cristopher Celintano Piñeiro, Marina Concli Leite, Giovanna Brolese, Francine Tramontina, Ana Maria Feoli, Carmen Gottfried, Carlos-Alberto Gonçalve. Resveratrol increases glutamate uptake, glutathione content, and S100B secretion in cortical astrocyte cultures. Cellular and molecular neurobiology. vol 27. issue 5. 2008-01-22. PMID:17554623. |
typical polygonal morphology becomes stellated when astrocyte cultures were exposed to 250 microm resveratrol for 24 h. at concentration of 25 microm, resveratrol was able to increase glutamate uptake and glutathione content. |
2008-01-22 |
2023-08-12 |
rat |
| Ling-Hui Zeng, Yannan Ouyang, Vered Gazit, John R Cirrito, Laura A Jansen, Kevin C Ess, Kelvin A Yamada, David F Wozniak, David M Holtzman, David H Gutmann, Michael Won. Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex. Neurobiology of disease. vol 28. issue 2. 2008-01-11. PMID:17714952. |
mice with inactivation of the tuberous sclerosis complex-1 (tsc1) gene in glia (tsc1 gfap cko mice) have deficient astrocyte glutamate transporters and develop seizures, suggesting that abnormal glutamate homeostasis contributes to neurological abnormalities in these mice. |
2008-01-11 |
2023-08-12 |
mouse |
| Hong Z Yin, Darryl T Tang, John H Weis. Intrathecal infusion of a Ca(2+)-permeable AMPA channel blocker slows loss of both motor neurons and of the astrocyte glutamate transporter, GLT-1 in a mutant SOD1 rat model of ALS. Experimental neurology. vol 207. issue 2. 2008-01-08. PMID:17719032. |
intrathecal infusion of a ca(2+)-permeable ampa channel blocker slows loss of both motor neurons and of the astrocyte glutamate transporter, glt-1 in a mutant sod1 rat model of als. |
2008-01-08 |
2023-08-12 |
rat |