| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Diane B Re, Imane Nafia, Christophe Melon, Keiko Shimamoto, Lydia Kerkerian-Le Goff, Laurence Had-Aissoun. Glutamate leakage from a compartmentalized intracellular metabolic pool and activation of the lipoxygenase pathway mediate oxidative astrocyte death by reversed glutamate transport. Glia. vol 54. issue 1. 2006-07-27. PMID:16673373. |
these data strongly suggest that reversed uptake-mediated astrocyte death results from the leakage of glutamate from a compartmentalized intracellular metabolic pool specifically fuelled by eaat, crucial for preserving gsh contents. |
2006-07-27 |
2023-08-12 |
Not clear |
| Shilpa P Rao, S K Sikda. Astrocytes in 17beta-estradiol treated mixed hippocampal cultures show attenuated calcium response to neuronal activity. Glia. vol 53. issue 8. 2006-06-22. PMID:16565986. |
([ca(2+)](i)) rise in astrocytes in response to local application of the metabotropic glutamate receptor (mglur) agonist t-acpd was attenuated in estradiol treated cultures, suggesting functional changes in the astrocyte mglur following 24-h treatment with estradiol. |
2006-06-22 |
2023-08-12 |
Not clear |
| A R Jayakumar, K S Panickar, Ch R K Murthy, M D Norenber. Oxidative stress and mitogen-activated protein kinase phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 18. 2006-05-31. PMID:16672650. |
mechanisms mediating key aspects of ammonia-induced astrocyte dysfunction such as cell swelling and inhibition of glutamate uptake are not clear. |
2006-05-31 |
2023-08-12 |
Not clear |
| A R Jayakumar, K S Panickar, Ch R K Murthy, M D Norenber. Oxidative stress and mitogen-activated protein kinase phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 18. 2006-05-31. PMID:16672650. |
we now show that treatment with antioxidants significantly prevents ammonia-induced astrocyte swelling as well as glutamate uptake inhibition. |
2006-05-31 |
2023-08-12 |
Not clear |
| A R Jayakumar, K S Panickar, Ch R K Murthy, M D Norenber. Oxidative stress and mitogen-activated protein kinase phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 18. 2006-05-31. PMID:16672650. |
although sb239063 and sp600125 significantly reversed glutamate uptake inhibition and ammonia-induced decline in glutamate-aspartate transporter protein levels, uo126 did not, indicating a differential effect of these kinases in ammonia-induced astrocyte swelling and glutamate transport impairment. |
2006-05-31 |
2023-08-12 |
Not clear |
| Andrew Charle. Teaching resources. Glial intercellular waves. Science's STKE : signal transduction knowledge environment. vol 2005. issue 290. 2006-04-21. PMID:15985642. |
released glutamate is cotransported with na+ into neighboring cells; thus, glutamate uptake leads to an increase in astrocyte intracellular sodium concentration ([na+]i) that is also propagated from cell to cell. |
2006-04-21 |
2023-08-12 |
Not clear |
| Daniela Rossi, Liliana Brambilla, Chiara F Valori, Andrea Crugnola, Giorgio Giaccone, Raffaella Capobianco, Michela Mangieri, Ann E Kingston, Alain Bloc, Paola Bezzi, Andrea Volterr. Defective tumor necrosis factor-alpha-dependent control of astrocyte glutamate release in a transgenic mouse model of Alzheimer disease. The Journal of biological chemistry. vol 280. issue 51. 2006-04-04. PMID:16253995. |
defective tumor necrosis factor-alpha-dependent control of astrocyte glutamate release in a transgenic mouse model of alzheimer disease. |
2006-04-04 |
2023-08-12 |
mouse |
| Daniela Rossi, Liliana Brambilla, Chiara F Valori, Andrea Crugnola, Giorgio Giaccone, Raffaella Capobianco, Michela Mangieri, Ann E Kingston, Alain Bloc, Paola Bezzi, Andrea Volterr. Defective tumor necrosis factor-alpha-dependent control of astrocyte glutamate release in a transgenic mouse model of Alzheimer disease. The Journal of biological chemistry. vol 280. issue 51. 2006-04-04. PMID:16253995. |
acute inflammation in vitro, induced by adding reactive microglia to astrocyte cultures, enhances tnfalpha production and amplifies glutamate release, switching the pathway into a neurodamaging cascade (bezzi, p., domercq, m., brambilla, l., galli, r., schols, d., de clercq, e., vescovi, a., bagetta, g., kollias, g., meldolesi, j., and volterra, a. |
2006-04-04 |
2023-08-12 |
mouse |
| Nader Binesh, Amir Huda, M Albert Thomas, Nathaniel Wyckoff, Mary Bugbee, Steven Han, Natalie Rasgon, Pablo Davanzo, James Sayre, Barry Guze, Paul Martin, Fawzy Fawz. Hepatic encephalopathy: a neurochemical, neuroanatomical, and neuropsychological study. Journal of applied clinical medical physics. vol 7. issue 1. 2006-04-03. PMID:16518320. |
in summary, this study partially confirms a hypothesized mechanism of he pathogenesis, an increased synthesis of glutamine by brain glutamate in astrocytes due to excessive blood ammonia, followed by a compensatory loss of myo-inositol to maintain astrocyte volume homeostasis. |
2006-04-03 |
2023-08-12 |
Not clear |
| Andrew Charle. Reaching out beyond the synapse: glial intercellular waves coordinate metabolism. Science's STKE : signal transduction knowledge environment. vol 2005. issue 270. 2006-03-31. PMID:15701894. |
neuronal activity can stimulate an increase in astrocyte intracellular calcium concentration, which is propagated through neighboring astrocytes as a "calcium wave"; these calcium waves are accompanied by the release of glutamate. |
2006-03-31 |
2023-08-12 |
Not clear |
| Daniela Caccamo, Agata Campisi, Monica Currò, Mohammed Aguennouz, Giovanni Li Volti, Roberto Avola, Riccardo Ientil. Nuclear factor-kappab activation is associated with glutamate-evoked tissue transglutaminase up-regulation in primary astrocyte cultures. Journal of neuroscience research. vol 82. issue 6. 2006-03-14. PMID:16273541. |
we have previously demonstrated that alterations of cell redox state, evoked by glutamate, are associated with tissue transglutaminase increases in primary astrocyte cultures. |
2006-03-14 |
2023-08-12 |
Not clear |
| Daniela Caccamo, Agata Campisi, Monica Currò, Mohammed Aguennouz, Giovanni Li Volti, Roberto Avola, Riccardo Ientil. Nuclear factor-kappab activation is associated with glutamate-evoked tissue transglutaminase up-regulation in primary astrocyte cultures. Journal of neuroscience research. vol 82. issue 6. 2006-03-14. PMID:16273541. |
these preliminary data suggest that nf-kappab activation, which has been demonstrated to be involved in astrocyte response to glutamate, could also be associated with the molecular pathway leading to glutamate-evoked tissue transglutaminase up-regulation. |
2006-03-14 |
2023-08-12 |
Not clear |
| Raima Larter, Melissa Glendening Crai. Glutamate-induced glutamate release: a proposed mechanism for calcium bursting in astrocytes. Chaos (Woodbury, N.Y.). vol 15. issue 4. 2006-03-14. PMID:16396604. |
the glutamate feedback process considered here is shown to be critical for the generation of complex bursting oscillations in the astrocytes and to, perhaps, code for information which may be passed from neuron to neuron via the astrocyte. |
2006-03-14 |
2023-08-12 |
Not clear |
| Didier De Saint Jan, Gary L Westbroo. Detecting activity in olfactory bulb glomeruli with astrocyte recording. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 11. 2006-03-13. PMID:15772351. |
the astrocyte k+ current was dependent on ampa and nmda receptors in mitral/tufted cells as well as on a previously undescribed metabotropic glutamate receptor 1 component. |
2006-03-13 |
2023-08-12 |
Not clear |
| Raymond C Koehler, Debebe Gebremedhin, David R Harde. Role of astrocytes in cerebrovascular regulation. Journal of applied physiology (Bethesda, Md. : 1985). vol 100. issue 1. 2006-02-01. PMID:16357084. |
the increase in astrocyte calcium after neuronal activation is mediated, in part, by activation of metabotropic glutamate receptors. |
2006-02-01 |
2023-08-12 |
Not clear |
| Ning Kang, Jun Xu, Qiwu Xu, Maiken Nedergaard, Jian Kan. Astrocytic glutamate release-induced transient depolarization and epileptiform discharges in hippocampal CA1 pyramidal neurons. Journal of neurophysiology. vol 94. issue 6. 2006-01-25. PMID:16162834. |
the neuronal stc is mediated by ionotropic glutamate receptors leading to the td and epileptiform discharges; while the astrocytic tc is a glutamate reuptake current resulting from transporting released glutamate into the patched astrocyte. |
2006-01-25 |
2023-08-12 |
Not clear |
| Daniela Caccamo, Agata Campisi, Monica Currò, Vincenzo Bramanti, Michelangelo Tringali, Giovanni Li Volti, Angelo Vanella, Riccardo Ientil. Antioxidant treatment inhibited glutamate-evoked NF-kappaB activation in primary astroglial cell cultures. Neurotoxicology. vol 26. issue 5. 2005-12-22. PMID:15894376. |
altogether, these data confirm that the nf-kappab pathway is involved in cell response to oxidative stress induced by glutamate injury in primary astrocyte cultures, and suggest that the use of antioxidants, such as irfi 016, may be a helpful pharmacological strategy for neuroprotection. |
2005-12-22 |
2023-08-12 |
Not clear |
| Yun Zhang, Gang H. [Iptakalim enhances astrocytic glutamate uptake activity]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 39. issue 12. 2005-12-14. PMID:15813025. |
to investigate the effect of iptakalim (ipt), a novel atp-sensitive potassium channel opener (katpco), on astrocyte glutamate uptake activity. |
2005-12-14 |
2023-08-12 |
Not clear |
| Dieter Häussinger, Freimut Schlies. Astrocyte swelling and protein tyrosine nitration in hepatic encephalopathy. Neurochemistry international. vol 47. issue 1-2. 2005-09-01. PMID:15908046. |
recent findings suggest a close interrelation between astrocyte swelling, nmda receptor signaling, glutamate, oxidative stress and nitric oxide, which may result in mutual amplification of swelling and oxidative stress. |
2005-09-01 |
2023-08-12 |
Not clear |
| Jaekwang Lee, M Tommerdahl, O V Favorov, B L Whitse. Optically recorded response of the superficial dorsal horn: dissociation from neuronal activity, sensitivity to formalin-evoked skin nociceptor activation. Journal of neurophysiology. vol 94. issue 1. 2005-08-16. PMID:15744009. |
these observations from slices from normal subjects are interpreted to indicate that the ois(dr) mainly reflects cell volume and light scattering changes associated with dh(s) astrocyte uptake of k+ and glutamate (glu). |
2005-08-16 |
2023-08-12 |
human |